Type |
Details |
Score |
Publication |
First Author: |
Saab R |
Year: |
2009 |
Journal: |
Cancer Res |
Title: |
p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor. |
Volume: |
69 |
Issue: |
2 |
Pages: |
440-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muraoka RS |
Year: |
2001 |
Journal: |
J Cell Biol |
Title: |
Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function. |
Volume: |
153 |
Issue: |
5 |
Pages: |
917-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bailly-Maitre B |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Mice lacking bi-1 gene show accelerated liver regeneration. |
Volume: |
67 |
Issue: |
4 |
Pages: |
1442-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li F |
Year: |
2017 |
Journal: |
Eur J Pharmacol |
Title: |
Activation of PPARĪ³ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms. |
Volume: |
814 |
|
Pages: |
324-334 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueberham U |
Year: |
2014 |
Journal: |
Neuropathol Appl Neurobiol |
Title: |
Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease. |
Volume: |
40 |
Issue: |
7 |
Pages: |
815-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhuang SM |
Year: |
2000 |
Journal: |
Cancer Lett |
Title: |
Mutation analysis of the pRb pathway in 2',3'-dideoxycytidine- and 1, 3-butadiene-induced mouse lymphomas. |
Volume: |
152 |
Issue: |
2 |
Pages: |
129-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bagui TK |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1). |
Volume: |
20 |
Issue: |
23 |
Pages: |
8748-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Linardopoulos S |
Year: |
1995 |
Journal: |
Cancer Res |
Title: |
Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors. |
Volume: |
55 |
Issue: |
22 |
Pages: |
5168-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okuda T |
Year: |
1995 |
Journal: |
Genomics |
Title: |
Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. |
Volume: |
29 |
Issue: |
3 |
Pages: |
623-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ewen ME |
Year: |
1996 |
Journal: |
Biochim Biophys Acta |
Title: |
p53 and translational control. |
Volume: |
1242 |
Issue: |
3 |
Pages: |
181-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Palmero I |
Year: |
1997 |
Journal: |
Oncogene |
Title: |
Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status. |
Volume: |
15 |
Issue: |
5 |
Pages: |
495-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sinha R |
Year: |
1997 |
Journal: |
Carcinogenesis |
Title: |
Inhibition of cdk2 kinase activity by methylselenocysteine in synchronized mouse mammary epithelial tumor cells. |
Volume: |
18 |
Issue: |
8 |
Pages: |
1541-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goisset C |
Year: |
1998 |
Journal: |
Mech Dev |
Title: |
Identification and developmental expression of cyclin-dependent kinase 4 gene in Xenopus laevis. |
Volume: |
70 |
Issue: |
1-2 |
Pages: |
197-200 |
|
•
•
•
•
•
|
Publication |
First Author: |
CoppƩe F |
Year: |
1998 |
Journal: |
Oncogene |
Title: |
Differential patterns of cell cycle regulatory proteins expression in transgenic models of thyroid tumours. |
Volume: |
17 |
Issue: |
5 |
Pages: |
631-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang QS |
Year: |
1998 |
Journal: |
Carcinogenesis |
Title: |
Altered expression of cyclin D1 and cyclin-dependent kinase 4 in azoxymethane-induced mouse colon tumorigenesis. |
Volume: |
19 |
Issue: |
11 |
Pages: |
2001-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
PĆ©rez de Castro IP |
Year: |
1999 |
Journal: |
Carcinogenesis |
Title: |
Cooperative alterations of Rb pathway regulators in mouse primary T cell lymphomas. |
Volume: |
20 |
Issue: |
9 |
Pages: |
1675-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pirkmaier A |
Year: |
2003 |
Journal: |
Oncogene |
Title: |
Alternative mammary oncogenic pathways are induced by D-type cyclins; MMTV-cyclin D3 transgenic mice develop squamous cell carcinoma. |
Volume: |
22 |
Issue: |
28 |
Pages: |
4425-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malumbres M |
Year: |
2003 |
Journal: |
Adv Exp Med Biol |
Title: |
Driving the cell cycle to cancer. |
Volume: |
532 |
|
Pages: |
1-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto M |
Year: |
2006 |
Journal: |
Mol Carcinog |
Title: |
Neoplastic hepatocyte growth associated with cyclin D1 redistribution from the cytoplasm to the nucleus in mouse hepatocarcinogenesis. |
Volume: |
45 |
Issue: |
12 |
Pages: |
901-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carbone CJ |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts. |
Volume: |
67 |
Issue: |
9 |
Pages: |
4130-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Theodoraki MA |
Year: |
2007 |
Journal: |
Exp Cell Res |
Title: |
Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context. |
Volume: |
313 |
Issue: |
18 |
Pages: |
3851-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu G |
Year: |
2001 |
Journal: |
Development |
Title: |
Msx homeobox genes inhibit differentiation through upregulation of cyclin D1. |
Volume: |
128 |
Issue: |
12 |
Pages: |
2373-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao HS |
Year: |
2001 |
Journal: |
Circ Res |
Title: |
Cardiac-specific overexpression of cyclin-dependent kinase 2 increases smaller mononuclear cardiomyocytes. |
Volume: |
88 |
Issue: |
4 |
Pages: |
443-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gonzalez YR |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage. |
Volume: |
28 |
Issue: |
21 |
Pages: |
5559-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Salisbury E |
Year: |
2008 |
Journal: |
Exp Cell Res |
Title: |
Ectopic expression of cyclin D3 corrects differentiation of DM1 myoblasts through activation of RNA CUG-binding protein, CUGBP1. |
Volume: |
314 |
Issue: |
11-12 |
Pages: |
2266-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Macias E |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development. |
Volume: |
173 |
Issue: |
2 |
Pages: |
526-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Renner O |
Year: |
2008 |
Journal: |
Cancer Res |
Title: |
Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation. |
Volume: |
68 |
Issue: |
23 |
Pages: |
9643-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaproth-Joslin KA |
Year: |
2008 |
Journal: |
Biochem J |
Title: |
Phospholipase C delta 1 regulates cell proliferation and cell-cycle progression from G1- to S-phase by control of cyclin E-CDK2 activity. |
Volume: |
415 |
Issue: |
3 |
Pages: |
439-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Joshi I |
Year: |
2009 |
Journal: |
Blood |
Title: |
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. |
Volume: |
113 |
Issue: |
8 |
Pages: |
1689-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blancquaert S |
Year: |
2010 |
Journal: |
Mol Endocrinol |
Title: |
cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4. |
Volume: |
24 |
Issue: |
7 |
Pages: |
1453-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Badhai J |
Year: |
2009 |
Journal: |
Biochim Biophys Acta |
Title: |
Ribosomal protein S19 and S24 insufficiency cause distinct cell cycle defects in Diamond-Blackfan anemia. |
Volume: |
1792 |
Issue: |
10 |
Pages: |
1036-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis. |
Volume: |
178 |
Issue: |
1 |
Pages: |
345-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueberham U |
Year: |
2012 |
Journal: |
Neurobiol Aging |
Title: |
Transcriptional control of cell cycle-dependent kinase 4 by Smad proteins--implications for Alzheimer's disease. |
Volume: |
33 |
Issue: |
12 |
Pages: |
2827-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Panda DK |
Year: |
2012 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor. |
Volume: |
303 |
Issue: |
12 |
Pages: |
E1489-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khanjyan MV |
Year: |
2013 |
Journal: |
Hum Mol Genet |
Title: |
A high-content, high-throughput siRNA screen identifies cyclin D2 as a potent regulator of muscle progenitor cell fusion and a target to enhance muscle regeneration. |
Volume: |
22 |
Issue: |
16 |
Pages: |
3283-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang KH |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death. |
Volume: |
125 |
Issue: |
Pt 21 |
Pages: |
5124-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
DiRocco DP |
Year: |
2014 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury. |
Volume: |
306 |
Issue: |
4 |
Pages: |
F379-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kangwan N |
Year: |
2016 |
Journal: |
Int J Cancer |
Title: |
Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer. |
Volume: |
138 |
Issue: |
6 |
Pages: |
1482-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation. |
Volume: |
10 |
Issue: |
5 |
Pages: |
e0126459 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito H |
Year: |
2016 |
Journal: |
Biochim Biophys Acta |
Title: |
Schizophrenia susceptibility gene product dysbindin-1 regulates the homeostasis of cyclin D1. |
Volume: |
1862 |
Issue: |
8 |
Pages: |
1383-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2018 |
Journal: |
Nature |
Title: |
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. |
Volume: |
553 |
Issue: |
7686 |
Pages: |
91-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan J |
Year: |
2015 |
Journal: |
Oncotarget |
Title: |
Accelerated hepatocellular carcinoma development in CUL4B transgenic mice. |
Volume: |
6 |
Issue: |
17 |
Pages: |
15209-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo C |
Year: |
2020 |
Journal: |
Cancer Res |
Title: |
Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency. |
Volume: |
80 |
Issue: |
16 |
Pages: |
3215-3221 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo L |
Year: |
2020 |
Journal: |
Arch Biochem Biophys |
Title: |
S-petasin induces apoptosis and inhibits cell migration through activation of p53 pathway signaling in melanoma B16F10Ā cells and A375Ā cells. |
Volume: |
692 |
|
Pages: |
108519 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki R |
Year: |
2015 |
Journal: |
J Crohns Colitis |
Title: |
Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer. |
Volume: |
9 |
Issue: |
7 |
Pages: |
565-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsushime H |
Year: |
1991 |
Journal: |
Cell |
Title: |
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. |
Volume: |
65 |
Issue: |
4 |
Pages: |
701-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hall M |
Year: |
1996 |
Journal: |
Adv Cancer Res |
Title: |
Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. |
Volume: |
68 |
|
Pages: |
67-108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiong Y |
Year: |
1991 |
Journal: |
Cell |
Title: |
Human D-type cyclin. |
Volume: |
65 |
Issue: |
4 |
Pages: |
691-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kato J |
Year: |
1999 |
Journal: |
Front Biosci |
Title: |
Induction of S phase by G1 regulatory factors. |
Volume: |
4 |
|
Pages: |
D787-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Resnitzky D |
Year: |
1995 |
Journal: |
Mol Cell Biol |
Title: |
Different roles for cyclins D1 and E in regulation of the G1-to-S transition. |
Volume: |
15 |
Issue: |
7 |
Pages: |
3463-9 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].Among G1 regulators, D-type cyclins serve as targets of growth factors to integrate extracellular signals into the core cell cycle regulators. D-type cyclins were identified in three independent approaches; (I) a target gene of chromosomal translocations in a variety of cancers [], (II) a mammalian cyclin gene that can complement yeast G1 cyclin deficiency [], and (III) a delayed early growth factor inducible gene []. D-type cyclins are composed of three different but closely related subfamilies (D1, D2, and D3), all differentially expressed in a wide variety of organs and in a tissue-specific manner. Expression of D-type cyclins is induced in response to a variety of mitogenic signals and they function as a regulatory subunit of cyclin-dependent kinases (Cdk).D-type cyclins can interact with 4 different Cdks (Cdk2, 4, 5, and 6), among which Cdk4 and Cdk6 are apparently the major functional catalytic partners in proliferating cells. When cells are exposed to growth factor stimulation, the expression of cyclin D is maintained regardless of the point in the cell cycle. However, accumulation of active cyclin D/Cdk4 (or Cdk6) complex is rate-limiting and is required for cells to progress through G1 and to commit to entering S phase. The over expression of D-type cyclins shortens the length of G1 without affecting remainder of the cell cycle. This event is clearly different from phenotype of the cells over expressing another G1 cyclin, cyclin E, in which G1 is shortened but elongation of the S phase compensates this shortening and as a result, doubling time of the cell remains unchanged. Thus, the cyclin D/Cdk4 complex largely exerts effects on commitment of cells for the S phase entry during the G1 phase, while functions of cyclin E/Cdk2 kinase are more directly involved in the initiation of chromosomal DNA synthesis [, ].This entry is comprised of D-type cyclins that are evolutionarily conserved across a variety of species. |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuoka M |
Year: |
1994 |
Journal: |
Mol Cell Biol |
Title: |
Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase. |
Volume: |
14 |
Issue: |
11 |
Pages: |
7265-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karst AM |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. |
Volume: |
108 |
Issue: |
18 |
Pages: |
7547-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Walter DM |
Year: |
2019 |
Journal: |
Nature |
Title: |
RB constrains lineage fidelity and multiple stages of tumour progression and metastasis. |
Volume: |
569 |
Issue: |
7756 |
Pages: |
423-427 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao X |
Year: |
2019 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Involvement of the STAT5-cyclin D/CDK4-pRb pathway in Ī²-cell proliferation stimulated by prolactin during pregnancy. |
Volume: |
316 |
Issue: |
1 |
Pages: |
E135-E144 |
|
•
•
•
•
•
|
Publication |
First Author: |
Novais EJ |
Year: |
2019 |
Journal: |
Matrix Biol |
Title: |
p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. |
Volume: |
82 |
|
Pages: |
54-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malstrom S |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. |
Volume: |
98 |
Issue: |
26 |
Pages: |
14967-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tateishi Y |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Development of mice without Cip/Kip CDK inhibitors. |
Volume: |
427 |
Issue: |
2 |
Pages: |
285-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Franklin DS |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. |
Volume: |
20 |
Issue: |
16 |
Pages: |
6147-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sabourin CL |
Year: |
1998 |
Journal: |
Exp Lung Res |
Title: |
Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors. |
Volume: |
24 |
Issue: |
4 |
Pages: |
499-521 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang T |
Year: |
1997 |
Journal: |
Cancer Res |
Title: |
Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. |
Volume: |
57 |
Issue: |
9 |
Pages: |
1638-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen MD |
Year: |
2003 |
Journal: |
J Neurosci |
Title: |
Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1. |
Volume: |
23 |
Issue: |
6 |
Pages: |
2131-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo S |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice. |
Volume: |
33 |
Issue: |
9 |
Pages: |
10207-10217 |
|
•
•
•
•
•
|
Publication |
First Author: |
Halaban R |
Year: |
1999 |
Journal: |
Cancer Metastasis Rev |
Title: |
Melanoma cell autonomous growth: the Rb/E2F pathway. |
Volume: |
18 |
Issue: |
3 |
Pages: |
333-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Agrawal D |
Year: |
1996 |
Journal: |
Mol Cell Biol |
Title: |
Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells. |
Volume: |
16 |
Issue: |
8 |
Pages: |
4327-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Said TK |
Year: |
1996 |
Journal: |
Cell Prolif |
Title: |
Immortal, non-tumourigenic mouse mammary outgrowths express high levels of cyclin B1 and activation of cyclin B1/cdc2 kinase. |
Volume: |
29 |
Issue: |
11 |
Pages: |
623-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sherburn TE |
Year: |
1998 |
Journal: |
DNA Cell Biol |
Title: |
Cloning and characterization of the CDKN2A and p19ARF genes from Monodelphis domestica. |
Volume: |
17 |
Issue: |
11 |
Pages: |
975-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balasubramanian S |
Year: |
1999 |
Journal: |
Oncogene |
Title: |
Activation of telomerase and its association with G1-phase of the cell cycle during UVB-induced skin tumorigenesis in SKH-1 hairless mouse. |
Volume: |
18 |
Issue: |
6 |
Pages: |
1297-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang Y |
Year: |
2002 |
Journal: |
Carcinogenesis |
Title: |
Altered expression of G1/S regulatory genes occurs early and frequently in lung carcinogenesis in transforming growth factor-beta1 heterozygous mice. |
Volume: |
23 |
Issue: |
7 |
Pages: |
1217-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vax VV |
Year: |
2003 |
Journal: |
J Endocrinol |
Title: |
Activating point mutations in cyclin-dependent kinase 4 are not seen in sporadic pituitary adenomas, insulinomas or Leydig cell tumours. |
Volume: |
178 |
Issue: |
2 |
Pages: |
301-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hino S |
Year: |
2004 |
Journal: |
Diabetologia |
Title: |
In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4. |
Volume: |
47 |
Issue: |
10 |
Pages: |
1819-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hacker E |
Year: |
2008 |
Journal: |
Int J Cancer |
Title: |
Reduced expression of IL-18 is a marker of ultraviolet radiation-induced melanomas. |
Volume: |
123 |
Issue: |
1 |
Pages: |
227-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li B |
Year: |
2010 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice. |
Volume: |
299 |
Issue: |
2 |
Pages: |
G413-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaid M |
Year: |
2010 |
Journal: |
Carcinogenesis |
Title: |
Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation. |
Volume: |
31 |
Issue: |
11 |
Pages: |
2004-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mukhopadhyay P |
Year: |
2016 |
Journal: |
Oncogene |
Title: |
Murine melanomas accelerated by a single UVR exposure carry photoproduct footprints but lack UV signature C>T mutations in critical genes. |
Volume: |
35 |
Issue: |
25 |
Pages: |
3342-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katz IS |
Year: |
2016 |
Journal: |
DNA Repair (Amst) |
Title: |
7,12-Dimethylbenz(a)anthracene-induced genotoxicity on bone marrow cells from mice phenotypically selected for low acute inflammatory response. |
Volume: |
37 |
|
Pages: |
43-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei Z |
Year: |
2018 |
Journal: |
Lipids Health Dis |
Title: |
Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells. |
Volume: |
17 |
Issue: |
1 |
Pages: |
210 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xia RM |
Year: |
2021 |
Journal: |
Front Cell Dev Biol |
Title: |
LHPP-Mediated Histidine Dephosphorylation Suppresses the Self-Renewal of Mouse Embryonic Stem Cells. |
Volume: |
9 |
|
Pages: |
638815 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hong JT |
Year: |
2001 |
Journal: |
Mol Carcinog |
Title: |
Inhibitory effect of glycolic acid on ultraviolet-induced skin tumorigenesis in SKH-1 hairless mice and its mechanism of action. |
Volume: |
31 |
Issue: |
3 |
Pages: |
152-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moore GD |
Year: |
1996 |
Journal: |
Mol Reprod Dev |
Title: |
Temporal patterns of gene expression of G1-S cyclins and cdks during the first and second mitotic cell cycles in mouse embryos. |
Volume: |
45 |
Issue: |
3 |
Pages: |
264-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jojima T |
Year: |
2019 |
Journal: |
Int J Mol Sci |
Title: |
The SGLT2 Inhibitor Canagliflozin Prevents Carcinogenesis in a Mouse Model of Diabetes and Non-Alcoholic Steatohepatitis-Related Hepatocarcinogenesis: Association with SGLT2 Expression in Hepatocellular Carcinoma. |
Volume: |
20 |
Issue: |
20 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
119
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
99
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
75
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
125
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
96
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
189
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
156
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
289
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
292
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
214
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
243
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
250
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
292
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
310
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
292
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
289
|
Fragment?: |
false |
|
•
•
•
•
•
|