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Search results 1301 to 1396 out of 1396 for Gcg

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Type Details Score
Allele
Gcg<tm1.1(cre/GFP)Rpa> | MGI:5896316
Name: glucagon; targeted mutation 1.1, Richard D Palmiter
Allele Type: Targeted
Attribute String: Recombinase, Reporter
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Allele
Malt1<tm2Jrld> | MGI:5752604
 
Name: MALT1 paracaspase; targeted mutation 2, Jurgen Ruland
Allele Type: Targeted
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Allele
Dpysl2<em1Rkha> | MGI:6712639
Name: dihydropyrimidinase-like 2; endonuclease-mediated mutation 1, Rajesh Khanna
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Strain
MGI:6865952 | C57BL/6J-Tg(Gcg-cre)1Mmsc/Mmmh
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Top6bl<em1Bdm> | MGI:6367799
Name: TOP6B like initiator of meiotic double strand breaks; endonuclease-mediated mutation 1, Bernard de Massy
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Aars1<tm1.1Slac> | MGI:5614439
Name: alanyl-tRNA synthetase 1; targeted mutation 1.1, Susan L Ackerman
Allele Type: Targeted
Attribute String: Hypomorph, Inducible
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Strain
MGI:5896321 | B6.Cg-Gcg<tm1.1(cre/GFP)Rpa>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Gcg<tm1(cre/ERT2)Cshi> | MGI:7439833
Name: glucagon; targeted mutation 1, Chiyo Shiota
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Src<tm2Goka> | MGI:7524671
 
Name: Rous sarcoma oncogene; targeted mutation 2, Goro Kato
Allele Type: Targeted
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Allele
Malt1<tm2.1Jrld> | MGI:5752611
 
Name: MALT1 paracaspase; targeted mutation 2.1, Jurgen Ruland
Allele Type: Targeted
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Allele
Malt1<em2Krad> | MGI:7571554
 
Name: MALT1 paracaspase; endonuclease-mediated mutation 2, Daniel Krappmann
Allele Type: Endonuclease-mediated
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Publication
32569093 | J:305668
First Author: Moutal A
Year: 2020
Journal: Pain
Title: Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain.
Volume: 161
Issue: 11
Pages: 2629-2651
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Publication
33478555 | J:303868
First Author: Gomez K
Year: 2021
Journal: Mol Brain
Title: Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15.
Volume: 14
Issue: 1
Pages: 20
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Allele
Celf1<tm1Timc> | MGI:6144284
 
Name: CUGBP, Elav-like family member 1; targeted mutation 1, Nikolai A Timchenko
Allele Type: Targeted
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Genotype
Genotype
Symbol: Aars1/Aars1<+>
Background: involves: C57BL/6J * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aars1/Aars1
Background: involves: C57BL/6J * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Publication
33169188 | J:302480
First Author: Vastagh C
Year: 2021
Journal: Brain Struct Funct
Title: Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and optogenetics.
Volume: 226
Issue: 1
Pages: 105-120
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Allele
Tg(Gcg-icre)12Fmgb | MGI:5432481
Name: transgene insertion 12, Fiona M Gribble
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Arx<tm4Kki> | MGI:4359177
Name: aristaless related homeobox; targeted mutation 4, Kunio Kitamura
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Src<tm2.1Goka> | MGI:7442897
 
Name: Rous sarcoma oncogene; targeted mutation 2.1, Goro Kato
Allele Type: Targeted
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Strain
MGI:6353224 | B6NCrSlc.129S-Src<tm2Goka>/GokaRbrc
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Cebpb<tm1Aki> | MGI:4362073
Name: CCAAT/enhancer binding protein beta; targeted mutation 1, Shizuo Akira
Allele Type: Targeted
Attribute String: Modified isoform(s)
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Publication
35675406 | J:326126
First Author: Huang Z
Year: 2022
Journal: Sci Adv
Title: Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism.
Volume: 8
Issue: 23
Pages: eabn5345
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Allele
Tg(Gcg-icre)23Cshi | MGI:5529611
Name: transgene insertion 23, Chiyo Shiota
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
28559429 | J:244612
 
First Author: Lewis K
Year: 2017
Journal: Mol Cell Biol
Title: RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.
Volume: 37
Issue: 16
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Publication
28535186 | J:245787
First Author: Valanejad L
Year: 2017
Journal: Carcinogenesis
Title: FXR-Gankyrin axis is involved in development of pediatric liver cancer.
Volume: 38
Issue: 7
Pages: 738-747
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Strain
MGI:6145584 | STOCK Arx<tm4Kki>/2Rbrc
Attribute String: mutant stock, targeted mutation
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Strain
MGI:6145582 | 129S-Arx<tm4Kki>/Rbrc
Attribute String: targeted mutation, mutant strain, coisogenic
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Strain
MGI:6145583 | B6;129-Arx<tm4Kki>/7-2Rbrc
Attribute String: mutant stock, targeted mutation
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Strain
MGI:6145581 | B6;129-Arx<tm4Kki>/7-1Rbrc
Attribute String: mutant stock, targeted mutation
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Strain
MGI:6145592 | STOCK Arx<tm(GCG)Kki>/7-2Rbrc
Attribute String: mutant stock, targeted mutation
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Publication
22628459 | J:210152
First Author: Beguin S
Year: 2013
Journal: Cereb Cortex
Title: An epilepsy-related ARX polyalanine expansion modifies glutamatergic neurons excitability and morphology without affecting GABAergic neurons development.
Volume: 23
Issue: 6
Pages: 1484-94
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Allele
Gcg<tm1.1(icre)Gkg> | MGI:5898434
Name: glucagon; targeted mutation 1.1, George K Gittes
Allele Type: Targeted
Attribute String: Recombinase
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Publication
36396648 | J:331787
First Author: Nore A
Year: 2022
Journal: Nat Commun
Title: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
Volume: 13
Issue: 1
Pages: 7048
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Genotype
Genotype
Symbol: Arx/?
Background: involves: 129S/SvEv * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cebpb/Cebpb
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Arx/?
Background: involves: 129S/SvEv * C57BL/6NHsd
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Arx/Arx
Background: involves: 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
17911624 | J:153025
First Author: Uematsu S
Year: 2007
Journal: J Immunol
Title: The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing.
Volume: 179
Issue: 8
Pages: 5378-86
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Publication
29898400 | J:270771
First Author: Briant LJB
Year: 2018
Journal: Cell Rep
Title: CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
Volume: 23
Issue: 11
Pages: 3300-3311
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Strain
MGI:5898438 | B6;129S-Gcg<tm1.1(icre)Gkg>/J
Attribute String: targeted mutation, mutant stock
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Genotype
Genotype
Symbol: Aars1/Aars1
Background: involves: C57BL/6J * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Gcg-icre)23Cshi/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Publication
32041793 | J:286997
First Author: Lund ML
Year: 2020
Journal: Diabetes
Title: L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling.
Volume: 69
Issue: 4
Pages: 614-623
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Publication
24237703 | J:302347
First Author: Wichmann A
Year: 2013
Journal: Cell Host Microbe
Title: Microbial modulation of energy availability in the colon regulates intestinal transit.
Volume: 14
Issue: 5
Pages: 582-90
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Publication
25422440 | J:216802
First Author: Liu Y
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy.
Volume: 111
Issue: 49
Pages: 17570-5
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Publication
23515163 | J:196449
First Author: Satoh T
Year: 2013
Journal: Nature
Title: Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.
Volume: 495
Issue: 7442
Pages: 524-8
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Publication
22095691 | J:180600
First Author: Hirata M
Year: 2012
Journal: Hum Mol Genet
Title: C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.
Volume: 21
Issue: 5
Pages: 1111-23
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Publication
26166562 | J:224840
First Author: Solloway MJ
Year: 2015
Journal: Cell Rep
Title: Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass.
Volume: 12
Issue: 3
Pages: 495-510
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Publication
33239450 | J:307110
First Author: Bozadjieva Kramer N
Year: 2021
Journal: Diabetes
Title: Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia.
Volume: 70
Issue: 2
Pages: 477-491
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Publication
24487799 | J:306019
First Author: Sunnen CN
Year: 2014
Journal: J Neuropathol Exp Neurol
Title: Arx is required for specification of the zona incerta and reticular nucleus of the thalamus.
Volume: 73
Issue: 3
Pages: 253-61
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Publication
24315372 | J:206136
First Author: Zhang Q
Year: 2013
Journal: Cell Metab
Title: Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.
Volume: 18
Issue: 6
Pages: 871-82
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Publication
35094084 | J:334646
First Author: Drongitis D
Year: 2022
Journal: Hum Mol Genet
Title: Deregulation of microtubule organization and RNA metabolism in Arx models for lissencephaly and developmental epileptic encephalopathy.
Volume: 31
Issue: 11
Pages: 1884-1908
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Publication
29050859 | J:269795
 
First Author: Tai J
Year: 2018
Journal: Brain Res
Title: Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease.
Volume: 1678
Pages: 64-74
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Publication
33459136 | J:345481
First Author: Springer MZ
Year: 2021
Journal: Autophagy
Title: BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
Volume: 17
Issue: 11
Pages: 3530-3546
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Publication
25205821 | J:217822
First Author: Barnes TM
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Interleukin-6 amplifies glucagon secretion: coordinated control via the brain and pancreas.
Volume: 307
Issue: 10
Pages: E896-905
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Publication
31673703 | J:284596
 
First Author: Nason SR
Year: 2020
Journal: Endocrinology
Title: Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression.
Volume: 161
Issue: 1
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Publication
23183186 | J:194205
First Author: Chiang YA
Year: 2013
Journal: Endocrinology
Title: P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice.
Volume: 154
Issue: 1
Pages: 77-88
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Publication
11401471 | J:68635
First Author: Lin CT
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Generation and analysis of canine retinal ESTs: isolation and expression of retina-specific gene transcripts.
Volume: 282
Issue: 2
Pages: 394-403
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Publication
18854429 | J:145624
First Author: Islam D
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines.
Volume: 296
Issue: 1
Pages: E174-81
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Publication
30772257 | J:302348
 
First Author: Beaudry JL
Year: 2019
Journal: Mol Metab
Title: The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.
Volume: 22
Pages: 37-48
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Publication
30694690 | J:275109
First Author: Dickerson MT
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion.
Volume: 316
Issue: 4
Pages: E646-E659
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Publication
23115082 | J:195945
First Author: Pedersen J
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Glucose metabolism is altered after loss of L cells and α-cells but not influenced by loss of K cells.
Volume: 304
Issue: 1
Pages: E60-73
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Publication
36368622 | J:334203
 
First Author: Zheng H
Year: 2022
Journal: Mol Metab
Title: A Cre-driver rat model for anatomical and functional analysis of glucagon (Gcg)-expressing cells in the brain and periphery.
Volume: 66
Pages: 101631
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Publication
25762440 | J:221349
First Author: Vourekas A
Year: 2015
Journal: Genes Dev
Title: The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.
Volume: 29
Issue: 6
Pages: 617-29
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Publication
28627419 | J:243952
 
First Author: Lee K
Year: 2017
Journal: Neuroscience
Title: ARX polyalanine expansion mutations lead to migration impediment in the rostral cortex coupled with a developmental deficit of calbindin-positive cortical GABAergic interneurons.
Volume: 357
Pages: 220-231
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Publication
33711494 | J:307693
 
First Author: Loring KE
Year: 2021
Journal: Neurobiol Dis
Title: Early 17β-estradiol treatment reduces seizures but not abnormal behaviour in mice with expanded polyalanine tracts in the Aristaless related homeobox gene (ARX).
Volume: 153
Pages: 105329
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Publication
27798109 | J:241394
First Author: Mattiske T
Year: 2016
Journal: Hum Mol Genet
Title: Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.
Volume: 25
Issue: 24
Pages: 5433-5443
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Publication
28602636 | J:260340
 
First Author: Jackson MR
Year: 2017
Journal: Neurobiol Dis
Title: Extensive phenotyping of two ARX polyalanine expansion mutation mouse models that span clinical spectrum of intellectual disability and epilepsy.
Volume: 105
Pages: 245-256
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Publication
24122442 | J:206228
First Author: Lee K
Year: 2014
Journal: Hum Mol Genet
Title: Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation.
Volume: 23
Issue: 4
Pages: 1084-94
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Publication
27447725 | J:240119
First Author: Pais R
Year: 2016
Journal: Endocrinology
Title: Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.
Volume: 157
Issue: 10
Pages: 3821-3831
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Publication
31666353 | J:282356
First Author: Holt MK
Year: 2019
Journal: J Neurosci
Title: Synaptic Inputs to the Mouse Dorsal Vagal Complex and Its Resident Preproglucagon Neurons.
Volume: 39
Issue: 49
Pages: 9767-9781
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Publication
30415925 | J:273747
First Author: Knudsen JG
Year: 2019
Journal: Cell Metab
Title: Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Volume: 29
Issue: 2
Pages: 430-442.e4
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Publication
26483393 | J:309434
First Author: Svendsen B
Year: 2016
Journal: J Endocrinol
Title: GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness.
Volume: 228
Issue: 1
Pages: 39-48
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Publication
25456129 | J:225698
First Author: Gewies A
Year: 2014
Journal: Cell Rep
Title: Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
Volume: 9
Issue: 4
Pages: 1292-305
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Publication
27926862 | J:241674
First Author: Roth S
Year: 2016
Journal: Cell Rep
Title: Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.
Volume: 17
Issue: 10
Pages: 2572-2583
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Gcg-icre)23Cshi/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Gcg-icre)23Cshi/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Gcg-icre)12Fmgb/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
22565167 | J:197588
First Author: Olivetti PR
Year: 2012
Journal: Curr Opin Neurobiol
Title: Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms.
Volume: 22
Issue: 5
Pages: 859-65
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Publication
19605412 | J:152416
First Author: Kitamura K
Year: 2009
Journal: Hum Mol Genet
Title: Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice.
Volume: 18
Issue: 19
Pages: 3708-24
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Publication
22638549 | J:186436
First Author: Parker HE
Year: 2012
Journal: Diabetologia
Title: Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion.
Volume: 55
Issue: 9
Pages: 2445-55
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Publication
27097661 | J:242429
First Author: Anesten F
Year: 2016
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6.
Volume: 311
Issue: 1
Pages: R115-23
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Publication
29196663 | J:279554
First Author: Kashiwagi K
Year: 2017
Journal: Sci Rep
Title: A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice.
Volume: 7
Issue: 1
Pages: 16779
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Publication
30963106 | J:277680
 
First Author: Kato G
Year: 2019
Journal: eNeuro
Title: Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice.
Volume: 6
Issue: 2
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Publication
29056294 | J:256114
First Author: Liu J
Year: 2017
Journal: Neuron
Title: Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus.
Volume: 96
Issue: 4
Pages: 897-909.e5
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Publication
32723474 | J:298668
   
First Author: Worth AA
Year: 2020
Journal: Elife
Title: The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling.
Volume: 9
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Publication
30279161 | J:268267
First Author: Holt MK
Year: 2019
Journal: Diabetes
Title: Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food.
Volume: 68
Issue: 1
Pages: 21-33
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Publication
36592795 | J:339511
 
First Author: Wagner S
Year: 2023
Journal: Mol Metab
Title: Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression.
Volume: 68
Pages: 101665
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Publication
25325736 | J:246159
First Author: Emery EC
Year: 2015
Journal: Diabetes
Title: Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1.
Volume: 64
Issue: 4
Pages: 1202-10
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Publication
25190708 | J:217060
First Author: Zac-Varghese S
Year: 2014
Journal: Dis Model Mech
Title: The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice.
Volume: 7
Issue: 11
Pages: 1275-86
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Publication
29106387 | J:281408
First Author: Bozadjieva N
Year: 2017
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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