Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 240 out of 240 for Cyp24a1

<< First < Previous | Next > Last >>

0.019s

Type

Details

Score

Publication

- | J:75000

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Mouse Genome Informatics Computational Sequence to Gene Associations

•

Publication

- | J:157972

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2010
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).

•

Publication

- | J:57747

First Author:	MGI Genome Annotation Group and UniGene Staff
Year:	2015
Journal:	Database Download
Title:	MGI-UniGene Interconnection Effort

•

Publication

- | J:161428

First Author:	Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year:	2010

Title:	Annotation inferences using phylogenetic trees

•

Publication

- | J:63103

First Author:	Mouse Genome Database and National Center for Biotechnology Information
Year:	2000
Journal:	Database Release
Title:	Entrez Gene Load

•

Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

•

Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

•

Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

•

Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

•

Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

•

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

•

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

•

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

•

Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

•

Publication

32165494 | J:289832

First Author:	Huang W
Year:	2020
Journal:	J Biol Chem
Title:	The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independent of its catalytic activity.
Volume:	295
Issue:	18
Pages:	5906-5917

•

Publication

16617161 | -

First Author:	Hamamoto H
Year:	2006
Journal:	Mol Pharmacol
Title:	Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats.
Volume:	70
Issue:	1
Pages:	120-8

•

Publication

21664253 | J:184113

First Author:	St-Arnaud R
Year:	2011
Journal:	Mol Cell Endocrinol
Title:	Vitamin D metabolism, cartilage and bone fracture repair.
Volume:	347
Issue:	1-2
Pages:	48-54

•

Protein Domain

IPR002949 | Cyt_P450_E_CYP24A_mit

Type:

Family

Description:

Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty acids and xenobiotics, and are important for the detoxification and clearance of various compounds, as well as for hormone synthesis and breakdown, cholesterol synthesis and vitamin D metabolism. In plants, these proteins are important for the biosynthesis of several compounds such as hormones, defensive compounds and fatty acids. In bacteria, they are important for several metabolic processes, such as the biosynthesis of antibiotic erythromycin in Saccharopolyspora erythraea (Streptomyces erythraeus).Cytochrome P450 enzymes use haem to oxidise their substrates, using protons derived from NADH or NADPH to split the oxygen so a single atom can be added to a substrate. They also require electrons, which they receive from a variety of redox partners. In certain cases, cytochrome P450 can be fused to its redox partner to produce a bi-functional protein, such as with P450BM-3 from Bacillus megaterium [], which has haem and flavin domains.Organisms produce many different cytochrome P450 enzymes (at least 58 in humans), which together with alternative splicing can provide a wide array of enzymes with different substrate and tissue specificities. Individual cytochrome P450 proteins follow the nomenclature: CYP, followed by a number (family), then a letter (subfamily), and another number (protein); e.g. CYP3A4 is the fourth protein in family 3, subfamily A. In general, family members should share >40% identity, while subfamily members should share >55% identity.Cytochrome P450 proteins can also be grouped by two different schemes. One scheme was based on a taxonomic split: class I (prokaryotic/mitochondrial) and class II (eukaryotic microsomes). The other scheme was based on the number of components in the system: class B (3-components) and class E (2-components). These classes merge to a certain degree. Most prokaryotes and mitochondria (and fungal CYP55) have 3-component systems (class I/class B) - a FAD-containing flavoprotein (NAD(P)H-dependent reductase), an iron-sulphur protein and P450. Most eukaryotic microsomes have 2-component systems (class II/class E) - NADPH:P450 reductase (FAD and FMN-containing flavoprotein) and P450. There are exceptions to this scheme, such as 1-component systems that resemble class E enzymes [, , ]. The class E enzymes can be further subdivided into five sequence clusters, groups I-V, each of which may contain more than one cytochrome P450 family (eg, CYP1 and CYP2 are both found in group I). The divergence of the cytochrome P450 superfamily into B- and E-classes, and further divergence into stable clusters within the E-class, appears to be very ancient, occurring before the appearance of eukaryotes.This entry represents the CYP24A (Vitamin D 24-hydroxylase) family from class E, cytochrome P450 proteins. These enzymes are mitochondrial in origin. CYP24A1 has a role in maintaining calcium homeostasis, catalysing the NADPH-dependent 24-hydroxylation of 25-hydroxyvitamin D(3) in the presence of adrenodoxin and NADPH-adrenodoxin reductase. Human CYP24A1 catalyses both C-23 and C-24 oxidation, while the rat enzyme only catalyses C-24 oxidation [].

•

Publication

26588476 | J:244427

First Author:	Portale AA
Year:	2015
Journal:	PLoS One
Title:	Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule.
Volume:	10
Issue:	11
Pages:	e0142924

•

Publication

24601885 | J:210730

First Author:	Ma Y
Year:	2014
Journal:	Endocrinology
Title:	Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization.
Volume:	155
Issue:	5
Pages:	1596-605

•

Publication

28808057 | J:246808

First Author:	Meyer MB
Year:	2017
Journal:	J Biol Chem
Title:	A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D₃ activation.
Volume:	292
Issue:	42
Pages:	17541-17558

•

Publication

24202304 | J:222831

First Author:	Lomashvili KA
Year:	2014
Journal:	Arterioscler Thromb Vasc Biol
Title:	Role of local versus systemic vitamin D receptors in vascular calcification.
Volume:	34
Issue:	1
Pages:	146-51

•

Publication

24949660 | J:217009

First Author:	Girgis CM
Year:	2014
Journal:	Endocrinology
Title:	The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers.
Volume:	155
Issue:	9
Pages:	3227-37

•

Publication

30833469 | J:273776

First Author:	Aatsinki SM
Year:	2019
Journal:	Diabetes
Title:	Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes.
Volume:	68
Issue:	5
Pages:	918-931

•

Publication

36009040 | J:327905

First Author:	Scherler L
Year:	2022
Journal:	Biomolecules
Title:	Adenine-Induced Nephropathy Reduces Atherosclerosis in ApoE Knockout Mice.
Volume:	12
Issue:	8

•

Publication

26893158 | J:234300

First Author:	Morin G
Year:	2016
Journal:	Am J Physiol Gastrointest Liver Physiol
Title:	Vitamin D attenuates inflammation in CFTR knockdown intestinal epithelial cells but has no effect in cells with intact CFTR.
Volume:	310
Issue:	8
Pages:	G539-49

•

Publication

22739976 | J:198168

First Author:	Dai B
Year:	2012
Journal:	Kidney Int
Title:	Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites.
Volume:	82
Issue:	10
Pages:	1061-70

•

Publication

22896638 | J:189942

First Author:	Spanier JA
Year:	2012
Journal:	J Immunol
Title:	The Ifng gene is essential for Vdr gene expression and vitamin D₃-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model.
Volume:	189
Issue:	6
Pages:	3188-97

•

Publication

31616013 | J:285233

First Author:	Parsanathan R
Year:	2019
Journal:	Sci Rep
Title:	Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice.
Volume:	9
Issue:	1
Pages:	14784

•

Publication

26121239 | J:233883

First Author:	Wilson RL
Year:	2015
Journal:	PLoS One
Title:	Vitamin D Receptor Gene Ablation in the Conceptus Has Limited Effects on Placental Morphology, Function and Pregnancy Outcome.
Volume:	10
Issue:	6
Pages:	e0131287

•

Publication

23873717 | J:233246

First Author:	Clinkenbeard EL
Year:	2014
Journal:	J Bone Miner Res
Title:	Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice.
Volume:	29
Issue:	2
Pages:	361-9

•

Publication

23505097 | J:318624

First Author:	Kirby BJ
Year:	2013
Journal:	J Bone Miner Res
Title:	Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone.
Volume:	28
Issue:	9
Pages:	1987-2000

•

Publication

30281599 | J:266205

First Author:	Hirota Y
Year:	2018
Journal:	PLoS One
Title:	Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.
Volume:	13
Issue:	10
Pages:	e0199856

•

Publication

23426901 | J:345183

First Author:	Teramachi J
Year:	2013
Journal:	J Bone Miner Res
Title:	Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
Volume:	28
Issue:	6
Pages:	1489-500

•

Publication

24365583 | J:323205

First Author:	Chow EC
Year:	2014
Journal:	Gastroenterology
Title:	Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.
Volume:	146
Issue:	4
Pages:	1048-59

•

Protein

Q3TP55

Organism:	Mus musculus/domesticus
Length:	480
Fragment?:	true

•

Publication

16042601 | -

First Author:	McLean KJ
Year:	2005
Journal:	Biochem Soc Trans
Title:	Biodiversity of cytochrome P450 redox systems.
Volume:	33
Issue:	Pt 4
Pages:	796-801

•

Publication

17023115 | -

First Author:	Munro AW
Year:	2007
Journal:	Biochim Biophys Acta
Title:	Cytochrome P450--redox partner fusion enzymes.
Volume:	1770
Issue:	3
Pages:	345-59

•

Publication

15128046 | J:87417

First Author:	Nelson DR
Year:	2004
Journal:	Pharmacogenetics
Title:	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
Volume:	14
Issue:	1
Pages:	1-18

•

Publication

8637843 | -

First Author:	Degtyarenko KN
Year:	1995
Journal:	Protein Eng
Title:	Structural domains of P450-containing monooxygenase systems.
Volume:	8
Issue:	8
Pages:	737-47

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do;jsessionid=33143893D1261263BF52A0159638F7BF?searchTerm=Cyp24a1&searchBag=&searchOffset=200

MouseMine

Search our database by keyword

Examples

Search results 201 to 240 out of 240 for Cyp24a1

Categories

Hits by Pathway

Hits by Strain

Hits by Category