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Search results 501 to 589 out of 589 for Crx

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Hits by Strain

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Type Details Score
Allele
Crx<em1Smgc> | MGI:7576952
Name: cone-rod homeobox; endonuclease-mediated mutation 1, Shiming Chen
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Crx<Rip> | MGI:5515375
 
Name: cone-rod homeobox; retina with immature photoreceptors
Allele Type: Spontaneous
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Allele
Crx<em2Smgc> | MGI:7576954
Name: cone-rod homeobox; endonuclease-mediated mutation 2, Shiming Chen
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Interaction Experiment
Peng GH (2005)
Description: The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes.
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Genotype
Genotype
Symbol: Crx/Crx
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crx/Crx<+>
Background: C57BL/6J-Crx
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0110333 | Leber congenital amaurosis 7
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DO Term
DOID:0111005 | cone-rod dystrophy 2
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Genotype
Genotype
Symbol: Crx/Crx<+>
Background: C57BL/6J-Crx
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Crx/Crx<+>
Background: C57BL/6J-Crx
Zygosity: ht
Has Mutant Allele: true
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Allele
Tg(Crx-lacZ)#Tfur | MGI:5464993
Name: transgene insertion, Takahisa Furukawa
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Crx-cre/ERT2)1Tfur | MGI:5302219
Name: transgene insertion 1, Takahisa Furukawa
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Publication
20949100 | -
First Author: Lambard S
Year: 2010
Journal: PLoS One
Title: Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.
Volume: 5
Issue: 10
Pages: e13075
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Strain
MGI:6146295 | B6.Cg-Tg(Crx-cre/ERT2)1Tfur/TfurRbrc
Attribute String: mutant strain, congenic, transgenic
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Allele
Tg(Crx-lacZ,IRES-PLAP)1Clc | MGI:5927756
Name: transgene insertion 1, Constance L Cepko
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Crx-GFP,IRES-PLAP)1Clc | MGI:5927757
Name: transgene insertion 1, Constance L Cepko
Allele Type: Transgenic
Attribute String: Reporter
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HT Experiment
E-GEOD-52006 | OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness
Series Id: GSE52006
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-65506 | Graded Expression Changes Determine Phenotype Severity In Mouse Models of CRX-Associated Retinopathy
Series Id: GSE65506
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Tg(Crx-AIPL1*P351)#Visu | MGI:5621018
Name: transgene insertion, Visvanathan Ramamurthy
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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HT Experiment
E-GEOD-24625 | Transcriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
Series Id: GSE24625
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE61389 | MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers (RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(Crx-Atoh7,-cre)60Gla | MGI:5433290
Name: transgene insertion 60, Tom Glaser
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Crx-cre)352Gla | MGI:5433216
Name: transgene insertion 352, Tom Glaser
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Crx-cre)764Gla | MGI:5433291
Name: transgene insertion 764, Tom Glaser
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Crx-Atoh7,-cre)251Gla | MGI:5433215
Name: transgene insertion 251, Tom Glaser
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:3709321 | B6.SJL-Tg(Crx-GFP,-ALPP)1Clc
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:3709323 | B6.SJL-Tg(Crx-GFP,-ALPP)1Clc/J
Attribute String: mutant strain, transgenic, congenic
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Genotype
Genotype
Symbol: Tg(Crx-GFP,-ALPP)1Clc/?
Background: B6.SJL-Tg(Crx-GFP,-ALPP)1Clc
Zygosity: ot
Has Mutant Allele: true
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Publication
35011723 | J:318726
 
First Author: Swinkels D
Year: 2022
Journal: Cells
Title: Cell Type-Selective Loss of Peroxisomal β-Oxidation Impairs Bipolar Cell but Not Photoreceptor Survival in the Retina.
Volume: 11
Issue: 1
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Publication
25274777 | J:218096
First Author: Ku CA
Year: 2015
Journal: Hum Mol Genet
Title: Viral-mediated vision rescue of a novel AIPL1 cone-rod dystrophy model.
Volume: 24
Issue: 3
Pages: 670-84
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Strain
MGI:6143685 | B6.Cg-Tg(Crx-cre)764Gla/Mmucd
Attribute String: mutant strain, congenic, transgenic
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Publication
26565912 | J:228952
First Author: Kim HT
Year: 2015
Journal: Cell Rep
Title: Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons.
Volume: 13
Issue: 5
Pages: 990-1002
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Publication
27205882 | J:247511
   
First Author: Tang JC
Year: 2016
Journal: Elife
Title: Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies.
Volume: 5
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Genotype
Genotype
Symbol: Rax/Rax Tg(Crx-cre/ERT2)1Tfur/?
Background: involves: 129S6/SvEvTac * C3H * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aipl1/Aipl1 Tg(Crx-AIPL1*P351)#Visu/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
11477108 | J:71808
First Author: Swain PK
Year: 2001
Journal: J Biol Chem
Title: Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors.
Volume: 276
Issue: 39
Pages: 36824-30
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Publication
34475267 | J:313639
 
First Author: Pensieri P
Year: 2021
Journal: eNeuro
Title: Photoreceptor cKO of OTX2 Enhances OTX2 Intercellular Transfer in the Retina and Causes Photophobia.
Volume: 8
Issue: 5
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Genotype
Genotype
Symbol: Nmnat1/Nmnat1 Tg(Crx-cre/ERT2)1Tfur/?
Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rnf7/Rnf7 Tg(Crx-cre)352Gla/?
Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-cat,-lacZ)34Pva/? Tg(Crx-cre/ERT2)1Tfur/?
Background: involves: C3H * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
11694879 | J:78692
First Author: Mears AJ
Year: 2001
Journal: Nat Genet
Title: Nrl is required for rod photoreceptor development.
Volume: 29
Issue: 4
Pages: 447-52
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Publication
12575948 | J:82072
First Author: Yoo SY
Year: 2003
Journal: Neuron
Title: SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.
Volume: 37
Issue: 3
Pages: 383-401
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Publication
36070393 | J:329268
First Author: Langouët M
Year: 2022
Journal: Sci Adv
Title: Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration.
Volume: 8
Issue: 36
Pages: eabh2868
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Publication
15207851 | J:90895
First Author: Ozawa Y
Year: 2004
Journal: Mol Cell Neurosci
Title: Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina.
Volume: 26
Issue: 2
Pages: 258-70
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Publication
29225067 | J:260417
 
First Author: Miesfeld JB
Year: 2018
Journal: Gene Expr Patterns
Title: The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody.
Volume: 27
Pages: 114-121
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Genotype
Genotype
Symbol: Atoh7/Atoh7 Tg(Crx-Atoh7,-cre)251Gla/? Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atoh7/Atoh7 Tg(Crx-Atoh7,-cre)60Gla/? Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Crx-cre)352Gla/?
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Publication
2911011 | J:9533
First Author: Paul MS
Year: 1989
Journal: J Immunol
Title: The murine complement receptor gene family. Analysis of mCRY gene products and their homology to human CR1.
Volume: 142
Issue: 2
Pages: 582-9
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Publication
17666527 | J:123470
First Author: Manavathi B
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Repression of Six3 by a corepressor regulates rhodopsin expression.
Volume: 104
Issue: 32
Pages: 13128-33
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Publication
10585447 | J:58784
First Author: Xu S
Year: 1999
Journal: J Biol Chem
Title: PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments.
Volume: 274
Issue: 50
Pages: 35676-85
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Publication
10625658 | J:59390
First Author: Kimura A
Year: 2000
Journal: J Biol Chem
Title: Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression.
Volume: 275
Issue: 2
Pages: 1152-60
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Publication
15028672 | J:90124
First Author: Wang QL
Year: 2004
Journal: Hum Mol Genet
Title: QRX, a novel homeobox gene, modulates photoreceptor gene expression.
Volume: 13
Issue: 10
Pages: 1025-40
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Publication
22993419 | J:188105
First Author: Ziccardi L
Year: 2012
Journal: J Neurosci
Title: Loss of retinoschisin (RS1) cell surface protein in maturing mouse rod photoreceptors elevates the luminance threshold for light-driven translocation of transducin but not arrestin.
Volume: 32
Issue: 38
Pages: 13010-21
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Publication
15277472 | J:92920
First Author: Otteson DC
Year: 2004
Journal: Invest Ophthalmol Vis Sci
Title: Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters.
Volume: 45
Issue: 8
Pages: 2522-30
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Publication
21813656 | J:176686
First Author: Cheng H
Year: 2011
Journal: Hum Mol Genet
Title: Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors.
Volume: 20
Issue: 21
Pages: 4102-15
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Publication
23922782 | J:204696
First Author: Hennig AK
Year: 2013
Journal: PLoS One
Title: Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression.
Volume: 8
Issue: 7
Pages: e69721
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Publication
28993200 | J:251932
First Author: Remez LA
Year: 2017
Journal: Dev Biol
Title: Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis.
Volume: 432
Issue: 1
Pages: 140-150
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Publication
25392503 | J:217399
First Author: Masuda T
Year: 2014
Journal: J Neurosci
Title: The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina.
Volume: 34
Issue: 46
Pages: 15356-68
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Publication
30445545 | J:337797
First Author: Campla CK
Year: 2019
Journal: Hum Mol Genet
Title: Targeted deletion of an NRL- and CRX-regulated alternative promoter specifically silences FERM and PDZ domain containing 1 (Frmpd1) in rod photoreceptors.
Volume: 28
Issue: 5
Pages: 804-817
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Publication
22570183 | J:194571
First Author: West EL
Year: 2012
Journal: Stem Cells
Title: Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors.
Volume: 30
Issue: 7
Pages: 1424-35
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Publication
17242361 | J:119504
First Author: Oh EC
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL.
Volume: 104
Issue: 5
Pages: 1679-84
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Publication
16868010 | J:114905
First Author: Cheng H
Year: 2006
Journal: Hum Mol Genet
Title: In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development.
Volume: 15
Issue: 17
Pages: 2588-602
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Publication
31915147 | J:293534
 
First Author: Perez-Cervantes C
Year: 2020
Journal: Development
Title: Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Volume: 147
Issue: 3
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Publication
26426291 | J:227649
First Author: Fant B
Year: 2015
Journal: Genesis
Title: Comprehensive interactome of Otx2 in the adult mouse neural retina.
Volume: 53
Issue: 11
Pages: 685-94
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Publication
24558479 | J:213348
First Author: Samuel A
Year: 2014
Journal: PLoS One
Title: Otx2 ChIP-seq reveals unique and redundant functions in the mature mouse retina.
Volume: 9
Issue: 2
Pages: e89110
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Publication
20059961 | J:339173
First Author: Muranishi Y
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Gene expression analysis of embryonic photoreceptor precursor cells using BAC-Crx-EGFP transgenic mouse.
Volume: 392
Issue: 3
Pages: 317-22
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Publication
18791169 | J:146689
First Author: Sasaki T
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Elevated intraocular pressure, optic nerve atrophy, and impaired retinal development in ODAG transgenic mice.
Volume: 50
Issue: 1
Pages: 242-8
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Publication
10783262 | J:62105
First Author: Tubb BE
Year: 2000
Journal: Genomics
Title: Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes.
Volume: 65
Issue: 2
Pages: 146-56
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Publication
12215455 | J:80042
First Author: Wang X
Year: 2002
Journal: J Biol Chem
Title: Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function.
Volume: 277
Issue: 45
Pages: 43288-300
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Publication
21392589 | J:175011
First Author: Kraus D
Year: 2011
Journal: Biochim Biophys Acta
Title: Retinal expression of the X-linked juvenile retinoschisis (RS1) gene is controlled by an upstream CpG island and two opposing CRX-bound regions.
Volume: 1809
Issue: 4-6
Pages: 245-54
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Publication
22171059 | J:178898
First Author: Pinzon-Guzman C
Year: 2011
Journal: J Neurosci
Title: Specific protein kinase C isoforms are required for rod photoreceptor differentiation.
Volume: 31
Issue: 50
Pages: 18606-17
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Publication
24888636 | J:214747
First Author: Tran NM
Year: 2014
Journal: Dev Dyn
Title: Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies.
Volume: 243
Issue: 10
Pages: 1153-66
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Publication
28900179 | J:255729
First Author: Ji HP
Year: 2017
Journal: Sci Rep
Title: MicroRNA-28 potentially regulates the photoreceptor lineage commitment of Müller glia-derived progenitors.
Volume: 7
Issue: 1
Pages: 11374
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Publication
12589770 | J:90863
First Author: Chen Q
Year: 2003
Journal: Exp Eye Res
Title: SPACRCAN in the interphotoreceptor matrix of the mouse retina: molecular, developmental and promoter analysis.
Volume: 76
Issue: 1
Pages: 1-14
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Publication
23646198 | J:200547
First Author: Nashine S
Year: 2013
Journal: PLoS One
Title: Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration.
Volume: 8
Issue: 4
Pages: e63205
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Publication
22589437 | J:280574
First Author: Kunte MM
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: ER stress is involved in T17M rhodopsin-induced retinal degeneration.
Volume: 53
Issue: 7
Pages: 3792-800
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Publication
23818861 | J:199143
First Author: Cho KI
Year: 2013
Journal: PLoS Genet
Title: Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
Volume: 9
Issue: 6
Pages: e1003555
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Publication
11504847 | J:71094
First Author: Germot A
Year: 2001
Journal: Mol Biol Evol
Title: Structural evolution of Otx genes in craniates.
Volume: 18
Issue: 9
Pages: 1668-78
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Publication
17325188 | J:123258
First Author: Rhee KD
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa.
Volume: 48
Issue: 3
Pages: 1389-400
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Publication
34494680 | J:336553
First Author: Ortin-Martinez A
Year: 2021
Journal: EMBO J
Title: Photoreceptor nanotubes mediate the in vivo exchange of intracellular material.
Volume: 40
Issue: 22
Pages: e107264
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Publication
18854042 | J:296097
 
First Author: Mali RS
Year: 2008
Journal: BMC Mol Biol
Title: FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo.
Volume: 9
Pages: 87
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Publication
11875050 | J:75385
First Author: Bowne SJ
Year: 2002
Journal: Hum Mol Genet
Title: Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa.
Volume: 11
Issue: 5
Pages: 559-68
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Publication
33712461 | J:308269
 
First Author: Brodie-Kommit J
Year: 2021
Journal: Sci Adv
Title: Atoh7-independent specification of retinal ganglion cell identity.
Volume: 7
Issue: 11
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Publication
29361558 | J:257927
 
First Author: Fairchild CL
Year: 2018
Journal: Development
Title: RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion.
Volume: 145
Issue: 3
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Publication
37659708 | J:341373
 
First Author: Ramachandra Rao S
Year: 2023
Journal: Exp Eye Res
Title: A simple, rapid fluorescent reporter-based method for detection of ectopic cre recombinase expression in presumed retinal cell type-targeted mouse lines.
Volume: 235
Pages: 109637
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Publication
29674119 | J:267630
 
First Author: Eblimit A
Year: 2018
Journal: Exp Eye Res
Title: NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype.
Volume: 173
Pages: 32-43
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Publication
25489226 | J:220255
 
First Author: Mitton KP
Year: 2014
Journal: Mol Vis
Title: Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice.
Volume: 20
Pages: 1527-44
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Publication
32267917 | J:291861
 
First Author: Mosleh E
Year: 2020
Journal: Endocrinology
Title: Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation.
Volume: 161
Issue: 8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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