This entry represents a domain found in the OS9 protein, which is a lectin that functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD) []. The sequences of this domainare similar to a region found in the beta-subunit of glucosidase II (), which is also known as protein kinase C substrate 80K-H (PRKCSH).
OS9 is conserved among eukaryotes and shows similarities with mannose-6-phosphate receptors (MPRs). Proteins in this family are lectins that functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD) [, ]. Proteins in this entry also include endoplasmic reticulum lectin 1 (ERLEC1, also known as XTP3-B), which may function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins [, ].
