BCL9 is associated with B-cell acute lymphoblastic leukemia []. This entry includes BCL9 and BCL9L. They are tissue-specific transcriptional cofactors that cooperate with beta-catenin. In the nucleus, Bcl9 and Bcl9l simultaneously bind beta-catenin and the transcriptional activator Pygo2 to promote the transcription of a subset of Wnt target genes. They may also have a cytoplasmic role [].
The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis.B-cell lymphoma 9 (BCL9) associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes [].This entry represents a beta-catenin binding domain found in BCL9 and BCL9 homologues.