Zinc finger CCHC domain-containing protein 3 (ZCCHC3) is a zinc-finger protein that acts as a co-sensor of cGAS in innate immune response to cytosolic dsDNA and DNA virus []. It has been shown to bind DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS [, ].
This proteins in this entry belong to the herpesvirus U10 family.Family member Protein UL31 is involved in the inhibition of the host innate immune system. It targets host CGAS, promoting dissociation of DNA from CGAS, thus inhibiting the enzymatic activity of CGAS [].
This entry represents Poxin (poxvirus immune nucleases) from Baculovirus and Vaccinia virus. Poxin is a nuclease that cleaves host 2',3'-cGAMP []. In human hosts, enzyme cGAS recognizes cytosolic DNA and synthesizes 2'3' cGAMP to activate STING-dependent interferon and NF-kappaB immune responses. Poxin is the viral factor responsible for 2'3' cGAMP degradation []. Interestingly, in some poxviruses the poxin is expressed as a poxin-schlafen fusion protein.
