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Search results 701 to 800 out of 901 for Traf6

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Type Details Score
Publication
First Author: Buchta CM
Year: 2014
Journal: J Immunol
Title: TRAF5 negatively regulates TLR signaling in B lymphocytes.
Volume: 192
Issue: 1
Pages: 145-50
Publication
First Author: Li C
Year: 2015
Journal: PLoS Pathog
Title: The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.
Volume: 11
Issue: 4
Pages: e1004824
Publication
First Author: Burger ML
Year: 2014
Journal: Blood
Title: Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation.
Volume: 123
Issue: 26
Pages: 4089-100
Publication
First Author: Zahoor A
Year: 2020
Journal: J Cell Physiol
Title: Gas6 negatively regulates the Staphylococcus aureus-induced inflammatory response via TLR signaling in the mouse mammary gland.
Volume: 235
Issue: 10
Pages: 7081-7093
Publication
First Author: Ishizuka H
Year: 2011
Journal: J Bone Miner Res
Title: ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo.
Volume: 26
Issue: 1
Pages: 169-81
Publication  
First Author: Ren J
Year: 2016
Journal: J Mol Cell Cardiol
Title: Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia.
Volume: 93
Pages: 18-31
Publication
First Author: Fessing MY
Year: 2006
Journal: Am J Pathol
Title: Involvement of the Edar signaling in the control of hair follicle involution (catagen).
Volume: 169
Issue: 6
Pages: 2075-84
Publication
First Author: Kara FM
Year: 2010
Journal: FASEB J
Title: Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function.
Volume: 24
Issue: 7
Pages: 2325-33
Publication
First Author: Petrova T
Year: 2021
Journal: FEBS J
Title: HOIL-1-catalysed, ester-linked ubiquitylation restricts IL-18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages.
Volume: 288
Issue: 20
Pages: 5909-5924
Publication
First Author: Wang Q
Year: 2020
Journal: Cancer Res
Title: ARC Is a Critical Protector against Inflammatory Bowel Disease (IBD) and IBD-Associated Colorectal Tumorigenesis.
Volume: 80
Issue: 19
Pages: 4158-4171
Publication
First Author: Karki R
Year: 2017
Journal: Cell Cycle
Title: NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer.
Volume: 16
Issue: 13
Pages: 1243-1251
Publication
First Author: Dahan J
Year: 2013
Journal: Mol Cell Biol
Title: LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis.
Volume: 33
Issue: 16
Pages: 3299-308
Publication
First Author: Cheng D
Year: 2018
Journal: Exp Cell Res
Title: Butyrate ameliorated-NLRC3 protects the intestinal barrier in a GPR43-dependent manner.
Volume: 368
Issue: 1
Pages: 101-110
Publication
First Author: Zhu Z
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury.
Volume: 313
Issue: 1
Pages: L104-L114
Publication
First Author: Zhong B
Year: 2013
Journal: Sci Signal
Title: Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3.
Volume: 6
Issue: 275
Pages: ra35
Publication  
First Author: Wang T
Year: 2018
Journal: Bone Res
Title: CHIP regulates bone mass by targeting multiple TRAF family members in bone marrow stromal cells.
Volume: 6
Pages: 10
Publication  
First Author: Oh SY
Year: 2021
Journal: Front Cell Dev Biol
Title: Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 Interaction.
Volume: 9
Pages: 646803
Publication
First Author: Chattopadhyay S
Year: 2010
Journal: EMBO J
Title: Viral apoptosis is induced by IRF-3-mediated activation of Bax.
Volume: 29
Issue: 10
Pages: 1762-73
Publication
First Author: Song Z
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions.
Volume: 32
Issue: 1
Pages: 50-64
Publication  
First Author: Simon D
Year: 2017
Journal: Bone
Title: Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis.
Volume: 105
Pages: 35-41
Publication
First Author: Zhang L
Year: 2023
Journal: J Biol Chem
Title: Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.
Volume: 299
Issue: 7
Pages: 104911
Publication
First Author: Xia ZP
Year: 2009
Journal: Nature
Title: Direct activation of protein kinases by unanchored polyubiquitin chains.
Volume: 461
Issue: 7260
Pages: 114-9
Publication
First Author: Minoda Y
Year: 2006
Journal: Biochem Biophys Res Commun
Title: A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.
Volume: 344
Issue: 3
Pages: 1023-30
Publication
First Author: Feng Y
Year: 2005
Journal: Mol Cell Biol
Title: The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.
Volume: 25
Issue: 10
Pages: 4010-22
Publication
First Author: Ahmad R
Year: 2008
Journal: Blood
Title: Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1.
Volume: 112
Issue: 6
Pages: 2360-8
Publication
First Author: Takayanagi H
Year: 2000
Journal: Nature
Title: T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.
Volume: 408
Issue: 6812
Pages: 600-5
Publication
First Author: O'Neill LA
Year: 1998
Journal: J Leukoc Biol
Title: Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.
Volume: 63
Issue: 6
Pages: 650-7
Publication
First Author: Cusson-Hermance N
Year: 2005
Journal: J Biol Chem
Title: Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.
Volume: 280
Issue: 44
Pages: 36560-6
Publication
First Author: Moore CR
Year: 2005
Journal: J Immunol
Title: Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes.
Volume: 175
Issue: 6
Pages: 3780-9
Publication
First Author: Lee NK
Year: 2005
Journal: Blood
Title: A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
Volume: 106
Issue: 3
Pages: 852-9
Publication
First Author: McCully RR
Year: 2008
Journal: Mol Cell Biol
Title: The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.
Volume: 28
Issue: 18
Pages: 5668-86
Publication
First Author: Kim SI
Year: 2009
Journal: J Biol Chem
Title: Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells.
Volume: 284
Issue: 33
Pages: 22285-96
Publication
First Author: Taguchi Y
Year: 2009
Journal: Genes Cells
Title: A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals.
Volume: 14
Issue: 11
Pages: 1331-45
Publication
First Author: Pore D
Year: 2010
Journal: Mol Immunol
Title: 34 kDa MOMP of Shigella flexneri promotes TLR2 mediated macrophage activation with the engagement of NF-kappaB and p38 MAP kinase signaling.
Volume: 47
Issue: 9
Pages: 1739-46
Publication
First Author: Brown GT
Year: 2011
Journal: J Immunol
Title: Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles.
Volume: 186
Issue: 9
Pages: 5489-96
Publication
First Author: Srivastav S
Year: 2012
Journal: J Immunol
Title: Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response.
Volume: 189
Issue: 2
Pages: 924-34
Publication  
First Author: Shang C
Year: 2022
Journal: Cancer Lett
Title: CXCL10 conditions alveolar macrophages within the premetastatic niche to promote metastasis.
Volume: 537
Pages: 215667
Publication
First Author: Chung JY
Year: 2013
Journal: Lab Invest
Title: Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.
Volume: 93
Issue: 6
Pages: 663-76
Publication
First Author: Akiyama T
Year: 2014
Journal: PLoS One
Title: Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN.
Volume: 9
Issue: 5
Pages: e95992
Publication
First Author: Ersek A
Year: 2015
Journal: J Clin Invest
Title: Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.
Volume: 125
Issue: 6
Pages: 2279-92
Publication
First Author: Takahashi H
Year: 2015
Journal: Oncogene
Title: MUC1-C activates the TAK1 inflammatory pathway in colon cancer.
Volume: 34
Issue: 40
Pages: 5187-97
Publication
First Author: Tikhanovich I
Year: 2015
Journal: J Biol Chem
Title: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling.
Volume: 290
Issue: 36
Pages: 22236-49
Publication
First Author: Jean-Charles PY
Year: 2016
Journal: J Biol Chem
Title: Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.
Volume: 291
Issue: 14
Pages: 7450-64
Publication
First Author: Tanishima M
Year: 2017
Journal: J Biol Chem
Title: Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling.
Volume: 292
Issue: 42
Pages: 17250-17257
Publication
First Author: Han L
Year: 2017
Journal: Sci Rep
Title: Interleukin-33 promotes inflammation-induced lymphangiogenesis via ST2/TRAF6-mediated Akt/eNOS/NO signalling pathway.
Volume: 7
Issue: 1
Pages: 10602
Publication
First Author: Lu Y
Year: 2018
Journal: Hepatology
Title: Hepatic leukocyte immunoglobulin-like receptor B4 (LILRB4) attenuates nonalcoholic fatty liver disease via SHP1-TRAF6 pathway.
Volume: 67
Issue: 4
Pages: 1303-1319
Publication  
First Author: Li J
Year: 2020
Journal: Int Immunopharmacol
Title: LncRNA GAS5 inhibits Th17 differentiation and alleviates immune thrombocytopenia via promoting the ubiquitination of STAT3.
Volume: 80
Pages: 106127
Publication  
First Author: Li D
Year: 2020
Journal: Int J Mol Sci
Title: METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.
Volume: 21
Issue: 5
Publication
First Author: Mestre-Farrera A
Year: 2021
Journal: Cancer Res
Title: Glutamine-Directed Migration of Cancer-Activated Fibroblasts Facilitates Epithelial Tumor Invasion.
Volume: 81
Issue: 2
Pages: 438-451
Publication
First Author: Zhao X
Year: 2020
Journal: J Mol Cell Biol
Title: PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation.
Volume: 12
Issue: 1
Pages: 55-70
Publication
First Author: Bellet MM
Year: 2020
Journal: Cell Death Dis
Title: HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6.
Volume: 11
Issue: 10
Pages: 865
Publication  
First Author: Pradhan P
Year: 2021
Journal: Sci Adv
Title: TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation.
Volume: 7
Issue: 3
Publication  
First Author: Liu H
Year: 2024
Journal: Free Radic Biol Med
Title: Protectin D1 inhibits TLR4 signaling pathway to alleviate non-alcoholic steatohepatitis via upregulating IRAK-M.
Volume: 210
Pages: 42-53
Publication  
First Author: Ernst O
Year: 2021
Journal: Sci Signal
Title: A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation.
Volume: 14
Issue: 694
Protein
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
Publication
First Author: Bradley JR
Year: 2001
Journal: Oncogene
Title: Tumor necrosis factor receptor-associated factors (TRAFs).
Volume: 20
Issue: 44
Pages: 6482-91
Publication  
First Author: Garland P
Year: 2008
Journal: Brain Res
Title: Expression of the MAST family of serine/threonine kinases.
Volume: 1195
Pages: 12-9
Publication
First Author: Buettner N
Year: 2010
Journal: J Gen Virol
Title: Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor.
Volume: 91
Issue: Pt 1
Pages: 220-7
Publication
First Author: Yang M
Year: 2016
Journal: J Gen Virol
Title: pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating.
Volume: 97
Issue: 9
Pages: 2149-56
Protein Domain
Type: Domain
Description: This entry represents the N-terminal domain of family members such as the Matrix (Mx) and Matrix protein long (ML) proteins. They are found in Thogoto virus (THOV), a tick-transmitted orthomyxovirus with a genome consisting of six single-stranded RNA segments that encode seven structural proteins []. Matrix proteins of the family Orthomyxoviridae are major structural components of the viral capsid, located below the viral lipid membrane and provide protection for viral ribonucleoproteins (vRNPs) []. They serve as a major participant during the processes of virus invasion and budding. Furthermore, they play specific roles throughout the viral life cycle, usually by interacting with other viral components or host cellular proteins [].ML protein, an extended version of the viral M protein, is a viral IFN antagonist. ML is essential for virus growth and pathogenesis in an IFN-competent host. In the presence of ML the activation and/or action of the interferon regulatory factor-3 (IRF-3) is severely affected. This effect depends on direct interaction of ML with the transcription factor IIB (TFIIB). ML suppresses IRF-7 in a similar manner as it suppresses IRF-3. Studies have revealed that ML associates with IRF-7 and prevents IRF-7 dimerization and interaction with TRAF6 [].Structural analysis revealed that N-terminal fragment of M protein (MN) undergoes conformational changes that result in specific, pH-dependent inter-molecular interactions. Comparison of THOV MN and influenza A virus (IAV) MN region, showed low sequence identity. However, superimposition of the two structures in neutral condition showed that both matrix proteins contain nine helices connected with same topology. Since the matrix layer of IAV disassembles in acidic endosome at the beginning of infection and repacks in the neutral cytoplasm, a change of pH might be a key regulator for the capsid assembly/disassembly transition during these processes. Hence, pH-dependent conformational transition model was studied in THOV MN, where interactions such as hydrogen bonds and hydrophobic interactions are suggested to be involved in THOV matrix assembly [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 2412  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
Publication
First Author: Grech A
Year: 2000
Journal: Mol Immunol
Title: Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.
Volume: 37
Issue: 12-13
Pages: 721-34
Publication
First Author: Lu W
Year: 2017
Journal: Oncogene
Title: SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.
Volume: 36
Issue: 10
Pages: 1364-1373
Publication
First Author: Liu S
Year: 2011
Journal: PLoS One
Title: The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis.
Volume: 6
Issue: 3
Pages: e17161
Publication
First Author: Lochhead RB
Year: 2014
Journal: PLoS Pathog
Title: MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi.
Volume: 10
Issue: 6
Pages: e1004212
Publication
First Author: Gyurko R
Year: 2005
Journal: Bone
Title: Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss.
Volume: 36
Issue: 3
Pages: 472-9
Publication  
First Author: Zahoor A
Year: 2020
Journal: Mol Immunol
Title: MerTK negatively regulates Staphylococcus aureus induced inflammatory response via Toll-like receptor signaling in the mammary gland.
Volume: 122
Pages: 1-12
Publication
First Author: Song Z
Year: 2011
Journal: PLoS One
Title: CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury.
Volume: 6
Issue: 8
Pages: e23239
Publication
First Author: Weinberg EO
Year: 2019
Journal: PLoS One
Title: IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages.
Volume: 14
Issue: 1
Pages: e0210827
Publication
First Author: Kissner TL
Year: 2011
Journal: PLoS One
Title: Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules.
Volume: 6
Issue: 1
Pages: e15985
Publication
First Author: Portillo JA
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling.
Volume: 55
Issue: 12
Pages: 8590-7
Publication
First Author: Johnson M
Year: 2018
Journal: PLoS One
Title: Genomic and transcriptomic comparison of allergen and silver nanoparticle-induced mast cell degranulation reveals novel non-immunoglobulin E mediated mechanisms.
Volume: 13
Issue: 3
Pages: e0193499
Publication
First Author: Wang L
Year: 2020
Journal: J Neuroinflammation
Title: Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord.
Volume: 17
Issue: 1
Pages: 83
Protein
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
Publication
First Author: Ye H
Year: 1999
Journal: Mol Cell
Title: The structural basis for the recognition of diverse receptor sequences by TRAF2.
Volume: 4
Issue: 3
Pages: 321-30
Publication  
First Author: Huang N
Year: 2017
Journal: Nat Commun
Title: Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68.
Volume: 8
Pages: 15057
Protein
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false