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Search results 201 to 275 out of 275 for Rai1

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Type Details Score
GXD Expression  
Probe: MGI:6306286
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6306296
Age: postnatal adult
Note: Expression is in the cytosol and neurites of the neurons.
Specimen Label: 8G
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5002213
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542767
Age: embryonic day 15.5
Image: GUDMAP:11143
Specimen Label: GUDMAP:11143
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-11-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668017
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3687569
Age: embryonic day 10.5
Note: Expression is in the epithelium.
Specimen Label: 2E
Detected: true
Specimen Num: 5
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5523464
Age: postnatal adult
Specimen Label: not shown
Detected: true
Specimen Num: 23
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-12-11
Strength: Present
Sex: Female
Emaps: EMAPS:3562728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5523464
Age: postnatal adult
Specimen Label: 2F
Detected: true
Specimen Num: 14
Publication
First Author: Savino MT
Year: 2013
Journal: J Leukoc Biol
Title: The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development.
Volume: 93
Issue: 4
Pages: 549-59
Publication  
First Author: Zhou J
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders.
Volume: 119
Issue: 4
Publication
First Author: Ricard G
Year: 2010
Journal: PLoS Biol
Title: Phenotypic consequences of copy number variation: insights from Smith-Magenis and Potocki-Lupski syndrome mouse models.
Volume: 8
Issue: 11
Pages: e1000543
Publication      
First Author: Luo L
Year: 2020
Journal: Neuron
Title: Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Strain
Attribute String: congenic, mutant strain, transgenic
Allele
Name: transgene insertion 760, Sarah Elsea
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Transgene
Type: transgene
Organism: mouse, laboratory
Allele
Name: transgene insertion 479, Katherina Walz
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Reporter
Allele
Name: transgene insertion 463, Katherina Walz
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Reporter
Protein
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
Publication
First Author: Pane A
Year: 2011
Journal: EMBO J
Title: The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline.
Volume: 30
Issue: 22
Pages: 4601-15
Protein Domain
Type: Family
Description: Yeast RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z (DXO). They have both decapping and 5'-3' exoribonuclease activity and are a component of the mRNA 5'-end capping quality control mechanism [, ]. RAI1 is a single-copy gene in most organisms; however S. cerevisiae contains a second homologue, DXO1, which also possesses decapping and 5'-3' exoribonuclease activity, whereas RAI1 has decapping and pyrophosphohydrolase activities []. This domain is also found in DXO1 homologue from Arabidopsis []. This entry also includes protein Cutoff (Cuff) from Drosophila. Differently from Rai1, Cuff does not display a Dom3Z domain, which is critical for Rai1 activity. Rai1 has been shown to regulate piRNA cluster expression and piRNA production in the Drosophila germline [].
Allele
Name: deletion, Chr 11, James R Lupski 2
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: retinoic acid induced 1; targeted mutation 2.1, Liqun Luo
Allele Type: Targeted
Attribute String: Conditional ready
Allele
Name: retinoic acid induced 1; targeted mutation 1, James R Lupski
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: deletion, Chr 11, James R Lupski 1
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: retinoic acid induced 1; targeted mutation 1, Liqun Luo
Allele Type: Targeted
Attribute String: Conditional ready, Reporter
Chromosome Structure Variation
Type: chromosomal_deletion
Organism: mouse, laboratory
Chromosome Structure Variation
Type: chromosomal_deletion
Organism: mouse, laboratory
Genotype
Symbol: Del(11Cops3-Rnf112)1Jrl/+
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Del(11Cops3-Gid4)2Jrl/+
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Rai1/Rai1<+>
Background: involves: 129S/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Rai1/Rai1<+>
Background: B6.129S7-Rai1/J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Rai1/Rai1 Tg(Nes-cre)1Kln/?
Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)
Zygosity: cn
Has Mutant Allele: true
DO Term
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: congenic, mutant strain, transgenic
Genotype
Symbol: Tg(RP23-326M22)760She/?
Background: B6.Cg-Tg(RP23-326M22)760She
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(RP23-326M22)760She/Tg(RP23-326M22)760She
Background: B6.Cg-Tg(RP23-326M22)760She
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-Rai1,-EGFP)463Walz/?
Background: involves: C57BL/6J * CBA/J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-Rai1,-EGFP)479Walz/?
Background: involves: C57BL/6J * CBA/J
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Jiao X
Year: 2013
Journal: Mol Cell
Title: A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.
Volume: 50
Issue: 1
Pages: 104-15
Publication
First Author: Doamekpor SK
Year: 2020
Journal: Nucleic Acids Res
Title: DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
Volume: 48
Issue: 11
Pages: 6136-6148
Publication
First Author: Yan J
Year: 2004
Journal: Hum Mol Genet
Title: Reduced penetrance of craniofacial anomalies as a function of deletion size and genetic background in a chromosome engineered partial mouse model for Smith-Magenis syndrome.
Volume: 13
Issue: 21
Pages: 2613-24
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7