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Search results 101 to 200 out of 1199 for Mdm2

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Type Details Score
Publication
8917101 | J:36310
First Author: Jones SN
Year: 1996
Journal: Gene
Title: Genomic organization of the mouse double minute 2 gene.
Volume: 175
Issue: 1-2
Pages: 209-13
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Publication
21730132 | J:174368
First Author: Pant V
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
Volume: 108
Issue: 29
Pages: 11995-2000
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Publication
31749402 | J:283328
First Author: Klimovich B
Year: 2020
Journal: Cell Cycle
Title: Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo.
Volume: 19
Issue: 1
Pages: 109-123
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Publication
19380490 | J:149898
First Author: Sashida G
Year: 2009
Journal: Mol Cell Biol
Title: ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.
Volume: 29
Issue: 13
Pages: 3687-99
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Publication
16492743 | J:107178
First Author: Xiong S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.
Volume: 103
Issue: 9
Pages: 3226-31
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Publication
16492744 | J:120591
First Author: Francoz S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.
Volume: 103
Issue: 9
Pages: 3232-7
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Publication
30012555 | J:272583
First Author: Van Alstyne M
Year: 2018
Journal: Genes Dev
Title: Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy.
Volume: 32
Issue: 15-16
Pages: 1045-1059
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Publication
12145204 | J:78409
First Author: Lin HK
Year: 2002
Journal: EMBO J
Title: Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase.
Volume: 21
Issue: 15
Pages: 4037-48
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Publication
25624478 | J:219561
First Author: Batuello CN
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase.
Volume: 112
Issue: 6
Pages: 1749-54
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Publication
26748827 | J:232859
First Author: Wienken M
Year: 2016
Journal: Mol Cell
Title: MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Volume: 61
Issue: 1
Pages: 68-83
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Publication
29704532 | J:266659
First Author: Guo W
Year: 2018
Journal: Biochim Biophys Acta Mol Cell Res
Title: MDM2 controls NRF2 antioxidant activity in prevention of diabetic kidney disease.
Volume: 1865
Issue: 8
Pages: 1034-1045
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Publication
17018606 | J:113394
First Author: Chandler DS
Year: 2006
Journal: Cancer Res
Title: Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.
Volume: 66
Issue: 19
Pages: 9502-8
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Publication
21389118 | J:182974
First Author: Yin C
Year: 2011
Journal: Mol Biol Cell
Title: Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2.
Volume: 22
Issue: 9
Pages: 1608-16
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Publication
25720496 | J:222127
First Author: Fu D
Year: 2015
Journal: J Biol Chem
Title: Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT/enhancer-binding protein β.
Volume: 290
Issue: 16
Pages: 10200-7
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Publication
33277368 | J:303986
First Author: Yang J
Year: 2021
Journal: Cancer Res
Title: MDMX Recruits UbcH5c to Facilitate MDM2 E3 Ligase Activity and Subsequent p53 Degradation In Vivo.
Volume: 81
Issue: 4
Pages: 898-909
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Publication
29123033 | J:256782
First Author: Tian H
Year: 2017
Journal: J Biol Chem
Title: Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice.
Volume: 292
Issue: 52
Pages: 21614-21622
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Publication
15467748 | J:94714
First Author: Eischen CM
Year: 2004
Journal: Oncogene
Title: Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development.
Volume: 23
Issue: 55
Pages: 8931-40
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Publication
21060154 | J:171869
First Author: Jung CR
Year: 2010
Journal: J Clin Invest
Title: Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.
Volume: 120
Issue: 12
Pages: 4493-506
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Publication
29016848 | J:249678
First Author: Liu DC
Year: 2017
Journal: Hum Mol Genet
Title: Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity.
Volume: 26
Issue: 20
Pages: 3895-3908
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Publication
12509446 | J:81065
First Author: Mendrysa SM
Year: 2003
Journal: Mol Cell Biol
Title: mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation.
Volume: 23
Issue: 2
Pages: 462-72
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Publication
10050879 | J:100754
First Author: Alkhalaf M
Year: 1999
Journal: Oncogene
Title: MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.
Volume: 18
Issue: 7
Pages: 1419-34
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Publication
22297670 | J:198187
First Author: Mulay SR
Year: 2012
Journal: Kidney Int
Title: MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice.
Volume: 81
Issue: 12
Pages: 1199-211
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Publication
19132120 | J:142705
First Author: Volk EL
Year: 2009
Journal: Dis Model Mech
Title: MDM2-A, a common Mdm2 splice variant, causes perinatal lethality, reduced longevity and enhanced senescence.
Volume: 2
Issue: 1-2
Pages: 47-55
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Publication
10075719 | J:53589
First Author: Saucedo LJ
Year: 1999
Journal: J Biol Chem
Title: Multiple murine double minute gene 2 (MDM2) proteins are induced by ultraviolet light.
Volume: 274
Issue: 12
Pages: 8161-8
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Publication
18483220 | J:134767
First Author: Terzian T
Year: 2008
Journal: Genes Dev
Title: The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.
Volume: 22
Issue: 10
Pages: 1337-44
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Publication
9380404 | J:43292
First Author: Reinke V
Year: 1997
Journal: Oncogene
Title: The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo.
Volume: 15
Issue: 13
Pages: 1527-34
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Publication
29992578 | J:301655
First Author: Song H
Year: 2019
Journal: Int J Cancer
Title: GPRC5A deficiency leads to dysregulated MDM2 via activated EGFR signaling for lung tumor development.
Volume: 144
Issue: 4
Pages: 777-787
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Publication
15734743 | J:99937
First Author: Alt JR
Year: 2005
Journal: J Biol Chem
Title: Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
Volume: 280
Issue: 19
Pages: 18771-81
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Publication
7958853 | J:19613
First Author: Barak Y
Year: 1994
Journal: Genes Dev
Title: Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.
Volume: 8
Issue: 15
Pages: 1739-49
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Publication
21040902 | J:167536
First Author: Abbas HA
Year: 2010
Journal: Cell Stem Cell
Title: Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.
Volume: 7
Issue: 5
Pages: 606-17
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Publication
22624716 | J:189297
First Author: Gannon HS
Year: 2012
Journal: Cancer Cell
Title: ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice.
Volume: 21
Issue: 5
Pages: 668-79
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Publication
25263199 | J:217191
First Author: Zhang Y
Year: 2014
Journal: Dev Biol
Title: Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.
Volume: 396
Issue: 1
Pages: 19-30
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Publication
2026149 | J:18287
First Author: Fakharzadeh SS
Year: 1991
Journal: EMBO J
Title: Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.
Volume: 10
Issue: 6
Pages: 1565-9
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Publication
23029416 | J:192121
First Author: Eischen CM
Year: 2012
Journal: PLoS One
Title: Decreased Mdm2 expression inhibits tumor development and extends survival independent of Arf and dependent on p53.
Volume: 7
Issue: 9
Pages: e46148
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Publication
33601405 | J:306031
First Author: Beauchamp MC
Year: 2021
Journal: Hum Mol Genet
Title: Mutation in Eftud2 causes craniofacial defects in mice via mis-splicing of Mdm2 and increased P53.
Volume: 30
Issue: 9
Pages: 739-757
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Publication
10419603 | J:56319
First Author: McDonnell TJ
Year: 1999
Journal: J Pathol
Title: Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice.
Volume: 188
Issue: 3
Pages: 322-8
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Publication
11335127 | J:69786
First Author: Daujat S
Year: 2001
Journal: Mech Dev
Title: Preferential expression of Mdm2 oncogene during the development of neural crest and its derivatives in mouse early embryogenesis.
Volume: 103
Issue: 1-2
Pages: 163-5
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Publication
31767619 | J:292836
 
First Author: Sui P
Year: 2019
Journal: Development
Title: E3 ubiquitin ligase MDM2 acts through p53 to control respiratory progenitor cell number and lung size.
Volume: 146
Issue: 24
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Publication
21420949 | J:173795
First Author: Hilliard S
Year: 2011
Journal: Dev Biol
Title: Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching.
Volume: 353
Issue: 2
Pages: 354-66
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Publication
17936560 | J:126004
First Author: Itahana K
Year: 2007
Journal: Cancer Cell
Title: Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation.
Volume: 12
Issue: 4
Pages: 355-66
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Publication
15361844 | J:93838
First Author: Iwakuma T
Year: 2004
Journal: Oncogene
Title: Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.
Volume: 23
Issue: 46
Pages: 7644-50
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Publication
11528400 | J:71532
First Author: Parant J
Year: 2001
Journal: Nat Genet
Title: Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.
Volume: 29
Issue: 1
Pages: 92-5
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Publication
24163099 | J:211903
First Author: Frum RA
Year: 2014
Journal: Nucleic Acids Res
Title: The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing.
Volume: 42
Issue: 2
Pages: 926-40
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Publication
29267372 | J:254690
First Author: Hauck L
Year: 2017
Journal: PLoS One
Title: Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death.
Volume: 12
Issue: 12
Pages: e0189861
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Publication
20386595 | J:160166
First Author: Qin Q
Year: 2010
Journal: PLoS One
Title: Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.
Volume: 5
Issue: 4
Pages: e9999
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Publication
9294611 | J:42941
First Author: Midgley CA
Year: 1997
Journal: Oncogene
Title: p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.
Volume: 15
Issue: 10
Pages: 1179-89
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Publication
22821713 | J:188490
First Author: Zhang Q
Year: 2012
Journal: J Pathol
Title: Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.
Volume: 228
Issue: 3
Pages: 416-28
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Publication
16543935 | J:126382
First Author: Marine JC
Year: 2006
Journal: Cell Death Differ
Title: Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Volume: 13
Issue: 6
Pages: 927-34
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Publication
37071397 | J:337015
     
First Author: Langenbach M
Year: 2023
Journal: Mol Cancer Res
Title: MDM2 inhibition enhances immune checkpoint inhibitor efficacy by increasing IL-15 and MHC class II production.
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Publication
27042854 | J:248884
First Author: Kamio T
Year: 2016
Journal: PLoS One
Title: Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis.
Volume: 11
Issue: 4
Pages: e0152263
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Publication
28118981 | J:240406
First Author: Zhang Y
Year: 2017
Journal: Dev Biol
Title: Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner.
Volume: 423
Issue: 1
Pages: 34-45
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Publication
17157790 | J:116672
First Author: Ringshausen I
Year: 2006
Journal: Cancer Cell
Title: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.
Volume: 10
Issue: 6
Pages: 501-14
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Publication
9241268 | J:42048
First Author: Montes de Oca Luna R
Year: 1997
Journal: Nat Genet
Title: Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality.
Volume: 16
Issue: 4
Pages: 336-7
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Publication
33468664 | J:301075
 
First Author: Chibaya L
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis.
Volume: 118
Issue: 4
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Publication
21317535 | J:172038
First Author: Zhao R
Year: 2011
Journal: J Clin Invest
Title: Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Volume: 121
Issue: 3
Pages: 851-65
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Publication
27956626 | J:239063
First Author: Carr MI
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.
Volume: 113
Issue: 52
Pages: 15024-15029
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Publication
25117711 | J:214218
First Author: Tollini LA
Year: 2014
Journal: Cancer Cell
Title: Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage.
Volume: 26
Issue: 2
Pages: 235-47
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GXD Expression
GXD Expression
Probe: MGI:7531830
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7532832
Age: postnatal day 14
Image: 7Fd
Note: Proximity ligation assay indicated that the interaction between MDM2 and DLX3 was enhanced in the secretory odontoblasts.
Specimen Label: 7Fd
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7531830
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-04
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3289428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7532832
Age: postnatal day 14
Image: 7Fc
Note: Proximity ligation assay indicated that the interaction between MDM2 and DLX3 was weak in undifferentiated dental mesenchymal cells.
Specimen Label: 7Fc
Detected: true
Specimen Num: 1
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Publication
19491200 | J:205244
First Author: Volk EL
Year: 2009
Journal: Mol Cancer Res
Title: The MDM2-a splice variant of MDM2 alters transformation in vitro and the tumor spectrum in both Arf- and p53-null models of tumorigenesis.
Volume: 7
Issue: 6
Pages: 863-9
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Publication
11100897 | J:65689
First Author: Thisse C
Year: 2000
Journal: Differentiation
Title: The Mdm2 gene of zebrafish (Danio rerio): preferential expression during development of neural and muscular tissues, and absence of tumor formation after overexpression of its cDNA during early embryogenesis.
Volume: 66
Issue: 2-3
Pages: 61-70
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Publication
25751059 | J:222100
First Author: Zhu D
Year: 2015
Journal: J Clin Invest
Title: BAI1 regulates spatial learning and synaptic plasticity in the hippocampus.
Volume: 125
Issue: 4
Pages: 1497-508
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Publication
34974536 | J:319558
     
First Author: Bizen N
Year: 2022
Journal: Cell Death Differ
Title: Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression.
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Publication
20019182 | J:156447
First Author: Fernandez K
Year: 2010
Journal: Am J Pathol
Title: Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts.
Volume: 176
Issue: 1
Pages: 416-34
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Publication
21804542 | J:241062
First Author: Sasaki M
Year: 2011
Journal: Nat Med
Title: Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Volume: 17
Issue: 8
Pages: 944-51
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Protein
J3QP04
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Gene
609080 | MTBP
Type: gene
Organism: dog, domestic
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Gene
500870 | Mtbp
Type: gene
Organism: rat
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Gene
464361 | MTBP
Type: gene
Organism: chimpanzee
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Gene
617904 | MTBP
Type: gene
Organism: cattle
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Gene
420354 | MTBP
Type: gene
Organism: chicken
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Gene
100534898 | mtbp
Type: gene
Organism: zebrafish
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Gene
703121 | MTBP
Type: gene
Organism: macaque, rhesus
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Gene
779505 | mtbp
Type: gene
Organism: frog, western clawed
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Gene
108711092 | mdm2.L
Type: gene
Organism: frog, African clawed
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Gene
108713153 | LOC108713153
Type: gene
Organism: frog, African clawed
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Gene
444499 | mdm2.S
Type: gene
Organism: frog, African clawed
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Protein
P23804-2
Organism: Mus musculus/domesticus
Length: 440  
Fragment?: false
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HT Experiment
E-MEXP-1431 | Transcription profiling by array of Mdm2 knock out mice
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
24598047 | J:211567
First Author: Li Q
Year: 2014
Journal: Mol Cancer Res
Title: Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors.
Volume: 12
Issue: 6
Pages: 901-11
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UniProt Feature
UniProt Feature
Begin: 1
Description: E3 ubiquitin-protein ligase Mdm2
Type: chain
End: 489
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Publication
29903771 | J:266012
First Author: Wasylishen AR
Year: 2018
Journal: Mol Cancer Res
Title: Daxx Functions Are p53-Independent In Vivo.
Volume: 16
Issue: 10
Pages: 1523-1529
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Publication
12297306 | J:79230
First Author: Xirodimas DP
Year: 2002
Journal: FEBS Lett
Title: P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.
Volume: 528
Issue: 1-3
Pages: 207-11
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Publication
16391230 | J:104174
First Author: Mendrysa SM
Year: 2006
Journal: Genes Dev
Title: Tumor suppression and normal aging in mice with constitutively high p53 activity.
Volume: 20
Issue: 1
Pages: 16-21
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Publication
10754200 | J:61971
First Author: Nasir L
Year: 2000
Journal: Cancer Lett
Title: Cloning, sequence analysis and expression of the cDNAs encoding the canine and equine homologues of the mouse double minute 2 (mdm2) proto-oncogene.
Volume: 152
Issue: 1
Pages: 9-13
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Protein Domain
IPR015459 | MDM2_E3_ligase
Type: Family
Description: MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription []. In addition, MDM2 acts as an E3 ubiquitin ligase responsible for the ubiquitination and subsequent degradation of p53 []. P53 acts in response to DNA damage, inducing cell cycle arrest and apoptosis. Inactivation of p53 is a common occurrence in neoplastic transformations. MDM2 is also known to have p53-independent functions.The core of MDM2 folds into an open bundle of four helices that is capped by two small 3-stranded β-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 α-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.
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Publication
9285554 | J:42620
First Author: Piette J
Year: 1997
Journal: Oncogene
Title: Mdm2: keeping p53 under control.
Volume: 15
Issue: 9
Pages: 1001-10
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Publication
10721693 | J:60295
First Author: Momand J
Year: 2000
Journal: Gene
Title: MDM2--master regulator of the p53 tumor suppressor protein.
Volume: 242
Issue: 1-2
Pages: 15-29
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Publication
1614537 | J:18290
First Author: Oliner JD
Year: 1992
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