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Search results 201 to 231 out of 231 for Med25

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Type Details Score
Protein Domain
IPR045191 | MBR1/2-like
Type: Family
Description: This entry represents a group of confirmed and predicted E3 ubiquitin-protein ligases, including RHG1A/MBR1-2 from Arabidopsis and C4G3.12c from fission yeasts. MBR1 and MBR2 are E3 ubiquitin-protein ligases that function as regulator of MED25 (a subunit of the Mediator complex) stability by targeting MED25 for degradation in a RING-H2-dependent way []. The function of RHG1A and C4G3.12c is not known.
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Protein Domain
IPR021406 | Mediator_Med25_NR-box
Type: Domain
Description: The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR [].
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Protein Domain
IPR021397 | Mediator_Med25_SD1
Type: Domain
Description: The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear [].
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Protein Domain
IPR021419 | Mediator_Med25_VWA
Type: Domain
Description: The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex [].
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Protein
A0A140LHM8
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: false
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Protein
A0A140LHI1
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Protein
A0A140LJ84
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: false
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Protein
A0A140LIH0
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: true
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Protein
Q8VCB2
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
A0A140LHQ0
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: false
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Protein
A0A140LHG7
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: false
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Publication
21785987 | -
First Author: Eletsky A
Year: 2011
Journal: J Struct Funct Genomics
Title: Solution NMR structure of MED25(391-543) comprising the activator-interacting domain (ACID) of human mediator subunit 25.
Volume: 12
Issue: 3
Pages: 159-66
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Publication
11313889 | J:68629
First Author: Benedit P
Year: 2001
Journal: Oncogene
Title: PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks.
Volume: 20
Issue: 12
Pages: 1455-64
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Publication
21378963 | -
First Author: Milbradt AG
Year: 2011
Journal: Nat Struct Mol Biol
Title: Structure of the VP16 transactivator target in the Mediator.
Volume: 18
Issue: 4
Pages: 410-5
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Protein Domain
IPR038196 | Med25_PTOV_sf
Type: Homologous_superfamily
Description: Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [, ]. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II, but it would appear that each of the four different sections has a slightly different function []. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. The PTOV domain is the domain through which Med25 co-operates with the histone acetyltransferase CBP, which is involved in chromatin remodeling []. This entry represents the ACID domain found in subunit 25 of the mediator complex (MED25). This domain is also known as VP16-binding domain (VBD) or prostate tumor overexpressed (PTOV) protein domain []. Protein PTOV1, which is overexpressed in prostate cancer tumors, contains two ACID domains [].Unlike other known activator targets, ACID forms a seven-stranded β-barrel framed by three helices. The ACID domain appears to impose a critical control on transcription activation by VP16 in mammalian cells, uncovering a novel molecular activation pathway of VP16 through transcriptional complexes containing the MED25 subunit [, ].
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Protein
A0A140LI51
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: true
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Publication
15713644 | -
First Author: Santamaría A
Year: 2005
Journal: Mol Cell Biol
Title: PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts.
Volume: 25
Issue: 5
Pages: 1900-11
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Protein Domain
IPR045105 | Med25/PTOV1
Type: Family
Description: This entry includes mediator of RNA polymerase II transcription subunit 25 (Med25) and prostate tumor-overexpressed gene 1 protein (PTOV1). PTOV1 shares protein sequence similarity with Med25, however, it has not been identified as a component of the Mediator complex. PTOV1 is required for cell proliferation [].Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [, ]. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II, but it would appear that each of the four different sections has a slightly different function []. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. The PTOV domain is the domain through which Med25 co-operates with the histone acetyltransferase CBP, which is involved in chromatin remodeling [].
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Protein Domain
IPR021394 | Med25_PTOV
Type: Domain
Description: Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [, ]. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II, but it would appear that each of the four different sections has a slightly different function []. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. The PTOV domain is the domain through which Med25 co-operates with the histone acetyltransferase CBP, which is involved in chromatin remodeling [].
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Publication
27166374 | J:246822
First Author: Lee B
Year: 2016
Journal: Nucleic Acids Res
Title: Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling.
Volume: 44
Issue: 16
Pages: 7568-79
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Protein
Q91VU8
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
A0A140LI15
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
A0A140LIC3
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
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Protein
A0A140LHX3
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
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Protein
A0A140LJ65
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Protein
A0A140LJ23
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
A0A140LIL1
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Publication
14983011 | -
First Author: Yang F
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.
Volume: 101
Issue: 8
Pages: 2339-44
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Publication
18381891 | -
First Author: Larivière L
Year: 2008
Journal: Genes Dev
Title: Structure-system correlation identifies a gene regulatory Mediator submodule.
Volume: 22
Issue: 7
Pages: 872-7
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Publication
14638676 | J:88488
First Author: Tomomori-Sato C
Year: 2004
Journal: J Biol Chem
Title: A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
Volume: 279
Issue: 7
Pages: 5846-51
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Protein
A0A0R4J2A4
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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