PDZ and LIM domain protein 1 (PDZ-LIM1, also known as CLP-36) is a member of the PDZ-LIM family of adapter proteins that have been implicated in cytoskeleton organisation, neuronal signalling, cell lineage specification, organ development, and oncogenesis []. Several PDZ-LIM proteins are predominantly expressed in striated muscle. However, CLP36 is expressed in several nonmuscle tissues []. CLP36 binds to alpha-actinin-1 and may direct alpha-actinin-1 to specific actin structures []. CLP36 also recruits the Clik1 kinase to actin stress fibres in nonmuscle cells [].
