|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 374 out of 374 for Cyp1a2

<< First    < Previous  |  Next >    Last >>
0.026s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
10469630 | J:57281
First Author: Kimura S
Year: 1999
Journal: Carcinogenesis
Title: CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice.
Volume: 20
Issue: 9
Pages: 1825-30
•
•
•
•
•
Publication
21781866 | J:48609
First Author: Gupta M
Year: 1998
Journal: Environ Toxicol Pharmacol
Title: Ah receptor-independent induction of CYP1A2 gene expression in genetically inbred mice.
Volume: 5
Issue: 3
Pages: 205-13
•
•
•
•
•
Publication
9244376 | J:41932
First Author: Black VH
Year: 1997
Journal: Arch Biochem Biophys
Title: Molecular cloning of cDNA for guinea pig CYP1A2 comparison with guinea pig CYP1A1.
Volume: 344
Issue: 1
Pages: 11-7
•
•
•
•
•
Publication
1520328 | J:2182
First Author: Vasiliou V
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Negative regulation of the murine cytosolic aldehyde dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2 proteins.
Volume: 187
Issue: 1
Pages: 413-9
•
•
•
•
•
Publication
10064569 | J:53795
First Author: Sakuma T
Year: 1999
Journal: Drug Metab Dispos
Title: Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice.
Volume: 27
Issue: 3
Pages: 379-84
•
•
•
•
•
Publication
9441719 | J:45838
First Author: Casley WL
Year: 1997
Journal: Fundam Appl Toxicol
Title: Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains.
Volume: 40
Issue: 2
Pages: 228-37
•
•
•
•
•
Pathway
R-MMU-211957 | Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
•
•
•
•
•
Publication
20829355 | J:166864
First Author: Nukaya M
Year: 2010
Journal: J Biol Chem
Title: The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes.
Volume: 285
Issue: 46
Pages: 35599-605
•
•
•
•
•
Publication
10423181 | J:55743
First Author: Gorman N
Year: 1999
Journal: Biochem Pharmacol
Title: Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice.
Volume: 58
Issue: 2
Pages: 375-82
•
•
•
•
•
Allele
Cyp1a2<tm2024.1(CYP1A2)Arte> | MGI:6405047
Name: cytochrome P450, family 1, subfamily a, polypeptide 2; targeted mutation 2024.1, TaconicArtemis
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
•
•
•
•
•
Strain
MGI:6405114 | B6(Cg)-Cyp1a2<tm2024.1(CYP1A2)Arte>
Attribute String: targeted mutation, mutant strain
•
•
•
•
•
Genotype
Genotype
Symbol: Cyp1a2/Cyp1a2
Background: B6(Cg)-Cyp1a2
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Protein
P00186
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: false
•
•
•
•
•
Allele
Tg(CYP1A1,CYP1A2)1Dwn | MGI:3721236
Name: transgene insertion 1, Daniel W Nebert
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Allele
Cyp1a2<tm3Dwn> | MGI:3722076
Name: cytochrome P450, family 1, subfamily a, polypeptide 2; targeted mutation 3, Daniel W Nebert
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Publication
26582657 | J:237564
First Author: Chen JX
Year: 2016
Journal: Cancer Lett
Title: Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice.
Volume: 371
Issue: 1
Pages: 71-8
•
•
•
•
•
Publication
22581815 | J:231719
First Author: Li G
Year: 2012
Journal: Cancer Prev Res (Phila)
Title: Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
Volume: 5
Issue: 7
Pages: 963-72
•
•
•
•
•
Publication
37348155 | J:337247
 
First Author: Grimm SL
Year: 2023
Journal: Redox Biol
Title: Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation.
Volume: 64
Pages: 102790
•
•
•
•
•
Publication
23692925 | J:203227
First Author: Dong H
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.
Volume: 435
Issue: 4
Pages: 727-32
•
•
•
•
•
Publication
15331171 | J:92416
First Author: Ide F
Year: 2004
Journal: Cancer Lett
Title: Skin and salivary gland carcinogenicity of 7,12-dimethylbenz[a]anthracene is equivalent in the presence or absence of aryl hydrocarbon receptor.
Volume: 214
Issue: 1
Pages: 35-41
•
•
•
•
•
Publication
9364010 | J:45981
First Author: Sakuma T
Year: 1997
Journal: Carcinogenesis
Title: Marmoset CYP1A2: primary structure and constitutive expression in livers.
Volume: 18
Issue: 10
Pages: 1985-91
•
•
•
•
•
Allele
Cyp1a<tm1Dwn> | MGI:3721229
Name: cytochrome P450, family 1, subfamily a cluster; targeted mutation 1, Daniel W Nebert
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:3721792 | B6.129-Cyp1a<tm1Dwn>
Attribute String: targeted mutation, mutant strain, congenic, deletion
•
•
•
•
•
Publication
31776611 | J:285230
First Author: Ibrahim M
Year: 2020
Journal: Diabetologia
Title: Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure.
Volume: 63
Issue: 1
Pages: 162-178
•
•
•
•
•
Publication
27207656 | J:232782
First Author: Wang H
Year: 2016
Journal: Carcinogenesis
Title: Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc.
Volume: 37
Issue: 7
Pages: 723-730
•
•
•
•
•
Genotype
Genotype
Symbol: Cyp1a/Cyp1a
Background: B6.129-Cyp1a
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Publication
28377578 | J:337414
First Author: Lingappan K
Year: 2017
Journal: Sci Rep
Title: Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome.
Volume: 7
Issue: 1
Pages: 642
•
•
•
•
•
Strain
MGI:3721798 | B6.Cg-Cyp1a<tm1Dwn> Tg(CYP1A1,CYP1A2)1Dwn
Attribute String: congenic, mutant strain, targeted mutation, transgenic, deletion
•
•
•
•
•
Strain
MGI:3721805 | STOCK Cyp1a<tm1Dwn> Tg(CYP1A1,CYP1A2)1Dwn/J
Attribute String: targeted mutation, transgenic, mutant stock, deletion
•
•
•
•
•
Publication
30576387 | J:269445
First Author: O'Driscoll CA
Year: 2018
Journal: PLoS One
Title: Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro.
Volume: 13
Issue: 12
Pages: e0209690
•
•
•
•
•
Publication
27664423 | J:257718
First Author: Chen JX
Year: 2017
Journal: Toxicol Sci
Title: From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells.
Volume: 155
Issue: 1
Pages: 224-233
•
•
•
•
•
Genotype
Genotype
Symbol: Cyp1a/Cyp1a Tg(CYP1A1,CYP1A2)1Dwn/Tg(CYP1A1,CYP1A2)1Dwn
Background: B6.Cg-Cyp1a Tg(CYP1A1,CYP1A2)1Dwn
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
10639156 | J:59890
First Author: Shimizu Y
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.
Volume: 97
Issue: 2
Pages: 779-82
•
•
•
•
•
Publication
15258110 | J:210924
First Author: Choudhary D
Year: 2004
Journal: Drug Metab Dispos
Title: Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1.
Volume: 32
Issue: 8
Pages: 840-7
•
•
•
•
•
Publication
28201809 | J:253856
First Author: Maturu P
Year: 2017
Journal: Toxicol Sci
Title: Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.
Volume: 157
Issue: 1
Pages: 260-271
•
•
•
•
•
Publication
19047483 | J:163973
First Author: Dong H
Year: 2009
Journal: Mol Pharmacol
Title: Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle.
Volume: 75
Issue: 3
Pages: 555-67
•
•
•
•
•
Publication
22291093 | J:181870
First Author: Hur KY
Year: 2012
Journal: J Exp Med
Title: IRE1α activation protects mice against acetaminophen-induced hepatotoxicity.
Volume: 209
Issue: 2
Pages: 307-18
•
•
•
•
•
Publication
25063867 | J:317747
First Author: Feng D
Year: 2014
Journal: J Immunol
Title: Acute and chronic effects of IL-22 on acetaminophen-induced liver injury.
Volume: 193
Issue: 5
Pages: 2512-8
•
•
•
•
•
Publication
16557553 | J:153937
First Author: Sekine S
Year: 2006
Journal: Hepatology
Title: Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.
Volume: 43
Issue: 4
Pages: 817-25
•
•
•
•
•
Publication
22442665 | J:187039
First Author: Do KN
Year: 2012
Journal: PLoS One
Title: TLR2 controls intestinal carcinogen detoxication by CYP1A1.
Volume: 7
Issue: 3
Pages: e32309
•
•
•
•
•
Publication
14978233 | J:102075
First Author: Wu Y
Year: 2004
Journal: Mol Pharmacol
Title: Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver.
Volume: 65
Issue: 3
Pages: 550-7
•
•
•
•
•
Publication
23967274 | J:205850
First Author: Lian Y
Year: 2013
Journal: PLoS One
Title: Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice.
Volume: 8
Issue: 8
Pages: e72058
•
•
•
•
•
Publication
28963035 | J:248834
First Author: Chowdhary V
Year: 2017
Journal: Am J Pathol
Title: miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression.
Volume: 187
Issue: 12
Pages: 2758-2774
•
•
•
•
•
Publication
22728710 | J:329067
First Author: He CY
Year: 2012
Journal: Acta Pharmacol Sin
Title: The dual role of osteopontin in acetaminophen hepatotoxicity.
Volume: 33
Issue: 8
Pages: 1004-12
•
•
•
•
•
Publication
30224520 | J:267995
     
First Author: Sasaki S
Year: 2018
Journal: Mol Cell Biol
Title: Induction of hepatic metabolic functions by a novel variant of hepatocyte nuclear factor 4γ.
•
•
•
•
•
Publication
12730383 | J:132380
First Author: Moriguchi T
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.
Volume: 100
Issue: 10
Pages: 5652-7
•
•
•
•
•
Publication
19525444 | J:152427
First Author: Yanagiba Y
Year: 2009
Journal: Toxicol Sci
Title: Octachlorostyrene induces cytochrome P450, UDP-glucuronosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and constitutive androstane receptor.
Volume: 111
Issue: 1
Pages: 19-26
•
•
•
•
•
Publication
26751575 | J:248823
First Author: Lee HJ
Year: 2016
Journal: PLoS One
Title: Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure.
Volume: 11
Issue: 1
Pages: e0146841
•
•
•
•
•
Publication
15123765 | J:100359
First Author: Jiang W
Year: 2004
Journal: J Pharmacol Exp Ther
Title: Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.
Volume: 310
Issue: 2
Pages: 512-9
•
•
•
•
•
Publication
22230337 | J:181214
First Author: Bui P
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment alters eicosanoid levels in several organs of the mouse in an aryl hydrocarbon receptor-dependent fashion.
Volume: 259
Issue: 2
Pages: 143-51
•
•
•
•
•
Publication
26335255 | J:227928
First Author: Krais AM
Year: 2016
Journal: Int J Cancer
Title: Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice.
Volume: 138
Issue: 4
Pages: 976-82
•
•
•
•
•
Publication
28535182 | J:245728
First Author: Crawford DR
Year: 2017
Journal: Carcinogenesis
Title: Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice.
Volume: 38
Issue: 7
Pages: 717-727
•
•
•
•
•
Publication
8314464 | J:12869
First Author: Harper N
Year: 1993
Journal: Fundam Appl Toxicol
Title: Immunosuppressive and monooxygenase induction activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice.
Volume: 20
Issue: 4
Pages: 496-502
•
•
•
•
•
Publication
7665010 | J:26630
First Author: De Jongh J
Year: 1995
Journal: Fundam Appl Toxicol
Title: Induction of cytochrome P450 isoenzymes after toxicokinetic interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2',4,4',5,5'-hexachlorobiphenyl in the liver of the mouse.
Volume: 25
Issue: 2
Pages: 264-70
•
•
•
•
•
Publication
23118901 | J:192281
First Author: Sliva D
Year: 2012
Journal: PLoS One
Title: Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
Volume: 7
Issue: 10
Pages: e47873
•
•
•
•
•
Publication
28860658 | J:255800
First Author: Asakawa M
Year: 2017
Journal: Sci Rep
Title: Modification of the response of olfactory receptors to acetophenone by CYP1a2.
Volume: 7
Issue: 1
Pages: 10167
•
•
•
•
•
Publication
27638959 | J:237369
First Author: Takahashi S
Year: 2016
Journal: J Lipid Res
Title: Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.
Volume: 57
Issue: 12
Pages: 2130-2137
•
•
•
•
•
Strain
MGI:6405110 | B6.Cg-Nr1i3<tm1(NR1I3)Arte> Cyp3a13<tm1Nki> Cyp3a<tm1109(CYP3A4,CYP3A7)Arte> Cyp1a2<tm2024.1(CYP1A2)Arte> Cyp1a1<tm2025.1(CYP1A1)Arte> Cyp2d<tm1836.1(CYP2D6_i2)Arte> Nr1i2<tm1(NR1I2)Arte> Cyp2c<tm1897.1(Alb-CYP2C9)Arte>/Tac
Attribute String: targeted mutation, mutant strain
•
•
•
•
•
Publication
27434302 | J:248735
First Author: de Vries EM
Year: 2016
Journal: PLoS One
Title: Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR.
Volume: 11
Issue: 7
Pages: e0159552
•
•
•
•
•
Publication
10605936 | J:58872
First Author: Nebert DW
Year: 2000
Journal: Biochem Pharmacol
Title: Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis.
Volume: 59
Issue: 1
Pages: 65-85
•
•
•
•
•
Publication
8937451 | J:36221
First Author: Constantin D
Year: 1996
Journal: Biochem Pharmacol
Title: Uroporphyria induced by 5-aminolaevulinic acid alone in Ahrd SWR mice.
Volume: 52
Issue: 9
Pages: 1407-13
•
•
•
•
•
Publication
9233375 | J:42406
First Author: Ryu DY
Year: 1997
Journal: Chem Biol Interact
Title: Regulation of hepatic CYP1A isozymes by piperonyl butoxide and acenaphthylene in the mouse.
Volume: 105
Issue: 1
Pages: 53-63
•
•
•
•
•
Publication
9434738 | J:45020
First Author: Mori T
Year: 1997
Journal: Arch Biochem Biophys
Title: Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs.
Volume: 348
Issue: 2
Pages: 268-77
•
•
•
•
•
Publication
9882005 | J:52333
First Author: Taras-Valéro D
Year: 1998
Journal: Environ Mol Mutagen
Title: Inhibition of 5,9-dimethyldibenzo[c,g]carbazole-DNA adduct formation in mouse liver by pretreatment with cytochrome P4501A inducers in vivo.
Volume: 32
Issue: 4
Pages: 314-24
•
•
•
•
•
Publication
12663521 | J:82833
First Author: Kimura S
Year: 2003
Journal: Carcinogenesis
Title: Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.
Volume: 24
Issue: 3
Pages: 583-7
•
•
•
•
•
Publication
21362406 | J:171945
First Author: Jiang W
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo.
Volume: 407
Issue: 1
Pages: 79-85
•
•
•
•
•
Publication
7840637 | J:22637
First Author: Nemoto N
Year: 1995
Journal: Arch Biochem Biophys
Title: Maintenance of phenobarbital-inducible Cyp2b gene expression in C57BL/6 mouse hepatocytes in primary culture as spheroids.
Volume: 316
Issue: 1
Pages: 362-9
•
•
•
•
•
Publication
28146477 | J:244974
First Author: Schiering C
Year: 2017
Journal: Nature
Title: Feedback control of AHR signalling regulates intestinal immunity.
Volume: 542
Issue: 7640
Pages: 242-245
•
•
•
•
•
Strain
MGI:3818514 | B6.Cg-Cyp1<tm1Dwn> Ahr<d> Tg(CYP1A1,CYP1A2)1Dwn/DwnJ
Attribute String: transgenic, spontaneous mutation, congenic, targeted mutation, deletion
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom