Reprimo (RPRM) has been identified as a downstream effector of p53-induced cell cycle arrest at G2/M []. Overexpression of RPRM induces G2 arrest by inhibiting both Cdc2 activity and nuclear translocation of the Cdc2-cyclin B1 complex. RPRM promoter methylation has been reported in several tumours [, , ].
This entry includes Reprimo and Reprimo-like proteins. Reprimo (RPRM) has been identified as a downstream effector of p53-induced cell cycle arrest at G2/M [, ]. Overexpression of RPRM induces G2 arrest by inhibiting both Cdc2 activity and nuclear translocation of the Cdc2-cyclin B1 complex. RPRM promoter methylation has been reported in several tumours [, , ].The function of reprimo-like protein is not known. It is a paralogue of Reprimo, a downstream effector of p53-induced cell cycle arrest at G2/M [, ].
