|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 600 out of 611 for Prkaa1

<< First    < Previous  |  Next >    Last >>
0.037s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
26926143 | J:233765
First Author: Peng Y
Year: 2016
Journal: J Neurochem
Title: Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons.
Volume: 137
Issue: 5
Pages: 701-13
•
•
•
•
•
Publication
10098881 | J:54164
First Author: Turnley AM
Year: 1999
Journal: J Neurochem
Title: Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system.
Volume: 72
Issue: 4
Pages: 1707-16
•
•
•
•
•
Publication
14985505 | J:88909
First Author: Shaw RJ
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Volume: 101
Issue: 10
Pages: 3329-35
•
•
•
•
•
Publication
21106494 | J:170133
First Author: Kim ST
Year: 2011
Journal: Hum Reprod
Title: Adiponectin and adiponectin receptors in the mouse preimplantation embryo and uterus.
Volume: 26
Issue: 1
Pages: 82-95
•
•
•
•
•
Publication
28496133 | J:310006
First Author: Weng Q
Year: 2017
Journal: Sci Rep
Title: Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity.
Volume: 7
Issue: 1
Pages: 1705
•
•
•
•
•
Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
•
•
•
•
•
Publication
23479225 | J:194901
First Author: Través PG
Year: 2013
Journal: J Immunol
Title: Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.
Volume: 190
Issue: 8
Pages: 4226-35
•
•
•
•
•
Publication
32807950 | J:334054
First Author: Babetto E
Year: 2020
Journal: Nat Neurosci
Title: A glycolytic shift in Schwann cells supports injured axons.
Volume: 23
Issue: 10
Pages: 1215-1228
•
•
•
•
•
Publication
21436046 | J:171212
First Author: Williams T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.
Volume: 108
Issue: 14
Pages: 5849-54
•
•
•
•
•
Publication
24209762 | J:205532
First Author: Wang S
Year: 2013
Journal: Cell Stem Cell
Title: Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency.
Volume: 13
Issue: 5
Pages: 617-25
•
•
•
•
•
Publication
27307439 | J:234284
First Author: Chen L
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Volume: 113
Issue: 26
Pages: 7219-24
•
•
•
•
•
Publication
32414840 | J:305107
 
First Author: Ulisse V
Year: 2020
Journal: Life Sci Alliance
Title: Regulation of axonal morphogenesis by the mitochondrial protein Efhd1.
Volume: 3
Issue: 7
•
•
•
•
•
Publication
25975226 | J:317793
First Author: De Zio D
Year: 2015
Journal: Cell Mol Life Sci
Title: Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth.
Volume: 72
Issue: 21
Pages: 4173-91
•
•
•
•
•
Publication
27430620 | J:259116
First Author: Mahboubi H
Year: 2016
Journal: Mol Pharmacol
Title: AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization.
Volume: 90
Issue: 4
Pages: 460-8
•
•
•
•
•
Publication
20399150 | J:160941
First Author: Zhang N
Year: 2010
Journal: Cell Metab
Title: The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.
Volume: 11
Issue: 5
Pages: 364-78
•
•
•
•
•
Publication
35081489 | J:319888
 
First Author: Son JS
Year: 2022
Journal: EBioMedicine
Title: Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling.
Volume: 76
Pages: 103842
•
•
•
•
•
Publication
25505152 | J:218247
First Author: Cossette SM
Year: 2014
Journal: Biol Open
Title: Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.
Volume: 4
Issue: 1
Pages: 48-61
•
•
•
•
•
Publication
26091038 | J:223511
First Author: Wei J
Year: 2015
Journal: Cell
Title: Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.
Volume: 161
Issue: 7
Pages: 1576-1591
•
•
•
•
•
Publication
20450902 | J:163880
First Author: Zhou X
Year: 2010
Journal: Dev Biol
Title: Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism.
Volume: 344
Issue: 1
Pages: 185-95
•
•
•
•
•
Publication
36996814 | J:335218
First Author: Knaus LS
Year: 2023
Journal: Cell
Title: Large neutral amino acid levels tune perinatal neuronal excitability and survival.
Volume: 186
Issue: 9
Pages: 1950-1967.e25
•
•
•
•
•
Publication
26518685 | J:232360
First Author: Anastasiou V
Year: 2016
Journal: Diabetologia
Title: Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.
Volume: 59
Issue: 1
Pages: 139-50
•
•
•
•
•
Publication
35099001 | J:324720
 
First Author: Zhao Q
Year: 2022
Journal: J Cell Sci
Title: Drp1 regulates transcription of ribosomal protein genes in embryonic hearts.
Volume: 135
Issue: 4
•
•
•
•
•
Publication
36189989 | J:329985
First Author: Chae SA
Year: 2022
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism.
Volume: 323
Issue: 5
Pages: R728-R738
•
•
•
•
•
Publication
28162974 | J:239679
First Author: Vila IK
Year: 2017
Journal: Cancer Cell
Title: A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
Volume: 31
Issue: 2
Pages: 208-224
•
•
•
•
•
Publication
25588837 | J:223226
First Author: Krawchuk D
Year: 2015
Journal: J Cell Sci
Title: Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.
Volume: 128
Issue: 5
Pages: 1011-22
•
•
•
•
•
Publication
33913477 | J:305946
 
First Author: Xu M
Year: 2021
Journal: Development
Title: The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development.
Volume: 148
Issue: 8
•
•
•
•
•
Publication
26595272 | J:228212
First Author: Cinque L
Year: 2015
Journal: Nature
Title: FGF signalling regulates bone growth through autophagy.
Volume: 528
Issue: 7581
Pages: 272-5
•
•
•
•
•
Publication
22872236 | J:208504
First Author: Qiao L
Year: 2012
Journal: Diabetes
Title: Adiponectin enhances mouse fetal fat deposition.
Volume: 61
Issue: 12
Pages: 3199-207
•
•
•
•
•
Publication
18227155 | J:134078
First Author: Hezel AF
Year: 2008
Journal: Mol Cell Biol
Title: Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
Volume: 28
Issue: 7
Pages: 2414-25
•
•
•
•
•
Publication
37493331 | J:341543
First Author: Meng TG
Year: 2023
Journal: Adv Sci (Weinh)
Title: NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition.
Volume: 10
Issue: 27
Pages: e2301940
•
•
•
•
•
Publication
36198274 | J:329967
First Author: Li H
Year: 2022
Journal: Cell Rep
Title: Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.
Volume: 41
Issue: 1
Pages: 111435
•
•
•
•
•
Publication
19217427 | J:146618
First Author: Dasgupta B
Year: 2009
Journal: Dev Cell
Title: AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.
Volume: 16
Issue: 2
Pages: 256-70
•
•
•
•
•
Publication
33372189 | J:313922
First Author: Kuiper-Makris C
Year: 2020
Journal: Sci Rep
Title: Mendelian randomization and experimental IUGR reveal the adverse effect of low birth weight on lung structure and function.
Volume: 10
Issue: 1
Pages: 22395
•
•
•
•
•
Publication
34157307 | J:308817
First Author: Fu Y
Year: 2021
Journal: Mol Cell
Title: OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.
Volume: 81
Issue: 15
Pages: 3187-3204.e7
•
•
•
•
•
Publication
33059001 | J:306153
First Author: Zhu M
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice.
Volume: 1867
Issue: 1
Pages: 165988
•
•
•
•
•
Publication
30818059 | J:291414
 
First Author: Pérez-Estrada JR
Year: 2019
Journal: Free Radic Biol Med
Title: Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging.
Volume: 135
Pages: 102-115
•
•
•
•
•
Publication
28542142 | J:301834
First Author: Li G
Year: 2017
Journal: Cell Death Dis
Title: Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.
Volume: 8
Issue: 5
Pages: e2811
•
•
•
•
•
Publication
35237793 | J:321836
 
First Author: Zhao K
Year: 2022
Journal: Development
Title: LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Volume: 149
Issue: 6
•
•
•
•
•
Publication
31636950 | J:330942
 
First Author: Chu Q
Year: 2019
Journal: Cell Discov
Title: STK11 is required for the normal program of ciliated cell differentiation in airways.
Volume: 5
Pages: 36
•
•
•
•
•
Publication
35293971 | J:331835
First Author: Salazar-Petres E
Year: 2022
Journal: Biol Reprod
Title: Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice†.
Volume: 106
Issue: 6
Pages: 1292-1311
•
•
•
•
•
Publication
36841836 | J:333724
First Author: Park EJ
Year: 2023
Journal: Nat Commun
Title: Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation.
Volume: 14
Issue: 1
Pages: 1097
•
•
•
•
•
Publication
27215380 | J:236179
First Author: Bowman CE
Year: 2016
Journal: Mol Cell Biol
Title: Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Volume: 36
Issue: 15
Pages: 2089-104
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:72245
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
•
•
•
•
•
Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
•
•
•
•
•
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
•
•
•
•
•
Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
•
•
•
•
•
Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
•
•
•
•
•
Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
•
•
•
•
•
Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Protein
Q5EG47
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
•
•
•
•
•
Allele
Prkaa1<em1Smoc> | MGI:7291802
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Allele
Prkaa1<tm1.1Mrl> | MGI:6435152
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit; targeted mutation 1.1, Merck Research Laboratory
Allele Type: Targeted
Attribute String: Not Specified
•
•
•
•
•
Strain
MGI:6438530 | C57BL/6-Prkaa1<tm1.1Mrl>/Tac
Attribute String: mutant strain, coisogenic, targeted mutation
•
•
•
•
•
Strain
MGI:6476082 | C57BL/6J-Prkaa1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Publication
17712357 | -
First Author: Hardie DG
Year: 2007
Journal: Nat Rev Mol Cell Biol
Title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Volume: 8
Issue: 10
Pages: 774-85
•
•
•
•
•
Protein Domain
IPR028797 | PRKAA1_UBA
Type: Domain
Description: 5'-AMP-activated protein kinase catalytic subunit alpha (PRKAA or AMPKalpha) is the catalytic subunit of the AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism []. There are two AMPK alpha-subunit isoforms in mammals: PRKAA1 and PRKAA2. They have an N-terminal Ser/Thr kinase domain followed by an ubiquitin-associated (UBA)-like AID and a C-terminal AMPK regulatory domain [].This entry represents the AID that is responsible for PRKAA autoinhibition.
•
•
•
•
•
Publication
16505254 | -
First Author: Sun MW
Year: 2006
Journal: Diabetes
Title: Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.
Volume: 55
Issue: 3
Pages: 849-55
•
•
•
•
•
Publication
17950019 | -
First Author: Keshavarz P
Year: 2008
Journal: Mol Genet Metab
Title: Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes.
Volume: 93
Issue: 2
Pages: 200-9
•
•
•
•
•
Protein Domain
IPR028783 | PRKAA2
Type: Domain
Description: 5'-AMP-activated protein kinase catalytic subunit alpha (PRKAA) is the catalytic subunit of the AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism []. There are two AMPK alpha-subunit isoforms in mammals: PRKAA1 and PRKAA2. They have an N-terminal Ser/Thr kinase domain followed by an ubiquitin-associated (UBA)-like AID and a C-terminal AMPK regulatory domain [].This entry represents the AID that is responsible for PRKAA autoinhibition. PRKAA2 has been associated with type 2 diabetes [, ].
•
•
•
•
•
Allele
Tn(Tol2-CAG-AMPKAR-EV)#Kete | MGI:6195077
Name: transposon concatemer, Kenta Terai
Allele Type: Transposon induced
Attribute String: Reporter
•
•
•
•
•
Publication
25126727 | J:303034
First Author: Cho MH
Year: 2014
Journal: Autophagy
Title: Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome.
Volume: 10
Issue: 10
Pages: 1761-75
•
•
•
•
•
Publication
38094249 | J:343426
First Author: Malawsky DS
Year: 2023
Journal: iScience
Title: Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells.
Volume: 26
Issue: 12
Pages: 108443
•
•
•
•
•
Publication
29186696 | J:254233
First Author: Konagaya Y
Year: 2017
Journal: Cell Rep
Title: A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs.
Volume: 21
Issue: 9
Pages: 2628-2638
•
•
•
•
•
Publication
33524391 | J:302168
   
First Author: Pinto PR
Year: 2021
Journal: J Biol Chem
Title: Dietary sodium restriction alters muscle lipidomics that relates to insulin resistance in mice.
Pages: 100344
•
•
•
•
•
Publication
22333580 | -
First Author: Pinter K
Year: 2012
Journal: Cell Cycle
Title: Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification.
Volume: 11
Issue: 5
Pages: 917-21
•
•
•
•
•
Publication
9693118 | J:320077
 
First Author: Salt I
Year: 1998
Journal: Biochem J
Title: AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.
Volume: 334 ( Pt 1)
Pages: 177-87
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom