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Search results 201 to 291 out of 291 for Hcn3

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_10
Specimen Label: euxassay_002974_10
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_19
Specimen Label: euxassay_002974_19
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_20
Specimen Label: euxassay_002974_20
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_21
Specimen Label: euxassay_002974_21
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_22
Specimen Label: euxassay_002974_22
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_23
Specimen Label: euxassay_002974_23
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_24
Specimen Label: euxassay_002974_24
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_04
Specimen Label: euxassay_001127_04
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_05
Specimen Label: euxassay_001127_05
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_06
Specimen Label: euxassay_001127_06
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_22
Specimen Label: euxassay_001127_22
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_23
Specimen Label: euxassay_001127_23
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_05
Specimen Label: euxassay_002974_05
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_23
Specimen Label: euxassay_002974_23
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_07
Specimen Label: euxassay_001127_07
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_08
Specimen Label: euxassay_001127_08
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_20
Specimen Label: euxassay_001127_20
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_21
Specimen Label: euxassay_001127_21
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_07
Specimen Label: euxassay_002974_07
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_08
Specimen Label: euxassay_002974_08
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_20
Specimen Label: euxassay_002974_20
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_10
Specimen Label: euxassay_002974_10
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_11
Specimen Label: euxassay_002974_11
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_12
Specimen Label: euxassay_002974_12
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_13
Specimen Label: euxassay_002974_13
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_14
Specimen Label: euxassay_002974_14
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_15
Specimen Label: euxassay_002974_15
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_16
Specimen Label: euxassay_002974_16
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_17
Specimen Label: euxassay_002974_17
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_09
Specimen Label: euxassay_001127_09
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_10
Specimen Label: euxassay_001127_10
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825337
Age: embryonic day 14.5
Image: euxassay_001127_19
Specimen Label: euxassay_001127_19
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_09
Specimen Label: euxassay_002974_09
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1631161
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825336
Age: embryonic day 14.5
Image: euxassay_002974_19
Specimen Label: euxassay_002974_19
Detected: true
Specimen Num: 16
•
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•
Publication
31543264 | J:293042
First Author: Zhang J
Year: 2019
Journal: Cell
Title: Sour Sensing from the Tongue to the Brain.
Volume: 179
Issue: 2
Pages: 392-402.e15
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Publication
25042871 | J:321455
First Author: Honsa P
Year: 2014
Journal: Glia
Title: Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.
Volume: 62
Issue: 12
Pages: 2004-21
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Publication
9405696 | J:45084
First Author: Santoro B
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.
Volume: 94
Issue: 26
Pages: 14815-20
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Publication
30886335 | J:302698
First Author: Shao LX
Year: 2019
Journal: Mol Psychiatry
Title: Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.
Volume: 24
Issue: 10
Pages: 1461-1477
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Publication
21233488 | J:170717
First Author: Good CH
Year: 2011
Journal: FASEB J
Title: Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease.
Volume: 25
Issue: 4
Pages: 1333-44
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Publication
15564593 | J:96808
First Author: Santoro B
Year: 2004
Journal: J Neurosci
Title: Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.
Volume: 24
Issue: 47
Pages: 10750-62
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Publication
34429357 | J:309566
 
First Author: Schlusche AK
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.
Volume: 118
Issue: 35
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Publication
27956497 | J:247285
First Author: Zhang D
Year: 2017
Journal: Nucleic Acids Res
Title: Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.
Volume: 45
Issue: 6
Pages: 3102-3115
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Publication
29107716 | J:276621
 
First Author: Semmler J
Year: 2018
Journal: Pharmacol Res
Title: Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.
Volume: 128
Pages: 200-210
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Publication
35905011 | J:327332
 
First Author: Kurz J
Year: 2022
Journal: Development
Title: GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter.
Volume: 149
Issue: 15
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Publication
30916783 | J:279388
First Author: Weiss AC
Year: 2019
Journal: J Pathol
Title: Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme.
Volume: 248
Issue: 4
Pages: 452-463
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Publication
16985003 | J:119550
First Author: Harrell MD
Year: 2007
Journal: Physiol Genomics
Title: Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Volume: 28
Issue: 3
Pages: 273-83
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Hcn3<em1Csz> | MGI:6728131
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 3; endonuclease-mediated mutation 1, Charles S Zuker
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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HT Experiment
GSE228531 | Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 3 Promotes HCC Development in a Female-biased Manner
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GO Term
GO:0098855 | HCN channel complex
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Publication
31494281 | J:282586
 
First Author: Aladeokin AC
Year: 2019
Journal: Neurobiol Dis
Title: Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease.
Volume: 132
Pages: 104603
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Publication
30914453 | J:290282
 
First Author: Edling CE
Year: 2019
Journal: Biosci Rep
Title: Ageing in Pgc-1β-/- mice modelling mitochondrial dysfunction induces differential expression of a range of genes regulating ventricular electrophysiology.
Volume: 39
Issue: 4
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Publication
11459060 | -
First Author: Wainger BJ
Year: 2001
Journal: Nature
Title: Molecular mechanism of cAMP modulation of HCN pacemaker channels.
Volume: 411
Issue: 6839
Pages: 805-10
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Publication
15351778 | -
First Author: Gill CH
Year: 2004
Journal: Br J Pharmacol
Title: Characterization of the human HCN1 channel and its inhibition by capsazepine.
Volume: 143
Issue: 3
Pages: 411-21
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Publication
12161074 | -
First Author: Biel M
Year: 2002
Journal: Trends Cardiovasc Med
Title: Cardiac HCN channels: structure, function, and modulation.
Volume: 12
Issue: 5
Pages: 206-12
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Publication
11248683 | -
First Author: Moosmang S
Year: 2001
Journal: Eur J Biochem
Title: Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
Volume: 268
Issue: 6
Pages: 1646-52
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Publication
18953682 | -
First Author: Wahl-Schott C
Year: 2009
Journal: Cell Mol Life Sci
Title: HCN channels: structure, cellular regulation and physiological function.
Volume: 66
Issue: 3
Pages: 470-94
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Publication
11102480 | -
First Author: Petrecca K
Year: 2000
Journal: J Neurosci
Title: Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
Volume: 20
Issue: 23
Pages: 8736-44
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Publication
12923176 | J:113938
First Author: Sampson LJ
Year: 2003
Journal: J Biol Chem
Title: Direct interaction between the actin-binding protein filamin-A and the inwardly rectifying potassium channel, Kir2.1.
Volume: 278
Issue: 43
Pages: 41988-97
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Publication
15550252 | J:94775
First Author: Nolan MF
Year: 2004
Journal: Cell
Title: A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons.
Volume: 119
Issue: 5
Pages: 719-32
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Publication
14651847 | J:86763
First Author: Nolan MF
Year: 2003
Journal: Cell
Title: The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells.
Volume: 115
Issue: 5
Pages: 551-64
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Publication
15292205 | J:93990
First Author: Gravante B
Year: 2004
Journal: J Biol Chem
Title: Interaction of the pacemaker channel HCN1 with filamin A.
Volume: 279
Issue: 42
Pages: 43847-53
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Protein Domain
IPR030169 | K/Na_HCN1
Type: Family
Description: This entry represents HCN1, which belongs to the hyperpolarisation-activated cyclic nucleotide-gated (HCN) channel family. HCN1 is expressed in the brain, spinal cord, dorsal root ganglion and heart muscle []. It contributes to the native pacemaker currents in heart and in neurons [, , ]. It may be involved in motor learning and hippocampal-dependent network oscillation in mice [, ]. It binds to filaminA, a putative cytoplasmic scaffold protein that binds actin and links transmembrane proteins, such as the K+ channels Kv4.2 and Kir2.1, to the actin cytoskeleton [, , ].The hyperpolarisation-activated cation current (termed I(f), I(h), or I(q)) plays a key role in the initiation and modulation of cardiac and neuronal pacemaker depolarisations. This current is carried by both K+ and Na+ through I(h) or I(f) channels, such as members of the hyperpolarisation-activated cyclic nucleotide-gated (HCN) family. HCN channels belong to the superfamilyof voltage-gated pore loop channels. The voltage-dependent opening ofthe HCN channels is directly regulated by the binding ofcAMP. In vertebrates, the HCN channel family comprises four members (HCN1-4) []. Whereas HCN3 seems to be specifically expressed in neurons, the other three channels (HCN1, 2, and 4) have been detected in both heart and brain [, ]. HCN channels contain six membrane-spanning helices (S1-S6), including a positively charged voltage-sensing S4 segment and an ion-conducting pore between S5 and S6. In the C terminus the channels carry a cyclic nucleotide-binding domain (CNBD) []. Binding of cAMP to the CNBD speeds up channel opening and shifts the voltage-dependence of activation to more positive voltages []. HCN channels exhibit weak selectivity for potassium over sodium ions.
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Protein
O88704
Organism: Mus musculus/domesticus
Length: 910  
Fragment?: false
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