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Search results 501 to 600 out of 609 for Epha2

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Type Details Score
Publication
25073978 | J:216216
First Author: Agrawal P
Year: 2014
Journal: Dev Dyn
Title: Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.
Volume: 243
Issue: 11
Pages: 1470-6
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Publication
17304517 | J:119722
First Author: Shaut CA
Year: 2007
Journal: Dev Dyn
Title: HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia.
Volume: 236
Issue: 4
Pages: 951-60
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Publication
8967950 | J:37450
First Author: Studer M
Year: 1996
Journal: Nature
Title: Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1.
Volume: 384
Issue: 6610
Pages: 630-4
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Publication
26644518 | J:230727
First Author: Stark DA
Year: 2015
Journal: J Cell Biol
Title: Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation.
Volume: 211
Issue: 5
Pages: 1077-91
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Publication
15145949 | J:91751
First Author: Aoki M
Year: 2004
Journal: J Biol Chem
Title: EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway.
Volume: 279
Issue: 31
Pages: 32643-50
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Publication
16547242 | J:129912
First Author: Freywald A
Year: 2006
Journal: J Immunol
Title: EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.
Volume: 176
Issue: 7
Pages: 4066-74
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Publication
11403717 | J:69086
First Author: Bovenkamp DE
Year: 2001
Journal: DNA Cell Biol
Title: Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.
Volume: 20
Issue: 4
Pages: 203-13
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Publication
9256343 | J:42028
First Author: Seitanidou T
Year: 1997
Journal: Mech Dev
Title: Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain.
Volume: 65
Issue: 1-2
Pages: 31-42
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Publication
15517401 | J:95080
First Author: Luukko K
Year: 2005
Journal: Cell Tissue Res
Title: Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues.
Volume: 319
Issue: 1
Pages: 143-52
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Publication
1281307 | J:3319
First Author: Gilardi-Hebenstreit P
Year: 1992
Journal: Oncogene
Title: An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.
Volume: 7
Issue: 12
Pages: 2499-506
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Publication
7737295 | J:24486
First Author: Birkeland ML
Year: 1995
Journal: Eur J Immunol
Title: Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein.
Volume: 25
Issue: 4
Pages: 926-30
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Publication
11157778 | J:67399
First Author: Abu-Abed S
Year: 2001
Journal: Genes Dev
Title: The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures.
Volume: 15
Issue: 2
Pages: 226-40
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Publication
24550361 | J:229511
First Author: Son AI
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice.
Volume: 55
Issue: 3
Pages: 1594-606
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Publication
11222144 | J:67679
First Author: Knöll B
Year: 2001
Journal: Development
Title: A role for the EphA family in the topographic targeting of vomeronasal axons.
Volume: 128
Issue: 6
Pages: 895-906
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Publication
16481423 | J:105744
First Author: Tsai HH
Year: 2006
Journal: J Neurosci
Title: Netrin-1 is required for the normal development of spinal cord oligodendrocytes.
Volume: 26
Issue: 7
Pages: 1913-22
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Publication
7890684 | J:23764
First Author: Shao H
Year: 1995
Journal: J Biol Chem
Title: Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase.
Volume: 270
Issue: 10
Pages: 5636-41
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10323857 | J:55048
First Author: Gale NW
Year: 1999
Journal: Genes Dev
Title: Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.
Volume: 13
Issue: 9
Pages: 1055-66
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Publication
12528186 | J:81281
First Author: Yun ME
Year: 2003
Journal: J Comp Neurol
Title: EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.
Volume: 456
Issue: 3
Pages: 203-16
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Publication
17039519 | J:116642
First Author: Fujii H
Year: 2006
Journal: Dev Dyn
Title: Eph-ephrin A system regulates murine blastocyst attachment and spreading.
Volume: 235
Issue: 12
Pages: 3250-8
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Publication
21465626 | J:171618
First Author: Saeger BM
Year: 2011
Journal: Dev Dyn
Title: Ephrin/ephrin receptor expression during early stages of mouse inner ear development.
Volume: 240
Issue: 6
Pages: 1578-85
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Publication
21436445 | J:169836
First Author: Lachke SA
Year: 2011
Journal: Science
Title: Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.
Volume: 331
Issue: 6024
Pages: 1571-6
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Publication
10654602 | J:53473
First Author: Niederreither K
Year: 2000
Journal: Development
Title: Retinoic acid synthesis and hindbrain patterning in the mouse embryo.
Volume: 127
Issue: 1
Pages: 75-85
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Publication
12702665 | J:82804
First Author: Niederreither K
Year: 2003
Journal: Development
Title: The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system.
Volume: 130
Issue: 11
Pages: 2525-34
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Publication
9267020 | J:42086
 
Year: 1997
Journal: Cell
Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.
Volume: 90
Issue: 3
Pages: 403-4
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Publication
12684176 | J:83513
First Author: Pickles JO
Year: 2003
Journal: Hear Res
Title: Expression of Ephs and ephrins in developing mouse inner ear.
Volume: 178
Issue: 1-2
Pages: 44-51
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Publication
20112066 | J:162837
First Author: Islam S
Year: 2010
Journal: Dig Dis Sci
Title: Developmental expression of Eph and ephrin family genes in mammalian small intestine.
Volume: 55
Issue: 9
Pages: 2478-88
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Publication
7893599 | J:22208
First Author: Ruiz JC
Year: 1994
Journal: Mech Dev
Title: Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.
Volume: 48
Issue: 3
Pages: 153-64
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Publication
23906066 | J:199282
First Author: Günschmann C
Year: 2013
Journal: Dev Cell
Title: Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.
Volume: 26
Issue: 2
Pages: 176-87
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Publication
34518365 | J:312458
 
First Author: Kisseleff E
Year: 2021
Journal: eNeuro
Title: Glycogen Synthase Kinase 3 Regulates the Genesis of Displaced Retinal Ganglion Cells3.
Volume: 8
Issue: 5
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Publication
30254164 | J:266434
First Author: Hong SH
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.
Volume: 115
Issue: 41
Pages: 10381-10386
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Publication
25480914 | J:217584
First Author: Gerstmann K
Year: 2015
Journal: Development
Title: Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions.
Volume: 142
Issue: 1
Pages: 140-50
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Publication
19542359 | J:150346
First Author: North HA
Year: 2009
Journal: Development
Title: Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.
Volume: 136
Issue: 14
Pages: 2467-76
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Publication
15254900 | J:91730
First Author: Verma-Kurvari S
Year: 2004
Journal: Dev Dyn
Title: Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.
Volume: 230
Issue: 4
Pages: 660-5
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Publication
16446123 | J:105961
First Author: van Eyll JM
Year: 2006
Journal: Gene Expr Patterns
Title: Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.
Volume: 6
Issue: 4
Pages: 353-9
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Publication
11423996 | J:70201
First Author: Kannan K
Year: 2001
Journal: Oncogene
Title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.
Volume: 20
Issue: 26
Pages: 3449-55
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Publication
19769959 | J:154920
First Author: Zirzow S
Year: 2009
Journal: Dev Biol
Title: Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse.
Volume: 336
Issue: 2
Pages: 145-55
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Publication
11439183 | J:70266
First Author: Graef IA
Year: 2001
Journal: Cell
Title: Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.
Volume: 105
Issue: 7
Pages: 863-75
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Publication
14660441 | J:87048
First Author: Gu G
Year: 2004
Journal: Development
Title: Global expression analysis of gene regulatory pathways during endocrine pancreatic development.
Volume: 131
Issue: 1
Pages: 165-79
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Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE181358 | Mutation of the EPHA2 tyrosine-kinase domain dysregulates cell pattern formation and cytoskeletal gene expression in the lens
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
18794797 | J:155186
First Author: Wykosky J
Year: 2008
Journal: Oncogene
Title: Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor.
Volume: 27
Issue: 58
Pages: 7260-73
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Publication
30501625 | J:317235
First Author: De Robertis M
Year: 2018
Journal: Mol Cancer
Title: EphB2 stem-related and EphA2 progression-related miRNA-based networks in progressive stages of CRC evolution: clinical significance and potential miRNA drivers.
Volume: 17
Issue: 1
Pages: 169
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Publication
21516087 | J:171575
First Author: Lupberger J
Year: 2011
Journal: Nat Med
Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
Volume: 17
Issue: 5
Pages: 589-95
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Allele
Epha2<Gt(KST085)Byg> | MGI:3688255
Name: Eph receptor A2; gene trap KST085, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Publication
21142802 | -
First Author: Tandon M
Year: 2011
Journal: Expert Opin Ther Targets
Title: Emerging strategies for EphA2 receptor targeting for cancer therapeutics.
Volume: 15
Issue: 1
Pages: 31-51
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Publication
12651595 | -
First Author: Walker-Daniels J
Year: 2003
Journal: Am J Pathol
Title: Differential regulation of EphA2 in normal and malignant cells.
Volume: 162
Issue: 4
Pages: 1037-42
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Publication
20679435 | -
First Author: Hiramoto-Yamaki N
Year: 2010
Journal: J Cell Biol
Title: Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.
Volume: 190
Issue: 3
Pages: 461-77
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Publication
19074825 | -
First Author: Wykosky J
Year: 2008
Journal: Mol Cancer Res
Title: The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting.
Volume: 6
Issue: 12
Pages: 1795-806
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Publication
21621533 | -
First Author: Harada K
Year: 2011
Journal: Exp Cell Res
Title: Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase.
Volume: 317
Issue: 12
Pages: 1701-13
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Genotype
Genotype
Symbol: Epha2/Epha2
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110229 | cataract 6 multiple types
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Publication
16236711 | -
First Author: Tanaka M
Year: 2005
Journal: J Biol Chem
Title: EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability.
Volume: 280
Issue: 51
Pages: 42375-82
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Publication
20197042 | -
First Author: Bocharov EV
Year: 2010
Journal: Biophys J
Title: Left-handed dimer of EphA2 transmembrane domain: Helix packing diversity among receptor tyrosine kinases.
Volume: 98
Issue: 5
Pages: 881-9
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Publication
19525919 | -
First Author: Himanen JP
Year: 2009
Journal: EMBO Rep
Title: Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Volume: 10
Issue: 7
Pages: 722-8
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Publication
22094251 | J:178956
First Author: Mansour MR
Year: 2011
Journal: Cancer Cell
Title: Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma.
Volume: 20
Issue: 5
Pages: 559-61
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Publication
19306875 | J:147984
First Author: Takeuchi S
Year: 2009
Journal: FEBS Lett
Title: Beta2-chimaerin binds to EphA receptors and regulates cell migration.
Volume: 583
Issue: 8
Pages: 1237-42
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Publication
15133129 | -
First Author: Ellerbroek SM
Year: 2004
Journal: Mol Biol Cell
Title: SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.
Volume: 15
Issue: 7
Pages: 3309-19
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Publication
25063526 | J:218482
First Author: Lee J
Year: 2014
Journal: Biochim Biophys Acta
Title: Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation.
Volume: 1843
Issue: 11
Pages: 2438-47
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Protein Domain
IPR034263 | EphA2_rcpt_lig-bd
Type: Domain
Description: This entry represents the ligand-binding domain found in ephrin type-A receptor 2 (EphA2). EphA2 negatively regulates cell differentiation and has been shown to be overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression [, , ]. Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands [, ]. Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) [].
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Protein Domain
IPR035797 | ARHGEF16/ARHGEF26_SH3
Type: Domain
Description: ARHGEF16, also called ephexin-4, acts as a guanine nucleotide exchange factor (GEF) for RhoG, activating it by exchanging bound GDP for free GTP. RhoG is a small GTPase that is a crucial regulator of Rac in migrating cells. ARHGEF16 interacts directly with the ephrin receptor EphA2 and mediates cell migration and invasion in breast cancer cells by activating RhoG [, ]. ARHGEF26, also called SGEF (SH3 domain-containing GEF), also activates RhoG. It is highly expressed in liver and may play a role in regulating membrane dynamics []. ARHGEF16 and ARHGEF26 contain RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology(PH), and SH3 domains. The SH3 domains of ARHGEFs play an autoinhibitory role through intramolecular interactions with a proline-rich region N-terminal to the DH domain. The SH3 domain of ARHGEF16 also binds to Elmo, and this interaction may relieve the self-inhibitory state ofARHGEF16 [].This entry represents the SH3 domains of ARHGEF16 and ARHGEF26.
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Publication
27619642 | J:242097
 
First Author: Lee H
Year: 2016
Journal: Nat Commun
Title: Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis.
Volume: 7
Pages: 12799
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Publication
20154726 | J:168266
First Author: Zhang W
Year: 2010
Journal: Oncogene
Title: A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Volume: 29
Issue: 17
Pages: 2467-76
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