Mitochondrial calcium uniporter regulator 1 (MCUR1), also known as CCDC90A, is a key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. It plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU [, , ].
This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1 [, , ]. A study in mammals and in yeast homologue fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU [], however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU [, ]. The role of CCDC90B proteins is still not known.
