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Search results 1 to 100 out of 20126 for Rest

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
key_1584471 | REST
Type: gene
Organism: Not Specified
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Gene
5978 | REST
Type: gene
Organism: human
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Gene
564772 | rest
Type: gene
Organism: zebrafish
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Gene
100425257 | REST
Type: gene
Organism: macaque, rhesus
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Gene
734016 | rest
Type: gene
Organism: frog, western clawed
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Gene
83618 | Rest
Type: gene
Organism: rat
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Gene
471235 | REST
Type: gene
Organism: chimpanzee
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Gene
482163 | REST
Type: gene
Organism: dog, domestic
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Gene
422623 | REST
Type: gene
Organism: chicken
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Protein Domain
IPR027757 | REST
Type: Family
Description: The Repressor Element-1 (RE-1) Silencing Transcription (REST) factor is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells [, ]. REST is involved in neural differentiation and in preservation of the neural phenotype. REST also plays a role in proliferation, although its effect differs depending on the cell type [].
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Protein Coding Gene
MGI:104897 | Rest
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
7697725 | J:24162
First Author: Chong JA
Year: 1995
Journal: Cell
Title: REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons.
Volume: 80
Issue: 6
Pages: 949-57
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Gene
55758 | RCOR3
Type: gene
Organism: human
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Gene
283248 | RCOR2
Type: gene
Organism: human
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Gene
23186 | RCOR1
Type: gene
Organism: human
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Gene
441644 | LOC441644
Type: gene
Organism: human
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Gene
100419092 | LOC100419092
Type: gene
Organism: human
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Publication
15907476 | J:98945
First Author: Ballas N
Year: 2005
Journal: Cell
Title: REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.
Volume: 121
Issue: 4
Pages: 645-57
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Publication
20346398 | J:164132
First Author: Ravanpay AC
Year: 2010
Journal: Mol Cell Neurosci
Title: Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation.
Volume: 44
Issue: 2
Pages: 178-89
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Publication
1916105 | J:320124
First Author: van der Rest M
Year: 1991
Journal: FASEB J
Title: Collagen family of proteins.
Volume: 5
Issue: 13
Pages: 2814-23
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Publication
23414932 | -
First Author: Negrini S
Year: 2013
Journal: Trends Cell Biol
Title: REST: an oncogene or a tumor suppressor?
Volume: 23
Issue: 6
Pages: 289-95
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Publication
12399542 | -
First Author: Lunyak VV
Year: 2002
Journal: Science
Title: Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.
Volume: 298
Issue: 5599
Pages: 1747-52
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Publication
19242417 | J:145959
First Author: Jørgensen HF
Year: 2009
Journal: Nature
Title: Is REST required for ESC pluripotency?
Volume: 457
Issue: 7233
Pages: E4-5; discussion E7
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Publication
19242418 | J:145958
First Author: Buckley NJ
Year: 2009
Journal: Nature
Title: Is REST a regulator of pluripotency?
Volume: 457
Issue: 7233
Pages: E5-6; discussion E7
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Protein
Q8VIG1
Organism: Mus musculus/domesticus
Length: 1082  
Fragment?: false
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Protein
F8V330
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Protein
Q60694
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: true
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Publication
25074806 | J:216215
First Author: Lee M
Year: 2014
Journal: J Cell Sci
Title: p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation.
Volume: 127
Issue: Pt 18
Pages: 4037-51
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Publication
28049845 | J:239534
First Author: Monaghan CE
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.
Volume: 114
Issue: 3
Pages: E406-E415
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Publication
24670762 | J:208883
First Author: Lu T
Year: 2014
Journal: Nature
Title: REST and stress resistance in ageing and Alzheimer's disease.
Volume: 507
Issue: 7493
Pages: 448-54
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Publication
18362916 | J:136051
First Author: Singh SK
Year: 2008
Journal: Nature
Title: REST maintains self-renewal and pluripotency of embryonic stem cells.
Volume: 453
Issue: 7192
Pages: 223-7
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Publication
29961578 | J:265659
First Author: Nakano Y
Year: 2018
Journal: Cell
Title: Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness.
Volume: 174
Issue: 3
Pages: 536-548.e21
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Publication
27819263 | J:242726
 
First Author: Mukherjee S
Year: 2016
Journal: Nat Commun
Title: REST regulation of gene networks in adult neural stem cells.
Volume: 7
Pages: 13360
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Publication
18354483 | J:134170
First Author: Westbrook TF
Year: 2008
Journal: Nature
Title: SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.
Volume: 452
Issue: 7185
Pages: 370-4
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Publication
22952733 | J:191661
First Author: Singh SK
Year: 2012
Journal: PLoS One
Title: Dynamic status of REST in the mouse ESC pluripotency network.
Volume: 7
Issue: 8
Pages: e43659
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Publication
29215012 | J:255076
First Author: Zhang D
Year: 2017
Journal: Nat Commun
Title: REST regulates the cell cycle for cardiac development and regeneration.
Volume: 8
Issue: 1
Pages: 1979
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Publication
26156633 | J:225823
First Author: Martin D
Year: 2015
Journal: Dev Biol
Title: REST represses a subset of the pancreatic endocrine differentiation program.
Volume: 405
Issue: 2
Pages: 316-27
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Publication
26745185 | J:229930
 
First Author: Nechiporuk T
Year: 2016
Journal: Elife
Title: The REST remodeling complex protects genomic integrity during embryonic neurogenesis.
Volume: 5
Pages: e09584
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Publication
16461918 | J:106059
First Author: Conaco C
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Reciprocal actions of REST and a microRNA promote neuronal identity.
Volume: 103
Issue: 7
Pages: 2422-7
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Publication
10734093 | J:61357
First Author: Grimes JA
Year: 2000
Journal: J Biol Chem
Title: The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.
Volume: 275
Issue: 13
Pages: 9461-7
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Publication
20351065 | J:158800
First Author: Kohyama J
Year: 2010
Journal: J Cell Biol
Title: BMP-induced REST regulates the establishment and maintenance of astrocytic identity.
Volume: 189
Issue: 1
Pages: 159-70
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Publication
18959480 | J:141079
First Author: Johnson R
Year: 2008
Journal: PLoS Biol
Title: REST regulates distinct transcriptional networks in embryonic and neural stem cells.
Volume: 6
Issue: 10
Pages: e256
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Publication
24861183 | J:214998
First Author: Tint GS
Year: 2014
Journal: Dev Neurosci
Title: Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed.
Volume: 36
Issue: 2
Pages: 132-42
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Publication
24291638 | J:210031
First Author: Bersten DC
Year: 2014
Journal: Biochim Biophys Acta
Title: Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs.
Volume: 1839
Issue: 1
Pages: 13-24
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Publication
34385258 | J:321932
First Author: Rovira M
Year: 2021
Journal: Genes Dev
Title: REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.
Volume: 35
Issue: 17-18
Pages: 1229-1242
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Publication
23022299 | J:190948
First Author: Okamura D
Year: 2012
Journal: Dev Biol
Title: REST and its downstream molecule Mek5 regulate survival of primordial germ cells.
Volume: 372
Issue: 2
Pages: 190-202
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Publication
16195345 | J:107105
First Author: Sun YM
Year: 2005
Journal: Mol Biol Cell
Title: Distinct profiles of REST interactions with its target genes at different stages of neuronal development.
Volume: 16
Issue: 12
Pages: 5630-8
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DO Term
DOID:1786 | adrenal rest tumor
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Publication
33211397 | J:309683
First Author: Aoki H
Year: 2021
Journal: Genes Cells
Title: Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of the vagal nerve.
Volume: 26
Issue: 2
Pages: 45-55
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Publication
26119235 | J:224858
First Author: Masserdotti G
Year: 2015
Journal: Cell Stem Cell
Title: Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes.
Volume: 17
Issue: 1
Pages: 74-88
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Publication
35418568 | J:324179
First Author: Li H
Year: 2022
Journal: Cell Death Dis
Title: Downregulation of REST in the cochlea contributes to age-related hearing loss via the p53 apoptosis pathway.
Volume: 13
Issue: 4
Pages: 343
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Publication
19201947 | J:146460
First Author: Jørgensen HF
Year: 2009
Journal: Development
Title: REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells.
Volume: 136
Issue: 5
Pages: 715-21
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Publication
25197063 | J:216366
First Author: Nesti E
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.
Volume: 111
Issue: 37
Pages: E3929-36
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Publication
26538656 | J:227048
First Author: Kim HJ
Year: 2015
Journal: J Neurosci
Title: REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II.
Volume: 35
Issue: 44
Pages: 14872-84
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Publication
27956497 | J:247285
First Author: Zhang D
Year: 2017
Journal: Nucleic Acids Res
Title: Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.
Volume: 45
Issue: 6
Pages: 3102-3115
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Publication
36282915 | J:330714
First Author: Cloud AS
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis.
Volume: 119
Issue: 44
Pages: e2205524119
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Publication
22241837 | J:181188
First Author: Aoki H
Year: 2012
Journal: Development
Title: Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis.
Volume: 139
Issue: 4
Pages: 667-77
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Publication
20969844 | J:167071
First Author: Mao CA
Year: 2011
Journal: Dev Biol
Title: Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development.
Volume: 349
Issue: 1
Pages: 90-9
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Publication
24752154 | J:215180
First Author: Seki M
Year: 2014
Journal: PLoS One
Title: A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells.
Volume: 9
Issue: 4
Pages: e95374
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Publication
21402785 | J:173970
First Author: Ren X
Year: 2011
Journal: Mol Cell Biol
Title: REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements.
Volume: 31
Issue: 10
Pages: 2100-10
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Publication
34542211 | J:322393
First Author: Kimura R
Year: 2022
Journal: Dev Dyn
Title: Detection of REST expression in the testis using epitope-tag knock-in mice generated by genome editing.
Volume: 251
Issue: 3
Pages: 525-535
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Publication
36230906 | J:330184
 
First Author: Tuomainen T
Year: 2022
Journal: Cells
Title: PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes.
Volume: 11
Issue: 19
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Publication
23029270 | J:191978
First Author: Martin D
Year: 2012
Journal: PLoS One
Title: Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival.
Volume: 7
Issue: 9
Pages: e45844
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Publication
32001620 | J:286246
First Author: Pajarillo E
Year: 2020
Journal: J Biol Chem
Title: The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity.
Volume: 295
Issue: 10
Pages: 3040-3054
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Publication
28285139 | J:251415
First Author: Kim M
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Regulation of REST levels overcomes dysregulation of neural stem cell differentiation caused by disruption of polyubiquitin gene Ubb.
Volume: 486
Issue: 1
Pages: 171-177
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Publication
25818501 | J:230341
First Author: Aoki H
Year: 2015
Journal: Genes Cells
Title: White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage.
Volume: 20
Issue: 5
Pages: 439-49
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Publication
33563726 | J:313796
First Author: Ryan BJ
Year: 2021
Journal: J Neurosci
Title: REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.
Volume: 41
Issue: 16
Pages: 3731-3746
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Publication
20085738 | J:157076
First Author: Yamada Y
Year: 2010
Journal: Cell Stem Cell
Title: Rest promotes the early differentiation of mouse ESCs but is not required for their maintenance.
Volume: 6
Issue: 1
Pages: 10-5
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Publication
25135772 | J:230224
First Author: Aoki H
Year: 2014
Journal: Genes Cells
Title: Neonatal lethality of neural crest cell-specific Rest knockout mice is associated with gastrointestinal distension caused by aberrations of myenteric plexus.
Volume: 19
Issue: 10
Pages: 723-42
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GXD Expression
GXD Expression
   
Probe: MGI:6182116
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191201
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Rest
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6182116
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191201
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Rest
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6182116
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191201
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Rest
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6182116
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191201
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Rest
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6182116
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191201
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Rest
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6182116
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191201
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Rest
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6182116
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191201
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Rest
Detected: true
Specimen Num: 7
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Publication
11092847 | -
First Author: van der Rest ME
Year: 2000
Journal: J Bacteriol
Title: Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Escherichia coli.
Volume: 182
Issue: 24
Pages: 6892-9
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Publication
27631609 | J:251150
First Author: Aoki H
Year: 2016
Journal: PLoS One
Title: Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells.
Volume: 11
Issue: 9
Pages: e0163042
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Publication
36130284 | J:330216
First Author: Li J
Year: 2022
Journal: Nucleic Acids Res
Title: The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity.
Volume: 50
Issue: 18
Pages: 10343-10359
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Protein Domain
IPR038280 | ResT_sf
Type: Homologous_superfamily
Description: Telomere resolvase ResT (protelomerase) catalyses the conversion of linear double-stranded DNA into hairpin telomeres [].
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Protein Domain
IPR032047 | Telomere_res
Type: Family
Description: Telomere resolvase ResT (protelomerase) catalyses the conversion of linear double-stranded DNA into hairpin telomeres [].
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Publication
24794437 | J:211802
First Author: Volvert ML
Year: 2014
Journal: Cell Rep
Title: MicroRNA targeting of CoREST controls polarization of migrating cortical neurons.
Volume: 7
Issue: 4
Pages: 1168-83
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GO Term
GO:0043336 | site-specific telomere resolvase activity
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Publication
33087486 | J:305017
 
First Author: Nakano Y
Year: 2020
Journal: Life Sci Alliance
Title: Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.
Volume: 3
Issue: 12
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Gene
480018 | RCOR3
Type: gene
Organism: dog, domestic
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Gene
612620 | RCOR1
Type: gene
Organism: dog, domestic
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Gene
457710 | RCOR3
Type: gene
Organism: chimpanzee
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Gene
467562 | RCOR1
Type: gene
Organism: chimpanzee
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Gene
742635 | RCOR2
Type: gene
Organism: chimpanzee
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Gene
305811 | Rcor2
Type: gene
Organism: rat
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Gene
684192 | Rcor3
Type: gene
Organism: rat
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Gene
483768 | RCOR2
Type: gene
Organism: dog, domestic
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Gene
506525 | RCOR1
Type: gene
Organism: cattle
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Gene
532635 | RCOR3
Type: gene
Organism: cattle
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Gene
541233 | RCOR2
Type: gene
Organism: cattle
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Gene
100612658 | LOC100612658
Type: gene
Organism: chimpanzee
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Gene
421380 | RCOR3
Type: gene
Organism: chicken
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Gene
428911 | RCOR1
Type: gene
Organism: chicken
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Gene
402934 | rcor2
Type: gene
Organism: zebrafish
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Gene
563808 | rcor3
Type: gene
Organism: zebrafish
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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