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Search results 701 to 756 out of 756 for Abl1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Strain
MGI:4361736 | B6.Cg-Tg(ACTB-Abl1*I)1Spg/J
Attribute String: transgenic, mutant strain, congenic
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Strain
MGI:6145075 | B6.Cg-Tg(Tec-BCR/ABL1)1Hhi/HomyRbrc
Attribute String: mutant strain, congenic, transgenic
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Allele
Tg(ACTB-Abl1*K290R)1Spg | MGI:4361573
Name: transgene insertion 1, Stephen P Goff
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
19903482 | J:155307
First Author: Baruzzi A
Year: 2010
Journal: FEBS Lett
Title: c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.
Volume: 584
Issue: 1
Pages: 15-21
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Publication
19620960 | J:151543
First Author: Sanada M
Year: 2009
Journal: Nature
Title: Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Volume: 460
Issue: 7257
Pages: 904-8
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Publication
21848808 | J:309066
First Author: Seo S
Year: 2011
Journal: Cancer Sci
Title: Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl.
Volume: 102
Issue: 12
Pages: 2109-17
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Publication
11489947 | J:95640
First Author: Di Cristofano A
Year: 2001
Journal: J Exp Med
Title: p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl).
Volume: 194
Issue: 3
Pages: 275-84
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Genotype
Genotype
Symbol: Dok1/Dok1 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok2/Dok2 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok1/Dok1<+> Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok2/Dok2<+> Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok1/Dok1 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok2/Dok2 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cbl/Cbl<+> Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cbl/Cbl Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abl1/Abl1 Tg(ACTB-Abl1*I)1Spg/?
Background: involves: 129S/SvEv * C57BL/6J * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abl1/Abl1 Tg(ACTB-Abl1*IV)1Spg/?
Background: involves: 129S/SvEv * C57BL/6J * CBA
Zygosity: cx
Has Mutant Allele: true
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Publication
37165001 | J:335559
First Author: Hiroki H
Year: 2023
Journal: Sci Rep
Title: Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells.
Volume: 13
Issue: 1
Pages: 7588
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Publication
10666183 | J:60817
First Author: Honda H
Year: 2000
Journal: Blood
Title: Acquired loss of p53 induces blastic transformation in p210(bcr/abl)-expressing hematopoietic cells: a transgenic study for blast crisis of human CML.
Volume: 95
Issue: 4
Pages: 1144-50
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Publication
15611294 | J:95335
First Author: Yasuda T
Year: 2004
Journal: J Exp Med
Title: Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.
Volume: 200
Issue: 12
Pages: 1681-7
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Genotype
Genotype
Symbol: Dok1/Dok1 Dok2/Dok2 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abl1/Abl1 Tg(ACTB-Abl1*K290R)1Spg/?
Background: involves: 129S/SvEv * C57BL/6J * CBA
Zygosity: cx
Has Mutant Allele: true
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Publication
16109371 | -
First Author: Hantschel O
Year: 2005
Journal: Mol Cell
Title: Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl.
Volume: 19
Issue: 4
Pages: 461-73
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Publication
9037071 | J:38602
First Author: Yuan ZM
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.
Volume: 94
Issue: 4
Pages: 1437-40
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Protein Domain
IPR015015 | F-actin-binding
Type: Domain
Description: The F-actin binding domain forms a compact bundle of four antiparallel α-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function []. Proteins containing this domain include tyrosine-protein kinases Abl1, which is a non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis [, ]. Abl1 is linked to different forms of leukemia in humans.
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Publication
10640270 | J:95641
First Author: Yamanashi Y
Year: 2000
Journal: Genes Dev
Title: Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.
Volume: 14
Issue: 1
Pages: 11-6
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Publication
9490692 | J:46392
First Author: Honda H
Year: 1998
Journal: Blood
Title: Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias.
Volume: 91
Issue: 6
Pages: 2067-75
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Publication
36010887 | J:327859
 
First Author: Gómez C
Year: 2022
Journal: Cancers (Basel)
Title: Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia.
Volume: 14
Issue: 16
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Genotype
Genotype
Symbol: Abl1/Abl1 Tg(ACTB-Abl1*I)1Spg/? Tg(ACTB-Abl1*IV)1Spg/?
Background: involves: 129S/SvEv * C57BL/6J * CBA
Zygosity: cx
Has Mutant Allele: true
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Publication
33848469 | J:307052
First Author: Ibrayeva A
Year: 2021
Journal: Cell Stem Cell
Title: Early stem cell aging in the mature brain.
Volume: 28
Issue: 5
Pages: 955-966.e7
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Publication
22307624 | J:182036
First Author: Drake JM
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.
Volume: 109
Issue: 5
Pages: 1643-8
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Publication
36542718 | J:340442
First Author: Luan Y
Year: 2022
Journal: Sci Adv
Title: TAp63 determines the fate of oocytes against DNA damage.
Volume: 8
Issue: 51
Pages: eade1846
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Publication
30107177 | J:264234
First Author: Vanden Bempt M
Year: 2018
Journal: Cancer Cell
Title: Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.
Volume: 34
Issue: 2
Pages: 271-285.e7
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Publication
24747972 | J:216528
First Author: Sato T
Year: 2014
Journal: Oncogene
Title: Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Volume: 33
Issue: 42
Pages: 5028-38
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Publication
31622281 | J:285270
 
First Author: Yin M
Year: 2019
Journal: JCI Insight
Title: A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.
Volume: 4
Issue: 23
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Publication
33402532 | J:299612
 
First Author: Rodríguez de Los Santos M
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions.
Volume: 118
Issue: 2
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Publication
24600045 | J:315944
First Author: Ma XM
Year: 2014
Journal: Mol Biol Cell
Title: Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.
Volume: 25
Issue: 9
Pages: 1458-71
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Publication
31681772 | J:290180
 
First Author: Lu Y
Year: 2019
Journal: Front Cell Dev Biol
Title: A cAbl-MRTF-A Feedback Loop Contributes to Hepatic Stellate Cell Activation.
Volume: 7
Pages: 243
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Publication
25111230 | J:216058
First Author: Bi Y
Year: 2014
Journal: Am J Pathol
Title: Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth.
Volume: 184
Issue: 10
Pages: 2791-802
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Protein Domain
IPR035837 | ABL_SH2
Type: Domain
Description: ABL-family proteins are highly conserved tyrosine kinases. Each ABL protein contains an SH3-SH2-TK (Src homology 3-Src homology 2-tyrosine kinase) domain cassette, which confers autoregulated kinase activity and is common among nonreceptor tyrosine kinases. Several types of posttranslational modifications control ABL catalytic activity, subcellular localization, and stability, with consequences for both cytoplasmic and nuclear ABL functions. Binding partners provide additional regulation of ABL catalytic activity, substrate specificity, and downstream signaling. By combining this cassette with actin-binding and -bundling domains, ABL proteins are capable of connecting phosphoregulation with actin-filament reorganization []. Vertebrate paralogs, ABL1 and ABL2, have evolved to perform specialized functions. ABL1 includes nuclear localization signals and a DNA binding domain which is used to mediate DNA damage-repair functions, while ABL2 has additional binding capacity for actin and for microtubules to enhance its cytoskeletal remodeling functions. SH2 is involved in several autoinhibitory mechanism that constrain the enzymatic activity of the ABL-family kinases. In one mechanism SH2 and SH3 cradle the kinase domain while a cap sequence stabilizes the inactive conformation resulting in a locked inactive state. Another involves phosphatidylinositol 4,5-bisphosphate (PIP2) which binds the SH2 domain through residues normally required for phosphotyrosine binding in the linker segment between the SH2 and kinase domains. The SH2 domain contributes to ABL catalytic activity and target site specificity. It is thought that the ABL catalytic site and SH2 pocket have co-evolved to recognize the same sequences. Recent work now supports a hierarchical processivity model in which the substrate target site most compatible with ABL kinase domain preferences is phosphorylated with greatest efficiency. If this site is compatible with the ABL SH2 domain specificity, it will then reposition and dock in the SH2 pocket. This mechanism also explains how ABL kinases phosphorylates poor targets on the same substrate if they are properly positioned and how relatively poor substrate proteins might be recruited to ABL through a complex with strong substrates that can also dock with the SH2 pocket [].This entry includes the SH2 domain of ABL-family proteins. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , , ].
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Publication
9241420 | -
 
First Author: Kuriyan J
Year: 1997
Journal: Annu Rev Biophys Biomol Struct
Title: Modular peptide recognition domains in eukaryotic signaling.
Volume: 26
Pages: 259-88
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Publication
10398925 | -
First Author: Grucza RA
Year: 1999
Journal: Med Res Rev
Title: SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.
Volume: 19
Issue: 4
Pages: 273-93
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Protein
A0A087WQB7
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: true
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Publication
19273114 | -
 
First Author: Kasembeli MM
Year: 2009
Journal: Front Biosci (Landmark Ed)
Title: SH2 domain binding to phosphopeptide ligands: potential for drug targeting.
Volume: 14
Pages: 1010-22
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Protein
Q4JIM5
Organism: Mus musculus/domesticus
Length: 1182  
Fragment?: false
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Protein
F8VQH0
Organism: Mus musculus/domesticus
Length: 1182  
Fragment?: false
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Protein
B7ZMZ2
Organism: Mus musculus/domesticus
Length: 1078  
Fragment?: false
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Protein
B2RQ57
Organism: Mus musculus/domesticus
Length: 1078  
Fragment?: false
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Publication
19926274 | -
First Author: Filippakopoulos P
Year: 2009
Journal: Curr Opin Struct Biol
Title: SH2 domains: modulators of nonreceptor tyrosine kinase activity.
Volume: 19
Issue: 6
Pages: 643-9
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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