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Search results 201 to 249 out of 249 for Atxn2

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Type Details Score
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Allele
Tg(ATXN2*72Q)#Plt | MGI:5697198
Name: transgene insertion, Stefan M Pulst
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Atxn2<em1Smoc> | MGI:7288408
Name: ataxin 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
33802796 | -
 
First Author: López-Juárez ZM
Year: 2021
Journal: Int J Mol Sci
Title: The ATXN2 Orthologs CID3 and CID4, Act Redundantly to In-Fluence Developmental Pathways throughout the Life Cycle of Arabidopsis thaliana.
Volume: 22
Issue: 6
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Genotype
Genotype
Symbol: Tg(ATXN2*72Q)#Plt/?
Background: FVB/N-Tg(ATXN2*72Q)#Plt
Zygosity: ot
Has Mutant Allele: true
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Interaction Experiment
Halbach MV (2015)
Description: Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.
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Allele
Atxn2<tm2.1Aub> | MGI:5467982
Name: ataxin 2; targeted mutation 2.1, Georg Auburger
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Tg(Pcp2-ATXN2*127Q)#Plt | MGI:5467321
Name: transgene insertion, Stefan M Pulst
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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DO Term
DOID:0060204 | amyotrophic lateral sclerosis type 13
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HT Experiment
E-GEOD-39640 | ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice
Series Id: GSE39640
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Transgene
MGI:5697197 | Tg(ATXN2*72Q)#Plt
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5467322 | Tg(Pcp2-ATXN2*127Q)#Plt
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(Pcp2-ATXN2*127Q)#Plt/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atxn2/Atxn2
Background: B6.129S2-Atxn2
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0050955 | spinocerebellar ataxia type 2
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HT Experiment
E-GEOD-55177 | Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth
Series Id: GSE55177
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE57998 | Ataxin-2 modulates mRNA levels of proteins in ribosomal large and small subunit and in translation initiation complex
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
28405024 | J:252524
First Author: Scoles DR
Year: 2017
Journal: Nature
Title: Antisense oligonucleotide therapy for spinocerebellar ataxia type 2.
Volume: 544
Issue: 7650
Pages: 362-366
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Strain
MGI:5697199 | FVB/N-Tg(ATXN2*72Q)#Plt
Attribute String: coisogenic, mutant strain, transgenic
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Protein Domain
IPR025852 | SM_dom_ATX
Type: Domain
Description: This SM domain is found in Ataxin-2 [, ]. This domain has been shown to interact with RNA helicase DDX6 [].Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].
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Protein
J3QP59
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
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Publication
17392519 | -
First Author: Nonhoff U
Year: 2007
Journal: Mol Biol Cell
Title: Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
Volume: 18
Issue: 4
Pages: 1385-96
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Protein
Q7TQH0
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: false
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Protein
A0A0U1RPL0
Organism: Mus musculus/domesticus
Length: 1096  
Fragment?: false
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Protein
E9Q5Q0
Organism: Mus musculus/domesticus
Length: 863  
Fragment?: true
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Protein
Q3TYH7
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
Q3TGG2
Organism: Mus musculus/domesticus
Length: 994  
Fragment?: false
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Publication
9462862 | -
First Author: Neuwald AF
Year: 1998
Journal: J Mol Med (Berl)
Title: Ataxin-2, global regulators of bacterial gene expression, and spliceosomal snRNP proteins share a conserved domain.
Volume: 76
Issue: 1
Pages: 3-5
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Publication
9819425 | -
First Author: Mangus DA
Year: 1998
Journal: Mol Cell Biol
Title: Pbp1p, a factor interacting with Saccharomyces cerevisiae poly(A)-binding protein, regulates polyadenylation.
Volume: 18
Issue: 12
Pages: 7383-96
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Publication
15121841 | -
First Author: Mangus DA
Year: 2004
Journal: Mol Cell Biol
Title: Identification of factors regulating poly(A) tail synthesis and maturation.
Volume: 24
Issue: 10
Pages: 4196-206
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Publication
30982600 | -
First Author: Yang YS
Year: 2019
Journal: Cell
Title: Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth.
Volume: 177
Issue: 3
Pages: 697-710.e17
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Publication
18981231 | -
First Author: Buchan JR
Year: 2008
Journal: J Cell Biol
Title: P bodies promote stress granule assembly in Saccharomyces cerevisiae.
Volume: 183
Issue: 3
Pages: 441-55
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Protein
A0A0U1RNZ9
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Publication
11917006 | -
First Author: Anantharaman V
Year: 2002
Journal: Nucleic Acids Res
Title: Comparative genomics and evolution of proteins involved in RNA metabolism.
Volume: 30
Issue: 7
Pages: 1427-64
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Publication
16115810 | -
First Author: Ralser M
Year: 2005
Journal: Hum Mol Genet
Title: Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
Volume: 14
Issue: 19
Pages: 2893-909
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Protein Domain
IPR009604 | LsmAD_domain
Type: Domain
Description: This domain can be found in eukaryotic ataxin-2 []. Ataxin-2 is predicted to consist of mostly non-globular domains []. This domain has been shown to interact with RNA helicase DDX6 [].Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].Proteins containing this domain also include Pbp1 from budding yeasts, Pbp1 interacts with Pab1 to regulate mRNA polyadenylation [, ]. It promotes mating-type switching in mother cells by positively regulating HO mRNA translation []and forms a condensate in response to respiratory status to regulate TORC1 signaling []. It is also involved in P-body-dependent granule assembly [].
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Protein Domain
IPR045117 | ATXN2-like
Type: Family
Description: This entry represents a group of RNA-binding proteins , including Ataxin-2 from animals, Pbp1 from fungi and Cid3/4 from Arabidopsis.Ataxin-2 has many functions, such as endocytic receptor cycling [], translational regulation, embryonic development [], energy metabolism and weight regulation []. Mutations of the Ataxin-2 gene cause spinocerebellar ataxia 2 (SCA2), a neurodegenerative disorder leading to predominant loss of Purkinje cells in the cerebellum and impairment of motor coordination []. In SCA2, expansion of a CAG repeat in exon 1 of the Ataxin-2 (ATXN2) gene causes expansion of a polyQ domain in the ATXN2 protein []. ATXN2 has been shown to interact with many proteins. It interacts with multiple RNA-binding proteins (RBPs), staufen, IP3R, RGS8 mRNA, endophilins and CIN85 [].Pbp1 interacts with Pab1 to regulate mRNA polyadenylation [, ]. It promotes mating-type switching in mother cells by positively regulating HO mRNA translation []and forms a condensate in response to respiratory status to regulate TORC1 signalling []. It is also involved in P-body-dependent granule assembly [].Cid3/4 may have a role in developmental pathways throughout the life cycle of plants [].
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Publication
29556029 | J:261673
First Author: White MA
Year: 2018
Journal: Nat Neurosci
Title: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.
Volume: 21
Issue: 4
Pages: 552-563
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Publication
27240544 | J:253882
First Author: Lastres-Becker I
Year: 2016
Journal: Biochim Biophys Acta
Title: Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation.
Volume: 1862
Issue: 9
Pages: 1558-69
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HT Experiment
E-GEOD-54418 | Dysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue
Series Id: GSE54418
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
32698485 | J:294770
 
First Author: Key J
Year: 2020
Journal: Int J Mol Sci
Title: Mid-Gestation lethality of Atxn2l-Ablated Mice.
Volume: 21
Issue: 14
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Publication
15082763 | -
First Author: Tadauchi T
Year: 2004
Journal: Mol Cell Biol
Title: Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex.
Volume: 24
Issue: 9
Pages: 3670-81
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Publication
22914732 | J:188775
First Author: Scoles DR
Year: 2012
Journal: Hum Mol Genet
Title: ETS1 regulates the expression of ATXN2.
Volume: 21
Issue: 23
Pages: 5048-65
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