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Search results 301 to 351 out of 351 for Snx3

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Type

Details

Score

Publication

14610273 | J:86696

First Author:	Zambrowicz BP
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume:	100
Issue:	24
Pages:	14109-14

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Publication

- | J:141210

First Author:	Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year:	2008
Journal:	Database Download
Title:	Mouse Gene Trap Data Load from dbGSS

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Publication

38355793 | J:345621

First Author:	Adams DJ
Year:	2024
Journal:	Nature
Title:	Genetic determinants of micronucleus formation in vivo.
Volume:	627
Issue:	8002
Pages:	130-136

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Publication

- | J:293217

First Author:	GemPharmatech
Year:	2020

Title:	GemPharmatech Website.

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Publication

- | J:342587

First Author:	AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year:	2011

Title:	Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

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Publication

12466851 | J:80000

First Author:	Okazaki Y
Year:	2002
Journal:	Nature
Title:	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume:	420
Issue:	6915
Pages:	563-73

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Publication

- | J:164563

First Author:	The Gene Ontology Consortium
Year:	2010

Title:	Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

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Publication

21267068 | J:153498

First Author:	Diez-Roux G
Year:	2011
Journal:	PLoS Biol
Title:	A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume:	9
Issue:	1
Pages:	e1000582

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Publication

- | J:157972

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2010
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).

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Publication

- | J:57747

First Author:	MGI Genome Annotation Group and UniGene Staff
Year:	2015
Journal:	Database Download
Title:	MGI-UniGene Interconnection Effort

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Publication

- | J:75000

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Mouse Genome Informatics Computational Sequence to Gene Associations

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Publication

- | J:161428

First Author:	Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year:	2010

Title:	Annotation inferences using phylogenetic trees

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Publication

- | J:63103

First Author:	Mouse Genome Database and National Center for Biotechnology Information
Year:	2000
Journal:	Database Release
Title:	Entrez Gene Load

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Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

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Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

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Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

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Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

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Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

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Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

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Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

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Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

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Publication

11433298 | -

First Author:	Xu Y
Year:	2001
Journal:	Nat Cell Biol
Title:	SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P.
Volume:	3
Issue:	7
Pages:	658-66

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Publication

18767904 | -

First Author:	Pons V
Year:	2008
Journal:	PLoS Biol
Title:	Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.
Volume:	6
Issue:	9
Pages:	e214

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Publication

11439350 | -

First Author:	Soncini C
Year:	2001
Journal:	Oncogene
Title:	Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.
Volume:	20
Issue:	29
Pages:	3869-79

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Publication

20096447 | -

First Author:	Yuan J
Year:	2010
Journal:	Cell
Title:	USP10 regulates p53 localization and stability by deubiquitinating p53.
Volume:	140
Issue:	3
Pages:	384-96

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Publication

19398555 | -

First Author:	Bomberger JM
Year:	2009
Journal:	J Biol Chem
Title:	The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells.
Volume:	284
Issue:	28
Pages:	18778-89

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Protein Domain

IPR028767 | USP10

Type:	Family
Description:	Ubiquitin carboxyl-terminal hydrolase 10 (USP10) isa hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR []. It regulates the localisation and stability of p53 by de-ubiquitinatiing p53 []. It is also implicated in vesicular transport and trafficking of membrane proteins [].

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Allele

Hprt1<tm73(Ple142-lacZ)Ems> | MGI:4835011

Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 73, Elizabeth M Simpson
Allele Type:	Targeted
Attribute String:	Null/knockout, Reporter

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Strain

MGI:4835719 | B6.129P2(Cg)-Hprt1<tm73(Ple142-lacZ)Ems>/Mmjax

Attribute String:

congenic, mutant strain, targeted mutation

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Genotype

Symbol:	Hprt1/?
Background:	B6.129P2(Cg)-Hprt1/Mmjax
Zygosity:	ot
Has Mutant Allele:	true

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Publication

18632802 | -

First Author:	Boulkroun S
Year:	2008
Journal:	Am J Physiol Renal Physiol
Title:	Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3.
Volume:	295
Issue:	4
Pages:	F889-900

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Protein Domain

IPR042137 | PX_SNX3_Vert

Type:

Domain

Description:

This entry represents the PX domain found in Sorting nexin-3 (SNX3) from vertebrates. In budding yeasts, Snx3 homologue has been shown to associate with early endosomes through a PX domain-mediated interaction with phosphatidylinositol-3-phosphate (PI3P) []. It associates with the retromer complex, a membrane coat multimeric complex required for endosomal retrieval of lysosomal hydrolase receptors to the Golgi, and functions as a cargo-specific adaptor for the retromer. SNX3 is required for the formation of multivesicular bodies, which function as transport intermediates to late endosomes [, ]. It also promotes cell surface expression of the amiloride-sensitive epithelial Na+ channel (ENaC), which is critical in sodium homeostasis and maintenance of extracellular fluid volume [].The Phox Homology (PX) domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions. Sorting nexins (SNXs) make up the largest group among PX domain containing proteins. They are involved in regulating membrane traffic and protein sorting in the endosomal system. The PX domain of SNXs binds phosphoinositides (PIs) and targets the protein to PI-enriched membranes [, ]. SNXs differ from each other in PI-binding specificity and affinity, and the presence of other protein-protein interaction domains, which help determine subcellular localization and specific function in the endocytic pathway [, , ].

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Publication

26092486 | J:244099

First Author:	Corso-Díaz X
Year:	2015
Journal:	Mol Brain
Title:	Nr2e1 regulates retinal lamination and the development of Müller glia, S-cones, and glycineric amacrine cells during retinogenesis.
Volume:	8

Pages:	37

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Publication

14514667 | -

First Author:	Zhou CZ
Year:	2003
Journal:	J Biol Chem
Title:	Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate.
Volume:	278
Issue:	50
Pages:	50371-6

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Publication

17420293 | -

First Author:	Strochlic TI
Year:	2007
Journal:	J Cell Biol
Title:	Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling.
Volume:	177
Issue:	1
Pages:	115-25

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Protein Domain

IPR042138 | PX_Grd19_PX

Type:

Domain

Description:

This entry represents the PX domain found in SNX3 (also known as Grd19) from fungi. Grd19 has been shown to associate with early endosomes through a PX domain-mediated interaction with phosphatidylinositol-3-phosphate (PI3P) []. Grd19 is involved in the localization of late Golgi membrane proteins in yeast. It associates with the retromer complex, a membrane coat multimeric complex required for endosomal retrieval of lysosomal hydrolase receptors to the Golgi, and functions as a cargo-specific adaptor for the retromer [].The Phox Homology (PX) domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions. Sorting nexins (SNXs) make up the largest group among PX domain containing proteins. They are involved in regulating membrane traffic and protein sorting in the endosomal system. The PX domain of SNXs binds phosphoinositides (PIs) and targets the protein to PI-enriched membranes [, ]. SNXs differ from each other in PI-binding specificity and affinity, and the presence of other protein-protein interaction domains, which help determine subcellular localization and specific function in the endocytic pathway [, , ].

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Publication

9819414 | J:212820

First Author:	Haft CR
Year:	1998
Journal:	Mol Cell Biol
Title:	Identification of a family of sorting nexin molecules and characterization of their association with receptors.
Volume:	18
Issue:	12
Pages:	7278-87

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Protein

O70492

Organism:	Mus musculus/domesticus
Length:	162
Fragment?:	false

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Protein

Q78ZM0

Organism:	Mus musculus/domesticus
Length:	162
Fragment?:	false

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Publication

22290436 | J:183689

First Author:	Schmouth JF
Year:	2012
Journal:	Mol Cell Biol
Title:	Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice.
Volume:	32
Issue:	7
Pages:	1296-311

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Publication

24124870 | J:205141

First Author:	Schmouth JF
Year:	2013
Journal:	BMC Biol
Title:	Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice.
Volume:	11

Pages:	106

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Publication

15634208 | -

First Author:	Carlton J
Year:	2005
Journal:	Traffic
Title:	Sorting nexins--unifying trends and new perspectives.
Volume:	6
Issue:	2
Pages:	75-82

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Publication

16782399 | -

First Author:	Seet LF
Year:	2006
Journal:	Biochim Biophys Acta
Title:	The Phox (PX) domain proteins and membrane traffic.
Volume:	1761
Issue:	8
Pages:	878-96

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Publication

11439176 | -

First Author:	Wishart MJ
Year:	2001
Journal:	Cell
Title:	Phoxy lipids: revealing PX domains as phosphoinositide binding modules.
Volume:	105
Issue:	7
Pages:	817-20

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Publication

12461558 | -

First Author:	Worby CA
Year:	2002
Journal:	Nat Rev Mol Cell Biol
Title:	Sorting out the cellular functions of sorting nexins.
Volume:	3
Issue:	12
Pages:	919-31

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Publication

16243015 | -

First Author:	Carlton JG
Year:	2005
Journal:	Curr Biol
Title:	Sorting nexins.
Volume:	15
Issue:	20
Pages:	R819-20

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Protein

P52479

Organism:	Mus musculus/domesticus
Length:	792
Fragment?:	false

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Publication

18950699 | J:144244

First Author:	Yang GS
Year:	2009
Journal:	Genomics
Title:	Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus.
Volume:	93
Issue:	3
Pages:	196-204

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Publication

- | J:145689

First Author:	The Pleiades Promoter Project
Year:	2009
Journal:	MGI Direct Data Submission
Title:	Generation of reporter and cre-expressing targeted transgenic mice in the Hprt1 gene using human MiniPromoters that drive region- and cell-specific gene expression in the mouse brain

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Publication

20807748 | J:164356

First Author:	Portales-Casamar E
Year:	2010
Journal:	Proc Natl Acad Sci U S A
Title:	A regulatory toolbox of MiniPromoters to drive selective expression in the brain.
Volume:	107
Issue:	38
Pages:	16589-94

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