|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 3801 to 3900 out of 3963 for Mtor

0.07s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication  
First Author: Pan B
Year: 2019
Journal: Front Physiol
Title: Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress.
Volume: 10
Pages: 758
Publication  
First Author: Getz SA
Year: 2016
Journal: Neurobiol Dis
Title: Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.
Volume: 93
Pages: 12-20
Publication
First Author: Barrows CM
Year: 2017
Journal: J Neurosci
Title: PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network.
Volume: 37
Issue: 36
Pages: 8595-8611
Publication
First Author: Domènech-Estévez E
Year: 2016
Journal: J Neurosci
Title: Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS.
Volume: 36
Issue: 16
Pages: 4506-21
Publication
First Author: Wang S
Year: 2019
Journal: Autophagy
Title: Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
Volume: 15
Issue: 11
Pages: 1954-1969
Publication      
First Author: Megat S
Year: 2019
Journal: J Neurosci
Title: Differences between dorsal root and trigeminal ganglion nociceptors in mice revealed by translational profiling.
Publication  
First Author: Iwasaki K
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.
Volume: 14
Pages: 1203534
Publication
First Author: Rhine MA
Year: 2019
Journal: Autism Res
Title: Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism.
Volume: 12
Issue: 3
Pages: 401-421
Publication
First Author: Wan H
Year: 2020
Journal: Autophagy
Title: WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death.
Volume: 16
Issue: 3
Pages: 531-547
Publication
First Author: Wang L
Year: 2022
Journal: Autophagy
Title: Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TGFBI (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy.
Volume: 18
Issue: 4
Pages: 765-782
Publication  
First Author: Nordströma U
Year: 2015
Journal: Neurobiol Dis
Title: Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease.
Volume: 73
Pages: 70-82
Publication  
First Author: Ding J
Year: 2018
Journal: Front Genet
Title: Aberrant Protein Turn-Over Associated With Myofibrillar Disorganization in FHL1 Knockout Mice.
Volume: 9
Pages: 273
Publication
First Author: Fedeli C
Year: 2019
Journal: Autophagy
Title: PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis.
Volume: 15
Issue: 12
Pages: 2044-2062
Publication      
First Author: Chao X
Year: 2021
Journal: J Hepatol
Title: Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy.
Publication
First Author: Tao R
Year: 2015
Journal: Diabetes
Title: Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Volume: 64
Issue: 4
Pages: 1211-23
Publication
First Author: Tan H
Year: 2017
Journal: Immunity
Title: Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation.
Volume: 46
Issue: 3
Pages: 488-503
Publication
First Author: Newton RH
Year: 2018
Journal: Nat Immunol
Title: Maintenance of CD4 T cell fitness through regulation of Foxo1.
Volume: 19
Issue: 8
Pages: 838-848
Publication
First Author: Menk AV
Year: 2018
Journal: Cell Rep
Title: Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.
Volume: 22
Issue: 6
Pages: 1509-1521
Publication
First Author: Xiao M
Year: 2017
Journal: Blood
Title: Osteoblasts support megakaryopoiesis through production of interleukin-9.
Volume: 129
Issue: 24
Pages: 3196-3209
Publication  
First Author: Canaud G
Year: 2019
Journal: Sci Transl Med
Title: Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair.
Volume: 11
Issue: 476
Publication
First Author: Artinian J
Year: 2019
Journal: J Neurosci
Title: Regulation of Hippocampal Memory by mTORC1 in Somatostatin Interneurons.
Volume: 39
Issue: 43
Pages: 8439-8456
Publication
First Author: Zhang X
Year: 2018
Journal: Cell Rep
Title: Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway.
Volume: 24
Issue: 12
Pages: 3180-3193
Publication
First Author: Iskarpatyoti JA
Year: 2022
Journal: Cell Rep
Title: Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
Volume: 40
Issue: 13
Pages: 111346
Publication
First Author: Jiang M
Year: 2017
Journal: J Cell Biochem
Title: mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis.
Volume: 118
Issue: 4
Pages: 748-753
Publication
First Author: Wiebe S
Year: 2023
Journal: Mol Brain
Title: Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.
Volume: 16
Issue: 1
Pages: 9
Publication
First Author: Asgarihafshejani A
Year: 2022
Journal: iScience
Title: Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory.
Volume: 25
Issue: 5
Pages: 104259
Publication  
First Author: Huang B
Year: 2016
Journal: Nat Commun
Title: Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone.
Volume: 7
Pages: 13885
Publication
First Author: Riahi Y
Year: 2023
Journal: Diabetologia
Title: Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production.
Volume: 66
Issue: 10
Pages: 1925-1942
Publication
First Author: Wang M
Year: 2017
Journal: Mol Cell Proteomics
Title: The Glial Cell-Derived Neurotrophic Factor (GDNF)-responsive Phosphoprotein Landscape Identifies Raptor Phosphorylation Required for Spermatogonial Progenitor Cell Proliferation.
Volume: 16
Issue: 6
Pages: 982-997
Publication
First Author: Haller S
Year: 2017
Journal: Cell Stem Cell
Title: mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.
Volume: 21
Issue: 6
Pages: 806-818.e5
Publication
First Author: Hu Y
Year: 2018
Journal: J Biol Chem
Title: Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.
Volume: 293
Issue: 6
Pages: 2006-2014
Publication
First Author: Canaud G
Year: 2013
Journal: Nat Med
Title: AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.
Volume: 19
Issue: 10
Pages: 1288-96
Publication
First Author: Armour EA
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules.
Volume: 303
Issue: 4
Pages: F584-92
Publication  
First Author: Tang Y
Year: 2016
Journal: Nat Commun
Title: Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
Volume: 7
Pages: 11365
Publication
First Author: Werlen G
Year: 2022
Journal: Nat Commun
Title: Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis.
Volume: 13
Issue: 1
Pages: 7404
Publication
First Author: Ou YH
Year: 2011
Journal: Mol Cell
Title: TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Volume: 41
Issue: 4
Pages: 458-70
Publication  
First Author: Zhang S
Year: 2023
Journal: J Clin Invest
Title: The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells.
Volume: 133
Issue: 4
Publication
First Author: Harada Y
Year: 2022
Journal: iScience
Title: Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes.
Volume: 25
Issue: 4
Pages: 104021
Publication
First Author: Moloughney JG
Year: 2016
Journal: Mol Cell
Title: mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1.
Volume: 63
Issue: 5
Pages: 811-26
Publication
First Author: Hertzler-Schaefer K
Year: 2014
Journal: Cell Rep
Title: Pten loss induces autocrine FGF signaling to promote skin tumorigenesis.
Volume: 6
Issue: 5
Pages: 818-26
Publication
First Author: Huang SC
Year: 2016
Journal: Immunity
Title: Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation.
Volume: 45
Issue: 4
Pages: 817-830
Publication
First Author: Kohnke S
Year: 2021
Journal: Cell Rep
Title: Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.
Volume: 36
Issue: 2
Pages: 109362
Publication
First Author: Hung CM
Year: 2014
Journal: Cell Rep
Title: Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.
Volume: 8
Issue: 1
Pages: 256-71
Publication  
First Author: Yang M
Year: 2016
Journal: Nat Commun
Title: NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Volume: 7
Pages: 12730
Protein
Organism: Mus musculus/domesticus
Length: 1333  
Fragment?: true
Publication
First Author: Kunz J
Year: 1993
Journal: Cell
Title: Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.
Volume: 73
Issue: 3
Pages: 585-96
Publication
First Author: Xia H
Year: 2020
Journal: Cell Rep
Title: Evasion of Type I Interferon by SARS-CoV-2.
Volume: 33
Issue: 1
Pages: 108234
Publication
First Author: Lee TY
Year: 2021
Journal: Autophagy
Title: Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism.
Volume: 17
Issue: 12
Pages: 4141-4158
Publication
First Author: Yau WW
Year: 2019
Journal: Autophagy
Title: Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.
Volume: 15
Issue: 1
Pages: 131-150
Publication
First Author: Malik TH
Year: 2001
Journal: EMBO J
Title: Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.
Volume: 20
Issue: 7
Pages: 1715-25
Publication
First Author: Zhang H
Year: 2014
Journal: Curr Biol
Title: Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice.
Volume: 24
Issue: 21
Pages: 2501-8
Publication
First Author: Castets P
Year: 2019
Journal: Nat Commun
Title: mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4.
Volume: 10
Issue: 1
Pages: 3187
Publication
First Author: Wang C
Year: 2016
Journal: Liver Int
Title: Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.
Volume: 36
Issue: 8
Pages: 1176-86
Publication
First Author: Kogot-Levin A
Year: 2020
Journal: Cell Rep
Title: Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors.
Volume: 32
Issue: 4
Pages: 107954
Publication
First Author: Lee JH
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: SREBP-1a-stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1.
Volume: 115
Issue: 52
Pages: E12228-E12234
Publication
First Author: Wan M
Year: 2011
Journal: Cell Metab
Title: Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Volume: 14
Issue: 4
Pages: 516-27
Publication
First Author: Karmaus PWF
Year: 2019
Journal: Nature
Title: Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity.
Volume: 565
Issue: 7737
Pages: 101-105
Publication
First Author: Wang C
Year: 2015
Journal: Hepatology
Title: 4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.
Volume: 61
Issue: 1
Pages: 200-13
Publication
First Author: Feng P
Year: 2021
Journal: Theranostics
Title: The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis.
Volume: 11
Issue: 19
Pages: 9503-9518
Publication
First Author: Do MH
Year: 2023
Journal: Immunity
Title: Reprogramming tumor-associated macrophages to outcompete endovascular endothelial progenitor cells and suppress tumor neoangiogenesis.
Volume: 56
Issue: 11
Pages: 2555-2569.e5
Publication    
First Author: Covarrubias AJ
Year: 2016
Journal: Elife
Title: Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation.
Volume: 5
Publication  
First Author: Yin N
Year: 2022
Journal: J Clin Invest
Title: SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation.
Volume: 132
Issue: 20
Publication
First Author: Ai D
Year: 2014
Journal: Circ Res
Title: Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.
Volume: 114
Issue: 10
Pages: 1576-84
Publication
First Author: Everts B
Year: 2014
Journal: Nat Immunol
Title: TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKÉ› supports the anabolic demands of dendritic cell activation.
Volume: 15
Issue: 4
Pages: 323-32
Publication
First Author: Gerlach BD
Year: 2021
Journal: Cell Metab
Title: Efferocytosis induces macrophage proliferation to help resolve tissue injury.
Volume: 33
Issue: 12
Pages: 2445-2463.e8
Publication
First Author: Bridges CR
Year: 2017
Journal: Sci Rep
Title: USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors.
Volume: 7
Issue: 1
Pages: 391
Publication
First Author: Guri Y
Year: 2017
Journal: Cancer Cell
Title: mTORC2 Promotes Tumorigenesis via Lipid Synthesis.
Volume: 32
Issue: 6
Pages: 807-823.e12
Publication
First Author: Magee JA
Year: 2012
Journal: Cell Stem Cell
Title: Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression.
Volume: 11
Issue: 3
Pages: 415-28
Publication    
First Author: Porter SN
Year: 2016
Journal: Elife
Title: Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.
Volume: 5
Publication
First Author: Huang L
Year: 2017
Journal: PLoS Biol
Title: Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin.
Volume: 15
Issue: 8
Pages: e2001750
Publication
First Author: Kang YJ
Year: 2011
Journal: Cell Death Differ
Title: The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
Volume: 18
Issue: 1
Pages: 133-44
Publication
First Author: Akgül S
Year: 2018
Journal: Cell Rep
Title: Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.
Volume: 24
Issue: 2
Pages: 463-478.e5
Publication
First Author: Nobs SP
Year: 2015
Journal: Immunity
Title: PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development.
Volume: 43
Issue: 4
Pages: 674-89
Publication
First Author: Venkatesh A
Year: 2015
Journal: J Clin Invest
Title: Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.
Volume: 125
Issue: 4
Pages: 1446-58
Protein
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: false
Publication
First Author: Wolff NC
Year: 2011
Journal: Mol Cell Biol
Title: Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
Volume: 31
Issue: 9
Pages: 1870-84
Publication
First Author: Ruegsegger C
Year: 2016
Journal: Neuron
Title: Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology.
Volume: 89
Issue: 1
Pages: 129-46
Publication
First Author: Charbonnier LM
Year: 2015
Journal: Nat Immunol
Title: Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.
Volume: 16
Issue: 11
Pages: 1162-73
Publication  
First Author: Imanishi T
Year: 2019
Journal: Life Sci Alliance
Title: Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.
Volume: 2
Issue: 1
Publication
First Author: Rodgers JT
Year: 2014
Journal: Nature
Title: mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).
Volume: 510
Issue: 7505
Pages: 393-6
Publication
First Author: Liu C
Year: 2021
Journal: Sci Adv
Title: Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.
Volume: 7
Issue: 41
Pages: eabg6262
Publication
First Author: Yi W
Year: 2017
Journal: Nat Commun
Title: The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity.
Volume: 8
Issue: 1
Pages: 254
Publication
First Author: Asrani K
Year: 2019
Journal: J Clin Invest
Title: mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.
Volume: 129
Issue: 12
Pages: 5584-5599
Publication
First Author: Van Nostrand JL
Year: 2020
Journal: Genes Dev
Title: AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
Volume: 34
Issue: 19-20
Pages: 1330-1344
Publication  
First Author: Lee PY
Year: 2017
Journal: Sci Immunol
Title: The metabolic regulator mTORC1 controls terminal myeloid differentiation.
Volume: 2
Issue: 11
Publication
First Author: McGuire VA
Year: 2013
Journal: Mol Cell Biol
Title: Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.
Volume: 33
Issue: 21
Pages: 4152-65
Publication
First Author: Yang T
Year: 2016
Journal: Cell Mol Immunol
Title: TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway.
Volume: 13
Issue: 5
Pages: 640-50
Publication
First Author: Feng D
Year: 2015
Journal: PLoS One
Title: mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
Volume: 10
Issue: 6
Pages: e0126240
Publication
First Author: Yousefi M
Year: 2018
Journal: Stem Cell Reports
Title: Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells.
Volume: 10
Issue: 3
Pages: 703-711
Publication
First Author: Huang H
Year: 2019
Journal: Cell Death Dis
Title: AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration.
Volume: 10
Issue: 3
Pages: 203
Publication
First Author: Fu X
Year: 2018
Journal: J Clin Invest
Title: Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss.
Volume: 128
Issue: 11
Pages: 4938-4955
Publication  
First Author: Jones I
Year: 2019
Journal: Biol Open
Title: Reduced mTORC1-signalling in retinal progenitor cells leads to visual pathway dysfunction.
Volume: 8
Issue: 8
Publication  
First Author: Huynh H
Year: 2018
Journal: Commun Biol
Title: mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1.
Volume: 1
Pages: 29
Publication
First Author: Xiang H
Year: 2022
Journal: Cell Rep
Title: Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation.
Volume: 39
Issue: 11
Pages: 110943
Publication
First Author: Gosis BS
Year: 2022
Journal: Science
Title: Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1.
Volume: 376
Issue: 6590
Pages: eabf8271
Publication
First Author: Martinez Calejman C
Year: 2020
Journal: Nat Commun
Title: mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis.
Volume: 11
Issue: 1
Pages: 575
Publication
First Author: Shrestha S
Year: 2015
Journal: Nat Immunol
Title: Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.
Volume: 16
Issue: 2
Pages: 178-87
Publication
First Author: Signer RA
Year: 2014
Journal: Nature
Title: Haematopoietic stem cells require a highly regulated protein synthesis rate.
Volume: 509
Issue: 7498
Pages: 49-54
Publication
First Author: Gu Y
Year: 2011
Journal: Diabetes
Title: Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.
Volume: 60
Issue: 3
Pages: 827-37