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Search results 101 to 188 out of 188 for Aqp7

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0.068s
Type Details Score
GXD Expression      
Probe: MGI:7541506
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7543050
Age: postnatal week 9
Specimen Label: Ad
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Specimen Label: 8A
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Note: Expression was detected in the saccular wall.
Specimen Label: 8A
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7541522
Assay Type: RNA in situ
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2828125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7542999
Age: embryonic day 17.5
Specimen Label: 2A E17.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7541522
Assay Type: RNA in situ
Annotation Date: 2023-10-24
Strength: Present
Sex: Male
Emaps: EMAPS:2828128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7542999
Age: postnatal week 9
Specimen Label: 2A AD
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Specimen Label: 8A
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Note: Expression was detected in the utricular wall.
Specimen Label: 8A
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Note: Strong immunoreactivity was observed at the Reissner's membrane.
Specimen Label: 7
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Specimen Label: 7
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Specimen Label: 7
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Specimen Label: 7
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Specimen Label: 7
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Note: The laminar surface of the stria marginal cells showed strong immunoreactivity.
Specimen Label: 7
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3623984
Assay Type: Immunohistochemistry
Annotation Date: 2006-06-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160403
Stage: TS03
Assay Id: MGI:3623988
Age: embryonic day 3.0
Specimen Label: 4B Morula
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3516628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Specimen Label: 7
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3623984
Assay Type: Immunohistochemistry
Annotation Date: 2006-06-07
Strength: Absent
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3623988
Age: postnatal adult
Specimen Label: 4B Oocyte
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5461370
Assay Type: Immunohistochemistry
Annotation Date: 2013-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2966128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5461486
Age: postnatal adult
Image: 3D
Specimen Label: 3D
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3623984
Assay Type: Immunohistochemistry
Annotation Date: 2006-06-07
Strength: Present
Sex: Male
Emaps: EMAPS:3576128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3623988
Age: postnatal
Specimen Label: not shown
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7506226
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-11
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3582728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506301
Age: postnatal adult
Specimen Label: 7
Detected: true
Specimen Num: 1
Publication
First Author: Raje V
Year: 2020
Journal: Sci Rep
Title: Adipocyte lipolysis drives acute stress-induced insulin resistance.
Volume: 10
Issue: 1
Pages: 18166
Publication
First Author: Kuriyama H
Year: 2002
Journal: Diabetes
Title: Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
Volume: 51
Issue: 10
Pages: 2915-21
Publication
First Author: Edashige K
Year: 2006
Journal: Biol Reprod
Title: Channel-dependent permeation of water and glycerol in mouse morulae.
Volume: 74
Issue: 4
Pages: 625-32
Publication
First Author: Ishihama S
Year: 2021
Journal: FASEB J
Title: LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.
Volume: 35
Issue: 12
Pages: e22048
Publication
First Author: Walker CG
Year: 2007
Journal: Int J Obes (Lond)
Title: Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency.
Volume: 31
Issue: 7
Pages: 1165-71
Publication
First Author: Hashemolhosseini S
Year: 2002
Journal: Mech Dev
Title: Restricted expression of mouse GCMa/Gcm1 in kidney and thymus.
Volume: 118
Issue: 1-2
Pages: 175-8
Publication
First Author: Verkman AS
Year: 2005
Journal: J Cell Sci
Title: More than just water channels: unexpected cellular roles of aquaporins.
Volume: 118
Issue: Pt 15
Pages: 3225-32
Publication
First Author: Knoers NV
Year: 1998
Journal: Curr Opin Pediatr
Title: Aquaporin molecular biology and clinical abnormalities of the water transport channels.
Volume: 10
Issue: 4
Pages: 428-34
Publication
First Author: Verkman AS
Year: 1998
Journal: Am J Med Sci
Title: Role of aquaporin water channels in kidney and lung.
Volume: 316
Issue: 5
Pages: 310-20
Publication
First Author: Offenberg H
Year: 2000
Journal: Mol Reprod Dev
Title: mRNAs encoding aquaporins are present during murine preimplantation development.
Volume: 57
Issue: 4
Pages: 323-30
Publication
First Author: Edashige K
Year: 2000
Journal: Cryobiology
Title: Expression of mRNAs of the aquaporin family in mouse oocytes and embryos.
Volume: 40
Issue: 2
Pages: 171-5
Publication  
First Author: Tanahashi H
Year: 2016
Journal: Sci Rep
Title: Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.
Volume: 6
Pages: 20241
Publication  
First Author: Okada N
Year: 2021
Journal: Biomed Res Int
Title: Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.
Volume: 2021
Pages: 6888494
Publication
First Author: Parreira KS
Year: 2009
Journal: Pflugers Arch
Title: Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.
Volume: 458
Issue: 4
Pages: 745-59
Publication
First Author: Kirchhof P
Year: 2011
Journal: Circ Cardiovasc Genet
Title: PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.
Volume: 4
Issue: 2
Pages: 123-33
Publication      
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication
First Author: Sohara E
Year: 2006
Journal: Biochim Biophys Acta
Title: Physiological roles of AQP7 in the kidney: Lessons from AQP7 knockout mice.
Volume: 1758
Issue: 8
Pages: 1106-10
Publication  
First Author: Verta R
Year: 2021
Journal: Biomolecules
Title: The Interplay between Histamine H4 Receptor and the Kidney Function: The Lesson from H4 Receptor Knockout Mice.
Volume: 11
Issue: 10
Publication
First Author: Sonntag Y
Year: 2019
Journal: J Biol Chem
Title: Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors.
Volume: 294
Issue: 18
Pages: 7377-7387
Publication
First Author: Ishibashi K
Year: 1997
Journal: J Biol Chem
Title: Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea.
Volume: 272
Issue: 33
Pages: 20782-6
Publication
First Author: Kuriyama H
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability.
Volume: 241
Issue: 1
Pages: 53-8
Protein Domain
Type: Family
Description: Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol []. In higher eukaryotes these proteins play diverse roles in the maintenance of water homeostasis, indicating that membrane water permeability can be regulated independently of solute permeability. In microorganisms however, many of which do not contain aquaporins, they do not appear to play such a broad role. Instead, they assist specific microbial lifestyles within the environment, e.g. they confer protection against freeze-thaw stress and may help maintain water permeability at low temperatures []. The regulation of aquaporins is complex, including transcriptional, post-translational, protein-trafficking and channel-gating mechanisms that are frequently distinct for each family member.Structural studies show that aquaporins are present in the membrane as tetramers, though each monomer contains its own channel [, , ]. The monomer has an overall "hourglass"structure made up of three structural elements: an external vestibule, an internal vestibule, and an extended pore which connects the two vestibules. Substrate selectivity is conferred by two mechanisms. Firstly, the diameter of the pore physically limits the size of molecules that can pass through the channel. Secondly, specific amino acids within the molecule regulate the preference for hydrophobic or hydrophilic substrates.Aquaporins are classified into two subgroups: the aquaporins (also known as orthodox aquaporins), which transport only water, and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water [, ].Aquaporin-7 (AQP7) contains the 6 transmembrane domains and intracellular N and C termini characteristic of aquaporins []. AQP7 is expressed abundantly in rat testis seminiferous tubules, in cells that appear to be late spermatids []. It expressed predominantly in human adipose tissue [], and in Xenopus laevis (African clawed frog) oocytes increased the coefficients of osmotic water permeability approximately 7-fold, and also facilitated the uptake of glycerol, suggesting that this aquaporin participates in glycerol transport in adipocytes [].Synonym(s): AQUAPORIN 7-LIKE,AQUAPORIN, ADIPOSE,AQP7L
Publication
First Author: Engevik AC
Year: 2018
Journal: Gastroenterology
Title: Loss of MYO5B Leads to Reductions in Na(+) Absorption With Maintenance of CFTR-Dependent Cl(-) Secretion in Enterocytes.
Volume: 155
Issue: 6
Pages: 1883-1897.e10
Publication
First Author: Ishibashi K
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.
Volume: 244
Issue: 1
Pages: 268-74
Publication
First Author: Carbrey JM
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver.
Volume: 100
Issue: 5
Pages: 2945-50
Publication
First Author: Gotfryd K
Year: 2018
Journal: Nat Commun
Title: Human adipose glycerol flux is regulated by a pH gate in AQP10.
Volume: 9
Issue: 1
Pages: 4749
Protein Domain
Type: Family
Description: Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol []. In higher eukaryotes these proteins play diverse roles in the maintenance of water homeostasis, indicating that membrane water permeability can be regulated independently of solute permeability. In microorganisms however, many of which do not contain aquaporins, they do not appear to play such a broad role. Instead, they assist specific microbial lifestyles within the environment, e.g. they confer protection against freeze-thaw stress and may help maintain water permeability at low temperatures []. The regulation of aquaporins is complex, including transcriptional, post-translational, protein-trafficking and channel-gating mechanisms that are frequently distinct for each family member.Structural studies show that aquaporins are present in the membrane as tetramers, though each monomer contains its own channel [, , ]. The monomer has an overall "hourglass"structure made up of three structural elements: an external vestibule, an internal vestibule, and an extended pore which connects the two vestibules. Substrate selectivity is conferred by two mechanisms. Firstly, the diameter of the pore physically limits the size of molecules that can pass through the channel. Secondly, specific amino acids within the molecule regulate the preference for hydrophobic or hydrophilic substrates.Aquaporins are classified into two subgroups: the aquaporins (also known as orthodox aquaporins), which transport only water, and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water [, ].Aquaporin-9 was identified from human leukocytes by homology cloning []. AQP9 has unusually broad solute permeability. It is expressed in hepatocyte plasma membranes and also in lung, small intestine and spleen cells []. Expression of AQP9 in liver was induced up to 20-fold in rats fasted for 24 to 96 hours, and the AQP9 level gradually declined after re-feeding []. AQP9 shares greater sequence identity with AQP3 and AQP7 than with other members of the family, suggesting that these 3 proteins belong to a subfamily.
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Publication
First Author: Harries WE
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: The channel architecture of aquaporin 0 at a 2.2-A resolution.
Volume: 101
Issue: 39
Pages: 14045-50
Publication
First Author: King LS
Year: 2004
Journal: Nat Rev Mol Cell Biol
Title: From structure to disease: the evolving tale of aquaporin biology.
Volume: 5
Issue: 9
Pages: 687-98
Publication
First Author: Tanghe A
Year: 2006
Journal: Trends Microbiol
Title: Why do microorganisms have aquaporins?
Volume: 14
Issue: 2
Pages: 78-85
Publication
First Author: Savage DF
Year: 2003
Journal: PLoS Biol
Title: Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z.
Volume: 1
Issue: 3
Pages: E72
Publication  
First Author: Gorelick DA
Year: 2006
Journal: BMC Biochem
Title: Aquaporin-11: a channel protein lacking apparent transport function expressed in brain.
Volume: 7
Pages: 14
Publication  
First Author: Borgnia M
Year: 1999
Journal: Annu Rev Biochem
Title: Cellular and molecular biology of the aquaporin water channels.
Volume: 68
Pages: 425-58
Publication
First Author: Sui H
Year: 2001
Journal: Nature
Title: Structural basis of water-specific transport through the AQP1 water channel.
Volume: 414
Issue: 6866
Pages: 872-8