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Search results 301 to 363 out of 363 for Rab27a

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Categories

Hits by Pathway

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Type Details Score
Protein Domain
IPR042783 | SYTL5_FYVE
Type: Domain
Description: Synaptotagmin-like protein 5 (SYTL5 or Slp5) is a novel Rab27A-specific effector that is highly expressed in placenta and liver. Slp5 specifically interacted with the GTP-bound form of Rab27A and is involved in Rab27A-dependent membrane trafficking in specific tissues. Slp5 contains an N-terminal Slp homology domain (SHD) and C-terminal tandem C2 domains. The Slp homology domain (SHD) consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of Slp5 are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif [].This entry represents the FYVE-related domain found in SYTL5.
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Publication
11956164 | J:76325
First Author: Zhao S
Year: 2002
Journal: Endocrinology
Title: Involvement of Rab27b in the regulated secretion of pituitary hormones.
Volume: 143
Issue: 5
Pages: 1817-24
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Strain
MGI:2161891 | C3H/HeSn-Rab27a<ash>/J
Attribute String: mutant strain, coisogenic, spontaneous mutation
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Strain
MGI:5650249 | (C3H/HeSn-Rab27a<ash> x C57BL/6J-Myo5a<d> Bmp5<se>)F1
Attribute String: mutant stock, F1 hybrid
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Publication
32024826 | J:286382
First Author: Zhao Y
Year: 2020
Journal: Nat Commun
Title: Liver governs adipose remodelling via extracellular vesicles in response to lipid overload.
Volume: 11
Issue: 1
Pages: 719
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Strain
MGI:5506736 | ASHA
Attribute String: inbred strain, spontaneous mutation
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Publication
16216924 | J:102610
First Author: Gomi H
Year: 2005
Journal: J Cell Biol
Title: Granuphilin molecularly docks insulin granules to the fusion machinery.
Volume: 171
Issue: 1
Pages: 99-109
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Publication
30770248 | J:305807
First Author: Zhang F
Year: 2019
Journal: Immunity
Title: Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses.
Volume: 50
Issue: 3
Pages: 738-750.e7
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Publication
10497219 | J:57922
First Author: Wang J
Year: 1999
Journal: J Biol Chem
Title: Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells.
Volume: 274
Issue: 40
Pages: 28542-8
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Publication
16481396 | -
First Author: Tsuboi T
Year: 2006
Journal: Mol Biol Cell
Title: The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex.
Volume: 17
Issue: 5
Pages: 2101-12
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Publication
15003533 | -
First Author: Manabe S
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells.
Volume: 316
Issue: 1
Pages: 218-25
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Publication
28559319 | -
First Author: Oberhofer A
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro.
Volume: 114
Issue: 24
Pages: E4714-E4723
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Protein Domain
IPR044134 | FYVE_Slp4
Type: Domain
Description: Synaptotagmin-like protein 4 (SYTL4, Slp4), also known as granuphilin or exophilin-2, belongs to the synaptotagmin-like protein family (Slp), which is a group of putative membrane trafficking proteins []. The characteristic feature of the Slp family is the N-terminal Slp homology domain (SHD), which functions as a Rab27-binding domain and C-terminal tandem C2 domains (known as the C2A domain and C2B domain), putative Ca2+-binding motifs [, ]. SHD consists of two conserved regions, designated SHD1 and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of Slp4 are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.There are several alternatively spliced isoform of Slp4. Slp4-a (granuphilin-a) has two C2 domains, whereas Slp4-b (granuphilin-b) contains only the first C2 domain. Expression of Slp4-a inhibits regulated secretion in endocrine cells. Slp4-a binds to both the GTP- and GDP-bound forms of Rab27A and inhibits a specific GTP/GDP exchange cycle required for dense-core vesicle exocytosis []. Slp4 has been detected in the pancreatic islet, in particular in insulin-positive beta cells, and in pituitary []. This entry represents the FYVE-related domain of synaptotagmin-like protein 4.
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Protein Domain
IPR028694 | SYTL4
Type: Family
Description: Synaptotagmin-like protein 4 (SYTL4, Slp4), also known as granuphilin or exophilin-2, belongs to the synaptotagmin-like protein family (Slp), which is a group of putative membrane trafficking proteins []. The characteristic feature of the Slp family is the N-terminal Slp homology domain (SHD), which functions as a Rab27-binding domain and C-terminal tandem C2 domains (known as the C2A domain and C2B domain), putative Ca2+-binding motifs [, ]. SHD consists of two conserved regions, designated SHD1 and SHD2, which may function as protein interaction sites. The SHD1 and SHD2 of Slp4 are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.There are several alternatively spliced isoform of Slp4. Slp4-a (granuphilin-a) has two C2 domains, whereas Slp4-b (granuphilin-b) contains only the first C2 domain. Expression of Slp4-a inhibits regulated secretion in endocrine cells. Slp4-a binds to both the GTP- and GDP-bound forms of Rab27A and inhibits a specific GTP/GDP exchange cycle required for dense-core vesicle exocytosis []. Slp4 has been detected inthe pancreatic islet, in particular in insulin-positive beta cells, and in pituitary [].
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Protein Domain
IPR037442 | Melanophilin_FYVE-rel_dom
Type: Domain
Description: Melanophilin, also termed SlaC2-a, or exophilin-3, is a GTP-bound form of Rab27A-, myosin Va-, and actin-binding protein present on melanosomes. It is involved in the control of transferring of melanosomes from microtubules to actin filaments. It also functions as a melanocyte type myosin Va (McM5) binding partner and directly activates the actin-activated ATPase activity of McM5 through forming a tripartite protein complex with Rab27A and an actin-based motor myosin Va [,]. SlaC2-a belongs to the Slp homologue lacking C2 domains (Slac2) family. It contains an N-terminal Slp homology domain (SHD), but lacks tandem C2 domains. The SHD consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites []. The SHD1 and SHD2 of SlaC2-a are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. Moreover, Slac2-a has a middle myosin-binding domain and a C-terminal actin-binding domain [].
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Publication
21291502 | J:196257
First Author: Beaumont KA
Year: 2011
Journal: Traffic
Title: The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking.
Volume: 12
Issue: 5
Pages: 627-43
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Publication
12221080 | J:80040
First Author: Fukuda M
Year: 2002
Journal: J Biol Chem
Title: Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin.
Volume: 277
Issue: 45
Pages: 43096-103
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Publication
11504925 | J:71302
First Author: Matesic LE
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice.
Volume: 98
Issue: 18
Pages: 10238-43
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Publication
17827149 | J:126951
First Author: Goehring AS
Year: 2007
Journal: J Biol Chem
Title: MyRIP anchors protein kinase A to the exocyst complex.
Volume: 282
Issue: 45
Pages: 33155-67
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Publication
16987870 | J:121600
First Author: Fairbank PD
Year: 2006
Journal: Development
Title: Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium.
Volume: 133
Issue: 20
Pages: 4109-18
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Publication
22984402 | J:191882
First Author: Rachel RA
Year: 2012
Journal: PLoS One
Title: Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.
Volume: 7
Issue: 9
Pages: e42446
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Publication
15702992 | J:105404
First Author: Bossi G
Year: 2005
Journal: Traffic
Title: Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV.
Volume: 6
Issue: 3
Pages: 243-51
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Publication
35367771 | J:323105
 
First Author: Han X
Year: 2022
Journal: EBioMedicine
Title: KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion.
Volume: 78
Pages: 103980
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Publication
28072828 | J:238704
First Author: Jiang C
Year: 2017
Journal: PLoS Genet
Title: GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary.
Volume: 13
Issue: 1
Pages: e1006535
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Publication
23630344 | J:204780
First Author: Yan B
Year: 2013
Journal: J Immunol
Title: IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation.
Volume: 190
Issue: 11
Pages: 5882-93
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Publication
16247022 | J:104400
First Author: Wu XS
Year: 2005
Journal: J Cell Biol
Title: Melanophilin and myosin Va track the microtubule plus end on EB1.
Volume: 171
Issue: 2
Pages: 201-7
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Publication
12060386 | J:77498
First Author: Chen Y
Year: 2002
Journal: J Invest Dermatol
Title: Rab27b association with melanosomes: dominant negative mutants disrupt melanosomal movement.
Volume: 118
Issue: 6
Pages: 933-40
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Publication
15760894 | J:99080
First Author: Li XD
Year: 2005
Journal: J Biol Chem
Title: Activation of myosin Va function by melanophilin, a specific docking partner of myosin Va.
Volume: 280
Issue: 18
Pages: 17815-22
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Publication
21441305 | J:182967
First Author: Mizuno K
Year: 2011
Journal: Mol Biol Cell
Title: Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis.
Volume: 22
Issue: 10
Pages: 1716-26
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Publication
35091681 | J:322733
First Author: Saliba J
Year: 2022
Journal: Oncogene
Title: Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment.
Volume: 41
Issue: 11
Pages: 1563-1575
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Publication
10196122 | -
First Author: Dumas JJ
Year: 1999
Journal: Structure
Title: Structural basis of activation and GTP hydrolysis in Rab proteins.
Volume: 7
Issue: 4
Pages: 413-23
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Protein
Q69ZF4
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: true
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Protein
A0A5F8MPI7
Organism: Mus musculus/domesticus
Length: 1280  
Fragment?: false
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Publication
35344582 | J:328213
First Author: Izquierdo E
Year: 2022
Journal: Blood
Title: Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies.
Volume: 139
Issue: 25
Pages: 3617-3629
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Publication
30816224 | J:275836
First Author: Neckles VN
Year: 2019
Journal: Sci Rep
Title: A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illuminates neonatal cortical astrocytes as a source of immunomodulatory extracellular vesicles.
Volume: 9
Issue: 1
Pages: 3094
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Protein
Q99N50
Organism: Mus musculus/domesticus
Length: 950  
Fragment?: false
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Protein
A0A5F8MPX2
Organism: Mus musculus/domesticus
Length: 2097  
Fragment?: false
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Protein
A0A5F8MPH5
Organism: Mus musculus/domesticus
Length: 2153  
Fragment?: false
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Protein
A7MCT9
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: false
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Publication
11387043 | -
First Author: Stenmark H
Year: 2001
Journal: Genome Biol
Title: The Rab GTPase family.
Volume: 2
Issue: 5
Pages: REVIEWS3007
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Protein
G3UYC6
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
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Protein
Q80T23
Organism: Mus musculus/domesticus
Length: 753  
Fragment?: false
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Protein
A2AF58
Organism: Mus musculus/domesticus
Length: 753  
Fragment?: false
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Protein
Q91V27
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: false
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Protein
Q99N80
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Protein
B7FAU1
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein
E0CYJ1
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
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Protein
A2AE95
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
Q6KAP5
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: true
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Protein
A0A0R4J075
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: false
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Protein
D3Z049
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
B9EKA5
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: false
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Protein
E9PXV1
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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Protein
Q3U0P9
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: true
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Protein
E9PUK9
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: false
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Protein
A2AE94
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
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Protein
F8WHG0
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Protein
Q9R0Q1
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Protein
Q549X6
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Protein
Q768S4
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
Q6KAN3
Organism: Mus musculus/domesticus
Length: 516  
Fragment?: true
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Protein
Q99N48
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
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Protein
Q0VF85
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom