Class E basic helix-loop-helix protein 22 (Bhlhe22, also known as Bhlhb5) is a neural-specific basic helix-loop-helix (bHLH) transcription factor. It is required for the subtype development of retinal amacrine and bipolar cells in mice [, ]. It is required for the survival of a specific population of inhibitory interneurons that regulate pruritus []. Bhlhb5 and Prdm8 form a repressor complex that directs neural circuit assembly [].
