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Search results 501 to 600 out of 606 for Acly

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Type Details Score
Publication    
First Author: Tian M
Year: 2021
Journal: Elife
Title: ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation.
Volume: 10
Publication
First Author: Fonseca TL
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Volume: 112
Issue: 45
Pages: 14018-23
Publication
First Author: Wei N
Year: 2015
Journal: Cell Rep
Title: SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing.
Volume: 13
Issue: 8
Pages: 1647-57
Publication
First Author: Mayeuf-Louchart A
Year: 2019
Journal: Cell Rep
Title: Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation.
Volume: 29
Issue: 6
Pages: 1410-1418.e6
Publication  
First Author: Song Z
Year: 2022
Journal: Mol Metab
Title: The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation.
Volume: 64
Pages: 101548
Publication  
First Author: Lim GE
Year: 2015
Journal: Nat Commun
Title: 14-3-3ΞΆ coordinates adipogenesis of visceral fat.
Volume: 6
Pages: 7671
Publication
First Author: Scavuzzo MA
Year: 2018
Journal: Nat Commun
Title: Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis.
Volume: 9
Issue: 1
Pages: 3356
Publication
First Author: Ehringer MA
Year: 2001
Journal: Mamm Genome
Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.
Volume: 12
Issue: 8
Pages: 657-63
Publication      
First Author: Overbeek PA
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission for Overbeek Lentiviral Transgenic Lines
Publication
First Author: Bowman CE
Year: 2016
Journal: Mol Cell Biol
Title: Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Volume: 36
Issue: 15
Pages: 2089-104
Publication
First Author: Bulusu V
Year: 2017
Journal: Dev Cell
Title: Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Volume: 40
Issue: 4
Pages: 331-341.e4
Publication
First Author: Wu Y
Year: 2016
Journal: PLoS Genet
Title: Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Volume: 12
Issue: 9
Pages: e1006355
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
Publication      
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
Publication
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
Publication
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Interaction Experiment
Description: Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.
Allele
Name: ATP citrate lyase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: ATP citrate lyase; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: ATP citrate lyase; gene trap NPX098, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
Genotype
Symbol: Acly/Acly
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Acly/Acly<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Nowrousian M
Year: 2000
Journal: Curr Genet
Title: The fungal acl1 and acl2 genes encode two polypeptides with homology to the N- and C-terminal parts of the animal ATP citrate lyase polypeptide.
Volume: 37
Issue: 3
Pages: 189-93
Publication
First Author: Elshourbagy NA
Year: 1990
Journal: J Biol Chem
Title: Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age.
Volume: 265
Issue: 3
Pages: 1430-5
Protein Domain
Type: Family
Description: This entry represents eukaryotic ATP-citrate synthase (ACLY) (), also known as ATP citrate lyase. In bacteria and archaea, ATP citrate synthase is composed of two distinct subunits []. In eukaryotes, ATP citrate synthase is a homotetramer of a single large polypeptide, and is used to produce cytosolic acetyl-CoA from mitochondrial produced citrate [, , , ]. Acetyl-CoA is the building block for de novo lipid synthesis. As such, ACLY couples energy metabolism with fatty acids synthesis and plays a critical role in supporting cell growth [].
Publication
First Author: Wartewig T
Year: 2023
Journal: Nat Cancer
Title: PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma.
Volume: 4
Issue: 10
Pages: 1508-1525
Publication
First Author: Comincini S
Year: 1997
Journal: Mamm Genome
Title: Isolation of coding sequences from bovine cosmids by means of exon trapping.
Volume: 8
Issue: 7
Pages: 486-90
Publication
First Author: Baardman J
Year: 2020
Journal: Nat Commun
Title: Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques.
Volume: 11
Issue: 1
Pages: 6296
Publication
First Author: Fernandez-Fuente G
Year: 2023
Journal: Commun Biol
Title: The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse.
Volume: 6
Issue: 1
Pages: 926
Publication  
First Author: Wang M
Year: 2018
Journal: Gene
Title: Obesity-induced overexpression of miRNA-24 regulates cholesterol uptake and lipid metabolism by targeting SR-B1.
Volume: 668
Pages: 196-203
Publication  
First Author: Chu DT
Year: 2017
Journal: Physiol Rep
Title: C57BL/6J mice as a polygenic developmental model of diet-induced obesity.
Volume: 5
Issue: 7
Publication
First Author: Chen LY
Year: 2018
Journal: J Biol Chem
Title: Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes.
Volume: 293
Issue: 31
Pages: 12259-12270
Publication
First Author: Shares BH
Year: 2018
Journal: J Biol Chem
Title: Active mitochondria support osteogenic differentiation by stimulating Ξ²-catenin acetylation.
Volume: 293
Issue: 41
Pages: 16019-16027
Publication  
First Author: Icard P
Year: 2020
Journal: Cancer Lett
Title: ATP citrate lyase: A central metabolic enzyme in cancer.
Volume: 471
Pages: 125-134
Publication
First Author: Shearn CT
Year: 2014
Journal: PLoS One
Title: Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.
Volume: 9
Issue: 5
Pages: e96553
Publication  
First Author: Zeng H
Year: 2022
Journal: Mol Metab
Title: CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.
Volume: 57
Pages: 101428
Publication
First Author: Lin R
Year: 2013
Journal: Mol Cell
Title: Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.
Volume: 51
Issue: 4
Pages: 506-518
Publication  
First Author: Jing Z
Year: 2023
Journal: Front Cell Dev Biol
Title: Epigenetic and transcriptomic alterations in the ClC-3-deficient mice consuming a normal diet.
Volume: 11
Pages: 1196684
Publication
First Author: Wiper-Bergeron N
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.
Volume: 104
Issue: 8
Pages: 2703-8
Protein
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
Publication
First Author: Grant PA
Year: 1997
Journal: Genes Dev
Title: Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.
Volume: 11
Issue: 13
Pages: 1640-50
Protein Domain
Type: Family
Description: This entry includes histone acetyltransferases GCN5, KAT2A and KAT2B (all of which are included in ). GCN5 acetylates histones H2B, H3 and H4, providing a specific tag for epigenetic transcription activation. GCN5 is a component of the transcription regulatory histone acetylation (HAT) complexes SAGA [], SLIK [], SALSA []and ADA []. Mammals have two paralogues: KAT2A (also known as GCN5) and KAT2B. KAT2A acetylates core histones to provide a specific tag for epigenetic transcription activation, but not nucleosome core particles. It also acetylates proteins such as CEBPB []. KAT2A is a component of the ATAC complex, which has acetyltransferase activity on histones H3 and H4 []. KAT2B (also known as P300/calcium-binding protein (CBP)-associated factor or PCAF) can acetylate the core histones H3 and H4 as well as nucleosome core particles and non-histone proteins such as ACLY [].The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B []. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 []. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [].SLIK (SAGA-like) is a multi-subunit histone acetyltransferase complex that preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B. It is an embellishment of the SAGA complex. The yeast SLIK complex consists of at least TRA1, CHD1, SPT7, CC TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8 (a deubiquitinase), GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9 [, ].The yeast SALSA complex is an altered form of the SAGA complex and consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3 [].The ADA complex is a transcription regulatory histone acetylation (HAT) complex. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. The complex consists of at least ADA2, ADA3, AHC1, and GCN5. AHC1 is required for the overall structural integrity of the ADA complex [].
Publication
First Author: Grant PA
Year: 1999
Journal: J Biol Chem
Title: Expanded lysine acetylation specificity of Gcn5 in native complexes.
Volume: 274
Issue: 9
Pages: 5895-900
Publication
First Author: Grant PA
Year: 1998
Journal: Mol Cell
Title: The ATM-related cofactor Tra1 is a component of the purified SAGA complex.
Volume: 2
Issue: 6
Pages: 863-7
Publication
First Author: Guelman S
Year: 2009
Journal: Mol Cell Biol
Title: The double-histone-acetyltransferase complex ATAC is essential for mammalian development.
Volume: 29
Issue: 5
Pages: 1176-88
Protein
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 813  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 830  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 829  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 830  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 813  
Fragment?: false
Publication
First Author: Kim W
Year: 2006
Journal: J Bacteriol
Title: Both subunits of ATP-citrate lyase from Chlorobium tepidum contribute to catalytic activity.
Volume: 188
Issue: 18
Pages: 6544-52
Publication
First Author: Bauer DE
Year: 2005
Journal: Oncogene
Title: ATP citrate lyase is an important component of cell growth and transformation.
Volume: 24
Issue: 41
Pages: 6314-22
Publication
First Author: Sterner DE
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription.
Volume: 99
Issue: 18
Pages: 11622-7
Protein
Organism: Mus musculus/domesticus
Length: 1091  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1091  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1034  
Fragment?: true