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Search results 1 to 7 out of 7 for Cdc45

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
Type Details Score
Protein Domain
Type: Family
Description: CDC45 is an essential gene required for initiation of DNA replication in Saccharomyces cerevisiae (cell division control protein 45), forming a complex with MCM5/CDC46. Homologs of CDC45 have been identified in human [], mouse and the smut fungus, Melampsora spp., (tsd2 protein) among others.
Protein Domain
Type: Family
Description: A member of this family of archaeal proteins has been characterised. Saci_0177 () encodes a protein previously known as RecJ, which has been renamed as Cdc45 based on its relationship to eukaryotic Cdc45 [, ]. Cdc45 may form a constitutive complex with GINS. This CG complex associates with the MCM complex at replication origins and during replication fork progression, and stimulates its helicase activity [].
Protein Domain
Type: Family
Description: Sld3 interacts with Cdc45 and plays a role in chromosomal DNA replication [, ].
Protein Domain
Type: Domain
Description: The Sld3 DNA replication regulator is required for loading and maintenance of Cdc45 on chromatin during DNA replication []. This entry represents the C-terminal domain of Sld3.
Protein Domain
Type: Family
Description: Treslin, a TopBP1-interacting protein, is necessary for DNA replication in vertebrates []. Prior to the initiation of DNA replication, treslin associates with TopBP1 in a Cdk2-dependent manner []. The proteins then collaborate in the Cdk2-mediated loading of Cdc45 onto replication origins [].Treslin is also an important checkpoint regulator, and is required to prevent mitotic entry after treatment with ionizing radiation [].
Protein Domain
Type: Family
Description: Sld7 interacts with Sld3 and is required for the proper function of Sld3 at the initiation of DNA replication []. The origin association of Sld3, Sld7, and Cdc45 is the key to determining the temporal order of origin firing []. Sld7 is also required for mitochondrial morphology [].
Protein Domain
Type: Family
Description: Geminin coiled-coil domain-containing protein 1 (GEMC1) is a regulator of DNA replication. It promotes initiation of chromosomal DNA replication by mediating TopBP1- and cdk2-dependent recruitment of cdc45 onto replication origins []. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein. However, only some of the amino acid residues critical for geminin function are conserved in GEMC1 [].