Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Drees B |
Year: |
1995 |
Journal: |
J Cell Biol |
Title: |
Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions. |
Volume: |
128 |
Issue: |
3 |
Pages: |
383-92 |
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DO Term |
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DO Term |
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Allele |
Name: |
transgene insertion 1, David F Wieczorek |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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Publication |
First Author: |
Schevzov G |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Divergent regulation of the sarcomere and the cytoskeleton. |
Volume: |
283 |
Issue: |
1 |
Pages: |
275-83 |
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•
•
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•
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Publication |
First Author: |
Mamidi R |
Year: |
2013 |
Journal: |
J Physiol |
Title: |
Identification of two new regions in the N-terminus of cardiac troponin T that have divergent effects on cardiac contractile function. |
Volume: |
591 |
Issue: |
5 |
Pages: |
1217-34 |
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Publication |
First Author: |
MacGowan GA |
Year: |
2001 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Compensatory changes in Ca(2+) and myocardial O(2) consumption in beta-tropomyosin transgenic hearts. |
Volume: |
281 |
Issue: |
6 |
Pages: |
H2539-48 |
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Publication |
First Author: |
Muthuchamy M |
Year: |
1998 |
Journal: |
J Mol Cell Cardiol |
Title: |
Beta-tropomyosin overexpression induces severe cardiac abnormalities. |
Volume: |
30 |
Issue: |
8 |
Pages: |
1545-57 |
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•
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•
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Publication |
First Author: |
Sussman MA |
Year: |
1998 |
Journal: |
Science |
Title: |
Prevention of cardiac hypertrophy in mice by calcineurin inhibition. |
Volume: |
281 |
Issue: |
5383 |
Pages: |
1690-3 |
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•
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•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
285
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
245
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
287
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
105
|
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
281
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
247
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
52
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
245
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
157
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
71
|
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
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Publication |
First Author: |
MacLeod AR |
Year: |
1987 |
Journal: |
Bioessays |
Title: |
Genetic origin of diversity of human cytoskeletal tropomyosins. |
Volume: |
6 |
Issue: |
5 |
Pages: |
208-12 |
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•
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Publication |
First Author: |
Lewis WG |
Year: |
1980 |
Journal: |
J Biol Chem |
Title: |
The amino acid sequence of rabbit cardiac tropomyosin. |
Volume: |
255 |
Issue: |
14 |
Pages: |
6854-9 |
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Publication |
First Author: |
Wolska BM |
Year: |
2003 |
Journal: |
Pflugers Arch |
Title: |
The role of tropomyosin in the regulation of myocardial contraction and relaxation. |
Volume: |
446 |
Issue: |
1 |
Pages: |
1-8 |
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Protein Domain |
Type: |
Family |
Description: |
Tropomyosins [], are a family of closely related proteins present in muscle and non-muscle cells. In striated muscle, tropomyosin mediate the interactions between the troponin complex and actin so as to regulate muscle contraction []. The role of tropomyosin in smooth muscle and non-muscle tissues is not clear. Tropomyosin is an α-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites []. There are multiple cell-specific isoforms, created by differential splicing of the messenger RNA from one gene, but the proportions of the isoforms vary between different cell types. Muscle isoforms of tropomyosin are characterised by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.This entry represents tropomyosin (Tmp) 1, 2 and 3. Within the yeast Tmp1 and Tmp2, biochemical and sequence analyses indicate that Tpm2 spans four actin monomers along a filament, whereas Tpm1 spans five. Despite its shorter length, Tpm2 can compete with Tpm1 for binding to F-actin. Over-expression of Tpm2 in vivo alters the axial budding of haploids to a bipolar pattern, and this can be partially suppressed by co-over-expression of Tpm1. This suggests distinct functions for the two tropomyosins, and indicates that the ratio between them is important for correct morphogenesis []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
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Fragment?: |
false |
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•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
326
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
285
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
|
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
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•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
248
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Fragment?: |
false |
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•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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