Type |
Details |
Score |
Publication |
First Author: |
Sonntag T |
Year: |
2018 |
Journal: |
FEBS J |
Title: |
14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs). |
Volume: |
285 |
Issue: |
3 |
Pages: |
467-480 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jaitovich A |
Year: |
2010 |
Journal: |
Biochim Biophys Acta |
Title: |
Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure. |
Volume: |
1802 |
Issue: |
12 |
Pages: |
1140-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takemori H |
Year: |
2003 |
Journal: |
J Steroid Biochem Mol Biol |
Title: |
Salt-inducible kinase-mediated regulation of steroidogenesis at the early stage of ACTH-stimulation. |
Volume: |
85 |
Issue: |
2-5 |
Pages: |
397-400 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uebi T |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Involvement of SIK3 in glucose and lipid homeostasis in mice. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e37803 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katoh Y |
Year: |
2004 |
Journal: |
Mol Cell Endocrinol |
Title: |
Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis. |
Volume: |
217 |
Issue: |
1-2 |
Pages: |
109-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hietakangas V |
Year: |
2008 |
Journal: |
Cell Metab |
Title: |
TORCing up metabolic control in the brain. |
Volume: |
7 |
Issue: |
5 |
Pages: |
357-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
SIKs are serine/threonine kinasse that are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure []. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells []. In the brain, both SIK1 and SIK2 regulate energy metabolism []. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1 []. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism []. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoon YS |
Year: |
2021 |
Journal: |
Commun Biol |
Title: |
Activation of the adipocyte CREB/CRTC pathway in obesity. |
Volume: |
4 |
Issue: |
1 |
Pages: |
1214 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dentin R |
Year: |
2007 |
Journal: |
Nature |
Title: |
Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. |
Volume: |
449 |
Issue: |
7160 |
Pages: |
366-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katoh M |
Year: |
2003 |
Journal: |
Int J Oncol |
Title: |
Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. |
Volume: |
23 |
Issue: |
5 |
Pages: |
1471-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ricarte FR |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling. |
Volume: |
293 |
Issue: |
52 |
Pages: |
20200-20213 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim MK |
Year: |
2019 |
Journal: |
Cell Death Dis |
Title: |
Salt-inducible kinase 1 regulates bone anabolism via the CRTC1-CREB-Id1 axis. |
Volume: |
10 |
Issue: |
11 |
Pages: |
826 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishimori S |
Year: |
2021 |
Journal: |
Bone |
Title: |
PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. |
Volume: |
142 |
|
Pages: |
115709 |
|
•
•
•
•
•
|
Publication |
First Author: |
Darling NJ |
Year: |
2021 |
Journal: |
Biochem J |
Title: |
Nuts and bolts of the salt-inducible kinases (SIKs). |
Volume: |
478 |
Issue: |
7 |
Pages: |
1377-1397 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katoh Y |
Year: |
2004 |
Journal: |
Eur J Biochem |
Title: |
Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm. |
Volume: |
271 |
Issue: |
21 |
Pages: |
4307-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stephenson A |
Year: |
2004 |
Journal: |
Genomics |
Title: |
snf1lk encodes a protein kinase that may function in cell cycle regulation. |
Volume: |
83 |
Issue: |
6 |
Pages: |
1105-15 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This entry represents the salt-inducible protein kinases, SIK1 and SIK2, which are serine/threonine-protein kinases primarily activated by the master kinase LKB1 (STK11). SIK1 is involved in a variety of processes, such as cell cycle regulation, gluconeogenesis and lipogenesis regulation and muscle growth [, , , ]. SIK2 phosphorylates insulin receptor substrate-1 (IRS1) in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction, and may have a role in the development of insulin resistance in diabetes [. SIK1/2 inhibit CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signalling []. |
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•
•
•
•
•
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Publication |
First Author: |
Lombardi MS |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis. |
Volume: |
12 |
Issue: |
10 |
Pages: |
e0185426 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koo SH |
Year: |
2005 |
Journal: |
Nature |
Title: |
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. |
Volume: |
437 |
Issue: |
7062 |
Pages: |
1109-11 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
779
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
929
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
931
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
927
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1369
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1319
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1214
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanks SK |
Year: |
1988 |
Journal: |
Science |
Title: |
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. |
Volume: |
241 |
Issue: |
4861 |
Pages: |
42-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manning G |
Year: |
2002 |
Journal: |
Trends Biochem Sci |
Title: |
Evolution of protein kinase signaling from yeast to man. |
Volume: |
27 |
Issue: |
10 |
Pages: |
514-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manning G |
Year: |
2002 |
Journal: |
Science |
Title: |
The protein kinase complement of the human genome. |
Volume: |
298 |
Issue: |
5600 |
Pages: |
1912-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stout TJ |
Year: |
2004 |
Journal: |
Curr Pharm Des |
Title: |
High-throughput structural biology in drug discovery: protein kinases. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1069-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li B |
Year: |
2004 |
Journal: |
Comb Chem High Throughput Screen |
Title: |
Creating chemical diversity to target protein kinases. |
Volume: |
7 |
Issue: |
5 |
Pages: |
453-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|