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Search results 1001 to 1100 out of 1176 for Frzb

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Type Details Score
Publication
9891778 | J:52724
 
First Author: Wodarz A
Year: 1998
Journal: Annu Rev Cell Dev Biol
Title: Mechanisms of Wnt signaling in development.
Volume: 14
Pages: 59-88
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Publication
22290867 | J:190506
First Author: Kele J
Year: 2012
Journal: Stem Cells
Title: SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells.
Volume: 30
Issue: 5
Pages: 865-75
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Publication
21185284 | J:170579
First Author: He F
Year: 2011
Journal: Dev Biol
Title: Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression.
Volume: 350
Issue: 2
Pages: 511-9
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Publication
12055200 | J:78619
First Author: Bennett CN
Year: 2002
Journal: J Biol Chem
Title: Regulation of Wnt signaling during adipogenesis.
Volume: 277
Issue: 34
Pages: 30998-1004
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Publication
11731265 | J:73304
First Author: Tebar M
Year: 2001
Journal: Mech Dev
Title: Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung.
Volume: 109
Issue: 2
Pages: 437-40
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Publication
10415363 | J:56622
First Author: Sarkar L
Year: 1999
Journal: Mech Dev
Title: Expression of Wnt signalling pathway genes during tooth development.
Volume: 85
Issue: 1-2
Pages: 197-200
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Publication
26859490 | J:253527
First Author: Geng R
Year: 2016
Journal: PLoS One
Title: Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.
Volume: 11
Issue: 2
Pages: e0148339
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Publication
33127760 | J:298597
First Author: Yan S
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CHD7 regulates cardiovascular development through ATP-dependent and -independent activities.
Volume: 117
Issue: 46
Pages: 28847-28858
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Publication
15385444 | J:94411
First Author: Kelly RG
Year: 2004
Journal: Hum Mol Genet
Title: The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis.
Volume: 13
Issue: 22
Pages: 2829-40
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Publication
24590292 | J:209623
First Author: Kurosaka H
Year: 2014
Journal: J Clin Invest
Title: Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis.
Volume: 124
Issue: 4
Pages: 1660-71
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Publication
21752936 | J:180902
First Author: van de Ven C
Year: 2011
Journal: Development
Title: Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.
Volume: 138
Issue: 16
Pages: 3451-62
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Publication
9817915 | J:51411
First Author: Bulfone A
Year: 1998
Journal: Hum Mol Genet
Title: The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function.
Volume: 7
Issue: 13
Pages: 1997-2006
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Publication
16059910 | J:100233
First Author: Shou S
Year: 2005
Journal: Dev Dyn
Title: Transcriptome analysis of the murine forelimb and hindlimb autopod.
Volume: 234
Issue: 1
Pages: 74-89
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Publication
22166339 | J:180300
First Author: Noda T
Year: 2012
Journal: Dev Biol
Title: Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.
Volume: 362
Issue: 1
Pages: 83-93
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Publication
9096311 | J:39275
First Author: Rattner A
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.
Volume: 94
Issue: 7
Pages: 2859-63
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Publication
35383354 | J:324161
 
First Author: Tang S
Year: 2022
Journal: Endocrinology
Title: BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy.
Volume: 163
Issue: 5
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Publication
22130515 | J:181526
First Author: Singh R
Year: 2012
Journal: Cell Mol Life Sci
Title: Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation.
Volume: 69
Issue: 8
Pages: 1377-89
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Publication
15857914 | J:98484
First Author: Lickert H
Year: 2005
Journal: Development
Title: Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.
Volume: 132
Issue: 11
Pages: 2599-609
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Publication
12812787 | J:84052
First Author: Stump RJ
Year: 2003
Journal: Dev Biol
Title: A role for Wnt/beta-catenin signaling in lens epithelial differentiation.
Volume: 259
Issue: 1
Pages: 48-61
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Publication
22863011 | J:187883
First Author: Van Handel B
Year: 2012
Journal: Cell
Title: Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.
Volume: 150
Issue: 3
Pages: 590-605
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Publication
17959802 | J:127039
First Author: Rash BG
Year: 2007
Journal: J Neurosci
Title: Patterning the dorsal telencephalon: a role for sonic hedgehog?
Volume: 27
Issue: 43
Pages: 11595-603
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Publication
12490556 | J:81152
First Author: Mukhopadhyay M
Year: 2003
Journal: Development
Title: Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation.
Volume: 130
Issue: 3
Pages: 495-505
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Publication
12412008 | J:80135
First Author: Heller RS
Year: 2002
Journal: Dev Dyn
Title: Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.
Volume: 225
Issue: 3
Pages: 260-70
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Publication
12815618 | J:84478
First Author: Liu H
Year: 2003
Journal: Dev Dyn
Title: Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina.
Volume: 227
Issue: 3
Pages: 323-34
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Publication
15745951 | J:98595
First Author: Kerns RT
Year: 2005
Journal: J Neurosci
Title: Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.
Volume: 25
Issue: 9
Pages: 2255-66
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Publication
15880404 | J:98792
First Author: Kemp C
Year: 2005
Journal: Dev Dyn
Title: Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development.
Volume: 233
Issue: 3
Pages: 1064-75
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Publication
23827310 | J:207050
 
First Author: Zhao X
Year: 2013
Journal: Neuroscience
Title: Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia.
Volume: 248
Pages: 594-601
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Publication
23376422 | J:314598
First Author: Nik AM
Year: 2013
Journal: Gastroenterology
Title: Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling.
Volume: 144
Issue: 5
Pages: 1001-11
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Publication
28009287 | J:239303
First Author: Amin S
Year: 2016
Journal: Cell Rep
Title: Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche.
Volume: 17
Issue: 12
Pages: 3165-3177
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Publication
20308569 | J:159315
First Author: Xie Z
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Zbtb20 is essential for the specification of CA1 field identity in the developing hippocampus.
Volume: 107
Issue: 14
Pages: 6510-5
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Publication
35831952 | J:327818
 
First Author: Murphy P
Year: 2022
Journal: Development
Title: Integrated analysis of Wnt signalling system component gene expression.
Volume: 149
Issue: 16
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Publication
19185060 | J:146657
First Author: Witte F
Year: 2009
Journal: Gene Expr Patterns
Title: Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.
Volume: 9
Issue: 4
Pages: 215-23
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Publication
20510229 | J:165759
First Author: Chiu HS
Year: 2010
Journal: Dev Biol
Title: Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation.
Volume: 344
Issue: 2
Pages: 1071-87
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Publication
21041481 | J:169706
First Author: Abdul-Ghani M
Year: 2011
Journal: Mol Cell Biol
Title: Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.
Volume: 31
Issue: 1
Pages: 163-78
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Publication
22432025 | J:187047
First Author: Gerber SD
Year: 2012
Journal: PLoS One
Title: Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.
Volume: 7
Issue: 3
Pages: e33457
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Publication
20359476 | J:161416
First Author: Collette NM
Year: 2010
Journal: Dev Biol
Title: Genetic evidence that SOST inhibits WNT signaling in the limb.
Volume: 342
Issue: 2
Pages: 169-79
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Publication
31351040 | J:282348
First Author: Dasgupta K
Year: 2019
Journal: Dev Biol
Title: Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling.
Volume: 455
Issue: 2
Pages: 434-448
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Publication
37279265 | J:343328
First Author: Xie Z
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: ZBTB20 is essential for cochlear maturation and hearing in mice.
Volume: 120
Issue: 24
Pages: e2220867120
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Publication
19562671 | J:152099
First Author: Bi Y
Year: 2009
Journal: J Cell Biochem
Title: Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.
Volume: 108
Issue: 1
Pages: 295-303
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Publication
26450967 | J:239872
First Author: Larsen BM
Year: 2015
Journal: Development
Title: Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.
Volume: 142
Issue: 22
Pages: 3859-68
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Publication
21905163 | J:176660
First Author: Abler LL
Year: 2011
Journal: Dev Dyn
Title: A high-resolution molecular atlas of the fetal mouse lower urogenital tract.
Volume: 240
Issue: 10
Pages: 2364-77
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Publication
- | J:101679
     
First Author: Deltagen Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
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Publication
19515997 | J:154534
First Author: Martinez G
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Volume: 50
Issue: 10
Pages: 4794-806
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Publication
32857879 | J:332131
First Author: Perera SN
Year: 2020
Journal: Glia
Title: Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach.
Volume: 68
Issue: 12
Pages: 2550-2584
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Publication
24006456 | J:221550
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47
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Publication
16919269 | J:112701
First Author: Bailey PJ
Year: 2006
Journal: Exp Cell Res
Title: A global genomic transcriptional code associated with CNS-expressed genes.
Volume: 312
Issue: 16
Pages: 3108-19
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
21731673 | J:174767
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
E-GEOD-33656 | Gene expression in articular cartilage - subchondral bone of FRZB knockout mice
Series Id: GSE33656
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Tg(Frzb-cre)1Tylz | MGI:3527940
Name: transgene insertion 1, Przemko Tylzanowski
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Frzb-EGFP)MK48Gsat | MGI:4847059
Name: transgene insertion MK48, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5560804 | STOCK Tg(Frzb-cre)1Tylz/Orl
Attribute String: mutant stock, transgenic
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Allele
Tg(Frzb-cre)3Tylz | MGI:4848048
Name: transgene insertion 3, Przemko Tylzanowski
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Frzb-cre)2Tylz | MGI:3527941
Name: transgene insertion 2, Przemko Tylzanowski
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:5004170 | STOCK Tg(Frzb-EGFP)MK48Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Frzb-cre)3Tylz/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Frzb-cre)1Tylz/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Frzb-cre)2Tylz/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
28684528 | J:245575
First Author: Bhagat TD
Year: 2017
Journal: Cancer Res
Title: Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation.
Volume: 77
Issue: 18
Pages: 4846-4857
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Publication
22461179 | J:185439
First Author: Yin L
Year: 2012
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Systems genetic analysis of multivariate response to iron deficiency in mice.
Volume: 302
Issue: 11
Pages: R1282-96
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Protein Domain
IPR020067 | Frizzled_dom
Type: Domain
Description: The frizzled (fz) domain is an extracellular domain of about 120 amino acids.It was first identified in the alpha-1 chain of type XVIII collagen and in members of the Frizzled family of seven transmembrane (7TM) proteins which act as receptors for secreted Wingless (Wg)/Wnt glycoproteins []. In addition to these proteins, one or two copies of the fz domain are also found [, , , , ]in:The Frzb family; secreted frizzled-like proteins.Smoothened; another 7TM receptor involved in hedgehog signaling.Carboxpeptidase Z (CPZ).Transmembrane serine protease corin (atrial natriuretic peptide-converting enzyme).Two receptor tyrosine kinases (RTKs) subfamilies, the Ror family and the muscle-specific kinase (MuSK) family.As the fz domain contains 10 cysteines which are largely conserved, it has also been called cysteine-rich domain (CRD) []. The fz domain also contains several other highly conserved residues, for example, a basic amino acid follows C6, and a conserved proline residues lies four residues C-terminal to C9 []. The crystal structure of a fz domain shows that it is predominantly α-helical with all cysteines forming disulphide bonds. In addition to helical regions, two short β-strands at the N terminus form a minimal β-sheet with the second beta sheet passing through a knot created by disulphide bonds [].Several fz domains have been shown to be both necessary and sufficient for Wg/Wnt ligand binding, strongly suggesting that the fz domain is a Wg/Wnt interacting domain [, ].
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Protein Domain
IPR036790 | Frizzled_dom_sf
Type: Homologous_superfamily
Description: This entry represents the frizzled domain superfamily.The frizzled (fz) domain is an extracellular domain of about 120 amino acids.It was first identified in the alpha-1 chain of type XVIII collagen and in members of the Frizzled family of seven transmembrane (7TM) proteins which act as receptors for secreted Wingless (Wg)/Wnt glycoproteins []. In addition to these proteins, one or two copies of the fz domain are also found [, , , , ]in:The Frzb family; secreted frizzled-like proteins.Smoothened; another 7TM receptor involved in hedgehog signaling.Carboxpeptidase Z (CPZ).Transmembrane serine protease corin (atrial natriuretic peptide-converting enzyme).Two receptor tyrosine kinases (RTKs) subfamilies, the Ror family and the muscle-specific kinase (MuSK) family.As the fz domain contains 10 cysteines which are largely conserved, it has also been called cysteine-rich domain (CRD) []. The fz domain also contains several other highly conserved residues, for example, a basic amino acid follows C6, and a conserved proline residues lies four residues C-terminal to C9 []. The crystal structure of a fz domain shows that it is predominantly α-helical with all cysteines forming disulphide bonds. In addition to helical regions, two short β-strands at the N terminus form a minimal β-sheet with the second beta sheet passing through a knot created by disulphide bonds [].Several fz domains have been shown to be both necessary and sufficient for Wg/Wnt ligand binding, strongly suggesting that the fz domain is a Wg/Wnt interacting domain [, ].
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Publication
18767925 | J:168528
First Author: Zhu M
Year: 2009
Journal: J Bone Miner Res
Title: Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.
Volume: 24
Issue: 1
Pages: 12-21
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Publication
7876242 | J:23590
First Author: Rehn M
Year: 1995
Journal: J Biol Chem
Title: Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins.
Volume: 270
Issue: 9
Pages: 4705-11
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Protein
D3YYF7
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Protein
A0A0U1RPV4
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
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