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Search results 1 to 100 out of 364 for Mybpc3

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
key_1584454 | Mybpc3
Type: gene
Organism: Not Specified
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Gene
4607 | MYBPC3
Type: gene
Organism: human
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Gene
767614 | MYBPC3
Type: gene
Organism: cattle
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Gene
396013 | MYBPC3
Type: gene
Organism: chicken
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Gene
556489 | mybpc3
Type: gene
Organism: zebrafish
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Gene
712093 | MYBPC3
Type: gene
Organism: macaque, rhesus
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Gene
100127177 | mybpc3
Type: gene
Organism: frog, western clawed
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Gene
295929 | Mybpc3
Type: gene
Organism: rat
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Gene
483624 | MYBPC3
Type: gene
Organism: dog, domestic
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Gene
451168 | MYBPC3
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:102844 | Mybpc3
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
   
Probe: MGI:3821351
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:3825685
Age: embryonic day 14.5
Image: Additional file 4 Mybpc3
Specimen Label: Additional file 4 Mybpc3
Detected: false
Specimen Num: 1
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Publication
26508994 | J:311785
 
First Author: Lynch TL 4th
Year: 2015
Journal: Oxid Med Cell Longev
Title: Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.
Volume: 2015
Pages: 424751
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Publication
27955979 | J:250964
 
First Author: Lynch TL 4th
Year: 2017
Journal: J Mol Cell Cardiol
Title: Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.
Volume: 102
Pages: 83-93
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Publication
25463264 | J:225695
 
First Author: Mearini G
Year: 2014
Journal: Nat Commun
Title: Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice.
Volume: 5
Pages: 5515
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Publication
25463273 | J:274794
 
First Author: Barefield D
Year: 2015
Journal: J Mol Cell Cardiol
Title: Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.
Volume: 79
Pages: 234-43
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Publication
24464755 | J:209649
First Author: Barefield D
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.
Volume: 306
Issue: 6
Pages: H807-15
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Publication
22465693 | J:185726
First Author: Fraysse B
Year: 2012
Journal: J Mol Cell Cardiol
Title: Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice.
Volume: 52
Issue: 6
Pages: 1299-307
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Publication
27108529 | J:251452
 
First Author: Wijnker PJ
Year: 2016
Journal: J Mol Cell Cardiol
Title: Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue.
Volume: 97
Pages: 82-92
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Publication
30674652 | J:307856
 
First Author: Toepfer CN
Year: 2019
Journal: Sci Transl Med
Title: Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin.
Volume: 11
Issue: 476
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Publication
26819945 | J:308093
First Author: Judge DP
Year: 2015
Journal: J Cardiovasc Dev Dis
Title: Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities.
Volume: 2
Issue: 2
Pages: 48-65
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Publication
27068630 | J:342312
First Author: Taylor EN
Year: 2016
Journal: J Am Heart Assoc
Title: Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C.
Volume: 5
Issue: 3
Pages: e002836
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Publication
33528507 | J:341669
 
First Author: Rahmanseresht S
Year: 2021
Journal: J Gen Physiol
Title: The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle.
Volume: 153
Issue: 3
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Publication
22235120 | -
First Author: Howarth JW
Year: 2012
Journal: J Biol Chem
Title: Structural insight into unique cardiac myosin-binding protein-C motif: a partially folded domain.
Volume: 287
Issue: 11
Pages: 8254-62
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Protein
A9JR55
Organism: Mus musculus/domesticus
Length: 1270  
Fragment?: false
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Publication
9769321 | J:50237
First Author: Yang Q
Year: 1998
Journal: J Clin Invest
Title: A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy.
Volume: 102
Issue: 7
Pages: 1292-300
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Publication
21961592 | J:341671
First Author: Palmer BM
Year: 2011
Journal: Biophys J
Title: Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime.
Volume: 101
Issue: 7
Pages: 1661-9
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Publication
34051236 | J:306270
First Author: Singh RR
Year: 2021
Journal: J Biol Chem
Title: Mutations in myosin S2 alter cardiac myosin-binding protein-C interaction in hypertrophic cardiomyopathy in a phosphorylation-dependent manner.
Volume: 297
Issue: 1
Pages: 100836
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Publication
17075052 | J:117119
First Author: Sadayappan S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Cardiac myosin binding protein C phosphorylation is cardioprotective.
Volume: 103
Issue: 45
Pages: 16918-23
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Publication
10532952 | J:59702
First Author: Yang Q
Year: 1999
Journal: Circ Res
Title: In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy.
Volume: 85
Issue: 9
Pages: 841-7
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Publication
30862451 | J:274773
 
First Author: Barefield DY
Year: 2019
Journal: J Mol Cell Cardiol
Title: Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.
Volume: 129
Pages: 236-246
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Publication
19237661 | J:166006
First Author: Sadayappan S
Year: 2009
Journal: Circulation
Title: Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.
Volume: 119
Issue: 9
Pages: 1253-62
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Publication
35288601 | J:329151
First Author: Hou L
Year: 2022
Journal: Sci Rep
Title: Modulation of myosin by cardiac myosin binding protein-C peptides improves cardiac contractility in ex-vivo experimental heart failure models.
Volume: 12
Issue: 1
Pages: 4337
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Publication
32554466 | J:300664
First Author: Kumar M
Year: 2020
Journal: J Biol Chem
Title: Phosphorylation of cardiac myosin-binding protein-C contributes to calcium homeostasis.
Volume: 295
Issue: 32
Pages: 11275-11291
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Publication
16224063 | J:117505
First Author: Sadayappan S
Year: 2005
Journal: Circ Res
Title: Cardiac myosin-binding protein-C phosphorylation and cardiac function.
Volume: 97
Issue: 11
Pages: 1156-63
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Publication
27021517 | J:250965
 
First Author: McNamara JW
Year: 2016
Journal: J Mol Cell Cardiol
Title: Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.
Volume: 94
Pages: 65-71
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Publication
29021349 | J:272088
 
First Author: Singh SR
Year: 2017
Journal: Circ Heart Fail
Title: Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice.
Volume: 10
Issue: 10
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Publication
27323879 | J:307882
 
First Author: Captur G
Year: 2016
Journal: Sci Rep
Title: The embryological basis of subclinical hypertrophic cardiomyopathy.
Volume: 6
Pages: 27714
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Publication
22076249 | J:308126
First Author: Schlossarek S
Year: 2012
Journal: J Muscle Res Cell Motil
Title: Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice.
Volume: 33
Issue: 1
Pages: 5-15
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Publication
23600722 | J:308124
First Author: Vignier N
Year: 2014
Journal: Fundam Clin Pharmacol
Title: AT1 blockade abolishes left ventricular hypertrophy in heterozygous cMyBP-C null mice: role of FHL1.
Volume: 28
Issue: 3
Pages: 249-56
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Publication
26153423 | J:223795
First Author: Jiang J
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis.
Volume: 112
Issue: 29
Pages: 9046-51
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Publication
31026178 | J:277639
First Author: Tabish AM
Year: 2019
Journal: Am J Physiol Heart Circ Physiol
Title: Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy.
Volume: 317
Issue: 1
Pages: H168-H180
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Publication
26825555 | J:252580
First Author: Najafi A
Year: 2016
Journal: Cardiovasc Res
Title: Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.
Volume: 110
Issue: 2
Pages: 200-14
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Publication
25010737 | J:308119
First Author: Najafi A
Year: 2015
Journal: Pflugers Arch
Title: Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice.
Volume: 467
Issue: 6
Pages: 1303-17
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Publication
33430602 | J:342830
First Author: Schuldt M
Year: 2021
Journal: Circ Heart Fail
Title: Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy.
Volume: 14
Issue: 1
Pages: e007022
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Publication
31796859 | J:287323
First Author: Dutsch A
Year: 2019
Journal: Sci Rep
Title: Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue.
Volume: 9
Issue: 1
Pages: 18152
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Publication
30573635 | J:295095
First Author: Giles J
Year: 2019
Journal: J Gen Physiol
Title: Recovery of left ventricular function following in vivo reexpression of cardiac myosin binding protein C.
Volume: 151
Issue: 1
Pages: 77-89
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Publication
28239655 | J:240683
First Author: Nixon BR
Year: 2017
Journal: JCI Insight
Title: Alterations in sarcomere function modify the hyperplastic to hypertrophic transition phase of mammalian cardiomyocyte development.
Volume: 2
Issue: 4
Pages: e90656
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Publication
19590044 | J:164934
First Author: Vignier N
Year: 2009
Journal: Circ Res
Title: Nonsense-mediated mRNA decay and ubiquitin-proteasome system regulate cardiac myosin-binding protein C mutant levels in cardiomyopathic mice.
Volume: 105
Issue: 3
Pages: 239-48
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Publication
28824454 | J:308146
 
First Author: Stücker S
Year: 2017
Journal: Front Physiol
Title: Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model.
Volume: 8
Pages: 558
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Publication
26453301 | J:325375
First Author: Kumar M
Year: 2015
Journal: J Biol Chem
Title: Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.
Volume: 290
Issue: 49
Pages: 29241-9
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Publication
28785686 | J:308145
 
First Author: Friedrich FW
Year: 2015
Journal: Int J Cardiol Heart Vasc
Title: I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model.
Volume: 8
Pages: 87-94
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Publication
28090637 | J:274517
First Author: Flenner F
Year: 2017
Journal: J Physiol
Title: Diltiazem prevents stress-induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3-knock-in mice.
Volume: 595
Issue: 12
Pages: 3987-3999
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Publication
33957110 | J:317177
 
First Author: Flenner F
Year: 2021
Journal: J Mol Cell Cardiol
Title: Translational investigation of electrophysiology in hypertrophic cardiomyopathy.
Volume: 157
Pages: 77-89
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Publication
26241864 | J:225492
First Author: Zhao W
Year: 2015
Journal: PLoS One
Title: A Murine Hypertrophic Cardiomyopathy Model: The DBA/2J Strain.
Volume: 10
Issue: 8
Pages: e0133132
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Publication
37435054 | J:342762
 
First Author: Chou C
Year: 2023
Journal: Front Cardiovasc Med
Title: A novel αB-crystallin R123W variant drives hypertrophic cardiomyopathy by promoting maladaptive calcium-dependent signal transduction.
Volume: 10
Pages: 1223244
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Publication
28659827 | J:307972
 
First Author: Farrell ET
Year: 2017
Journal: Front Physiol
Title: Increased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy.
Volume: 8
Pages: 414
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Protein Coding Gene
MGP_CAROLIEiJ_G0023954 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026142 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026103 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026084 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026112 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_102844 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026563 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025328 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025841 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025977 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025940 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026081 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026617 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025395 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025390 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024864 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
19541641 | J:151897
First Author: Ge Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state.
Volume: 106
Issue: 31
Pages: 12658-63
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Publication
17503784 | J:122293
First Author: Xiao L
Year: 2007
Journal: Biochemistry
Title: PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo.
Volume: 46
Issue: 23
Pages: 7054-61
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Publication
11909824 | J:95725
First Author: Harris SP
Year: 2002
Journal: Circ Res
Title: Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice.
Volume: 90
Issue: 5
Pages: 594-601
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Publication
26100051 | J:225738
 
First Author: Mamidi R
Year: 2015
Journal: J Mol Cell Cardiol
Title: Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C.
Volume: 85
Pages: 262-72
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Publication
22415774 | J:308091
First Author: Vydyanath A
Year: 2012
Journal: J Muscle Res Cell Motil
Title: Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle.
Volume: 33
Issue: 1
Pages: 61-74
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Publication
26913007 | J:312086
 
First Author: Mamidi R
Year: 2016
Journal: Front Physiol
Title: Cardiac Myosin Binding Protein-C Phosphorylation Modulates Myofilament Length-Dependent Activation.
Volume: 7
Pages: 38
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Publication
22855556 | J:308092
First Author: Merkulov S
Year: 2012
Journal: Circ Heart Fail
Title: In vivo cardiac myosin binding protein C gene transfer rescues myofilament contractile dysfunction in cardiac myosin binding protein C null mice.
Volume: 5
Issue: 5
Pages: 635-44
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Publication
24951619 | J:225562
First Author: Gresham KS
Year: 2014
Journal: J Physiol
Title: The contribution of cardiac myosin binding protein-c Ser282 phosphorylation to the rate of force generation and in vivo cardiac contractility.
Volume: 592
Issue: 17
Pages: 3747-65
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Publication
15472117 | J:102256
First Author: Harris SP
Year: 2004
Journal: Circ Res
Title: Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism.
Volume: 95
Issue: 9
Pages: 930-6
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Publication
22850286 | J:189140
First Author: Colson BA
Year: 2012
Journal: J Mol Cell Cardiol
Title: Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.
Volume: 53
Issue: 5
Pages: 609-16
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Publication
18599866 | J:151364
First Author: Colson BA
Year: 2008
Journal: Circ Res
Title: Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium.
Volume: 103
Issue: 3
Pages: 244-51
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Publication
17993479 | J:147680
First Author: Kensler RW
Year: 2008
Journal: Biophys J
Title: The structure of isolated cardiac Myosin thick filaments from cardiac Myosin binding protein-C knockout mice.
Volume: 94
Issue: 5
Pages: 1707-18
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Publication
18252826 | J:131967
First Author: Zoghbi ME
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Three-dimensional structure of vertebrate cardiac muscle myosin filaments.
Volume: 105
Issue: 7
Pages: 2386-90
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Publication
26454159 | J:254005
 
First Author: Wang C
Year: 2016
Journal: J Mol Cell Cardiol
Title: Slowing of contractile kinetics by myosin-binding protein C can be explained by its cooperative binding to the thin filament.
Volume: 96
Pages: 2-10
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Publication
30611859 | J:270764
First Author: Doh CY
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: The HCM-causing Y235S cMyBPC mutation accelerates contractile function by altering C1 domain structure.
Volume: 1865
Issue: 3
Pages: 661-677
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Publication
32750038 | J:308117
 
First Author: Li J
Year: 2020
Journal: JCI Insight
Title: AAV9 gene transfer of cMyBPC N-terminal domains ameliorates cardiomyopathy in cMyBPC-deficient mice.
Volume: 5
Issue: 17
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Publication
22923435 | J:187698
First Author: Previs MJ
Year: 2012
Journal: Science
Title: Molecular mechanics of cardiac myosin-binding protein C in native thick filaments.
Volume: 337
Issue: 6099
Pages: 1215-8
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Publication
21115695 | J:341672
First Author: Chen PP
Year: 2010
Journal: J Gen Physiol
Title: Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein C.
Volume: 136
Issue: 6
Pages: 615-27
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Publication
17254601 | J:121672
First Author: Colson BA
Year: 2007
Journal: J Mol Biol
Title: Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C.
Volume: 367
Issue: 1
Pages: 36-41
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Publication
18817784 | J:168956
First Author: Luther PK
Year: 2008
Journal: J Mol Biol
Title: Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle.
Volume: 384
Issue: 1
Pages: 60-72
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Publication
23277475 | J:307843
First Author: de Lange WJ
Year: 2013
Journal: J Gen Physiol
Title: Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.
Volume: 141
Issue: 1
Pages: 73-84
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Publication
25520665 | J:310509
 
First Author: Mamidi R
Year: 2014
Journal: Front Physiol
Title: Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation.
Volume: 5
Pages: 461
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Publication
16513777 | J:124733
First Author: Stelzer JE
Year: 2006
Journal: Biophys J
Title: Ablation of myosin-binding protein-C accelerates force development in mouse myocardium.
Volume: 90
Issue: 11
Pages: 4119-27
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Publication
18802026 | J:155293
First Author: Tong CW
Year: 2008
Journal: Circ Res
Title: Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function.
Volume: 103
Issue: 9
Pages: 974-82
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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