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Search results 101 to 200 out of 541 for Isg15

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:7565712
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7565759
Age: postnatal newborn
Specimen Label: Neonatal
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7565712
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565759
Age: postnatal week 2
Specimen Label: Week 2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7565712
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7565766
Age: postnatal newborn
Specimen Label: Neonatal
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7565712
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565766
Age: postnatal week 1
Specimen Label: wk 1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7565712
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565766
Age: postnatal week 3
Specimen Label: wk 3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7565712
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565766
Age: postnatal week 4
Specimen Label: wk 4
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6881743
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-24
Strength: Present
Sex: Female
Emaps: EMAPS:3526928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6881744
Age: postnatal adult
Note: Expression around embryo chamber extends into adjacent mesometrial decidua.
Specimen Label: 6A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6881743
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-24
Strength: Absent
Sex: Female
Emaps: EMAPS:3526928
Stage: TS28
Assay Id: MGI:6881744
Age: postnatal adult
Note: No expression in Isg15-/- sections.
Specimen Label: 6C
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6881743
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6881744
Age: embryonic day 12.5
Note: Expression localized extensively and specifically to labyrinth.
Specimen Label: 6D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6881743
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6881744
Age: embryonic day 12.5
Note: Expression localized extensively and specifically to labyrinth.
Specimen Label: 6E
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6881743
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-24
Strength: Present
Sex: Female
Emaps: EMAPS:3556228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6881744
Age: postnatal adult
Note: Expression around embryo chamber extends into adjacent mesometrial decidua.
Specimen Label: 6A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6881743
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-24
Strength: Absent
Sex: Female
Emaps: EMAPS:3556228
Stage: TS28
Assay Id: MGI:6881744
Age: postnatal adult
Note: No expression in Isg15-/- sections.
Specimen Label: 6C
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6881743
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3187620
Stage: TS20
Assay Id: MGI:6881744
Age: embryonic day 12.5
Note: Little or no expression in spongioblast.
Specimen Label: 6D
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6881743
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-24
Strength: Absent
Sex: Female
Emaps: EMAPS:3697128
Stage: TS28
Assay Id: MGI:6881744
Age: postnatal adult
Note: Little or no expression in metrial gland.
Specimen Label: 6D (maternal)
Detected: false
Specimen Num: 4
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Publication
- | J:61610
   
First Author: Fahey D
Year: 1992
Journal: GenBank Submission
Title: Mus musculus mRNA Interferon-induced 15-KDa protein
Pages: X56602
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Publication
24648452 | J:214425
First Author: Ma XZ
Year: 2014
Journal: J Virol
Title: Protein interferon-stimulated gene 15 conjugation delays but does not overcome coronavirus proliferation in a model of fulminant hepatitis.
Volume: 88
Issue: 11
Pages: 6195-204
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Publication
28264883 | J:241582
First Author: Lee AJ
Year: 2017
Journal: J Exp Med
Title: Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection.
Volume: 214
Issue: 4
Pages: 1153-1167
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Publication
24533902 | J:207464
First Author: Basters A
Year: 2014
Journal: FEBS J
Title: Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15.
Volume: 281
Issue: 7
Pages: 1918-28
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Publication
26210742 | J:225893
First Author: Brown AR
Year: 2015
Journal: Carcinogenesis
Title: Krüppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling.
Volume: 36
Issue: 9
Pages: 946-55
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Publication
23853600 | J:213363
First Author: Berghout J
Year: 2013
Journal: PLoS Pathog
Title: Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.
Volume: 9
Issue: 7
Pages: e1003491
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Publication
32202502 | J:290957
   
First Author: Adapala NS
Year: 2020
Journal: Elife
Title: Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO.
Volume: 9
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Publication
32277054 | J:288419
First Author: Bankers L
Year: 2020
Journal: J Immunol
Title: Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation.
Volume: 204
Issue: 10
Pages: 2791-2807
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Publication
15485925 | J:94130
First Author: Kim KI
Year: 2004
Journal: Mol Cell Biol
Title: Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation.
Volume: 24
Issue: 21
Pages: 9592-600
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Publication
22284419 | J:181257
First Author: Gall A
Year: 2012
Journal: Immunity
Title: Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.
Volume: 36
Issue: 1
Pages: 120-31
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Publication
26633895 | J:248539
First Author: Painter MM
Year: 2015
Journal: PLoS Pathog
Title: Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity.
Volume: 11
Issue: 12
Pages: e1005311
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Publication
34380029 | J:310901
First Author: de Reuver R
Year: 2021
Journal: Cell Rep
Title: ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.
Volume: 36
Issue: 6
Pages: 109500
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Publication
18991290 | J:141401
First Author: Okabe Y
Year: 2008
Journal: Eur J Immunol
Title: IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation.
Volume: 38
Issue: 11
Pages: 3150-8
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Publication
26371324 | J:226998
First Author: Gao D
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Volume: 112
Issue: 42
Pages: E5699-705
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Publication
15568025 | J:94874
First Author: Yoshida H
Year: 2005
Journal: Nat Immunol
Title: Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.
Volume: 6
Issue: 1
Pages: 49-56
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Ontology Term
- | Inhibition of host ISG15 by virus
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Publication
34279605 | J:333399
First Author: Rhee S
Year: 2021
Journal: Eur Heart J
Title: Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction.
Volume: 42
Issue: 41
Pages: 4264-4276
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Publication
35859175 | J:330287
First Author: de Reuver R
Year: 2022
Journal: Nature
Title: ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
Volume: 607
Issue: 7920
Pages: 784-789
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Publication
34655526 | J:320348
First Author: Aditi
Year: 2021
Journal: Neuron
Title: Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair.
Volume: 109
Issue: 24
Pages: 3962-3979.e6
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Publication
36458554 | J:333559
 
First Author: Rupani DN
Year: 2023
Journal: Development
Title: Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling.
Volume: 150
Issue: 2
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Publication
29632206 | J:261328
First Author: Zou J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Neddylation mediates ventricular chamber maturation through repression of Hippo signaling.
Volume: 115
Issue: 17
Pages: E4101-E4110
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Publication
31924792 | J:288683
First Author: Gacem N
Year: 2020
Journal: Nat Commun
Title: ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.
Volume: 11
Issue: 1
Pages: 198
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Publication
17222803 | -
First Author: Zou W
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Negative regulation of ISG15 E3 ligase EFP through its autoISGylation.
Volume: 354
Issue: 1
Pages: 321-7
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Publication
23012479 | J:190322
First Author: Archambaud C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Impact of lactobacilli on orally acquired listeriosis.
Volume: 109
Issue: 41
Pages: 16684-9
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GO Term
GO:0061653 | ISG15 conjugating enzyme activity
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GO Term
GO:0061662 | ISG15 ligase activity
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:345476
       
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
12582176 | -
First Author: Malakhov MP
Year: 2003
Journal: J Biol Chem
Title: High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction.
Volume: 278
Issue: 19
Pages: 16608-13
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Publication
17289916 | -
First Author: Okumura F
Year: 2007
Journal: Genes Dev
Title: ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.
Volume: 21
Issue: 3
Pages: 255-60
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Publication
18057259 | -
First Author: Kim MJ
Year: 2008
Journal: J Virol
Title: Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation.
Volume: 82
Issue: 3
Pages: 1474-83
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UniProt Feature
UniProt Feature
Begin: 1
Description: Ubiquitin-like protein ISG15
Type: chain
End: 155
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Allele
Isg15<em2Smoc> | MGI:7290590
Name: ISG15 ubiquitin-like modifier; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein
Q64339
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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GO Term
GO:0039579 | symbiont-mediated suppression of host ISG15-protein conjugation
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GO Term
GO:0019782 | ISG15 activating enzyme activity
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Allele
Isg15<em1Smoc> | MGI:7290589
Name: ISG15 ubiquitin-like modifier; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6770868 | C57BL/6-Isg15<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
11859133 | -
First Author: Hamerman JA
Year: 2002
Journal: J Immunol
Title: Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog.
Volume: 168
Issue: 5
Pages: 2415-23
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Protein
Q4FJR9
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Publication
11157743 | -
First Author: Yuan W
Year: 2001
Journal: EMBO J
Title: Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.
Volume: 20
Issue: 3
Pages: 362-71
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Allele
Isg15<+> | MGI:2438834
   
Name: ISG15 ubiquitin-like modifier; wild type
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Publication
38594382 | J:347095
First Author: Homma H
Year: 2024
Journal: Commun Biol
Title: Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage.
Volume: 7
Issue: 1
Pages: 413
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Pathway
R-MMU-1169408 | ISG15 antiviral mechanism
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Protein Coding Gene
MGI:1914500 | Ube2l6
Type: protein_coding_gene
Organism: mouse, laboratory
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DO Term
DOID:0111934 | immunodeficiency 38
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Protein Coding Gene
MGI:1349462 | Uba7
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Isg15<tm1Kpk> | MGI:3586990
Name: ISG15 ubiquitin-like modifier; targeted mutation 1, Klaus-Peter Knobeloch
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Isg15<em2Cya> | MGI:7584550
Name: ISG15 ubiquitin-like modifier; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Isg15<em1Cya> | MGI:7584549
Name: ISG15 ubiquitin-like modifier; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein Coding Gene
MGI:107411 | Ube2e1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384997 | Ube2e2
Type: protein_coding_gene
Organism: mouse, laboratory
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Strain
MGI:3844728 | B6.129P2-Isg15<tm1Kpk>/J
Attribute String: congenic, targeted mutation
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Strain
MGI:7587906 | C57BL/6J-Isg15<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7593271 | C57BL/6J-Isg15<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Isg15/Isg15
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Isg15/Isg15
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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GO Term
GO:0019785 | ISG15-specific peptidase activity
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Protein Domain
IPR004208 | NS1
Type: Family
Description: A specific region of the Influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of mouse ISG15 to its target proteins both in vitroand in infected cells. Of the several hundred proteins induced by interferon (IFN) alpha/beta, the ubiquitin-like ISG15 protein is one of the most predominant. Influenza A virus employs a different strategy: its NS1 protein does not bind the ISG15 protein, but little or no ISG15 protein is produced during infection [].
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Publication
20591702 | J:233125
First Author: Cong X
Year: 2010
Journal: Blood Cells Mol Dis
Title: Hematopoietic cells from Ube1L-deficient mice exhibit an impaired proliferation defect under the stress of bone marrow transplantation.
Volume: 45
Issue: 2
Pages: 103-11
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Publication
16382139 | J:144149
First Author: Kim KI
Year: 2006
Journal: Mol Cell Biol
Title: Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.
Volume: 26
Issue: 2
Pages: 472-9
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Publication
26515094 | J:227853
First Author: Fan JB
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation.
Volume: 112
Issue: 46
Pages: 14313-8
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Protein Coding Gene
MGI:1914440 | Eif4e2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2446089 | Flnb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1353449 | Eif2ak2
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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