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Search results 101 to 200 out of 220 for Ogg1

0.043s
Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lu R
Year: 1997
Journal: Curr Biol
Title: A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.
Volume: 7
Issue: 6
Pages: 397-407
Publication
First Author: Minowa O
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice.
Volume: 97
Issue: 8
Pages: 4156-61
Publication
First Author: Akatsuka S
Year: 2006
Journal: Am J Pathol
Title: Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.
Volume: 169
Issue: 4
Pages: 1328-42
Publication
First Author: Stuart JA
Year: 2005
Journal: Free Radic Biol Med
Title: No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA.
Volume: 38
Issue: 6
Pages: 737-45
Publication
First Author: Hofer T
Year: 2018
Journal: Neurotox Res
Title: Restoration of Cognitive Performance in Mice Carrying a Deficient Allele of 8-Oxoguanine DNA Glycosylase by X-ray Irradiation.
Volume: 33
Issue: 4
Pages: 824-836
Publication  
First Author: Russo MT
Year: 2021
Journal: Int J Mol Sci
Title: Oxidative Stress, Mutations and Chromosomal Aberrations Induced by In Vitro and In Vivo Exposure to Furan.
Volume: 22
Issue: 18
Publication  
First Author: Miller-Pinsler L
Year: 2015
Journal: Free Radic Biol Med
Title: Oxidative DNA damage in the in utero initiation of postnatal neurodevelopmental deficits by normal fetal and ethanol-enhanced oxidative stress in oxoguanine glycosylase 1 knockout mice.
Volume: 78
Pages: 23-9
Publication
First Author: Mabley JG
Year: 2005
Journal: FASEB J
Title: Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation.
Volume: 19
Issue: 2
Pages: 290-2
Publication  
First Author: Graupner A
Year: 2016
Journal: Sci Rep
Title: Gamma radiation at a human relevant low dose rate is genotoxic in mice.
Volume: 6
Pages: 32977
Publication
First Author: Takeda T
Year: 1981
Journal: Mech Ageing Dev
Title: A new murine model of accelerated senescence.
Volume: 17
Issue: 2
Pages: 183-94
Publication
First Author: Takeda T
Year: 1997
Journal: Exp Gerontol
Title: Senescence-accelerated mouse (SAM): a novel murine model of senescence.
Volume: 32
Issue: 1-2
Pages: 105-9
GXD Expression  
Probe: MGI:7545048
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3820526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7545049
Age: embryonic day 18.5
Image: 2H
Specimen Label: 2H
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7545048
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3820526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7545049
Age: embryonic day 18.5
Image: 2I
Note: Reduced expression compared with the wild-type.
Specimen Label: 2I
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7545048
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187826
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7545049
Age: embryonic day 18.5
Image: 2J
Specimen Label: 2J
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:7545048
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187826
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7545049
Age: embryonic day 18.5
Image: 2K
Note: Reduced expression compared with the wild-type.
Specimen Label: 2K
Detected: true
Specimen Num: 4
Publication
First Author: Jaruga P
Year: 2010
Journal: Biochemistry
Title: Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines.
Volume: 49
Issue: 6
Pages: 1053-5
Publication
First Author: Budworth H
Year: 2015
Journal: PLoS Genet
Title: Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease.
Volume: 11
Issue: 8
Pages: e1005267
Publication  
First Author: Ohno M
Year: 2014
Journal: Sci Rep
Title: 8-oxoguanine causes spontaneous de novo germline mutations in mice.
Volume: 4
Pages: 4689
Publication
First Author: Pilati C
Year: 2017
Journal: J Pathol
Title: Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.
Volume: 242
Issue: 1
Pages: 10-15
Publication
First Author: Freedman SD
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice.
Volume: 96
Issue: 24
Pages: 13995-4000
Publication
First Author: Trapp C
Year: 2007
Journal: Cancer Res
Title: The peroxisome proliferator WY-14,643 promotes hepatocarcinogenesis caused by endogenously generated oxidative DNA base modifications in repair-deficient Csbm/m/Ogg1-/- mice.
Volume: 67
Issue: 11
Pages: 5156-61
Publication
First Author: Fusser M
Year: 2011
Journal: Carcinogenesis
Title: Spontaneous mutagenesis in Csb(m/m)Ogg1⁻(/)⁻ mice is attenuated by dietary resveratrol.
Volume: 32
Issue: 1
Pages: 80-5
Publication
First Author: Osenbroch PØ
Year: 2009
Journal: FEBS J
Title: Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells.
Volume: 276
Issue: 10
Pages: 2811-21
Publication
First Author: Osterod M
Year: 2002
Journal: Oncogene
Title: A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage.
Volume: 21
Issue: 54
Pages: 8232-9
Publication
First Author: Kim SJ
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis.
Volume: 318
Issue: 5
Pages: L1084-L1096
Publication
First Author: Takao M
Year: 2002
Journal: J Biol Chem
Title: A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.
Volume: 277
Issue: 44
Pages: 42205-13
Publication
First Author: Larsen E
Year: 2007
Journal: Mutat Res
Title: Organ and cell specificity of base excision repair mutants in mice.
Volume: 614
Issue: 1-2
Pages: 56-68
Publication
First Author: Li G
Year: 2012
Journal: Free Radic Biol Med
Title: 8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice.
Volume: 52
Issue: 2
Pages: 392-401
Publication
First Author: Conlon KA
Year: 2005
Journal: DNA Repair (Amst)
Title: The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro.
Volume: 4
Issue: 4
Pages: 419-31
Publication
First Author: Campalans A
Year: 2013
Journal: Nucleic Acids Res
Title: Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair.
Volume: 41
Issue: 5
Pages: 3115-29
Publication
First Author: Leatherman JL
Year: 2000
Journal: Mech Dev
Title: Identification of a mouse germ cell-less homologue with conserved activity in Drosophila.
Volume: 92
Issue: 2
Pages: 145-53
Publication
First Author: Wu L
Year: 2014
Journal: Mol Immunol
Title: Active demethylation of the IL-2 Promoter in CD4+ T cells is mediated by an inducible DNA glycosylase, Myh.
Volume: 58
Issue: 1
Pages: 38-49
Publication  
First Author: Moreli JB
Year: 2023
Journal: Int J Mol Sci
Title: The Role of Annexin A1 in DNA Damage Response in Placental Cells: Impact on Gestational Diabetes Mellitus.
Volume: 24
Issue: 12
Publication
First Author: Goula AV
Year: 2009
Journal: PLoS Genet
Title: Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.
Volume: 5
Issue: 12
Pages: e1000749
Publication
First Author: Anjos-Afonso F
Year: 2016
Journal: Blood
Title: Perturbed hematopoiesis in mice lacking ATMIN.
Volume: 128
Issue: 16
Pages: 2017-2021
Publication
First Author: Capriati M
Year: 2023
Journal: Sci Rep
Title: Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites.
Volume: 13
Issue: 1
Pages: 8003
Publication
First Author: Sasaki K
Year: 2010
Journal: Mol Cell Biol
Title: PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis.
Volume: 30
Issue: 15
Pages: 3864-74
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
Publication
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Allele  
Name: 8-oxoguanine DNA-glycosylase 1; targeted mutation 1.1, Nils-Goran Larsson
Allele Type: Targeted
Publication
First Author: Wulff BC
Year: 2008
Journal: Photochem Photobiol
Title: Topical treatment with OGG1 enzyme affects UVB-induced skin carcinogenesis.
Volume: 84
Issue: 2
Pages: 317-21
Publication  
First Author: Green B
Year: 2018
Journal: Exp Hematol
Title: Deficiency in the DNA glycosylases UNG1 and OGG1 does not potentiate c-Myc-induced B-cell lymphomagenesis.
Volume: 61
Pages: 52-58
Publication
First Author: Cilli P
Year: 2016
Journal: Nucleic Acids Res
Title: Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.
Volume: 44
Issue: 11
Pages: 5190-203
Publication
First Author: Habib SL
Year: 2010
Journal: Eur J Cancer
Title: Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition.
Volume: 46
Issue: 15
Pages: 2806-20
Allele
Name: 8-oxoguanine DNA-glycosylase 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Visnes T
Year: 2018
Journal: Science
Title: Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Volume: 362
Issue: 6416
Pages: 834-839
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Gogos A
Year: 1999
Journal: J Biol Chem
Title: Characterization of an 8-oxoguanine DNA glycosylase from Methanococcus jannaschii.
Volume: 274
Issue: 43
Pages: 30447-50
Publication
First Author: Leipold MD
Year: 2003
Journal: Biochemistry
Title: Recognition and removal of oxidized guanines in duplex DNA by the base excision repair enzymes hOGG1, yOGG1, and yOGG2.
Volume: 42
Issue: 38
Pages: 11373-81
Protein Domain
Type: Family
Description: This entry represents bifunctional, thermostable 8-oxoguanine DNA glycosylase/DNA lyase enzymes (OGG or OG glycosylases), which are involved in base excision repair of DNAdamaged by oxidation or by mutagenic agents []. Most damage to bases in DNA is repaired by the base excision repair pathway []. These enzymes have both DNA glycosylase activity () and AP lyase activity (). OGG1 enzymes are active only towards the removal of 8-oxoguanine [].
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: GSE62594
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
Protein Domain
Type: Family
Description: Oxidative damage represents a major threat to genomic stability, as the major product of DNA oxidation, 8-oxoguanine (GO), frequently mispairs with adenine during replication. In order to prevent these mutagenic events, organisms have evolved GO-DNA glycosylases (or N-glycosylase/DNA lyases) that remove this oxidized base from DNA []. GO is removed from DNA predominantly by the base excision repair (BER) pathway. This process is initiated by 8-oxoguanine-DNA glycosylases, which cleave the N-glycosidic bond between the aberrant base and the sugar-phosphate backbone to generate an apurinic (AP) site. Some DNA glycosylases possess also an intrinsic AP lyase activity, which cleaves the phosphodiester bond 3' from the AP site by beta- or beta, delta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate [].This group represents archaeal GO-DNA glycosylases (AGOG). Pyrobaculum aerophilum PAE2237 has been shown to remove GO from single- and double-stranded substrates with great efficiency []. It has both GO-DNA glycosylase and AP-lyase () activities [].Archaeal GO-DNA glycosylases are not closely related to other DNA glycosylases. However, they share with the other HhH-GPD DNA glycosylase families the overall fold and the general active site architecture. AGOG possesses the principal hallmark of GO-DNA glycosylases: a helix-hairpin-helix motif and a glycine/proline-rich sequence followed by an absolutely conserved aspartate (HhH-GPD motif) []. It contains two α-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface []. AGOG belongs to a new class within the helix-hairpin-helix (HhH) superfamily of DNA repair enzymes. Its hairpin structure differs substantially from that of other proteins containing an HhH motif, and is predicted that to interact with the DNA backbone in a distinct manner. Furthermore, the mode of 8-oxoguanine recognition, which involves several hydrogen-bonding and pi-stacking interactions, is unlike that observed in human OGG1, the prototypic 8-oxoguanine HhH-type DNA glycosylase. Despite these differences, the predicted kinked conformation of bound DNA and the catalytic mechanism are likely to resemble thoseof human OGG1 [].
Publication
First Author: Habiel DM
Year: 2017
Journal: Sci Rep
Title: Divergent roles for Clusterin in Lung Injury and Repair.
Volume: 7
Issue: 1
Pages: 15444
Publication
First Author: Ishida T
Year: 1999
Journal: Cytogenet Cell Genet
Title: Structure and chromosome location of human OGG1.
Volume: 85
Issue: 3-4
Pages: 232-6
Publication  
First Author: Murakami T
Year: 2007
Journal: Brain Res
Title: Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene.
Volume: 1150
Pages: 182-9
Publication
First Author: Lingaraju GM
Year: 2005
Journal: Structure
Title: A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure.
Volume: 13
Issue: 1
Pages: 87-98
Publication
First Author: Sartori AA
Year: 2004
Journal: Nucleic Acids Res
Title: Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases.
Volume: 32
Issue: 22
Pages: 6531-9
Publication
First Author: Hironaka K
Year: 2003
Journal: Lab Invest
Title: Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
Volume: 83
Issue: 5
Pages: 643-54
Publication
First Author: Chan MK
Year: 2009
Journal: DNA Repair (Amst)
Title: Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.
Volume: 8
Issue: 7
Pages: 786-94
Publication  
First Author: Sakurada A
Year: 2018
Journal: Free Radic Biol Med
Title: An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma.
Volume: 129
Pages: 88-96