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Search results 101 to 126 out of 126 for Vps53

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Type Details Score
Allele
Vps53<tm1a(KOMP)Wtsi> | MGI:4451513
Name: VPS53 GARP complex subunit; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Genotype
Genotype
Symbol: Vps53/Vps53
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060271 | pontocerebellar hypoplasia type 2E
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Strain
MGI:6354340 | B6;129-Vps53<tm1Smoc>/Smoc
Attribute String: targeted mutation, mutant stock
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Strain
MGI:5630585 | C57BL/6N-Vps53<tm1a(KOMP)Wtsi>/Wtsi
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6335665 | C57BL/6NTac-Vps53<tm1a(KOMP)Wtsi>/Wtsi
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6347722 | C57BL/6N-Vps53<tm1a(KOMP)Wtsi>/Mmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Vps53/Vps53
Background: C57BL/6N-Vps53/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vps53/Vps53<+>
Background: C57BL/6N-Vps53/Wtsi
Zygosity: ht
Has Mutant Allele: true
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Protein
Q8C754
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein
G3UY33
Organism: Mus musculus/domesticus
Length: 612  
Fragment?: true
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Protein
A0A068BGT0
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein
Q3V3A4
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein Domain
IPR007258 | Vps52
Type: Family
Description: Vps52 complexes with Vps53 and Vps54 to form the Golgi-associated retrograde protein (GARP) complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network, regulating membrane trafficking events [, , ]. It is also part of the EARP (Endosome-Associated Recycling Protein) complex, involved in endocytic recycling [].
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Protein
F6TKZ2
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein Domain
IPR038260 | Vps53_C_sf
Type: Homologous_superfamily
Description: This superfamily represents the C-terminal domain of vacuolar protein sorting-associated protein 53 (Vps53), which is part of the of the GARP (Golgi-associated retrograde protein) complex involved in retrograde transport from early and late endosomes to late Golgi [, , ]. Budding yeast Vps53 is involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE Tgl1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles [].
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Protein Domain
IPR014812 | Vps51
Type: Family
Description: The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved in recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Ang2 or Vps67) is a subunit of VFT and interacts with the SNARE Tlg1 []. It is also part of the endosome-associated recycling protein (EARP) complex which is structurally related to GARP complex [].
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Protein Domain
IPR007234 | Vps53_N
Type: Domain
Description: Vps53 complexes with Vps52 and Vps54 to form a multi-subunit complex called Golgi-Associated Retrograde Protein complex (GARP) involved in retrograde transport from early and late endosomes to late Golgi [, , ]. They are members of the CATCHR (complexes associated with tethering containing helical rods) which includes the exocyst, COG, GARP, and DSL1 complexes which have structural and functional similarities. This is the N-terminal coiled-coil domain [].
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Publication
36239632 | J:345128
 
First Author: O'Brien CE
Year: 2023
Journal: J Cell Biol
Title: The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling.
Volume: 222
Issue: 1
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Publication
20005805 | -
First Author: Ren Y
Year: 2009
Journal: Cell
Title: A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1.
Volume: 139
Issue: 6
Pages: 1119-29
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Protein Domain
IPR031745 | Vps53_C
Type: Domain
Description: This entry represents the C-terminal domain of fungal vacuolar protein sorting-associated protein 53 (Vps53), a component of the Golgi-associated retrograde complex (GARP). Budding yeast Vps53 is involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE Tgl1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles [, ]. This domain has a fold consisting of an α-helical bundle known as the CATCHR fold (complexes associated with tethering containing helical rods) which is shared by proteins of other tethering complexes, namely exocyst, COG and Dsl1 [, ].
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Publication
19620288 | J:153910
First Author: Pérez-Victoria FJ
Year: 2009
Journal: Mol Cell Biol
Title: Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.
Volume: 29
Issue: 19
Pages: 5251-63
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Publication
18367545 | -
First Author: Pérez-Victoria FJ
Year: 2008
Journal: Mol Biol Cell
Title: Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.
Volume: 19
Issue: 6
Pages: 2350-62
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Protein
Q3UVL4
Organism: Mus musculus/domesticus
Length: 782  
Fragment?: false
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Publication
32409579 | -
First Author: Travis SM
Year: 2020
Journal: J Biol Chem
Title: Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1.
Volume: 295
Issue: 30
Pages: 10125-10135
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Publication
34061181 | -
 
First Author: Santana-Molina C
Year: 2021
Journal: Genome Biol Evol
Title: Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System.
Volume: 13
Issue: 7
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