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Search results 201 to 295 out of 295 for Rap1a

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Type Details Score
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
11836528 | J:74992
First Author: Sebzda E
Year: 2002
Journal: Nat Immunol
Title: Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling.
Volume: 3
Issue: 3
Pages: 251-8
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Publication
29966723 | J:265056
 
First Author: Gomi F
Year: 2018
Journal: Neuroscience
Title: Up-regulation of NSP3 by Oligomeric Aβ Accelerates Neuronal Death Through Cas-independent Rap1A Activation.
Volume: 386
Pages: 182-193
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Allele
Rap1a<em1Smoc> | MGI:7291971
Name: RAS-related protein 1a; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
13679863 | -
First Author: Mitra RS
Year: 2003
Journal: Oncogene
Title: Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.
Volume: 22
Issue: 40
Pages: 6243-56
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Publication
7791872 | -
First Author: Nassar N
Year: 1995
Journal: Nature
Title: The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.
Volume: 375
Issue: 6532
Pages: 554-60
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Allele
Tg(Rap1a-EGFP)IM69Gsat | MGI:4847362
Name: transgene insertion IM69, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003972 | STOCK Tg(Rap1a-EGFP)IM69Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
9611133 | -
First Author: D'Silva NJ
Year: 1998
Journal: Am J Physiol
Title: Beta-adrenergic-induced cytosolic redistribution of Rap1 in rat parotid acini: role in secretion.
Volume: 274
Issue: 6 Pt 1
Pages: C1667-73
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Publication
15286792 | -
First Author: Schwamborn JC
Year: 2004
Journal: Nat Neurosci
Title: The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.
Volume: 7
Issue: 9
Pages: 923-9
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Publication
21940635 | -
First Author: Zhang G
Year: 2011
Journal: J Biol Chem
Title: Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling.
Volume: 286
Issue: 45
Pages: 39466-77
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Protein Domain
IPR038851 | Rap1
Type: Family
Description: The Rap1 subgroup is part of the Rap subfamily of the Ras family. It can be further divided into the Rap1a and Rap1b isoforms. In humans, Rap1a and Rap1b share 95% sequence homology, but are products of two different genes located on chromosomes 1 and 12, respectively. Rap1a is sometimes called smg p21 or Krev1 in the older literature.Rap1 proteins are believed to perform different cellular functions, depending on the isoform, its subcellular localization, and the effector proteins it binds. For example, in rat salivary gland, neutrophils, and platelets, Rap1 localizes to secretory granules and is believed to regulate exocytosis or the formation of secretory granules [, ]. High expression of Rap1 has been observed in the nucleus of human oropharyngeal squamous cell carcinomas (SCCs) and cell lines; interestingly, in the SCCs, the active GTP-bound form localized to the nucleus, while the inactive GDP-bound form localized to the cytoplasm []. Rap1a, which is stimulated by T-cell receptor (TCR) activation, is a positive regulator of T cells by directing integrin activation and augmenting lymphocyte responses []. In murine hippocampal neurons, Rap1b determines which neurite will become the axon and directs the recruitment ofCdc42, which is required for formation of dendrites and axons []. In murine platelets, Rap1b is required for normal homeostasis in vivo and is involved in integrin activation [].
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Publication
23622247 | J:203359
First Author: Riou P
Year: 2013
Journal: Cell
Title: 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
Volume: 153
Issue: 3
Pages: 640-53
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Publication
15972668 | J:100567
First Author: Vielkind S
Year: 2005
Journal: J Immunol
Title: Integrin regulation by RhoA in thymocytes.
Volume: 175
Issue: 1
Pages: 350-7
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Protein
B2RX86
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
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Protein
Q3U5E2
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: true
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Publication
8806680 | -
First Author: Wienecke R
Year: 1996
Journal: Oncogene
Title: Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.
Volume: 13
Issue: 5
Pages: 913-23
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Protein Domain
IPR027107 | Tuberin/Ral-act_asu
Type: Family
Description: The activity of GTPases is regulated by the opposing effects of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Tuberin (tuberous sclerosis 2 protein or Tsc2) is believed to be a tumor suppressor and is able to stimulate specific GTPases. It stimulates the intrinsic GTPase activity of the Ras-related protein Rap1A and Rab5 [, ]. In complex with Tsc1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It acts as a GTPase-activating protein (GAP) for the small GTPase RheB, a direct activator of the protein kinase activity of mTORC1 [, ]. Ral GTPase-activating protein subunit alpha is the catalytic subunit of the heterodimeric RalGAP complex which acts as a GTPase activator for the Ras-like small GTPases RalA and RalB []. RalGAP complexes share structural and catalytic similarities with the tuberous sclerosis tumor suppressor complex [].
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Publication
8094051 | J:25192
First Author: Albright CF
Year: 1993
Journal: EMBO J
Title: Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.
Volume: 12
Issue: 1
Pages: 339-47
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Publication
35943805 | J:344980
 
First Author: Fan S
Year: 2022
Journal: JCI Insight
Title: Epithelial JAM-A is fundamental for intestinal wound repair in vivo.
Volume: 7
Issue: 17
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Publication
28917843 | J:251354
First Author: Farag MI
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression.
Volume: 493
Issue: 1
Pages: 139-145
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Publication
27111087 | J:248896
First Author: Shah B
Year: 2016
Journal: PLoS One
Title: C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development.
Volume: 11
Issue: 4
Pages: e0154174
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Publication
34166557 | J:310100
First Author: Ramshekar A
Year: 2021
Journal: FASEB J
Title: Active Rap1-mediated inhibition of choroidal neovascularization requires interactions with IQGAP1 in choroidal endothelial cells.
Volume: 35
Issue: 7
Pages: e21642
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Publication
18319399 | J:134353
First Author: Chen Y
Year: 2008
Journal: Blood
Title: A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development.
Volume: 111
Issue: 9
Pages: 4627-36
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Publication
18714009 | J:138946
First Author: Chu H
Year: 2008
Journal: J Immunol
Title: Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity.
Volume: 181
Issue: 5
Pages: 3373-83
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Publication
19429870 | J:151172
First Author: Molteni R
Year: 2009
Journal: Blood
Title: Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation.
Volume: 114
Issue: 5
Pages: 1073-82
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Publication
24368807 | J:208276
First Author: Montresor A
Year: 2013
Journal: J Cell Biol
Title: JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation.
Volume: 203
Issue: 6
Pages: 1003-19
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Publication
26476350 | J:227861
First Author: Wang H
Year: 2015
Journal: Am J Pathol
Title: Rap1 GTPase Inhibits Tumor Necrosis Factor-α-Induced Choroidal Endothelial Migration via NADPH Oxidase- and NF-κB-Dependent Activation of Rac1.
Volume: 185
Issue: 12
Pages: 3316-25
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Publication
32518959 | J:301394
First Author: Lagarrigue F
Year: 2020
Journal: Blood
Title: Talin-1 is the principal platelet Rap1 effector of integrin activation.
Volume: 136
Issue: 10
Pages: 1180-1190
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Publication
19520869 | -
First Author: Shirakawa R
Year: 2009
Journal: J Biol Chem
Title: Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases.
Volume: 284
Issue: 32
Pages: 21580-8
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Publication
9789079 | J:50543
First Author: Kawasaki H
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.
Volume: 95
Issue: 22
Pages: 13278-83
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Protein
A0A1W2P7Y4
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
A0A1W2P6Q0
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: true
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Protein
A0A1W2P7P2
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Protein
Q925J1
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Publication
15340059 | -
First Author: Li Y
Year: 2004
Journal: Mol Cell Biol
Title: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
Volume: 24
Issue: 18
Pages: 7965-75
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Publication
12271141 | -
First Author: Tee AR
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
Volume: 99
Issue: 21
Pages: 13571-6
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Protein
P62835
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q99JI6
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q3V3W9
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
A0A0G2JE52
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
Q3U7U8
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
C5H0E9
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q52L50
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q3TP98
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
Q3TQ10
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: true
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Protein
Q6GYP7
Organism: Mus musculus/domesticus
Length: 2035  
Fragment?: false
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Protein
A3KGS3
Organism: Mus musculus/domesticus
Length: 1872  
Fragment?: false
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Protein
A0A2I3BRX9
Organism: Mus musculus/domesticus
Length: 2538  
Fragment?: false
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Protein
Q3UI96
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
A0A2I3BPE9
Organism: Mus musculus/domesticus
Length: 1359  
Fragment?: true
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Protein
A0A0A0MQD7
Organism: Mus musculus/domesticus
Length: 1910  
Fragment?: false
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Protein
A0A1W2P712
Organism: Mus musculus/domesticus
Length: 2082  
Fragment?: false
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Protein
Q3UG84
Organism: Mus musculus/domesticus
Length: 1359  
Fragment?: true
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Protein
Q3TBX9
Organism: Mus musculus/domesticus
Length: 1416  
Fragment?: true
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Protein
A0A2I3BPN8
Organism: Mus musculus/domesticus
Length: 1957  
Fragment?: false
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Protein
F7AI67
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: true
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Protein
B7ZNA3
Organism: Mus musculus/domesticus
Length: 2082  
Fragment?: false
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Protein
A0A1W2P832
Organism: Mus musculus/domesticus
Length: 2082  
Fragment?: false
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Protein
F7CGP0
Organism: Mus musculus/domesticus
Length: 1567  
Fragment?: true
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Publication
9045618 | -
First Author: Xiao GH
Year: 1997
Journal: J Biol Chem
Title: The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.
Volume: 272
Issue: 10
Pages: 6097-100
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Protein
Q61037
Organism: Mus musculus/domesticus
Length: 1814  
Fragment?: false
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Protein
Q3UHB2
Organism: Mus musculus/domesticus
Length: 1808  
Fragment?: false
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Protein
A0A2I3BRT5
Organism: Mus musculus/domesticus
Length: 1741  
Fragment?: false
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Protein
A0A2I3BPP1
Organism: Mus musculus/domesticus
Length: 1785  
Fragment?: false
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Protein
Q3TCQ7
Organism: Mus musculus/domesticus
Length: 1742  
Fragment?: false
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Protein
Q3UG88
Organism: Mus musculus/domesticus
Length: 1785  
Fragment?: false
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Protein
Q3UGI8
Organism: Mus musculus/domesticus
Length: 1678  
Fragment?: true
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Protein
Q7TT21
Organism: Mus musculus/domesticus
Length: 1742  
Fragment?: false
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
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