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Search results 101 to 135 out of 135 for Cd84

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Type Details Score
Allele
Cd84<tm1Pls> | MGI:4438772
Name: CD84 antigen; targeted mutation 1, Pamela L Schwartzberg
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cd84<tm1b(KOMP)Mbp> | MGI:5515779
Name: CD84 antigen; targeted mutation 1b, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cd84<em1Gpt> | MGI:7296626
Name: CD84 antigen; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Cd84<em2Gpt> | MGI:7296627
Name: CD84 antigen; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cd84<tm1a(KOMP)Mbp> | MGI:4888788
Name: CD84 antigen; targeted mutation 1a, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Genotype
Genotype
Symbol: Cd84/Cd84
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein
Q18PI6
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
Q18PI6-2
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
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Protein
Q18PI6-3
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Strain
MGI:4439056 | C57BL/6J-Cd84<tm1Pls>
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:5529318 | B6N(Cg)-Cd84<tm1b(KOMP)Mbp>/J
Attribute String: mutant strain, targeted mutation
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Strain
MGI:5510505 | C57BL/6N-Cd84<tm1a(KOMP)Mbp>/J
Attribute String: mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Cd84/Cd84
Background: C57BL/6J-Cd84
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd84/Cd84
Background: B6N(Cg)-Cd84/J
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:4439080 | B6.Cg-Cd84<tm1Pls> Tg(TcraTcrb)425Cbn
Attribute String: transgenic, targeted mutation, mutant strain, congenic
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Strain
MGI:6343957 | C57BL/6N-A<tm1Brd> Cd84<tm1b(KOMP)Mbp>/JMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6343956 | C57BL/6N-A<tm1Brd> Cd84<tm1a(KOMP)Mbp>/JMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Cd84/Cd84 Tg(TcraTcrb)425Cbn/?
Background: B6.Cg-Cd84 Tg(TcraTcrb)425Cbn
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd84/Cd84<+>
Background: B6N(Cg)-Cd84/J
Zygosity: ht
Has Mutant Allele: true
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Publication
9774102 | J:50127
First Author: Sayos J
Year: 1998
Journal: Nature
Title: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.
Volume: 395
Issue: 6701
Pages: 462-9
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Publication
11689425 | -
First Author: Morra M
Year: 2001
Journal: EMBO J
Title: Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
Volume: 20
Issue: 21
Pages: 5840-52
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Publication
21219180 | -
 
First Author: Cannons JL
Year: 2011
Journal: Annu Rev Immunol
Title: SLAM family receptors and SAP adaptors in immunity.
Volume: 29
Pages: 665-705
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Publication
11823424 | -
First Author: Hwang PM
Year: 2002
Journal: EMBO J
Title: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
Volume: 21
Issue: 3
Pages: 314-23
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Publication
10549287 | -
First Author: Poy F
Year: 1999
Journal: Mol Cell
Title: Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Volume: 4
Issue: 4
Pages: 555-61
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Protein Domain
IPR035049 | EAT2_SH2
Type: Domain
Description: This entry represents the SH2 domain of EAT-2 (EWS-Fli1-activated transcript-2) and ERT (EAT-2-related transducer).The X-linked lymphoproliferative syndrome (XLP) gene encodes SAP (also called SH2D1A/DSHP) a protein that consists of a 5 residue N terminus, a single SH2 domain, and a short 25 residue C-terminal tail []. XLP is characterized by an extreme sensitivity to Epstein-Barr virus. Both T and natural killer (NK) cell dysfunctions have been seen in XLP patients. SAP binds the cytoplasmic tail of Signaling lymphocytic activation molecule (SLAM), 2B4, Ly-9, and CD84 []. SAP is believed to function as a signaling inhibitor, by blocking or regulating binding of other signaling proteins. SAP and the SAP-like protein EAT-2 recognize the sequence motif TIpYXX[VI], which is found in the cytoplasmic domains of a restricted number of T, B, and NK cell surface receptors and are proposed to be natural inhibitors or regulators of the physiological role of a small family of receptors on the surface of these cells [, ]. EAT-2 (also known as SH2 domain-containing protein 1B or SH2D1B) and ERT (also known as SH2 domain-containing protein 1C or SH2D1C), similar to SAP, are composed of a single SH2 domain and a short C terminus. They share approximately 50% amino acid identity with SAP [].
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Publication
12242590 | J:79900
First Author: Tovar V
Year: 2002
Journal: Immunogenetics
Title: Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors.
Volume: 54
Issue: 6
Pages: 394-402
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Publication
29337666 | J:254913
   
First Author: Burbage M
Year: 2018
Journal: Elife
Title: Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity.
Volume: 7
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Publication
17187680 | J:124150
 
First Author: Jabba SV
Year: 2006
Journal: BMC Med
Title: Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model.
Volume: 4
Pages: 37
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Protein
Q45HK4
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
O35324
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
Q149T1
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
B7ZWB7
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
M0QWP8
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: false
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Protein
Q45GR7
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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