Type |
Details |
Score |
Publication |
First Author: |
Tian M |
Year: |
2021 |
Journal: |
Elife |
Title: |
ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Fonseca TL |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. |
Volume: |
112 |
Issue: |
45 |
Pages: |
14018-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei N |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. |
Volume: |
13 |
Issue: |
8 |
Pages: |
1647-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayeuf-Louchart A |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation. |
Volume: |
29 |
Issue: |
6 |
Pages: |
1410-1418.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song Z |
Year: |
2022 |
Journal: |
Mol Metab |
Title: |
The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation. |
Volume: |
64 |
|
Pages: |
101548 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim GE |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
14-3-3ΞΆ coordinates adipogenesis of visceral fat. |
Volume: |
6 |
|
Pages: |
7671 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scavuzzo MA |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. |
Volume: |
9 |
Issue: |
1 |
Pages: |
3356 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ehringer MA |
Year: |
2001 |
Journal: |
Mamm Genome |
Title: |
High-throughput sequence identification of gene coding variants within alcohol-related QTLs. |
Volume: |
12 |
Issue: |
8 |
Pages: |
657-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Overbeek PA |
Year: |
2011 |
Journal: |
MGI Direct Data Submission |
Title: |
Direct Data Submission for Overbeek Lentiviral Transgenic Lines |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bowman CE |
Year: |
2016 |
Journal: |
Mol Cell Biol |
Title: |
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. |
Volume: |
36 |
Issue: |
15 |
Pages: |
2089-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bulusu V |
Year: |
2017 |
Journal: |
Dev Cell |
Title: |
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. |
Volume: |
40 |
Issue: |
4 |
Pages: |
331-341.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Y |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
Volume: |
12 |
Issue: |
9 |
Pages: |
e1006355 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Papin J |
Year: |
2004 |
Journal: |
Curr Opin Biotechnol |
Title: |
Bioinformatics and cellular signaling. |
Volume: |
15 |
Issue: |
1 |
Pages: |
78-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taconic |
Year: |
2006 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from Taconic website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hoffman BG |
Year: |
2008 |
Journal: |
Genome Biol |
Title: |
Identification of transcripts with enriched expression in the developing and adult pancreas. |
Volume: |
9 |
Issue: |
6 |
Pages: |
R99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pagliarini DJ |
Year: |
2008 |
Journal: |
Cell |
Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
Volume: |
134 |
Issue: |
1 |
Pages: |
112-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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|
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•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Rat to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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|
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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|
•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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•
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•
|
Interaction Experiment |
Description: |
Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice. |
|
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•
•
•
•
|
Allele |
Name: |
ATP citrate lyase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
ATP citrate lyase; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
ATP citrate lyase; gene trap NPX098, BayGenomics |
Allele Type: |
Gene trapped |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Acly/Acly |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Acly/Acly<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Nowrousian M |
Year: |
2000 |
Journal: |
Curr Genet |
Title: |
The fungal acl1 and acl2 genes encode two polypeptides with homology to the N- and C-terminal parts of the animal ATP citrate lyase polypeptide. |
Volume: |
37 |
Issue: |
3 |
Pages: |
189-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elshourbagy NA |
Year: |
1990 |
Journal: |
J Biol Chem |
Title: |
Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age. |
Volume: |
265 |
Issue: |
3 |
Pages: |
1430-5 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents eukaryotic ATP-citrate synthase (ACLY) (), also known as ATP citrate lyase. In bacteria and archaea, ATP citrate synthase is composed of two distinct subunits []. In eukaryotes, ATP citrate synthase is a homotetramer of a single large polypeptide, and is used to produce cytosolic acetyl-CoA from mitochondrial produced citrate [, , , ]. Acetyl-CoA is the building block for de novo lipid synthesis. As such, ACLY couples energy metabolism with fatty acids synthesis and plays a critical role in supporting cell growth []. |
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•
•
•
•
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Publication |
First Author: |
Wartewig T |
Year: |
2023 |
Journal: |
Nat Cancer |
Title: |
PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. |
Volume: |
4 |
Issue: |
10 |
Pages: |
1508-1525 |
|
•
•
•
•
•
|
Publication |
First Author: |
Comincini S |
Year: |
1997 |
Journal: |
Mamm Genome |
Title: |
Isolation of coding sequences from bovine cosmids by means of exon trapping. |
Volume: |
8 |
Issue: |
7 |
Pages: |
486-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baardman J |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques. |
Volume: |
11 |
Issue: |
1 |
Pages: |
6296 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fernandez-Fuente G |
Year: |
2023 |
Journal: |
Commun Biol |
Title: |
The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse. |
Volume: |
6 |
Issue: |
1 |
Pages: |
926 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang M |
Year: |
2018 |
Journal: |
Gene |
Title: |
Obesity-induced overexpression of miRNA-24 regulates cholesterol uptake and lipid metabolism by targeting SR-B1. |
Volume: |
668 |
|
Pages: |
196-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chu DT |
Year: |
2017 |
Journal: |
Physiol Rep |
Title: |
C57BL/6J mice as a polygenic developmental model of diet-induced obesity. |
Volume: |
5 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chen LY |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes. |
Volume: |
293 |
Issue: |
31 |
Pages: |
12259-12270 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shares BH |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
Active mitochondria support osteogenic differentiation by stimulating Ξ²-catenin acetylation. |
Volume: |
293 |
Issue: |
41 |
Pages: |
16019-16027 |
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•
•
•
•
•
|
Publication |
First Author: |
Icard P |
Year: |
2020 |
Journal: |
Cancer Lett |
Title: |
ATP citrate lyase: A central metabolic enzyme in cancer. |
Volume: |
471 |
|
Pages: |
125-134 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shearn CT |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. |
Volume: |
9 |
Issue: |
5 |
Pages: |
e96553 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zeng H |
Year: |
2022 |
Journal: |
Mol Metab |
Title: |
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing. |
Volume: |
57 |
|
Pages: |
101428 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin R |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. |
Volume: |
51 |
Issue: |
4 |
Pages: |
506-518 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jing Z |
Year: |
2023 |
Journal: |
Front Cell Dev Biol |
Title: |
Epigenetic and transcriptomic alterations in the ClC-3-deficient mice consuming a normal diet. |
Volume: |
11 |
|
Pages: |
1196684 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wiper-Bergeron N |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. |
Volume: |
104 |
Issue: |
8 |
Pages: |
2703-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
211
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
66
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
118
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Grant PA |
Year: |
1997 |
Journal: |
Genes Dev |
Title: |
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. |
Volume: |
11 |
Issue: |
13 |
Pages: |
1640-50 |
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Protein Domain |
Type: |
Family |
Description: |
This entry includes histone acetyltransferases GCN5, KAT2A and KAT2B (all of which are included in ). GCN5 acetylates histones H2B, H3 and H4, providing a specific tag for epigenetic transcription activation. GCN5 is a component of the transcription regulatory histone acetylation (HAT) complexes SAGA [], SLIK [], SALSA []and ADA []. Mammals have two paralogues: KAT2A (also known as GCN5) and KAT2B. KAT2A acetylates core histones to provide a specific tag for epigenetic transcription activation, but not nucleosome core particles. It also acetylates proteins such as CEBPB []. KAT2A is a component of the ATAC complex, which has acetyltransferase activity on histones H3 and H4 []. KAT2B (also known as P300/calcium-binding protein (CBP)-associated factor or PCAF) can acetylate the core histones H3 and H4 as well as nucleosome core particles and non-histone proteins such as ACLY [].The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B []. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 []. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [].SLIK (SAGA-like) is a multi-subunit histone acetyltransferase complex that preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B. It is an embellishment of the SAGA complex. The yeast SLIK complex consists of at least TRA1, CHD1, SPT7, CC TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8 (a deubiquitinase), GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9 [, ].The yeast SALSA complex is an altered form of the SAGA complex and consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3 [].The ADA complex is a transcription regulatory histone acetylation (HAT) complex. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. The complex consists of at least ADA2, ADA3, AHC1, and GCN5. AHC1 is required for the overall structural integrity of the ADA complex []. |
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Publication |
First Author: |
Grant PA |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Expanded lysine acetylation specificity of Gcn5 in native complexes. |
Volume: |
274 |
Issue: |
9 |
Pages: |
5895-900 |
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Publication |
First Author: |
Grant PA |
Year: |
1998 |
Journal: |
Mol Cell |
Title: |
The ATM-related cofactor Tra1 is a component of the purified SAGA complex. |
Volume: |
2 |
Issue: |
6 |
Pages: |
863-7 |
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Publication |
First Author: |
Guelman S |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
The double-histone-acetyltransferase complex ATAC is essential for mammalian development. |
Volume: |
29 |
Issue: |
5 |
Pages: |
1176-88 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
116
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
660
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
473
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
813
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
830
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
829
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Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
830
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Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
833
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
813
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Fragment?: |
false |
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Publication |
First Author: |
Kim W |
Year: |
2006 |
Journal: |
J Bacteriol |
Title: |
Both subunits of ATP-citrate lyase from Chlorobium tepidum contribute to catalytic activity. |
Volume: |
188 |
Issue: |
18 |
Pages: |
6544-52 |
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Publication |
First Author: |
Bauer DE |
Year: |
2005 |
Journal: |
Oncogene |
Title: |
ATP citrate lyase is an important component of cell growth and transformation. |
Volume: |
24 |
Issue: |
41 |
Pages: |
6314-22 |
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Publication |
First Author: |
Sterner DE |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription. |
Volume: |
99 |
Issue: |
18 |
Pages: |
11622-7 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1091
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1091
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Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1034
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Fragment?: |
true |
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