|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 132 out of 132 for Sik2

<< First    < Previous  |  Next >    Last >>
0.022s
Type Details Score
Publication
First Author: Sonntag T
Year: 2018
Journal: FEBS J
Title: 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).
Volume: 285
Issue: 3
Pages: 467-480
Publication
First Author: Jaitovich A
Year: 2010
Journal: Biochim Biophys Acta
Title: Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure.
Volume: 1802
Issue: 12
Pages: 1140-9
Publication
First Author: Takemori H
Year: 2003
Journal: J Steroid Biochem Mol Biol
Title: Salt-inducible kinase-mediated regulation of steroidogenesis at the early stage of ACTH-stimulation.
Volume: 85
Issue: 2-5
Pages: 397-400
Publication
First Author: Uebi T
Year: 2012
Journal: PLoS One
Title: Involvement of SIK3 in glucose and lipid homeostasis in mice.
Volume: 7
Issue: 5
Pages: e37803
Publication
First Author: Katoh Y
Year: 2004
Journal: Mol Cell Endocrinol
Title: Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis.
Volume: 217
Issue: 1-2
Pages: 109-12
Publication
First Author: Hietakangas V
Year: 2008
Journal: Cell Metab
Title: TORCing up metabolic control in the brain.
Volume: 7
Issue: 5
Pages: 357-8
Protein Domain
Type: Domain
Description: SIKs are serine/threonine kinasse that are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure []. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells []. In the brain, both SIK1 and SIK2 regulate energy metabolism []. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1 []. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism []. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein [].
Publication
First Author: Yoon YS
Year: 2021
Journal: Commun Biol
Title: Activation of the adipocyte CREB/CRTC pathway in obesity.
Volume: 4
Issue: 1
Pages: 1214
Publication
First Author: Dentin R
Year: 2007
Journal: Nature
Title: Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.
Volume: 449
Issue: 7160
Pages: 366-9
Publication
First Author: Katoh M
Year: 2003
Journal: Int J Oncol
Title: Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats.
Volume: 23
Issue: 5
Pages: 1471-6
Publication
First Author: Ricarte FR
Year: 2018
Journal: J Biol Chem
Title: Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling.
Volume: 293
Issue: 52
Pages: 20200-20213
Publication
First Author: Kim MK
Year: 2019
Journal: Cell Death Dis
Title: Salt-inducible kinase 1 regulates bone anabolism via the CRTC1-CREB-Id1 axis.
Volume: 10
Issue: 11
Pages: 826
Publication  
First Author: Nishimori S
Year: 2021
Journal: Bone
Title: PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate.
Volume: 142
Pages: 115709
Publication
First Author: Darling NJ
Year: 2021
Journal: Biochem J
Title: Nuts and bolts of the salt-inducible kinases (SIKs).
Volume: 478
Issue: 7
Pages: 1377-1397
Publication
First Author: Katoh Y
Year: 2004
Journal: Eur J Biochem
Title: Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.
Volume: 271
Issue: 21
Pages: 4307-19
Publication
First Author: Stephenson A
Year: 2004
Journal: Genomics
Title: snf1lk encodes a protein kinase that may function in cell cycle regulation.
Volume: 83
Issue: 6
Pages: 1105-15
Protein Domain
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This entry represents the salt-inducible protein kinases, SIK1 and SIK2, which are serine/threonine-protein kinases primarily activated by the master kinase LKB1 (STK11). SIK1 is involved in a variety of processes, such as cell cycle regulation, gluconeogenesis and lipogenesis regulation and muscle growth [, , , ]. SIK2 phosphorylates insulin receptor substrate-1 (IRS1) in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction, and may have a role in the development of insulin resistance in diabetes [. SIK1/2 inhibit CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signalling [].
Publication
First Author: Lombardi MS
Year: 2017
Journal: PLoS One
Title: Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis.
Volume: 12
Issue: 10
Pages: e0185426
Publication
First Author: Koo SH
Year: 2005
Journal: Nature
Title: The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
Volume: 437
Issue: 7062
Pages: 1109-11
Protein
Organism: Mus musculus/domesticus
Length: 779  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 929  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 927  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1369  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1319  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1214  
Fragment?: true
Publication
First Author: Hanks SK
Year: 1988
Journal: Science
Title: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Volume: 241
Issue: 4861
Pages: 42-52
Publication
First Author: Manning G
Year: 2002
Journal: Trends Biochem Sci
Title: Evolution of protein kinase signaling from yeast to man.
Volume: 27
Issue: 10
Pages: 514-20
Publication
First Author: Manning G
Year: 2002
Journal: Science
Title: The protein kinase complement of the human genome.
Volume: 298
Issue: 5600
Pages: 1912-34
Publication
First Author: Stout TJ
Year: 2004
Journal: Curr Pharm Des
Title: High-throughput structural biology in drug discovery: protein kinases.
Volume: 10
Issue: 10
Pages: 1069-82
Publication
First Author: Li B
Year: 2004
Journal: Comb Chem High Throughput Screen
Title: Creating chemical diversity to target protein kinases.
Volume: 7
Issue: 5
Pages: 453-72
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89