SFR is a component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination []. It interacts with estrogen receptor alpha and may be a transcriptional modulator for estrogen receptor alpha [].
This entry includes Mei5 from budding yeasts and SFR1 from animals and fission yeasts. Although the fission yeast Swi5-Sfr1 complex is critical for homologous recombination repair, the budding yeast counterpart Sae3-Mei5 complex is meiosis-specific, interacts with Dmc1, and promotes assembly of Dmc1 on meiotic chromosomes [].SFR is a component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination []. Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologues, Rad51 and Dmc1 []. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.
