|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 318 for Zap70

0.019s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
First Author: Pobezinsky LA
Year: 2012
Journal: Nat Immunol
Title: Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.
Volume: 13
Issue: 6
Pages: 569-78
Publication
First Author: Hata H
Year: 2004
Journal: J Clin Invest
Title: Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice.
Volume: 114
Issue: 4
Pages: 582-8
Publication
First Author: Park JH
Year: 2010
Journal: Nat Immunol
Title: Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.
Volume: 11
Issue: 3
Pages: 257-64
Publication
First Author: Hirota K
Year: 2007
Journal: J Exp Med
Title: T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.
Volume: 204
Issue: 1
Pages: 41-7
Publication
First Author: Luo H
Year: 2004
Journal: J Clin Invest
Title: EphB6-null mutation results in compromised T cell function.
Volume: 114
Issue: 12
Pages: 1762-73
Publication
First Author: Lesourne R
Year: 2012
Journal: J Immunol
Title: Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
Volume: 189
Issue: 3
Pages: 1154-61
Publication
First Author: Wiest DL
Year: 1997
Journal: Immunity
Title: A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.
Volume: 6
Issue: 6
Pages: 663-71
Publication
First Author: Hikosaka Y
Year: 2008
Journal: Immunity
Title: The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Volume: 29
Issue: 3
Pages: 438-50
Publication
First Author: Casey SC
Year: 2012
Journal: Mol Endocrinol
Title: The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.
Volume: 26
Issue: 6
Pages: 916-25
Publication
First Author: Tamehiro N
Year: 2015
Journal: PLoS One
Title: Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
Volume: 10
Issue: 6
Pages: e0131047
Publication
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
Publication      
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
Publication
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
UniProt Feature
Begin: 323
Description: Phosphotyrosine; by ZAP70
Type: modified residue
End: 323
UniProt Feature
Begin: 323
Description: Phosphotyrosine; by ZAP70
Type: modified residue
End: 323
Publication
First Author: Sadras T
Year: 2021
Journal: Mol Cell
Title: Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Volume: 81
Issue: 10
Pages: 2094-2111.e9
Allele
Name: zeta-chain (TCR) associated protein kinase; targeted mutation 3.1, Arthur Weiss
Allele Type: Targeted
Attribute String: Hypomorph
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Bekeredjian-Ding I
Year: 2008
Journal: J Immunol
Title: TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells.
Volume: 181
Issue: 12
Pages: 8267-77
DO Term
Publication  
First Author: Damen H
Year: 2022
Journal: Front Immunol
Title: Negative Regulation of Zap70 by Lck Forms the Mechanistic Basis of Differential Expression in CD4 and CD8 T Cells.
Volume: 13
Pages: 935367
Publication
First Author: Liu X
Year: 2003
Journal: J Exp Med
Title: Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection.
Volume: 197
Issue: 3
Pages: 363-73
Interaction Experiment
Description: Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKC Kinase Activity.
Allele
Name: transgene insertion 824, Shimon Sakaguchi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: zeta-chain (TCR) associated protein kinase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Naik E
Year: 2016
Journal: J Immunol
Title: Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.
Volume: 196
Issue: 8
Pages: 3438-51
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: zeta-chain (TCR) associated protein kinase; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
Allele  
Name: zeta-chain (TCR) associated protein kinase; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: transgene insertion 1, Andrew C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1, Andrew C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 2, Andrew C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: spleen tyrosine kinase; targeted mutation 2.1, Friedemann Kiefer
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Genotype
Symbol: Zap70/Zap70
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Königsberger S
Year: 2012
Journal: EMBO J
Title: Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state.
Volume: 31
Issue: 15
Pages: 3363-74
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Allele
Name: zeta-chain (TCR) associated protein kinase; mutation 8, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
Strain
Attribute String: mutant strain, coisogenic, chemically induced mutation
Genotype
Symbol: Syk/Syk
Background: B6.129-Syk
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Zap70/Zap70
Background: C57BL/6J-Zap70
Zygosity: hm
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Genotype
Symbol: Zap70/Zap70 Tg(Lck-ZAP70)824Saka/?
Background: involves: 129P2/OlaHsd * BALB/c
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Dorn T
Year: 2007
Journal: Blood
Title: RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Volume: 109
Issue: 6
Pages: 2346-55
Publication
First Author: Hope JL
Year: 2023
Journal: Cell Rep
Title: PSGL-1 attenuates early TCR signaling to suppress CD8(+) T cell progenitor differentiation and elicit terminal CD8(+) T cell exhaustion.
Volume: 42
Issue: 5
Pages: 112436
Publication
First Author: McGargill MA
Year: 2005
Journal: J Immunol
Title: Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling.
Volume: 175
Issue: 2
Pages: 656-64
Publication  
First Author: Märklin M
Year: 2020
Journal: Cell Immunol
Title: Genetic loss of NFAT2 (NFATc1) impairs B cell development of B1 and B2 B cells.
Volume: 349
Pages: 104048
Publication
First Author: Lee JM
Year: 2004
Journal: J Immunol
Title: IL-15Ralpha is a negative regulator of TCR-activated proliferation in CD4+ T cells.
Volume: 173
Issue: 5
Pages: 3155-64
Publication  
First Author: Cao W
Year: 2016
Journal: Nat Commun
Title: CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Volume: 7
Pages: 11687
Publication
First Author: Jiao A
Year: 2022
Journal: Sci Adv
Title: DExD/H-box helicase 9 intrinsically controls CD8+ T cell-mediated antiviral response through noncanonical mechanisms.
Volume: 8
Issue: 6
Pages: eabk2691
Publication
First Author: Klammt C
Year: 2015
Journal: Nat Immunol
Title: T cell receptor dwell times control the kinase activity of Zap70.
Volume: 16
Issue: 9
Pages: 961-9
Publication
First Author: Deng S
Year: 2024
Journal: Cell
Title: ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion.
Volume: 187
Issue: 9
Pages: 2305-2323.e33
Publication
First Author: Round JL
Year: 2007
Journal: Nat Immunol
Title: Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
Volume: 8
Issue: 2
Pages: 154-61
Publication
First Author: Courtney AH
Year: 2017
Journal: Mol Cell
Title: A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
Volume: 67
Issue: 3
Pages: 498-511.e6
Publication
First Author: Königsberger S
Year: 2015
Journal: Eur J Immunol
Title: Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms.
Volume: 45
Issue: 2
Pages: 603-11
Publication
First Author: Kim EY
Year: 2004
Journal: J Immunol
Title: Critical role of TNF receptor type-2 (p75) as a costimulator for IL-2 induction and T cell survival: a functional link to CD28.
Volume: 173
Issue: 7
Pages: 4500-9
Publication
First Author: Marquez ME
Year: 2005
Journal: J Immunol
Title: CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.
Volume: 175
Issue: 11
Pages: 7388-97
Publication
First Author: Bailey AR
Year: 2012
Journal: FASEB J
Title: Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-α: implications for autism.
Volume: 26
Issue: 3
Pages: 1040-51
Publication  
First Author: Liang W
Year: 2019
Journal: Mol Immunol
Title: Ablation of core fucosylation attenuates the signal transduction via T cell receptor to suppress the T cell development.
Volume: 112
Pages: 312-321
Publication
First Author: Leal-Sanchez J
Year: 2007
Journal: Cell Death Differ
Title: Requirement for Daxx in mature T-cell proliferation and activation.
Volume: 14
Issue: 4
Pages: 795-806
Publication
First Author: Troeger A
Year: 2013
Journal: J Biol Chem
Title: A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing.
Volume: 288
Issue: 51
Pages: 36451-62
Publication
First Author: Armstrong AJ
Year: 2010
Journal: J Immunol
Title: ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Volume: 184
Issue: 1
Pages: 173-83
Publication
First Author: Salojin K
Year: 1997
Journal: J Exp Med
Title: Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice.
Volume: 186
Issue: 6
Pages: 887-97
Publication
First Author: Haks MC
Year: 2002
Journal: J Exp Med
Title: Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.
Volume: 196
Issue: 1
Pages: 1-13
Publication
First Author: Herling M
Year: 2006
Journal: Leukemia
Title: TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state.
Volume: 20
Issue: 2
Pages: 280-5
Publication
First Author: Liu X
Year: 2005
Journal: J Immunol
Title: Analyzing expression of perforin, Runx3, and Thpok genes during positive selection reveals activation of CD8-differentiation programs by MHC II-signaled thymocytes.
Volume: 175
Issue: 7
Pages: 4465-74
Publication
First Author: Ambrogio C
Year: 2009
Journal: Cancer Res
Title: NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells.
Volume: 69
Issue: 22
Pages: 8611-9
Publication
First Author: Veronese A
Year: 2015
Journal: Leukemia
Title: Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia.
Volume: 29
Issue: 1
Pages: 86-95
Publication  
First Author: Moon S
Year: 2024
Journal: JCI Insight
Title: Flotillin-2 dampens T cell antigen sensitivity and functionality.
Volume: 9
Issue: 24
Publication
First Author: Law CL
Year: 1994
Journal: J Biol Chem
Title: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.
Volume: 269
Issue: 16
Pages: 12310-9
Publication
First Author: Taniguchi T
Year: 1991
Journal: J Biol Chem
Title: Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis.
Volume: 266
Issue: 24
Pages: 15790-6