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Search results 201 to 300 out of 308 for Zap70

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Type Details Score
Publication
First Author: Luo H
Year: 2004
Journal: J Clin Invest
Title: EphB6-null mutation results in compromised T cell function.
Volume: 114
Issue: 12
Pages: 1762-73
Publication
First Author: Lesourne R
Year: 2012
Journal: J Immunol
Title: Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
Volume: 189
Issue: 3
Pages: 1154-61
Publication
First Author: Wiest DL
Year: 1997
Journal: Immunity
Title: A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.
Volume: 6
Issue: 6
Pages: 663-71
Publication
First Author: Casey SC
Year: 2012
Journal: Mol Endocrinol
Title: The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.
Volume: 26
Issue: 6
Pages: 916-25
Publication
First Author: Hikosaka Y
Year: 2008
Journal: Immunity
Title: The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Volume: 29
Issue: 3
Pages: 438-50
Publication
First Author: Tamehiro N
Year: 2015
Journal: PLoS One
Title: Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
Volume: 10
Issue: 6
Pages: e0131047
Publication
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
Publication      
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
Publication
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication
First Author: Sadras T
Year: 2021
Journal: Mol Cell
Title: Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Volume: 81
Issue: 10
Pages: 2094-2111.e9
UniProt Feature
Begin: 323
Description: Phosphotyrosine; by ZAP70
Type: modified residue
End: 323
UniProt Feature
Begin: 323
Description: Phosphotyrosine; by ZAP70
Type: modified residue
End: 323
Allele
Name: zeta-chain (TCR) associated protein kinase; targeted mutation 3.1, Arthur Weiss
Allele Type: Targeted
Attribute String: Hypomorph
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Bekeredjian-Ding I
Year: 2008
Journal: J Immunol
Title: TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells.
Volume: 181
Issue: 12
Pages: 8267-77
DO Term
Publication  
First Author: Damen H
Year: 2022
Journal: Front Immunol
Title: Negative Regulation of Zap70 by Lck Forms the Mechanistic Basis of Differential Expression in CD4 and CD8 T Cells.
Volume: 13
Pages: 935367
Publication
First Author: Liu X
Year: 2003
Journal: J Exp Med
Title: Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection.
Volume: 197
Issue: 3
Pages: 363-73
Interaction Experiment
Description: Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKC Kinase Activity.
Allele
Name: zeta-chain (TCR) associated protein kinase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: transgene insertion 824, Shimon Sakaguchi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Naik E
Year: 2016
Journal: J Immunol
Title: Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.
Volume: 196
Issue: 8
Pages: 3438-51
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele  
Name: zeta-chain (TCR) associated protein kinase; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Allele
Name: transgene insertion 1, Andrew C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 2, Andrew C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1, Andrew C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: spleen tyrosine kinase; targeted mutation 2.1, Friedemann Kiefer
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Genotype
Symbol: Zap70/Zap70
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Allele
Name: zeta-chain (TCR) associated protein kinase; mutation 8, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
Strain
Attribute String: mutant strain, coisogenic, chemically induced mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Königsberger S
Year: 2012
Journal: EMBO J
Title: Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state.
Volume: 31
Issue: 15
Pages: 3363-74
Genotype
Symbol: Syk/Syk
Background: B6.129-Syk
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Zap70/Zap70
Background: C57BL/6J-Zap70
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Zap70/Zap70 Tg(Lck-ZAP70)824Saka/?
Background: involves: 129P2/OlaHsd * BALB/c
Zygosity: cx
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Dorn T
Year: 2007
Journal: Blood
Title: RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Volume: 109
Issue: 6
Pages: 2346-55
Publication
First Author: Lee JM
Year: 2004
Journal: J Immunol
Title: IL-15Ralpha is a negative regulator of TCR-activated proliferation in CD4+ T cells.
Volume: 173
Issue: 5
Pages: 3155-64
Publication  
First Author: Cao W
Year: 2016
Journal: Nat Commun
Title: CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Volume: 7
Pages: 11687
Publication
First Author: Jiao A
Year: 2022
Journal: Sci Adv
Title: DExD/H-box helicase 9 intrinsically controls CD8+ T cell-mediated antiviral response through noncanonical mechanisms.
Volume: 8
Issue: 6
Pages: eabk2691
Publication
First Author: McGargill MA
Year: 2005
Journal: J Immunol
Title: Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling.
Volume: 175
Issue: 2
Pages: 656-64
Publication
First Author: Hope JL
Year: 2023
Journal: Cell Rep
Title: PSGL-1 attenuates early TCR signaling to suppress CD8(+) T cell progenitor differentiation and elicit terminal CD8(+) T cell exhaustion.
Volume: 42
Issue: 5
Pages: 112436
Publication  
First Author: Märklin M
Year: 2020
Journal: Cell Immunol
Title: Genetic loss of NFAT2 (NFATc1) impairs B cell development of B1 and B2 B cells.
Volume: 349
Pages: 104048
Publication
First Author: Klammt C
Year: 2015
Journal: Nat Immunol
Title: T cell receptor dwell times control the kinase activity of Zap70.
Volume: 16
Issue: 9
Pages: 961-9
Publication
First Author: Round JL
Year: 2007
Journal: Nat Immunol
Title: Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
Volume: 8
Issue: 2
Pages: 154-61
Publication
First Author: Courtney AH
Year: 2017
Journal: Mol Cell
Title: A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
Volume: 67
Issue: 3
Pages: 498-511.e6
Publication
First Author: Cheng J
Year: 2023
Journal: Cell Metab
Title: Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8(+) T cells in the tumor microenvironment.
Volume: 35
Issue: 6
Pages: 961-978.e10
Publication
First Author: Königsberger S
Year: 2015
Journal: Eur J Immunol
Title: Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms.
Volume: 45
Issue: 2
Pages: 603-11
Publication  
First Author: Liang W
Year: 2019
Journal: Mol Immunol
Title: Ablation of core fucosylation attenuates the signal transduction via T cell receptor to suppress the T cell development.
Volume: 112
Pages: 312-321
Publication
First Author: Marquez ME
Year: 2005
Journal: J Immunol
Title: CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.
Volume: 175
Issue: 11
Pages: 7388-97
Publication
First Author: Kim EY
Year: 2004
Journal: J Immunol
Title: Critical role of TNF receptor type-2 (p75) as a costimulator for IL-2 induction and T cell survival: a functional link to CD28.
Volume: 173
Issue: 7
Pages: 4500-9
Publication
First Author: Leal-Sanchez J
Year: 2007
Journal: Cell Death Differ
Title: Requirement for Daxx in mature T-cell proliferation and activation.
Volume: 14
Issue: 4
Pages: 795-806
Publication
First Author: Bailey AR
Year: 2012
Journal: FASEB J
Title: Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-α: implications for autism.
Volume: 26
Issue: 3
Pages: 1040-51
Publication
First Author: Troeger A
Year: 2013
Journal: J Biol Chem
Title: A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing.
Volume: 288
Issue: 51
Pages: 36451-62
Publication
First Author: Armstrong AJ
Year: 2010
Journal: J Immunol
Title: ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Volume: 184
Issue: 1
Pages: 173-83
Publication
First Author: Salojin K
Year: 1997
Journal: J Exp Med
Title: Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice.
Volume: 186
Issue: 6
Pages: 887-97
Publication
First Author: Haks MC
Year: 2002
Journal: J Exp Med
Title: Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.
Volume: 196
Issue: 1
Pages: 1-13
Publication
First Author: Herling M
Year: 2006
Journal: Leukemia
Title: TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state.
Volume: 20
Issue: 2
Pages: 280-5
Publication
First Author: Liu X
Year: 2005
Journal: J Immunol
Title: Analyzing expression of perforin, Runx3, and Thpok genes during positive selection reveals activation of CD8-differentiation programs by MHC II-signaled thymocytes.
Volume: 175
Issue: 7
Pages: 4465-74
Publication
First Author: Ambrogio C
Year: 2009
Journal: Cancer Res
Title: NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells.
Volume: 69
Issue: 22
Pages: 8611-9
Publication
First Author: Veronese A
Year: 2015
Journal: Leukemia
Title: Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia.
Volume: 29
Issue: 1
Pages: 86-95
Publication
First Author: Law CL
Year: 1994
Journal: J Biol Chem
Title: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.
Volume: 269
Issue: 16
Pages: 12310-9
Publication
First Author: Taniguchi T
Year: 1991
Journal: J Biol Chem
Title: Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis.
Volume: 266
Issue: 24
Pages: 15790-6
Protein Domain
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This entry represents the non-receptor tyrosine kinases SYK and ZAP-70 [, , ]:SYK is a positive effector of BCR-stimulated responses. It couples the B-cell antigen receptor (BCR) to the mobilisation of calcium ion, either through a phosphoinositide 3-kinase-dependent pathway (when not phosphorylated on tyrosines of the linker region), or through a phospholipase C-gamma-dependent pathway (when phosphorylated on Tyr-342 and Tyr-346). Therefore, the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion [, ].ZAP70 plays a role in T-cell development and lymphocyte activation. It is essential for TCR-mediated IL-2 production. Isoform 1 of ZAP70 induces TCR-mediated signal transduction, isoform 2 does not [, ].
Publication
First Author: Chan AC
Year: 1992
Journal: Cell
Title: ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.
Volume: 71
Issue: 4
Pages: 649-62
Publication
First Author: Reeve JL
Year: 2009
Journal: J Immunol
Title: SLP-76 couples Syk to the osteoclast cytoskeleton.
Volume: 183
Issue: 3
Pages: 1804-12
Publication
First Author: Ruzza P
Year: 2009
Journal: Expert Opin Ther Pat
Title: Therapeutic prospect of Syk inhibitors.
Volume: 19
Issue: 10
Pages: 1361-76
Publication
First Author: Arpaia E
Year: 1994
Journal: Cell
Title: Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase.
Volume: 76
Issue: 5
Pages: 947-58
Protein
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 583  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false