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Search results 201 to 274 out of 274 for Itk

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Type Details Score
Protein Domain
IPR035583 | ITK_SH3
Type: Domain
Description: ITK (also known as Tsk or Emt) is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation [], and the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. ITK is expressed in T-cells and mast cells, and is important in their development and differentiation [, ]. Of the three Tec kinases expressed in T-cells, ITK plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization []. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28 [], the T-cell surface receptor CD2 [], and the chemokine receptor CXCR4 []. In addition, ITK is crucial for the development of T-helper(Th)2 effector responses []. This entry represents the SH3 domain of ITK.
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Allele
Itk<tm1Litt> | MGI:2178820
Name: IL2 inducible T cell kinase; targeted mutation 1, Dan R Littman
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:3842200 | B6.129S4-Itk<tm1Litt>
Attribute String: targeted mutation, congenic
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Strain
MGI:5565695 | B6.129S4-Itk<tm1Litt>/PlsJ
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Itk/Itk
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itk/Itk
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itk/Itk
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itk/Itk
Background: B6.129S4-Itk
Zygosity: hm
Has Mutant Allele: true
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Publication
14766749 | -
First Author: Brown K
Year: 2004
Journal: J Biol Chem
Title: Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.
Volume: 279
Issue: 18
Pages: 18727-32
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Publication
16802597 | -
 
First Author: Tsoukas CD
Year: 2006
Journal: Adv Exp Med Biol
Title: Inducible T cell tyrosine kinase (ITK): structural requirements and actin polymerization.
Volume: 584
Pages: 29-41
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Publication
20545945 | -
First Author: Kutach AK
Year: 2010
Journal: Chem Biol Drug Des
Title: Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation.
Volume: 76
Issue: 2
Pages: 154-63
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Protein Domain
IPR042785 | ITK_PTKc
Type: Domain
Description: PTKs catalyse the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region [, ].Itk is expressed in T-cells and mast cells, and is important in their development and differentiation []. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signalling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization []. It also plays a role in the downstream signalling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4 [, ]. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses [].
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Genotype
Genotype
Symbol: Il15/Il15 Itk/Itk
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Lck-cre)I57Jxm/?
Background: involves: 129S6/SvEvTac * ICR
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:3842212 | B6.129-Itk<tm1Litt> Cblb<tm1Pngr>
Attribute String: targeted mutation, congenic
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Strain
MGI:3842199 | B6.129-Itk<tm1Litt> Vav1<tm2Bbd>
Attribute String: congenic, targeted mutation
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Genotype
Genotype
Symbol: Itk/Itk Txk/Txk
Background: involves: 129S4/SvJae * 129S6/SvEvTac
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itk/Itk Vav1/Vav1
Background: B6.129-Itk Vav1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cblb/Cblb Itk/Itk
Background: B6.129-Itk Cblb
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cd4-cre)1Cwi/?
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
24376268 | J:207306
First Author: Bach MP
Year: 2014
Journal: J Immunol
Title: Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk.
Volume: 192
Issue: 3
Pages: 1024-33
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Strain
MGI:7571062 | STOCK Itk<tm1Litt> Tg(Tcra5CC7,Tcrb5CC7)IWep/Wep
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Itk/Itk Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itk/Itk Tg(TcrAND)53Hed/?
Background: involves: 129S4/SvJae * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il4/Il4 Itk/Itk
Background: involves: 129S4/SvJae * BALB/c * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itk/Itk Tg(DO11.10)10Dlo/?
Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Publication
10587356 | J:64938
First Author: Rajagopal K
Year: 1999
Journal: J Exp Med
Title: RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.
Volume: 190
Issue: 11
Pages: 1657-68
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Publication
16636016 | J:109137
First Author: Barbee SD
Year: 2006
Journal: Int Immunol
Title: Phosphatidylinositol 3-kinase improves the efficiency of positive selection.
Volume: 18
Issue: 6
Pages: 921-30
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Publication
15308100 | J:93591
First Author: Colgan J
Year: 2004
Journal: Immunity
Title: Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.
Volume: 21
Issue: 2
Pages: 189-201
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Publication
20601952 | J:162317
First Author: Weinreich MA
Year: 2010
Journal: Nat Immunol
Title: T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells.
Volume: 11
Issue: 8
Pages: 709-16
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Publication
23408840 | J:193676
First Author: Huang W
Year: 2013
Journal: J Immunol
Title: Cutting edge: innate memory CD8+ T cells are distinct from homeostatic expanded CD8+ T cells and rapidly respond to primary antigenic stimuli.
Volume: 190
Issue: 6
Pages: 2490-4
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Publication
11994416 | J:124747
First Author: Reynolds LF
Year: 2002
Journal: J Exp Med
Title: Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.
Volume: 195
Issue: 9
Pages: 1103-14
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Publication
21362140 | J:190802
First Author: Ellmeier W
Year: 2011
Journal: FEBS J
Title: Tec family kinases: regulation of FcεRI-mediated mast-cell activation.
Volume: 278
Issue: 12
Pages: 1990-2000
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Publication
17383541 | -
 
First Author: Felices M
Year: 2007
Journal: Adv Immunol
Title: Tec kinases in T cell and mast cell signaling.
Volume: 93
Pages: 145-84
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Publication
7542761 | J:27414
First Author: Sommers CL
Year: 1995
Journal: Oncogene
Title: Murine txk: a protein tyrosine kinase gene regulated by T cell activation.
Volume: 11
Issue: 2
Pages: 245-51
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Publication
19433445 | J:150146
First Author: Fukuyama T
Year: 2009
Journal: Mol Cell Biol
Title: Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development.
Volume: 29
Issue: 14
Pages: 3894-904
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Publication
21725281 | J:175902
First Author: Sela M
Year: 2011
Journal: EMBO J
Title: Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.
Volume: 30
Issue: 15
Pages: 3160-72
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Publication
12525577 | J:81210
First Author: Castro MA
Year: 2003
Journal: J Leukoc Biol
Title: OX52 is the rat homologue of CD6: evidence for an effector function in the regulation of CD5 phosphorylation.
Volume: 73
Issue: 1
Pages: 183-90
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Publication
17684099 | J:123766
First Author: Hantschel O
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib.
Volume: 104
Issue: 33
Pages: 13283-8
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Publication
20220094 | J:160051
First Author: Gorska MM
Year: 2010
Journal: J Immunol
Title: Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma.
Volume: 184
Issue: 8
Pages: 4488-96
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Protein
F6W1T9
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Publication
9218782 | -
First Author: Hyvönen M
Year: 1997
Journal: EMBO J
Title: Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
Volume: 16
Issue: 12
Pages: 3396-404
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Publication
8070576 | -
First Author: Vihinen M
Year: 1994
Journal: FEBS Lett
Title: Tec homology (TH) adjacent to the PH domain.
Volume: 350
Issue: 2-3
Pages: 263-5
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Publication
9280283 | -
First Author: Vihinen M
Year: 1997
Journal: FEBS Lett
Title: Missense mutations affecting a conserved cysteine pair in the TH domain of Btk.
Volume: 413
Issue: 2
Pages: 205-10
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Publication
9796816 | -
First Author: Jiang Y
Year: 1998
Journal: Nature
Title: The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain.
Volume: 395
Issue: 6704
Pages: 808-13
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Publication
15661031 | -
 
First Author: Lindvall JM
Year: 2005
Journal: Immunol Rev
Title: Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.
Volume: 203
Pages: 200-15
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Protein Domain
IPR001562 | Znf_Btk_motif
Type: Conserved_site
Description: The Btk-type zinc finger or Btk motif (BM) is a conserved zinc-binding motif containing conserved cysteines and a histidine that is present in certain eukaryotic signalling proteins. The motif is named after Bruton's tyrosine kinase (Btk), an enzyme which is essential for B cell maturation in humans and mice [, ]. Btk is a member of the Tec family of protein tyrosine kinases (PTK). These kinases contain a conserved Tec homology (TH) domain between the N-terminal pleckstrin homology (PH) domain () and the Src homology 3 (SH3) domain (). The N-terminal of the TH domain is highly conserved and known as the Btf motif, while the C-terminal region of the TH domain contains a proline-rich region (PRR). The Btk motif contains a conserved His and three Cys residues that form a zinc finger (although these differ from known zinc finger topologies), while PRRs are commonly involved in protein-protein interactions, including interactions with G proteins [, ]. The TH domain may be of functional importance in various signalling pathways in different species []. A complete TH domain, containing both the Btk and PRR regions, has not been found outside the Tec family; however, the Btk motif on its own does occur in other proteins, usually C-terminal to a PH domain (note that although a Btk motif always occurs C-terminal to a PH domain, not all PH domains are followed by a Btk motif).The crystal structures of Btk show that the Btk-type zinc finger has a globular core, formed by a long loop which is held together by a zinc ion, and that the Btk motif is packed against the PH domain []. The zinc-binding residues are a histidine and three cysteines, which are fully conserved in the Btk motif []. Proteins known to contain a Btk-type zinc finger include:Mammalian Bruton's tyrosine kinase (Btk), a protein tyrosine kinase involved in modulation of diverse cellular processes. Mutations affecting Btk are the cause of X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice. Mammalian Tec, Bmx, and Itk proteins, which are tyrosine protein kinases of the Tec subfamily. Drosophila tyrosine-protein kinase Btk29A, which is required for the development of proper ring canals and of male genitalia and required for adult survival. Mammalian Ras GTPase-activating proteins (RasGAP), which regulate the activation of inactive GDP-bound Ras by converting GDP to GTP.
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Protein
Q5STT7
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
Q3TQ19
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
Q03526
Organism: Mus musculus/domesticus
Length: 625  
Fragment?: false
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Protein
Q5STT8
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
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Protein
Q3U5G1
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Protein
A1A560
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
Q8CAW3
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: true
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Protein
D6RJM5
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
F6W8M5
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
Q8BNW5
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: true
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Protein
Q8C6G4
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Protein
Q9Z268
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Protein
Q6PFQ7
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Protein
P58069
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
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Protein
Q60790
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: false
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Protein
Q3UGJ5
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: false
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Protein
Q3U405
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Protein
P97504
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
P35991
Organism: Mus musculus/domesticus
Length: 659  
Fragment?: false
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Protein
P24604
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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Protein
Q3U436
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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Protein
B1AUL5
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
Q3TH41
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
Q7TMU1
Organism: Mus musculus/domesticus
Length: 659  
Fragment?: false
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Protein
B1AUL6
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Protein
A2BDW0
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
Q8CFK4
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom