DNA topoisomerase II (TOP2) makes double-strand breaks and is essential during mitosis and meiosis for proper segregation of daughter chromosomes []. TOP2 can produce DSB implicated in the pathogenesis of rearrangements in treatment related acute myeloid leukemia (t-AML) and childhood leukemias []. Mammalian cells encode two type II isozymes, topoisomerase II alpha (TOP2a) and beta (TOP2b), that have highly identical N-terminal ATPase and central core domains. However, they differ in their C-termini as well as expression patterns and cannot compensate for each other [].This entry represents DNA topoisomerase 2-beta.
