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Search results 1101 to 1179 out of 1179 for Grb10

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Type Details Score
Allele
Gigyf2<Gt(GC0143)Mist> | MGI:3853713
 
Name: GRB10 interacting GYF protein 2; gene trap GC0143, Telethon Institute of Genetics and Medicine
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(PST1188)Mfgc> | MGI:3868682
 
Name: GRB10 interacting GYF protein 2; gene trap PST1188, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(P147E09)Wrst> | MGI:3874751
 
Name: GRB10 interacting GYF protein 2; gene trap P147E09, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(IST12179B9)Tigm> | MGI:4119290
 
Name: GRB10 interacting GYF protein 2; gene trap IST12179B9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(A032B02)Wrst> | MGI:4335970
 
Name: GRB10 interacting GYF protein 2; gene trap A032B02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Gigyf2<tm1a(EUCOMM)Wtsi> | MGI:5000390
Name: GRB10 interacting GYF protein 2; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Gigyf2<Gt(E115G10)Wrst> | MGI:3896038
 
Name: GRB10 interacting GYF protein 2; gene trap E115G10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(IST14043E10)Tigm> | MGI:5209348
 
Name: GRB10 interacting GYF protein 2; gene trap IST14043E10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(IST13132E10)Tigm> | MGI:5151680
 
Name: GRB10 interacting GYF protein 2; gene trap IST13132E10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Gigyf2<em7Gpt> | MGI:7299575
Name: GRB10 interacting GYF protein 2; endonuclease-mediated mutation 7, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Gigyf2<Gt(PST11129)Mfgc> | MGI:3861472
 
Name: GRB10 interacting GYF protein 2; gene trap PST11129, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(AL0164)Wtsi> | MGI:3876989
 
Name: GRB10 interacting GYF protein 2; gene trap AL0164, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(EUCJ0016a02)Hmgu> | MGI:4874079
 
Name: GRB10 interacting GYF protein 2; gene trap EUCJ0016a02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(IST14647H2)Tigm> | MGI:5249047
 
Name: GRB10 interacting GYF protein 2; gene trap IST14647H2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(D033B10)Wrst> | MGI:3874648
 
Name: GRB10 interacting GYF protein 2; gene trap D033B10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(D089E05)Wrst> | MGI:3890262
 
Name: GRB10 interacting GYF protein 2; gene trap D089E05, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Gigyf2<Gt(IST13529A6)Tigm> | MGI:5173257
 
Name: GRB10 interacting GYF protein 2; gene trap IST13529A6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Genotype
Genotype
Symbol: Gigyf2/Gigyf2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
20980250 | -
First Author: Huang Q
Year: 2010
Journal: J Biol Chem
Title: Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4.
Volume: 285
Issue: 53
Pages: 42130-9
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Publication
10861285 | -
First Author: Blagitko N
Year: 2000
Journal: Hum Mol Genet
Title: Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.
Volume: 9
Issue: 11
Pages: 1587-95
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Publication
23246379 | -
First Author: Kazi JU
Year: 2013
Journal: Mol Oncol
Title: FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.
Volume: 7
Issue: 3
Pages: 402-18
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Strain
MGI:7471697 | C57BL/6N-Gigyf1<em1(IMPC)Bay>/BayMmucd
Attribute String: coisogenic
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Strain
MGI:7607511 | C57BL/6NJ-Gigyf1<em1(IMPC)Bay>/Mmmh
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6261004 | C57BL/6N-Gigyf2<tm1b(EUCOMM)Wtsi>/Bay
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6475357 | C57BL/6-Gigyf2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6143297 | C57BL/6N-Gigyf2<tm1a(EUCOMM)Wtsi> A<tm1Brd>/a/BayMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Gigyf2/Gigyf2<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gigyf1/Gigyf1
Background: C57BL/6N-Gigyf1/BayMmucd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gigyf2/Gigyf2
Background: C57BL/6N-Gigyf2/Bay
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gigyf2/Gigyf2<+>
Background: C57BL/6N-Gigyf2/Bay
Zygosity: ht
Has Mutant Allele: true
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Publication
22751931 | J:188802
First Author: Morita M
Year: 2012
Journal: Mol Cell Biol
Title: A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Volume: 32
Issue: 17
Pages: 3585-93
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Publication
36924980 | J:335507
     
First Author: Ding Z
Year: 2023
Journal: Biol Psychiatry
Title: Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.
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Protein
F2Z3X7
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
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Protein
Q3TS23
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
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Publication
15469846 | -
First Author: Lafuente EM
Year: 2004
Journal: Dev Cell
Title: RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.
Volume: 7
Issue: 4
Pages: 585-95
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Protein Domain
IPR035037 | Grb10_SH2
Type: Domain
Description: This entry represents the SH2 domain of Grb10.The Grb7 (growth factor receptor-bound 7) family includes Grb7, Grb10, and Grb14. These are adapter proteins mediating signal transduction from multiple cell surface receptors to diverse downstream pathways. They are composed of an N-terminal proline-rich domain, a Ras Associating-like (RA) domain, a Pleckstrin Homology (PH) domain, a PIR (phosphorylated insulin receptor interacting region) domain (also known as the family-specific BPS region), and a C-terminal SH2 domain []. Grb10 inhibits insulin receptor kinase activity and mediates insulin-stimulated degradation of the insulin receptor []. It binds to the regulatory kinase loop of the insulin receptor (IR) via its SH2 and BPS domains []. Grb10 is directly phosphorylated by mTORC1 and may participate in a feedback inhibition of the phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways [].
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Protein Domain
IPR039664 | GRB/APBB1IP
Type: Family
Description: Proteins in this entry consist of a Ras-associated (RA) domain, a PH domain, a family-specific BPS region, and a C-terminal SH2 domain. Grb7, Grb10 and Grb14 are paralogues that are also present in this entry []. These adapter proteins bind a variety of receptor tyrosine kinases, including the insulin and insulin-like growth factor-1 (IGF1) receptors. Grb10 and Grb14 are important tissue-specific negative regulators of insulin and IGF1 signaling based and may contribute to type 2 (non-insulin-dependent) diabetes in humans. RA-PH function as a single structural unit and is dimerized via a helical extension of the PH domain. The PH domain here are proposed to bind phosphoinositides non-cannonically and are unlikely to bind an activated GTPase []. This entry also includes APBB1IP (also known as RIAM), which functions in the signal transduction from Ras activation to actin cytoskeletal remodelling [].
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Publication
11239002 | J:67990
First Author: Wilson MD
Year: 2001
Journal: Nucleic Acids Res
Title: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.
Volume: 29
Issue: 6
Pages: 1352-65
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Publication
18057206 | J:127840
First Author: Chumley MJ
Year: 2007
Journal: J Neurosci
Title: EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis.
Volume: 27
Issue: 49
Pages: 13481-90
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Publication
17255342 | -
First Author: Kojima T
Year: 2007
Journal: Am J Pathol
Title: Proangiogenic role of ephrinB1/EphB1 in basic fibroblast growth factor-induced corneal angiogenesis.
Volume: 170
Issue: 2
Pages: 764-73
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Publication
19295152 | -
First Author: Petros TJ
Year: 2009
Journal: J Neurosci
Title: Specificity and sufficiency of EphB1 in driving the ipsilateral retinal projection.
Volume: 29
Issue: 11
Pages: 3463-74
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Publication
21235905 | -
First Author: Stein E
Year: 1997
Journal: Trends Cardiovasc Med
Title: Eph family receptors and ligands in vascular cell targeting and assembly.
Volume: 7
Issue: 8
Pages: 329-34
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Protein Domain
IPR042819 | EphB1_SAM
Type: Domain
Description: This entry represents the SAM (sterile alpha motif) domain of the EphB1 receptors. This domain, located in the cytoplasmic region of EphB1, is a potential C-terminal protein-protein interaction domain. In human vascular endothelial cells, it appears to mediate cell-cell initiated signal transduction via the binding of the adaptor protein GRB10 (growth factor) through its SH2 domain to a conserved tyrosine that is phosphorylated []. EphB1 receptors play a role in neurogenesis, in particular in regulation of proliferation and migration of neural progenitors in the hippocampus and in corneal neovascularization []; they are involved in converting the crossed retinal projection to ipsilateral retinal projection []. They may be potential targets in angiogenesis-related disorders [].
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Protein Domain
IPR039665 | PH_APBB1IP
Type: Domain
Description: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP) consists of a Ras-associated (RA) domain, a PH domain, a family-specific BPS region, and a C-terminal SH2 domain. Grb7, Grb10 and Grb14 are paralogues that are also present in this entry []. These adapter proteins bind a variety of receptor tyrosine kinases, including the insulin and insulin-like growth factor-1 (IGF1) receptors. Grb10 and Grb14 are important tissue-specific negative regulators of insulin and IGF1 signaling based and may contribute to type 2 (non-insulin-dependent) diabetes in humans. RA-PH function as a single structural unit and is dimerized via a helical extension of the PH domain. The PH domain here are proposed to bind phosphoinositides non-cannonically and are unlikely to bind an activated GTPase []. The tandem RA-PH domains are present in a second adapter-protein family, MRL proteins, Caenorhabditis elegansprotein MIG-1012, the mammalian proteins RIAM and lamellipodin and the Drosophila melanogasterprotein Pico12, all of which are Ena/VASP-binding proteins involved in actin-cytoskeleton rearrangement.PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane []. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
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Protein
S4R2K5
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Publication
17233582 | -
 
First Author: Lemmon MA
Year: 2007
Journal: Biochem Soc Symp
Title: Pleckstrin homology (PH) domains and phosphoinositides.
Issue: 74
Pages: 81-93
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Publication
23190452 | J:211541
First Author: Desbuquois B
Year: 2013
Journal: FEBS J
Title: Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins.
Volume: 280
Issue: 3
Pages: 794-816
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Protein
A2A555
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
A2ASX3
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
Q8R5A3
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
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Protein
F2Z3U3
Organism: Mus musculus/domesticus
Length: 1266  
Fragment?: false
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Protein
F2Z4B7
Organism: Mus musculus/domesticus
Length: 645  
Fragment?: false
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Protein
G5E867
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: false
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Protein
B1AYC9
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
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Publication
8776723 | J:327403
First Author: Dey BR
Year: 1996
Journal: Mol Endocrinol
Title: Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.
Volume: 10
Issue: 6
Pages: 631-41
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Publication
14724735 | J:86799
First Author: Monk D
Year: 2003
Journal: Mamm Genome
Title: Imprinted methylation profiles for proximal mouse chromosomes 11 and 7 as revealed by methylation-sensitive representational difference analysis.
Volume: 14
Issue: 12
Pages: 805-16
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Protein
A2ASX1
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
Q571B2
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: true
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Publication
18442417 | J:287669
 
First Author: Ramanathan P
Year: 2008
Journal: BMC Genomics
Title: Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice.
Volume: 9
Pages: 197
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Protein
A2ASX4
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
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Protein
Q03160
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
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Protein
Q9JLM9
Organism: Mus musculus/domesticus
Length: 538  
Fragment?: false
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Protein
A2ASX2
Organism: Mus musculus/domesticus
Length: 538  
Fragment?: false
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
14594214 | -
 
First Author: Cozier GE
Year: 2004
Journal: Curr Top Microbiol Immunol
Title: Membrane targeting by pleckstrin homology domains.
Volume: 282
Pages: 49-88
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Protein
Q8CBF3
Organism: Mus musculus/domesticus
Length: 984  
Fragment?: false
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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