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Search results 101 to 195 out of 195 for Glra3

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0.033s
Type Details Score
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1928728
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1857728
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Male
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 68
Specimen Label: Mouse 199335
Detected: false
Specimen Num: 7
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
GXD Expression        
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-07-27
Strength: Absent
Sex: Female
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3639238
Age: postnatal day 54
Specimen Label: Mouse 235765
Detected: false
Specimen Num: 11
GXD Expression  
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_10
Specimen Label: euxassay_010858_10
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_10
Specimen Label: euxassay_010858_10
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_11
Specimen Label: euxassay_010858_11
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_11
Specimen Label: euxassay_010858_11
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_14
Specimen Label: euxassay_010858_14
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_15
Specimen Label: euxassay_010858_15
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4425297
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1690623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825080
Age: embryonic day 14.5
Image: euxassay_010858_16
Specimen Label: euxassay_010858_16
Detected: true
Specimen Num: 5
Publication    
First Author: Noegel S
Year: 2001
Journal: GenBank Submission
Title: Mus musculus glycine receptor alpha 3 subunit (Glra3) mRNA, complete cds
Pages: AF362764
Publication
First Author: Harvey RJ
Year: 2004
Journal: Science
Title: GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.
Volume: 304
Issue: 5672
Pages: 884-7
Publication
First Author: Manzke T
Year: 2010
Journal: J Clin Invest
Title: Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice.
Volume: 120
Issue: 11
Pages: 4118-28
Publication
First Author: Nobles RD
Year: 2012
Journal: J Neurosci
Title: Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.
Volume: 32
Issue: 10
Pages: 3321-32
Publication
First Author: Ivanova E
Year: 2006
Journal: Eur J Neurosci
Title: Characterization of the glycinergic input to bipolar cells of the mouse retina.
Volume: 23
Issue: 2
Pages: 350-64
Publication
First Author: McCracken LM
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.
Volume: 114
Issue: 34
Pages: E7179-E7186
Publication
First Author: Graham BA
Year: 2011
Journal: J Physiol
Title: Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse.
Volume: 589
Issue: Pt 10
Pages: 2459-74
Publication
First Author: Heinze L
Year: 2007
Journal: J Comp Neurol
Title: Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit.
Volume: 500
Issue: 4
Pages: 693-707
Publication
First Author: Xiong W
Year: 2012
Journal: J Exp Med
Title: Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.
Volume: 209
Issue: 6
Pages: 1121-34
Publication  
First Author: Mesuret G
Year: 2018
Journal: Respir Physiol Neurobiol
Title: Breathing disturbances in a model of Rett syndrome: A potential involvement of the glycine receptor α3 subunit?
Volume: 248
Pages: 43-47
Publication
First Author: Weiss J
Year: 2008
Journal: Mol Cell Neurosci
Title: Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice.
Volume: 37
Issue: 1
Pages: 40-55
Publication
First Author: Majumdar S
Year: 2009
Journal: J Physiol
Title: Glycinergic input of widefield, displaced amacrine cells of the mouse retina.
Volume: 587
Issue: Pt 15
Pages: 3831-49
Publication
First Author: Kingsmore SF
Year: 1994
Journal: Mamm Genome
Title: Genetic mapping of the glycine receptor alpha 3 subunit on mouse chromosome 8.
Volume: 5
Issue: 12
Pages: 831-2
Publication
First Author: Zhu L
Year: 1999
Journal: Genomics
Title: Chromosomal mapping of the tankyrase gene in human and mouse.
Volume: 57
Issue: 2
Pages: 320-1
Publication
First Author: Heck S
Year: 1997
Journal: Brain Res Dev Brain Res
Title: Expression and mRNA splicing of glycine receptor subunits and gephyrin during neuronal differentiation of P19 cells in vitro, studied by RT-PCR and immunocytochemistry.
Volume: 98
Issue: 2
Pages: 211-20
Publication
First Author: Lynch JW
Year: 2009
Journal: Neuropharmacology
Title: Native glycine receptor subtypes and their physiological roles.
Volume: 56
Issue: 1
Pages: 303-9
Publication
First Author: Mordel J
Year: 2011
Journal: J Physiol
Title: Activation of glycine receptor phase-shifts the circadian rhythm in neuronal activity in the mouse suprachiasmatic nucleus.
Volume: 589
Issue: Pt 9
Pages: 2287-300
Publication
First Author: Becker CM
Year: 1997
Journal: Neuroscientist
Title: Glycine receptors: Molecular heterogeneity and implications for disease.
Volume: 1
Issue: 3
Pages: 130-41
Publication
First Author: Kunz PA
Year: 2012
Journal: J Physiol
Title: Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex.
Volume: 590
Issue: 22
Pages: 5749-64
Publication    
First Author: Kim H
Year: 2022
Journal: Elife
Title: Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression.
Volume: 11
Publication
First Author: Derry JM
Year: 1991
Journal: Genomics
Title: Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.
Volume: 10
Issue: 3
Pages: 593-7
Publication
First Author: Manceau V
Year: 2012
Journal: PLoS One
Title: The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.
Volume: 7
Issue: 8
Pages: e43946
Publication
First Author: Kennedy AJ
Year: 2016
Journal: Cell Rep
Title: Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Volume: 16
Issue: 10
Pages: 2666-2685
Publication
First Author: Guo Z
Year: 2012
Journal: J Neurosci
Title: Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
Volume: 32
Issue: 25
Pages: 8509-20
Publication
First Author: Boyle MP
Year: 2011
Journal: J Comp Neurol
Title: Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.
Volume: 519
Issue: 11
Pages: 2061-89
Publication      
First Author: Deltagen Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Nikolic Z
Year: 1998
Journal: J Biol Chem
Title: The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts.
Volume: 273
Issue: 31
Pages: 19708-14
Allele
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Jochen C Meier
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
Genotype
Symbol: Hprt1/? Pvalb/Pvalb<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hprt1/? Tg(Camk2a-cre)2Gsc/?
Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Winkelmann A
Year: 2014
Journal: J Clin Invest
Title: Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Volume: 124
Issue: 2
Pages: 696-711
Publication
First Author: Çaliskan G
Year: 2016
Journal: Cereb Cortex
Title: Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence.
Volume: 26
Issue: 5
Pages: 2325-2340
Protein Domain
Type: Family
Description: Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].Glycine is a major inhibitory neurotransmitter (NT) in the adult vertebratecentral nervous system (CNS). Glycinergic synapses have a well-establishedrole in the processing of motor and sensory information that controlsmovement, vision and audition []. This action of glycine is mediatedthrough its interaction with the glycine receptor (GlyR): an intrinsicchloride channel is opened in response to agonist binding. The subsequentinflux of anions prevents membrane depolarisation and neuronal firinginduced by excitatory NTs. Strychnine acts as a competitive antagonist ofglycine binding, thereby reducing the activity of inhibitory neurones.Poisoning with strychnine is characterised by over-excitation, muscle spasmsand convulsions. Whilst glycine is the principal physiological agonist atGlyRs, taurine and beta-alanine also behave as agonists []. Compounds thatmodulate GlyR activity include zinc, some alcohols and anaesthetics,picrotoxin, cocaine and some anticonvulsants. GlyRs were thought for sometime to be localised exclusively in the brain stem and spinal cord, but havesince been found to be expressed more widely, including the cochlear nuclei,cerebellar cortex and forebrain [].GlyRs belong to the ligand-gated ion channel family, which also includes theinhibitory gamma-aminobutyric acid type A (GABAA) and excitatory nicotinicacetylcholine (nACh) and serotonin type 3 (5-HT3) receptors [].Affinity-purified GlyR was found to contain two glycosylated membraneproteins of 48kDa and 56kDa, corresponding to alpha and beta subunits,respectively. Four genes encoding alpha subunits have been identified (GLRA1to 4), together with a single beta polypeptide (GLRB). The heterogeneity ofalpha subunits is further increased by alternative exon splicing, yieldingtwo isoforms of GLRA1 to 3 []. The characteristics of different GlyRsubtypes, therefore, can be largely explained by their GLRA content.GlyRs are generally believed to adopt a pentameric structure in vivo: fivesubunits assemble to form a ring structure with a central pore. Typically, astoichiometry of 3:2 (alpha:beta) is observed []. GlyR subunits share ahigh overall level of sequence similarity both with themselves and with thesubunits of the GABAA and nACh receptors. Four highly conserved segmentshave been proposed to correspond to transmembrane (TM) alpha helices (TM1-4), the second of which is thought to contribute to the pore wall []. A long extracellular N-terminal segment precedes TM1 and a long cytoplasmic loop links TM3 and 4. Short cytoplasmic and extracellular loops join TM1-2 andTM2-3, respectively, and a short C-terminal sequence follows TM4. Studiesusing radiolabelled strychnine have shown the alpha subunit to beresponsible for ligand binding, the critical residues for this interaction lying within the N-terminal domain. The beta subunit plays a structuralrole, contributing one of its TM domains to the pore wall as well as playinga putative role in postsynaptic clustering of the receptor.In several mammalian species, defects in glycinergic transmission areassociated with complex motor disorders. Mutations in the gene encodingGLRA1 give rise to hyperplexia, or startle disease []. This ischaracterised by muscular spasms in response to unexpected light or noisestimuli, similar to the symptoms of sublethal doses of strychnine. Themutations result in amino acid substitutions within the TM1-2 and TM3-4loops, suggesting that these regions are involved in the transduction ofligand binding into channel activation.GLRA3 is expressed in thecerebellum, olfactory bulb and hippocampus. GLRA3 trancripts, together withGLRA1, predominate in the postnatal CNS, replacing GLRA2, which is moreabundant in embryonic and neonatal neurones.
Protein
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
Publication  
First Author: Betz H
Year: 1999
Journal: Ann N Y Acad Sci
Title: Structure and functions of inhibitory and excitatory glycine receptors.
Volume: 868
Pages: 667-76
Publication
First Author: López-Corcuera B
Year: 2001
Journal: Mol Membr Biol
Title: Glycine neurotransmitter transporters: an update.
Volume: 18
Issue: 1
Pages: 13-20
Publication
First Author: Legendre P
Year: 2001
Journal: Cell Mol Life Sci
Title: The glycinergic inhibitory synapse.
Volume: 58
Issue: 5-6
Pages: 760-93
Publication
First Author: Sato C
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Proposed tertiary structure of the sodium channel.
Volume: 186
Issue: 2
Pages: 1158-67
Publication
First Author: Leite JF
Year: 2001
Journal: Mol Cell Neurosci
Title: Structure of ligand-gated ion channels: critical assessment of biochemical data supports novel topology.
Volume: 17
Issue: 5
Pages: 777-92
Publication
First Author: Kofuji P
Year: 1991
Journal: J Neurochem
Title: Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.
Volume: 56
Issue: 2
Pages: 713-5
Publication
First Author: Wagner K
Year: 1991
Journal: J Biol Chem
Title: Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.
Volume: 266
Issue: 35
Pages: 23784-9
Publication
First Author: Yan D
Year: 1999
Journal: J Biol Chem
Title: Structural features of the ligand-binding domain of the serotonin 5HT3 receptor.
Volume: 274
Issue: 9
Pages: 5537-41
Publication
First Author: Millar NS
Year: 2008
Journal: Mol Membr Biol
Title: Assembly and trafficking of nicotinic acetylcholine receptors (Review).
Volume: 25
Issue: 4
Pages: 279-92
Publication
First Author: Lynch JW
Year: 2004
Journal: Physiol Rev
Title: Molecular structure and function of the glycine receptor chloride channel.
Volume: 84
Issue: 4
Pages: 1051-95
Publication
First Author: Olsen RW
Year: 2009
Journal: Neuropharmacology
Title: GABA A receptors: subtypes provide diversity of function and pharmacology.
Volume: 56
Issue: 1
Pages: 141-8
Publication
First Author: Wollmuth LP
Year: 2004
Journal: Trends Neurosci
Title: Structure and gating of the glutamate receptor ion channel.
Volume: 27
Issue: 6
Pages: 321-8