Sorting nexin-8 (SNX8) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. It may play a role in intracellular protein transport from early endosomes to the trans-Golgi network []. SNX8 yeast counterpart, Mvp1, is required for sorting proteins to the vacuole [, ].
Sorting nexin-8 (SNX8) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. It may play a role in intracellular protein transport from early endosomes to the trans-Golgi network []. SNX8 yeast counterpart, Mvp1, is required for sorting proteins to the vacuole [, ].The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions []. Sorting nexins (SNXs) make up the largest group among PX domain containing proteins. They are involved in regulating membrane traffic and protein sorting in the endosomal system []. The PX domain of SNXs binds PIs and targets the protein to PI-enriched membranes. SNXs differ from each other in PI-binding specificity and affinity, and the presence of other protein-protein interaction domains, which help determine subcellular localization and specific function in the endocytic pathway. Some SNXs are localized in early endosome structures such as clathrin-coated pits, while others are located in late structures of the endocytic pathway [, , , , , , ].
