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Search results 1 to 100 out of 264 for Tpx2

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
22974 | TPX2
Type: gene
Organism: human
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Gene
712961 | TPX2
Type: gene
Organism: macaque, rhesus
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Gene
107966129 | tpx2
Type: gene
Organism: zebrafish
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Gene
458157 | TPX2
Type: gene
Organism: chimpanzee
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Gene
477186 | TPX2
Type: gene
Organism: dog, domestic
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Gene
507226 | TPX2
Type: gene
Organism: cattle
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Gene
100124787 | tpx2
Type: gene
Organism: frog, western clawed
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Gene
311546 | Tpx2
Type: gene
Organism: rat
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Gene
395081 | TPX2
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:1919369 | Tpx2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR009675 | TPX2_fam
Type: Family
Description: This family represents the eukaryotic targeting protein for Xklp2 (TPX2). TPX2 is a microtubule-associated protein that targets a plus end-directed motor (Xklp2) to the minus ends of microtubules in the mitotic spindle. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity []. It is phosphorylated during mitosis in a microtubule-dependent way []. TPX2 activates Aurora A kinase by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation [].
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Publication
18663142 | J:161103
First Author: Bird AW
Year: 2008
Journal: J Cell Biol
Title: Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.
Volume: 182
Issue: 2
Pages: 289-300
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GXD Expression
GXD Expression
Probe: MGI:7570100
Assay Type: RNA in situ
Annotation Date: 2024-01-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7570116
Age: embryonic day 14.5
Image: S4a Tpx2
Note: Strong expression in ventricular zone only.
Specimen Label: S4a Tpx2
Detected: true
Specimen Num: 1
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Publication
22266221 | J:184948
First Author: Aguirre-Portolés C
Year: 2012
Journal: Cancer Res
Title: Tpx2 controls spindle integrity, genome stability, and tumor development.
Volume: 72
Issue: 6
Pages: 1518-28
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Publication
21969468 | J:177721
First Author: Ma N
Year: 2011
Journal: J Cell Biol
Title: TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle.
Volume: 195
Issue: 1
Pages: 87-98
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Publication
26165940 | J:224841
First Author: Wei JH
Year: 2015
Journal: Cell
Title: GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules.
Volume: 162
Issue: 2
Pages: 287-299
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Publication
27753540 | J:319955
First Author: Lee SY
Year: 2016
Journal: Cell Cycle
Title: Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.
Volume: 15
Issue: 23
Pages: 3296-3305
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Publication
21441895 | J:171989
First Author: Kosodo Y
Year: 2011
Journal: EMBO J
Title: Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain.
Volume: 30
Issue: 9
Pages: 1690-704
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Publication
19668197 | J:158132
First Author: Mori D
Year: 2009
Journal: Nat Cell Biol
Title: An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.
Volume: 11
Issue: 9
Pages: 1057-68
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Publication
27624071 | J:238129
First Author: Treekitkarnmongkol W
Year: 2016
Journal: Carcinogenesis
Title: Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer.
Volume: 37
Issue: 12
Pages: 1180-1189
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Protein Coding Gene
MGP_CAROLIEiJ_G0024474 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026679 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026645 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026615 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026654 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026397 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1919369 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027103 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025858 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026375 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026511 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026477 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026615 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026498 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025592 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025917 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025395 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925226
Stage: TS26
Assay Id: MGI:7526200
Age: embryonic day 18.5
Image: S4
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925226
Stage: TS26
Assay Id: MGI:7526200
Age: embryonic day 18.5
Image: S4
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925227
Stage: TS27
Assay Id: MGI:7526202
Age: postnatal day 0
Image: S5
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925227
Stage: TS27
Assay Id: MGI:7526202
Age: postnatal day 0
Image: S5
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925227
Stage: TS27
Assay Id: MGI:7526204
Age: postnatal day 3
Image: S4
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925227
Stage: TS27
Assay Id: MGI:7526204
Age: postnatal day 3
Image: S4
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Stage: TS26
Assay Id: MGI:7526199
Age: embryonic day 18.5
Image: 6
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Stage: TS26
Assay Id: MGI:7526199
Age: embryonic day 18.5
Image: 6
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7526201
Age: postnatal day 0
Image: S5
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7526201
Age: postnatal day 0
Image: S5
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7526203
Age: postnatal day 3
Image: 6
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7526203
Age: postnatal day 3
Image: 6
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1059344
Assay Type: RNA in situ
Annotation Date: 2023-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7516946
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6696249
Assay Type: RNA in situ
Annotation Date: 2021-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2772122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6711649
Age: embryonic day 14.5
Specimen Label: S6C-Tpx2
Detected: true
Specimen Num: 1
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Publication
19376971 | J:148330
First Author: Zheng P
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.
Volume: 106
Issue: 18
Pages: 7473-8
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Publication
29229923 | J:317479
First Author: Bizzotto S
Year: 2017
Journal: Sci Rep
Title: Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.
Volume: 7
Issue: 1
Pages: 17308
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Publication
32294449 | J:304136
First Author: Journiac N
Year: 2020
Journal: Cell Rep
Title: Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.
Volume: 31
Issue: 2
Pages: 107506
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Publication
24741061 | J:210623
First Author: Yeh ML
Year: 2014
Journal: J Neurosci
Title: Robo1 modulates proliferation and neurogenesis in the developing neocortex.
Volume: 34
Issue: 16
Pages: 5717-31
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Publication
31598710 | J:282460
First Author: Rong Y
Year: 2019
Journal: Nucleic Acids Res
Title: ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.
Volume: 47
Issue: 21
Pages: 11387-11402
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Publication
38636517 | J:347974
     
First Author: Zhou B
Year: 2024
Journal: Dev Cell
Title: Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos.
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Publication
24301385 | J:206141
 
First Author: Eguren M
Year: 2013
Journal: Nat Commun
Title: The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors.
Volume: 4
Pages: 2880
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Publication
37269288 | J:337931
First Author: Li L
Year: 2023
Journal: Cell Rep
Title: Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
Volume: 42
Issue: 6
Pages: 112596
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Publication
35493520 | J:324243
 
First Author: Lei Z
Year: 2022
Journal: Front Immunol
Title: EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.
Volume: 13
Pages: 843378
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Publication
28535371 | J:241850
First Author: Naiman N
Year: 2017
Journal: Dev Cell
Title: Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Volume: 41
Issue: 4
Pages: 349-365.e3
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
12727873 | -
First Author: Schatz CA
Year: 2003
Journal: EMBO J
Title: Importin alpha-regulated nucleation of microtubules by TPX2.
Volume: 22
Issue: 9
Pages: 2060-70
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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