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Search results 1 to 2 out of 2 for Rtf2

Category restricted to ProteinDomain (x)

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Category: ProteinDomain
Type Details Score
Protein Domain
Type: Family
Description: Rtf2 is a replication termination factor which mediates replication termination at the site-specific replication barrier Rts1. It stabilizes the replication fork stalled at Rts1 until completion of DNA synthesis by a converging replication fork initiated at a flanking origin [].
Protein Domain
Type: Domain
Description: It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilises the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site [].