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Search results 501 to 600 out of 610 for Tet2

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Type Details Score
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Protein
Q4JK59
Organism: Mus musculus/domesticus
Length: 1912  
Fragment?: false
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Publication
21741591 | J:174544
First Author: Holmfeldt L
Year: 2011
Journal: Cancer Cell
Title: The role of TET2 in hematologic neoplasms.
Volume: 20
Issue: 1
Pages: 1-2
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HT Experiment
GSE232920 | Effect of Tet2 deletion on gene expression in mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
30510015 | J:268225
First Author: Shingleton JR
Year: 2018
Journal: Cancer Discov
Title: TET2 Deficiency Sets the Stage for B-cell Lymphoma.
Volume: 8
Issue: 12
Pages: 1515-1517
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Protein
Q4JK59-3
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q4JK59-2
Organism: Mus musculus/domesticus
Length: 612  
Fragment?: false
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Protein
A0A0G2JGM1
Organism: Mus musculus/domesticus
Length: 45  
Fragment?: true
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Publication
35962058 | J:344344
First Author: Burns SS
Year: 2022
Journal: Leukemia
Title: Il-1r1 drives leukemogenesis induced by Tet2 loss.
Volume: 36
Issue: 10
Pages: 2531-2534
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Publication
30944118 | J:276356
First Author: Jeong JJ
Year: 2019
Journal: Cancer Discov
Title: Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.
Volume: 9
Issue: 6
Pages: 778-795
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HT Experiment
GSE212715 | Tet2 and Tet3 mediated active cytosine hydroxymethylation in Six2 progenitor cells is critical for nephron progenitor differentiation and nephron endowment
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
32929842 | J:301081
First Author: Li S
Year: 2020
Journal: EMBO Rep
Title: TET2 promotes anti-tumor immunity by governing G-MDSCs and CD8+ T-cell numbers.
Volume: 21
Issue: 10
Pages: e49425
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Interaction Experiment
Costa Y (2013)
Description: NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.
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Publication
28416650 | J:242004
First Author: Ma S
Year: 2017
Journal: J Exp Med
Title: Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs.
Volume: 214
Issue: 5
Pages: 1471-1491
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Publication
38168657 | J:344626
 
First Author: Shi Y
Year: 2024
Journal: Redox Biol
Title: Endothelial TET2 regulates the white adipose browning and metabolism via fatty acid oxidation in obesity.
Volume: 69
Pages: 103013
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Publication
38062031 | J:343480
First Author: McClatchy J
Year: 2023
Journal: Nat Commun
Title: Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells.
Volume: 14
Issue: 1
Pages: 8102
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Publication
23827711 | J:199366
First Author: Song SJ
Year: 2013
Journal: Cell Stem Cell
Title: The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation.
Volume: 13
Issue: 1
Pages: 87-101
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Publication
32393787 | J:306095
     
First Author: Ji F
Year: 2020
Journal: Mol Psychiatry
Title: Brain-specific Wt1 deletion leads to depressive-like behaviors in mice via the recruitment of Tet2 to modulate Epo expression.
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Allele
Tet2<tm1Smoc> | MGI:7292729
Name: tet methylcytosine dioxygenase 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
25582196 | J:224293
First Author: Sohni A
Year: 2015
Journal: Mol Cell Biol
Title: Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation.
Volume: 35
Issue: 6
Pages: 1026-42
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Strain
MGI:6354430 | B6.129-Tet2<tm1Smoc>/Smoc
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Tet2<em1Smoc> | MGI:7292728
Name: tet methylcytosine dioxygenase 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6355246 | C57BL/6J-Tet2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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HT Experiment
GSE142163 | Oocyte RNA-seq data of WT, Tet1-/- and Tet2-/-; RNA seq of PGC at E13.5
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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DO Term
DOID:0081068 | ST2 diffuse large B-cell lymphoma
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Protein
A0A087WP90
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Publication
27036965 | -
First Author: Rasmussen KD
Year: 2016
Journal: Genes Dev
Title: Role of TET enzymes in DNA methylation, development, and cancer.
Volume: 30
Issue: 7
Pages: 733-50
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Protein Domain
IPR040175 | TET1/2/3
Type: Family
Description: The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression []. TET proteins, including TET1/2/3, convert 5-methylcytosine to 5-hydroxymethylcytosine. They can also convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine []. They play roles in epigenetic regulation [, ]. Human TET2 mutations have been linked to various leukaemias. TET2 and TET3 interact with O-GlcNAc transferase (OGT) and promotes OGT-mediated GlcNAcylation []. The double epigenetic modifications on both DNA and histones by TET2 and OGT coordinate together for the regulation of gene transcription [].
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Protein
D0VLQ5
Organism: Mus musculus/domesticus
Length: 1921  
Fragment?: false
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Protein
Q8BNB2
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Protein
A0A5K1VVP6
Organism: Mus musculus/domesticus
Length: 1668  
Fragment?: false
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Protein
A0A0G2JF55
Organism: Mus musculus/domesticus
Length: 1920  
Fragment?: false
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Protein
Q80U11
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
G3UXI7
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
G3UZN8
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Protein
G3UZ35
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: true
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Protein
A0A0G2JG87
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Publication
22975371 | J:192908
First Author: Shih AH
Year: 2012
Journal: Cancer Cell
Title: IDH1 mutations disrupt blood, brain, and barriers.
Volume: 22
Issue: 3
Pages: 285-7
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HT Experiment
GSE74938 | RNA-seq profiling of mouse PGC (Mus musculus)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE85674 | TET proteins regulate lineage specification and TCR-mediated expansion of iNKT cells (SMART-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-62594 | Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum
Series Id: GSE62594
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE172128 | Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture [bulk RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Protein
Q8BG87
Organism: Mus musculus/domesticus
Length: 1803  
Fragment?: false
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Protein
Q3URK3
Organism: Mus musculus/domesticus
Length: 2007  
Fragment?: false
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Protein
E9Q9Y4
Organism: Mus musculus/domesticus
Length: 2039  
Fragment?: false
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Protein
D0VLQ4
Organism: Mus musculus/domesticus
Length: 2039  
Fragment?: false
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Publication
23403289 | J:212599
First Author: Hahn MA
Year: 2013
Journal: Cell Rep
Title: Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.
Volume: 3
Issue: 2
Pages: 291-300
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Publication
24114270 | J:201964
First Author: Fu X
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation.
Volume: 110
Issue: 44
Pages: 17892-7
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Publication
22157888 | J:181117
First Author: Williams K
Year: 2011
Journal: EMBO Rep
Title: DNA methylation: TET proteins-guardians of CpG islands?
Volume: 13
Issue: 1
Pages: 28-35
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Publication
22980977 | J:187964
First Author: Lian CG
Year: 2012
Journal: Cell
Title: Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.
Volume: 150
Issue: 6
Pages: 1135-46
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Publication
22391558 | J:193374
First Author: Yang H
Year: 2013
Journal: Oncogene
Title: Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation.
Volume: 32
Issue: 5
Pages: 663-9
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Publication
24336466 | J:207899
 
First Author: Dan J
Year: 2013
Journal: Sci Rep
Title: Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells.
Volume: 3
Pages: 3492
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Publication
33264617 | J:304503
First Author: Qi T
Year: 2020
Journal: Cell Rep
Title: Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2/3-Mediated DNA Demethylation.
Volume: 33
Issue: 9
Pages: 108452
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Publication
32839607 | J:306004
First Author: Zhou B
Year: 2020
Journal: Nat Immunol
Title: The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury.
Volume: 21
Issue: 11
Pages: 1430-1443
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Publication
36848231 | J:340963
First Author: Brabson JP
Year: 2023
Journal: Cell Rep
Title: Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia.
Volume: 42
Issue: 1
Pages: 112027
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Publication
37643007 | J:341638
 
First Author: Li K
Year: 2023
Journal: J Clin Invest
Title: The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head and neck squamous cell carcinoma.
Volume: 133
Issue: 20
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HT Experiment
GSE172127 | Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture [scRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
23690950 | J:203146
First Author: Liu N
Year: 2013
Journal: PLoS One
Title: Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules.
Volume: 8
Issue: 5
Pages: e62755
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Publication
24336202 | J:207220
First Author: Di Stefano B
Year: 2014
Journal: Nature
Title: C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells.
Volume: 506
Issue: 7487
Pages: 235-9
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Publication
28053194 | J:240427
First Author: Liu J
Year: 2017
Journal: Blood
Title: miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism.
Volume: 129
Issue: 11
Pages: 1491-1502
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Publication
33432228 | J:302194
First Author: Rivas MA
Year: 2021
Journal: Nat Immunol
Title: Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Volume: 22
Issue: 2
Pages: 240-253
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Publication
36909232 | J:334978
 
First Author: Zhang M
Year: 2023
Journal: Front Physiol
Title: Delayed denervation-induced muscle atrophy in Opg knockout mice.
Volume: 14
Pages: 1127474
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Publication
28596252 | J:252696
First Author: Cull AH
Year: 2017
Journal: J Leukoc Biol
Title: Success in bone marrow failure? Novel therapeutic directions based on the immune environment of myelodysplastic syndromes.
Volume: 102
Issue: 2
Pages: 209-219
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Publication
22895193 | J:187151
First Author: Seshagiri S
Year: 2012
Journal: Nature
Title: Recurrent R-spondin fusions in colon cancer.
Volume: 488
Issue: 7413
Pages: 660-4
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Publication
23558522 | J:199020
First Author: Itzykson R
Year: 2013
Journal: Leukemia
Title: An evolutionary perspective on chronic myelomonocytic leukemia.
Volume: 27
Issue: 7
Pages: 1441-50
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Publication
24220273 | J:206977
First Author: Solary E
Year: 2014
Journal: Leukemia
Title: The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases.
Volume: 28
Issue: 3
Pages: 485-96
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Publication
25423485 | J:225280
First Author: Shpyleva S
Year: 2014
Journal: PLoS One
Title: Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum.
Volume: 9
Issue: 11
Pages: e113712
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Publication
26601783 | J:231190
First Author: Kiladjian JJ
Year: 2016
Journal: Leukemia
Title: Interferon-alpha for the therapy of myeloproliferative neoplasms: targeting the malignant clone.
Volume: 30
Issue: 4
Pages: 776-81
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Publication
28449087 | J:247059
First Author: Zhang P
Year: 2017
Journal: Nucleic Acids Res
Title: Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.
Volume: 45
Issue: 12
Pages: 7118-7136
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Publication
28855337 | J:253636
First Author: Yosefzon Y
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: An epigenetic switch repressing Tet1 in gonadotropes activates the reproductive axis.
Volume: 114
Issue: 38
Pages: 10131-10136
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Publication
29769264 | J:266032
First Author: Ng SY
Year: 2018
Journal: Blood
Title: RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice.
Volume: 132
Issue: 9
Pages: 935-947
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Publication
32938585 | J:299188
First Author: Li S
Year: 2020
Journal: Cancer Discov
Title: Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML.
Volume: 10
Issue: 12
Pages: 1934-1949
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Publication
32961550 | J:303755
First Author: Miller PG
Year: 2020
Journal: Blood
Title: Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis.
Volume: 136
Issue: 26
Pages: 3051-3055
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Publication
34622806 | J:312389
 
First Author: Man N
Year: 2021
Journal: JCI Insight
Title: p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia.
Volume: 6
Issue: 19
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Publication
34937926 | J:320564
First Author: Shukla V
Year: 2022
Journal: Nat Immunol
Title: TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures.
Volume: 23
Issue: 1
Pages: 99-108
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Publication
16606617 | J:114350
First Author: Cho YS
Year: 2006
Journal: J Biol Chem
Title: Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.
Volume: 281
Issue: 26
Pages: 17588-98
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Protein
Q3UQU6
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Protein
G3UXC9
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Protein Domain
IPR007759 | Asxl_HARE-HTH
Type: Domain
Description: This domain, known as the HARE-HTH domain, adopts the winged helix-turn-helix fold and is predicted to bind DNA. It can be found at the N terminus of the ASXL protein. It can also be found in several other eukaryotic chromatin proteins (such as HB1 in plants), diverse restriction endonucleases and DNA glycosylases, the RNA polymerase delta subunit of Gram-positive bacteria and certain bacterial proteins that combine features of the RNA polymerase alpha-subunit and sigma factors []. The genetic interaction of the HARE-HTH containing ASXL with the methyl cytosine hydroxylating Tet2 protein is suggestive of a role for the domain in discriminating sequences with DNA modifications such as hmC []. Bacterial versions include fusions to diverse restriction endonucleases, and a DNA glycosylase where it may play a similar role in detecting modified DNA. Certain bacterial version of the HARE-HTH domain show fusions to the helix-hairpin-helix domain of the RNA polymerase alpha subunit and the HTH domains found in regions 3 and 4 of the sigma factors []. These versions are predicted to function as a novel inhibitor of the binding of RNA polymerase to transcription start sites, similar to the Bacillus delta protein [, ].This domain consists of four α-helices (helices I-II-III-IV) and an antiparallel β-sheet composed of three short β-strands at the top of a "twisted tripod"formed by helices II, III, and IV [].The Asx-like (Asxl) proteins includes Asxl1-3. They are putative Polycomb group (PcG) proteins, which act by forming multiprotein complexes that are required to maintain the transcriptionally repressive state of homeotic genes throughout development. Asxl1 is involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) [].The delta protein is a dispensable subunit of Bacillus subtilis RNA polymerase (RNAP) that has major effects on the biochemical properties of the purified enzyme. In the presence of delta, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increasedefficiency of RNA synthesis because of enhanced recycling []. The delta protein, contains two distinct regions, an N-terminal domain and a glutamate and aspartate residue-rich C-terminal region []. It participates in both the initiation and recycling phases of transcription.
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Publication
34621263 | J:312385
 
First Author: Rivas MA
Year: 2021
Journal: Front Immunol
Title: Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes.
Volume: 12
Pages: 688493
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Publication
29615405 | J:264226
First Author: Inaba T
Year: 2018
Journal: Blood
Title: The enigma of monosomy 7.
Volume: 131
Issue: 26
Pages: 2891-2898
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Publication
33705482 | J:304554
First Author: Ono R
Year: 2021
Journal: PLoS One
Title: Tet1 is not required for myeloid leukemogenesis by MLL-ENL in novel mouse models.
Volume: 16
Issue: 3
Pages: e0248425
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Publication
10336502 | -
First Author: López de Saro FJ
Year: 1999
Journal: J Biol Chem
Title: Expression, abundance, and RNA polymerase binding properties of the delta factor of Bacillus subtilis.
Volume: 274
Issue: 22
Pages: 15953-8
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Publication
7545758 | -
First Author: López de Saro FJ
Year: 1995
Journal: J Mol Biol
Title: Structural analysis of the Bacillus subtilis delta factor: a protein polyanion which displaces RNA from RNA polymerase.
Volume: 252
Issue: 2
Pages: 189-202
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Publication
20310067 | -
First Author: Motácková V
Year: 2010
Journal: Proteins
Title: Solution structure of the N-terminal domain of Bacillus subtilis delta subunit of RNA polymerase and its classification based on structural homologs.
Volume: 78
Issue: 7
Pages: 1807-10
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Publication
35502657 | J:334535
First Author: Chakraborty R
Year: 2022
Journal: Circulation
Title: Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.
Volume: 145
Issue: 23
Pages: 1720-1737
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Publication
31649729 | J:311748
 
First Author: Malloy MA
Year: 2019
Journal: Front Genet
Title: Perinatal Bisphenol A Exposure and Reprogramming of Imprinted Gene Expression in the Adult Mouse Brain.
Volume: 10
Pages: 951
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Protein
P59598
Organism: Mus musculus/domesticus
Length: 1514  
Fragment?: false
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Protein
Q8BZ32
Organism: Mus musculus/domesticus
Length: 1370  
Fragment?: false
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•
•
Protein
Q8C4A5
Organism: Mus musculus/domesticus
Length: 2259  
Fragment?: false
•
•
•
•
•
Protein
Q24JP2
Organism: Mus musculus/domesticus
Length: 1514  
Fragment?: false
•
•
•
•
•
Protein
B2RUG8
Organism: Mus musculus/domesticus
Length: 1418  
Fragment?: false
•
•
•
•
•
Protein
F6WV21
Organism: Mus musculus/domesticus
Length: 1370  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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