Apoptosis antagonizing transcription factor (AATF, also known as Che-1) is a adaptor that connects transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis []. It contains a leucine zipper-containing domain []. AATF has been shown to inhibit the aberrant production of the amyloid beta peptide 1-42 by direct interaction with Par4; this interaction occurs via the leucine zipper. []. AATF has also been shown to form a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis [].This entry also includes the yeast protein Bfr2, which is a component of the SSU processome and 90S preribosomes [].
