Type |
Details |
Score |
Strain |
Attribute String: |
coisogenic, chemically induced mutation, mutant strain |
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•
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Allele |
Name: |
sodium channel modifier 1; susceptibility |
Allele Type: |
Spontaneous |
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•
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Genotype |
Symbol: |
Scn8a/Scn8a |
Background: |
involves: C3H * C3HeB/Fe * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Genotype |
Symbol: |
Scn8a/Scn8a |
Background: |
C57BL/6J-Scn8a |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
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•
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Publication |
First Author: |
Scala F |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway. |
Volume: |
23 |
Issue: |
2 |
Pages: |
555-567 |
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•
•
•
•
•
|
Genotype |
Symbol: |
Scn8a/Scn8a |
Background: |
involves: C3H * C57BL/6J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain |
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•
•
•
•
•
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Strain |
Attribute String: |
mutant strain |
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•
•
•
•
•
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Genotype |
Symbol: |
Scn8a/Scn8a Scnm1/Scnm1 |
Background: |
involves: C57BL/6 * FVB * SJL * STOCK Krt71 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Scn8a/Scn8a Scnm1/Scnm1 |
Background: |
involves: C57BL/6 * STOCK Krt71 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Scn8a/Scn8a |
Background: |
involves: STOCK Krt71 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Scn8a/Scn8a |
Background: |
involves: C3H |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression. |
Volume: |
8 |
Issue: |
1 |
Pages: |
355 |
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•
•
•
•
•
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Publication |
First Author: |
Sun W |
Year: |
2013 |
Journal: |
J Physiol |
Title: |
Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice. |
Volume: |
591 |
Issue: |
1 |
Pages: |
241-55 |
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•
•
•
•
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Publication |
First Author: |
Nutini M |
Year: |
2011 |
Journal: |
Mol Cell Neurosci |
Title: |
Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse. |
Volume: |
47 |
Issue: |
2 |
Pages: |
108-18 |
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•
•
•
•
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Publication |
First Author: |
Meisler MH |
Year: |
1997 |
Journal: |
Ann Med |
Title: |
Ion channel mutations in mouse models of inherited neurological disease. |
Volume: |
29 |
Issue: |
6 |
Pages: |
569-74 |
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•
•
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•
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Publication |
First Author: |
O'Brien JE |
Year: |
2012 |
Journal: |
Mol Cell Neurosci |
Title: |
Rbfox proteins regulate alternative splicing of neuronal sodium channel SCN8A. |
Volume: |
49 |
Issue: |
2 |
Pages: |
120-6 |
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•
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•
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Publication |
First Author: |
Chang B |
Year: |
2007 |
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Title: |
Mouse models of RP |
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|
Pages: |
149-161 |
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•
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Publication |
First Author: |
Follwaczny P |
Year: |
2017 |
Journal: |
Dis Model Mech |
Title: |
Pumilio2-deficient mice show a predisposition for epilepsy. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1333-1342 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
804
|
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
539
|
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1978
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1978
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1937
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1988
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1937
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1978
|
Fragment?: |
false |
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•
•
•
•
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Publication |
First Author: |
Noda M |
Year: |
1984 |
Journal: |
Nature |
Title: |
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. |
Volume: |
312 |
Issue: |
5990 |
Pages: |
121-7 |
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•
•
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Publication |
First Author: |
George AL Jr |
Year: |
1992 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family. |
Volume: |
89 |
Issue: |
11 |
Pages: |
4893-7 |
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•
•
•
•
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Publication |
First Author: |
Goldfarb M |
Year: |
2012 |
Journal: |
Cell Mol Life Sci |
Title: |
Voltage-gated sodium channel-associated proteins and alternative mechanisms of inactivation and block. |
Volume: |
69 |
Issue: |
7 |
Pages: |
1067-76 |
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Publication |
First Author: |
Kaplan DI |
Year: |
2016 |
Journal: |
Cold Spring Harb Perspect Med |
Title: |
Role of Sodium Channels in Epilepsy. |
Volume: |
6 |
Issue: |
6 |
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•
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Publication |
First Author: |
Sato C |
Year: |
1992 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Proposed tertiary structure of the sodium channel. |
Volume: |
186 |
Issue: |
2 |
Pages: |
1158-67 |
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•
•
•
•
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Publication |
First Author: |
Chang B |
Year: |
2005 |
Journal: |
Vis Neurosci |
Title: |
Mouse models of ocular diseases. |
Volume: |
22 |
Issue: |
5 |
Pages: |
587-93 |
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